Immunomodulatory effect of Rhaphidophora korthalsii on natural killer cell cytotoxicity
| Format: | Restricted Document |
|---|
| _version_ | 1860799734559539200 |
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| building | INTELEK Repository |
| collection | Online Access |
| collectionurl | https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 |
| date | 2014-08-20 10:43:00 |
| format | Restricted Document |
| id | 7187 |
| institution | UniSZA |
| originalfilename | 2430-01-FH02-FPBSM-14-01132.jpg |
| person | UniSZA Unisza unisza |
| recordtype | oai_dc |
| resourceurl | https://intelek.unisza.edu.my/intelek/pages/view.php?ref=7187 |
| spelling | 7187 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=7187 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal UniSZA Unisza unisza image/jpeg inches 96 96 1418 37 37 797 2014-08-20 10:43:00 1418x797 2430-01-FH02-FPBSM-14-01132.jpg UniSZA Private Access Immunomodulatory effect of Rhaphidophora korthalsii on natural killer cell cytotoxicity Evidence-based Complementary and alternative medicine The in vivo immunomodulatory effect of ethanolic extracts from leaves of Rhaphidophora korthalsii was determined via immune cell proliferation. T/NK cell phenotyping. and splenocyte cytotoxicity of IBALS/c mice after 5 consecutive days of i p administration at various concentrations Spenocyte proliferation index. cytotoxicity penpheral blood TrNK cell population and plasma cytokine (IL-2 and IFII-y) in mice were assessed on day 5 and day 15. High concentration of extract (35Oug/mice/day for 6 consecutive days) was able to stimulate immune cell proliferation. peripheral blood NK cell population. IL-2 and IFN-v cytokines. as well as splenocyte cytotoxicity against Vac-1 cell line Unlike it-2 which degraded rapidly the stimulatory effect from the extract managed to last until day 15 These results suggested the potential of this extract as an attemative immunostimulator. and they encourage further study on guided fractionation and purification to identify the active ingredients that contribute to this in vitro and in vivo immunomodulatory activity Copyright 0 2012 Swee Keong Yeap et al |
| spellingShingle | Immunomodulatory effect of Rhaphidophora korthalsii on natural killer cell cytotoxicity |
| summary | The in vivo immunomodulatory effect of ethanolic extracts from leaves of Rhaphidophora korthalsii was determined via immune cell proliferation. T/NK cell phenotyping. and splenocyte cytotoxicity of IBALS/c mice after 5 consecutive days of i p administration at various concentrations Spenocyte proliferation index. cytotoxicity penpheral blood TrNK cell population and plasma cytokine (IL-2 and IFII-y) in mice were assessed on day 5 and day 15. High concentration of extract (35Oug/mice/day for 6 consecutive days) was able to stimulate immune cell proliferation. peripheral blood NK cell population. IL-2 and IFN-v cytokines. as well as splenocyte cytotoxicity against Vac-1 cell line Unlike it-2 which degraded rapidly the stimulatory effect from the extract managed to last until day 15 These results suggested the potential of this extract as an attemative immunostimulator. and they encourage further study on guided fractionation and purification to identify the active ingredients that contribute to this in vitro and in vivo immunomodulatory activity Copyright 0 2012 Swee Keong Yeap et al |
| title | Immunomodulatory effect of Rhaphidophora korthalsii on natural killer cell cytotoxicity |
| title_full | Immunomodulatory effect of Rhaphidophora korthalsii on natural killer cell cytotoxicity |
| title_fullStr | Immunomodulatory effect of Rhaphidophora korthalsii on natural killer cell cytotoxicity |
| title_full_unstemmed | Immunomodulatory effect of Rhaphidophora korthalsii on natural killer cell cytotoxicity |
| title_short | Immunomodulatory effect of Rhaphidophora korthalsii on natural killer cell cytotoxicity |
| title_sort | immunomodulatory effect of rhaphidophora korthalsii on natural killer cell cytotoxicity |