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1860799470345650176
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INTELEK Repository
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Online Access
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https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072
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| date |
2017-01-22 08:02:39
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United Arab Emirates
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Restricted Document
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6126
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UniSZA
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0908-01-FH03-FBIM-17-08945.pdf
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oai_dc
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https://intelek.unisza.edu.my/intelek/pages/view.php?ref=6126
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6126 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=6126 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Conference Conference Paper application/pdf 1 1.6 Adobe Acrobat Pro DC 20 Paper Capture Plug-in 2017-01-22 08:02:39 0908-01-FH03-FBIM-17-08945.pdf UniSZA Private Access Layer-by-Layer Self-Assembled Dynamic Microcapsules (DynaMicCaps) with Polymer and Protein Shell-walls Triggered delivery is one of the key areas of ongoing research in the field of drug delivery. To achieve triggered drug delivery, a variety of stimuli have been used including light, heat, ultrasound, magnetic field, pH, chemical species, etc. The Murphy group Bioinspired Materials Lab (BML) at UW-Madison has demonstrated biochemical ligand triggered drug delivery from PEG-CaM-PEG (PEG- Poly(ethylene glycol), CaM-Calmodulin) hydrogel slabs and microspheres based on the nanoscale conformational changes of hinge motion protein calmodulin (King, Mohammed, & Murphy, 2009; King, Pytel, Ng, & Murphy, 2010). To our knowledge, there has been no report of triggered drug delivery from dynamic microcapsules. This work presents fabrication (refer to Figure 1) and preliminary results of layer-by-layer (LbL) selfassembled dynamic microcapsules (DynaMicCaps) whose multilayered shell-walls are comprised of polyelectrolytes (polymers whose repeating units bear an electrolyte group) and CaM. It is anticipated that the triggered volume changes in the nano-engineered hollow microcarriers, DynaMicCaps, can be used in triggered drug release applications. 3rd Edition Nanotech Dubai 2016 Conference and Exhibition United Arab Emirates
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| spellingShingle |
Layer-by-Layer Self-Assembled Dynamic Microcapsules (DynaMicCaps) with Polymer and Protein Shell-walls
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| summary |
Triggered delivery is one of the key areas of ongoing research in the field of drug delivery. To achieve triggered drug delivery, a variety of stimuli have been used including light, heat, ultrasound, magnetic field, pH, chemical species, etc. The Murphy group Bioinspired Materials Lab (BML) at UW-Madison has demonstrated biochemical ligand triggered drug delivery from PEG-CaM-PEG (PEG- Poly(ethylene glycol), CaM-Calmodulin) hydrogel slabs and microspheres based on the nanoscale conformational changes of hinge motion protein calmodulin (King, Mohammed, & Murphy, 2009; King, Pytel, Ng, & Murphy, 2010). To our knowledge, there has been no report of triggered drug delivery from dynamic microcapsules. This work presents fabrication (refer to Figure 1) and preliminary results of layer-by-layer (LbL) selfassembled dynamic microcapsules (DynaMicCaps) whose multilayered shell-walls are comprised of polyelectrolytes (polymers whose repeating units bear an electrolyte group) and CaM. It is anticipated that the triggered volume changes in the nano-engineered hollow microcarriers, DynaMicCaps, can be used in triggered drug release applications.
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| title |
Layer-by-Layer Self-Assembled Dynamic Microcapsules (DynaMicCaps) with Polymer and Protein Shell-walls
|
| title_full |
Layer-by-Layer Self-Assembled Dynamic Microcapsules (DynaMicCaps) with Polymer and Protein Shell-walls
|
| title_fullStr |
Layer-by-Layer Self-Assembled Dynamic Microcapsules (DynaMicCaps) with Polymer and Protein Shell-walls
|
| title_full_unstemmed |
Layer-by-Layer Self-Assembled Dynamic Microcapsules (DynaMicCaps) with Polymer and Protein Shell-walls
|
| title_short |
Layer-by-Layer Self-Assembled Dynamic Microcapsules (DynaMicCaps) with Polymer and Protein Shell-walls
|
| title_sort |
layer-by-layer self-assembled dynamic microcapsules (dynamiccaps) with polymer and protein shell-walls
|