Homology modeling of coagulase in Staphylococcus aureus
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| collectionurl | https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 |
| date | 2012-05-16 12:02:06 |
| format | Restricted Document |
| id | 7962 |
| institution | UniSZA |
| internalnotes | [1] Lindsay JA et al. Mol Microbiol. 1998 29: 527 [PMID: 9720870] [2] Archer GL, Clin Infect Dis. 1998 26: 1179 [PMID: 9597249]. [3] Boden MK & Flock JI, Infect Immun. 1989 57: 2358 [PMID: 2744851] [4] McDevitt D et al. Infect Immun. 1992 60: 1514 [PMID: 1548075] [5] Cheung AI et al. Infect Immun.1995 63: 1914 [PMID: 7729902] [6] McDevitt D et al. Mol Microbiol. 1994 11: 237 [PMID: 8170386] [7] Moreillon P et al. Infect Immun. 1995 63: 4738 [PMID: 7591130] [8] Panizzi P et al. J Biol Chem. 2006 281: 1179. [PMID: 16230339] [9] Friedrich R et al. J Biol Chem. 2006 281: 1188 [PMID: 16230338] [10] http://www.ncbi.nlm.nih.gov/ [11] http://blast.ncbi.nlm.nih.gov/Blast.cgi. [12] http://nihserver.mbi.ucla.edu/SAVES/ [13] Friedrich R et al. Nature. 2003 425: 535 [PMID: 14523451] [14] Laskowski RA et al. J Biomol NMR. 1996 4: 871 [PMID: 9008363] [15] Luthy R et al. Nature. 1992 356: 83 [PMID: 1538787] [16] Bowie JU et al. Science. 1991 253: 164 [PMID: 1853201] [17] http://source.rcsb.org/jfatcatserver/ceHome.jsp [18] Shindyalov IN & Bourne PE, Protein Eng. 1998 11: 739 [PMID: 9796821] |
| originalfilename | 3770-01-FH02-FBIM-19-25213.pdf |
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| spelling | 7962 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=7962 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal application/pdf 3 1.6 Adobe Acrobat Pro DC 20 Paper Capture Plug-in User user USER UsEr 2012-05-16 12:02:06 3770-01-FH02-FBIM-19-25213.pdf UniSZA Private Access Homology modeling of coagulase in Staphylococcus aureus Bioinformation The close correlation between the ability of coagulase to clot blood plasma and their capacity to produce disease, and the corresponding absence of this property in nonpathogenic strains, have led to the assumption that the coagulase, plays important role in the pathogenesis of disease. Currently, crystal structure of coagulase in Staphylococcus aureus remains indefinable. Thus, the objectives of this research is to generate the three dimensional model of coagulase in S. aureus by using homology modeling approach. In this study, we used bioinformatics tools and databases such as BLAST (Basic Local Alignment Search Tool), GenBank, PDB (Protein Databank), and Discovery Studio to gain specific functional insights into coagulase. The model was validated using protein structure checking tools such as PROCHECK, Verify 3D and CE (Combinatorial Extension) for reliability. Therefore, structure prediction of coagulase in S. aureus can provide preliminary knowledge for understanding the function of the protein. The information from this finding will provide important information into the action and regulation mechanism of the coagulase protein in S. aureus. 8 9 412-415 [1] Lindsay JA et al. Mol Microbiol. 1998 29: 527 [PMID: 9720870] [2] Archer GL, Clin Infect Dis. 1998 26: 1179 [PMID: 9597249]. [3] Boden MK & Flock JI, Infect Immun. 1989 57: 2358 [PMID: 2744851] [4] McDevitt D et al. Infect Immun. 1992 60: 1514 [PMID: 1548075] [5] Cheung AI et al. Infect Immun.1995 63: 1914 [PMID: 7729902] [6] McDevitt D et al. Mol Microbiol. 1994 11: 237 [PMID: 8170386] [7] Moreillon P et al. Infect Immun. 1995 63: 4738 [PMID: 7591130] [8] Panizzi P et al. J Biol Chem. 2006 281: 1179. [PMID: 16230339] [9] Friedrich R et al. J Biol Chem. 2006 281: 1188 [PMID: 16230338] [10] http://www.ncbi.nlm.nih.gov/ [11] http://blast.ncbi.nlm.nih.gov/Blast.cgi. [12] http://nihserver.mbi.ucla.edu/SAVES/ [13] Friedrich R et al. Nature. 2003 425: 535 [PMID: 14523451] [14] Laskowski RA et al. J Biomol NMR. 1996 4: 871 [PMID: 9008363] [15] Luthy R et al. Nature. 1992 356: 83 [PMID: 1538787] [16] Bowie JU et al. Science. 1991 253: 164 [PMID: 1853201] [17] http://source.rcsb.org/jfatcatserver/ceHome.jsp [18] Shindyalov IN & Bourne PE, Protein Eng. 1998 11: 739 [PMID: 9796821] |
| spellingShingle | Homology modeling of coagulase in Staphylococcus aureus |
| summary | The close correlation between the ability of coagulase to clot blood plasma and their capacity to produce disease, and the corresponding absence of this property in nonpathogenic strains, have led to the assumption that the coagulase, plays important role in the pathogenesis of disease. Currently, crystal structure of coagulase in Staphylococcus aureus remains indefinable. Thus, the objectives of this research is to generate the three dimensional model of coagulase in S. aureus by using homology modeling approach. In this study, we used bioinformatics tools and databases such as BLAST (Basic Local Alignment Search Tool), GenBank, PDB (Protein Databank), and Discovery Studio to gain specific functional insights into coagulase. The model was validated using protein structure checking tools such as PROCHECK, Verify 3D and CE (Combinatorial Extension) for reliability. Therefore, structure prediction of coagulase in S. aureus can provide preliminary knowledge for understanding the function of the protein. The information from this finding will provide important information into the action and regulation mechanism of the coagulase protein in S. aureus. |
| title | Homology modeling of coagulase in Staphylococcus aureus |
| title_full | Homology modeling of coagulase in Staphylococcus aureus |
| title_fullStr | Homology modeling of coagulase in Staphylococcus aureus |
| title_full_unstemmed | Homology modeling of coagulase in Staphylococcus aureus |
| title_short | Homology modeling of coagulase in Staphylococcus aureus |
| title_sort | homology modeling of coagulase in staphylococcus aureus |