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1860799683463479296
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INTELEK Repository
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Online Access
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https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072
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2011-03-01 08:05:25
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Restricted Document
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6989
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UniSZA
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2050-01-FH02-FSK-20-40903.pdf
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Arbortext Advanced Print Publisher 9.0.114/W
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oai_dc
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https://intelek.unisza.edu.my/intelek/pages/view.php?ref=6989
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6989 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=6989 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal application/pdf 6 1.6 Adobe Acrobat Pro DC 20 Paper Capture Plug-in Arbortext Advanced Print Publisher 9.0.114/W 2011-03-01 08:05:25 2050-01-FH02-FSK-20-40903.pdf UniSZA Private Access Inhibition of chemiluminescence and chemotactic activity of phagocytes in vitro by the extracts of selected medicinal plants Journal of natural medicine The methanol extracts of 20 selected medicinalplants were investigated for their effects on the respiratoryburst of human whole blood, isolated human polymorpho-nuclear leukocytes (PMNs) and isolated mice macrophagesusing a luminol/lucigenin-based chemiluminescence assay.We also tested the effect of the extracts on chemotacticmigration of PMNs using the Boyden chamber technique.The extracts ofCurcuma domesticaL.,Phyllanthus amarusSchum & Thonn andC. xanthorrhizaRoxb. were thesamples producing the strongest oxidative burst of PMNswith luminol-based chemiluminescence, with IC50valuesranging from 0.5 to 0.7lg/ml. For macrophage cells, theextracts which showed strong suppressive activity forluminol-based chemiluminescence wereC. xanthorrhizaandGarcinia mangostanaL.Among the extracts studied,C. manggaValton & Vazsjip, Piper nigrumL. andLabisiapumilavar.alatashowed strong inhibitory activity onlucigenin-amplified oxidative burst of PMNs, with IC50values ranging from 0.9 to 1.5lg/ml. The extracts ofZingiber officinaleRosc.,Alpinia galangal(L.) Willd andAverrhoa bilimbiLinn showed strong inhibition on thechemotaxic migration of cells, with IC50values compara-ble to that of ibuprofen (1.5lg/ml). The results suggestthat some of these plants were able to modulate the innateimmune response of phagocytes at different steps,emphasizing their potential as a source of new immuno-modulatory agents 65 1 400-405
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| spellingShingle |
Inhibition of chemiluminescence and chemotactic activity of phagocytes in vitro by the extracts of selected medicinal plants
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| summary |
The methanol extracts of 20 selected medicinalplants were investigated for their effects on the respiratoryburst of human whole blood, isolated human polymorpho-nuclear leukocytes (PMNs) and isolated mice macrophagesusing a luminol/lucigenin-based chemiluminescence assay.We also tested the effect of the extracts on chemotacticmigration of PMNs using the Boyden chamber technique.The extracts ofCurcuma domesticaL.,Phyllanthus amarusSchum & Thonn andC. xanthorrhizaRoxb. were thesamples producing the strongest oxidative burst of PMNswith luminol-based chemiluminescence, with IC50valuesranging from 0.5 to 0.7lg/ml. For macrophage cells, theextracts which showed strong suppressive activity forluminol-based chemiluminescence wereC. xanthorrhizaandGarcinia mangostanaL.Among the extracts studied,C. manggaValton & Vazsjip, Piper nigrumL. andLabisiapumilavar.alatashowed strong inhibitory activity onlucigenin-amplified oxidative burst of PMNs, with IC50values ranging from 0.9 to 1.5lg/ml. The extracts ofZingiber officinaleRosc.,Alpinia galangal(L.) Willd andAverrhoa bilimbiLinn showed strong inhibition on thechemotaxic migration of cells, with IC50values compara-ble to that of ibuprofen (1.5lg/ml). The results suggestthat some of these plants were able to modulate the innateimmune response of phagocytes at different steps,emphasizing their potential as a source of new immuno-modulatory agents
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| title |
Inhibition of chemiluminescence and chemotactic activity of phagocytes in vitro by the extracts of selected medicinal plants
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| title_full |
Inhibition of chemiluminescence and chemotactic activity of phagocytes in vitro by the extracts of selected medicinal plants
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| title_fullStr |
Inhibition of chemiluminescence and chemotactic activity of phagocytes in vitro by the extracts of selected medicinal plants
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| title_full_unstemmed |
Inhibition of chemiluminescence and chemotactic activity of phagocytes in vitro by the extracts of selected medicinal plants
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| title_short |
Inhibition of chemiluminescence and chemotactic activity of phagocytes in vitro by the extracts of selected medicinal plants
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| title_sort |
inhibition of chemiluminescence and chemotactic activity of phagocytes in vitro by the extracts of selected medicinal plants
|