Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer
Despite advanced screening technology and cancer treatments available today, metastasis remains an ongoing major cause of cancer-related deaths worldwide. Typically, colorectal cancer is one of the cancers treatable by surgery in conjunction with chemotherapy when it is detected at an early stage. H...
| Main Authors: | , , |
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| Format: | Journal Article |
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Springer New York LLC
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/10163 |
| _version_ | 1848746156679495680 |
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| author | Ko, S. Blatch, G. Dass, Crispin |
| author_facet | Ko, S. Blatch, G. Dass, Crispin |
| author_sort | Ko, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Despite advanced screening technology and cancer treatments available today, metastasis remains an ongoing major cause of cancer-related deaths worldwide. Typically, colorectal cancer is one of the cancers treatable by surgery in conjunction with chemotherapy when it is detected at an early stage. However, it still ranks as the second highest modality and mortality of cancer types in western countries, and this is mostly due to a recurrence of metastatic colorectal cancer post-resection of the primary malignancy. Colorectal cancer metastases predominantly occur in the liver and lung, and yet the molecular mechanisms that regulate these organ-specific colorectal cancer metastases are largely unknown. Therefore, the identification of any critical molecule, which triggers malignancy in colorectal cancer, would be an excellent target for treatment. Netrin-1 was initially discovered as a chemotropic neuronal guidance molecule, and has been marked as a regulator for many cancers including colorectal cancer. Here, we summarise key findings of the role of netrin-1 intrinsic to colorectal cancer cells, extrinsic to the tumour microenvironment and angiogenesis, and consequently, we evaluate netrin-1 as a potential target molecule for metastasis. |
| first_indexed | 2025-11-14T06:28:47Z |
| format | Journal Article |
| id | curtin-20.500.11937-10163 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:28:47Z |
| publishDate | 2014 |
| publisher | Springer New York LLC |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-101632017-09-13T14:48:43Z Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer Ko, S. Blatch, G. Dass, Crispin Netrin-1 receptors Netrin-1 Angiogenesis Colorectal cancer Microenvironment Metastasis Despite advanced screening technology and cancer treatments available today, metastasis remains an ongoing major cause of cancer-related deaths worldwide. Typically, colorectal cancer is one of the cancers treatable by surgery in conjunction with chemotherapy when it is detected at an early stage. However, it still ranks as the second highest modality and mortality of cancer types in western countries, and this is mostly due to a recurrence of metastatic colorectal cancer post-resection of the primary malignancy. Colorectal cancer metastases predominantly occur in the liver and lung, and yet the molecular mechanisms that regulate these organ-specific colorectal cancer metastases are largely unknown. Therefore, the identification of any critical molecule, which triggers malignancy in colorectal cancer, would be an excellent target for treatment. Netrin-1 was initially discovered as a chemotropic neuronal guidance molecule, and has been marked as a regulator for many cancers including colorectal cancer. Here, we summarise key findings of the role of netrin-1 intrinsic to colorectal cancer cells, extrinsic to the tumour microenvironment and angiogenesis, and consequently, we evaluate netrin-1 as a potential target molecule for metastasis. 2014 Journal Article http://hdl.handle.net/20.500.11937/10163 10.1007/s10555-013-9459-z Springer New York LLC restricted |
| spellingShingle | Netrin-1 receptors Netrin-1 Angiogenesis Colorectal cancer Microenvironment Metastasis Ko, S. Blatch, G. Dass, Crispin Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer |
| title | Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer |
| title_full | Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer |
| title_fullStr | Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer |
| title_full_unstemmed | Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer |
| title_short | Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer |
| title_sort | netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer |
| topic | Netrin-1 receptors Netrin-1 Angiogenesis Colorectal cancer Microenvironment Metastasis |
| url | http://hdl.handle.net/20.500.11937/10163 |