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1860799733739552768
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INTELEK Repository
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Online Access
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https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072
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2024-09-24 16:36
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Restricted Document
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7183
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UniSZA
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2424-01-FH02-FPBSM-14-00507.png
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oai_dc
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https://intelek.unisza.edu.my/intelek/pages/view.php?ref=7183
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7183 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=7183 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal Deflate/Inflate 900 1440x900 1440 image/png 2024-09-24 16:36 2424-01-FH02-FPBSM-14-00507.png UniSZA Private Access Noncytotoxic and antitumour-promoting activities of garcinia acid esters from Garcinia atroviridis Griff. ex T. Anders (Guttiferae) Evidence-based complementary and alternative medicine The in alio antitumour-promoting cytotoxic. and antioxidant activities of two ester denvahves of garcinia acid that is 2-(butoxycarbonylmethyl)-3- butoxycatbony1-2-hydroxy-3-propanoltde (1) and 1".1'-dibutyl methyl hydroxycarate (2) that had been previously isolated from the fruits of Garcinia atroviridis Grill ex T Anders (Guniferae) were examined Based on the inhibition of Epstein-Barr virus early antigen (EBV-EA) activation compound 1 (IC60 70M) showed much higher (84o/d)antitumour-promoting activity than compound 2 1050 560M) In addition both compounds were nontoxic towards CEM-SS (human Tlymphoblastic leukemia) cells (CNC 100M). Rap (human 13- lymphoblastoid) cells (CD60 600M) and brine shnmp (1060 300M) Ahhough the antitumour-promoting activity of compound 1 is moderate compared with the known antitumout promoter genistein. its non-toxicity suggests the potential of compound 1 and related structures as chernopreventhe agents. The weak antioxidant activity displayed by both compounds also suggested that the pnmary antitumour-promoting mechanism of compound 1 did not uwohe oxtdatne-stress quenching Copyright A 2012 fAukram M fAac keen et al
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| spellingShingle |
Noncytotoxic and antitumour-promoting activities of garcinia acid esters from Garcinia atroviridis Griff. ex T. Anders (Guttiferae)
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| summary |
The in alio antitumour-promoting cytotoxic. and antioxidant activities of two ester denvahves of garcinia acid that is 2-(butoxycarbonylmethyl)-3- butoxycatbony1-2-hydroxy-3-propanoltde (1) and 1".1'-dibutyl methyl hydroxycarate (2) that had been previously isolated from the fruits of Garcinia atroviridis Grill ex T Anders (Guniferae) were examined Based on the inhibition of Epstein-Barr virus early antigen (EBV-EA) activation compound 1 (IC60 70M) showed much higher (84o/d)antitumour-promoting activity than compound 2 1050 560M) In addition both compounds were nontoxic towards CEM-SS (human Tlymphoblastic leukemia) cells (CNC 100M). Rap (human 13- lymphoblastoid) cells (CD60 600M) and brine shnmp (1060 300M) Ahhough the antitumour-promoting activity of compound 1 is moderate compared with the known antitumout promoter genistein. its non-toxicity suggests the potential of compound 1 and related structures as chernopreventhe agents. The weak antioxidant activity displayed by both compounds also suggested that the pnmary antitumour-promoting mechanism of compound 1 did not uwohe oxtdatne-stress quenching Copyright A 2012 fAukram M fAac keen et al
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| title |
Noncytotoxic and antitumour-promoting activities of garcinia acid esters from Garcinia atroviridis Griff. ex T. Anders (Guttiferae)
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| title_full |
Noncytotoxic and antitumour-promoting activities of garcinia acid esters from Garcinia atroviridis Griff. ex T. Anders (Guttiferae)
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| title_fullStr |
Noncytotoxic and antitumour-promoting activities of garcinia acid esters from Garcinia atroviridis Griff. ex T. Anders (Guttiferae)
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| title_full_unstemmed |
Noncytotoxic and antitumour-promoting activities of garcinia acid esters from Garcinia atroviridis Griff. ex T. Anders (Guttiferae)
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| title_short |
Noncytotoxic and antitumour-promoting activities of garcinia acid esters from Garcinia atroviridis Griff. ex T. Anders (Guttiferae)
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| title_sort |
noncytotoxic and antitumour-promoting activities of garcinia acid esters from garcinia atroviridis griff. ex t. anders (guttiferae)
|