2024_The Relationship Between Dietary Fruit Intake, Camp Response Element-Binding (CREB) and Brain Derived Neurotrophic Factor (BDNF) Protein Levels Among Adolescents in Rural and Urban Terengganu
| Format: | General Document |
|---|
| _version_ | 1860798079762956288 |
|---|---|
| building | INTELEK Repository |
| collection | Online Access |
| collectionurl | https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection3 |
| copyright | Copyright©PWB2025 |
| country | Malaysia |
| date | 2024-07-04 |
| format | General Document |
| id | 15831 |
| institution | UniSZA |
| internalnotes | Sila masukkan subject wajib Dissertations, Academic. Terima kasih... |
| originalfilename | THEREL~1.PDF |
| person | Siti Noor Syarma Binti Mohd Sharif |
| recordtype | oai_dc |
| resourceurl | https://intelek.unisza.edu.my/intelek/pages/view.php?ref=15831 |
| sourcemedia | Server storage Scanned document |
| spelling | 15831 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=15831 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection3 General Document Malaysia Library Staff (Top Management) Library Staff (Management) Library Staff (Support) Terengganu Faculty of Health Sciences English application/pdf 1.5 Server storage Scanned document Universiti Sultan Zainal Abidin UniSZA Private Access UNIVERSITI SULTAN ZAINAL ABIDIN SAMBox 3.0.10; modified using iTextSharp™ 5.5.10 ©2000-2016 iText Group NV (AGPL-version) Copyright©PWB2025 136 2024-07-04 THEREL~1.PDF 2024_The Relationship Between Dietary Fruit Intake, Camp Response Element-Binding (CREB) and Brain Derived Neurotrophic Factor (BDNF) Protein Levels Among Adolescents in Rural and Urban Terengganu Siti Noor Syarma Binti Mohd Sharif Dietary habits—Adolescents Introduction: The declining trend in the adequacy of fruit intake among adolescents in Malaysia from 2012 to 2017 has been a cause for concern. Eating at least two servings of fruits daily helps to prevent micronutrient deficiencies, protects against diseases, cancers, and cognitive disorders, and is necessary for the maintenance of normal cognitive functions. The levels of cAMP Response Element-Binding (CREB) and Brain Derived Neurotrophic Factor (BDNF) protein could play a crucial role in neurogenesis and cognitive function. However, little is known about the effects of fruit consumption on CREB and BDNF protein levels among Malaysian adolescents. Therefore, this study aimed to determine the relationship between the types of fruit, serving intake, and nutrients consumed by adolescents in urban and rural Terengganu and their CREB and BDNF protein levels. Methodology: In this cross-sectional study, face-to-face interviews regarding fruit intake assessment were conducted using a validated MyUM Adolescent food frequency questionnaire after fasting blood sample collection among 352 students, aged 14 and 16 years old, from selected eleven secondary schools in Kuala Terengganu, Marang, and Hulu Terengganu districts consisting of rural and urban areas by using multistage random sampling techniques. Serum analyses using an ELISA method were done for CREB and BDNF levels. Data were analysed using Statistical Package for the Social Sciences (SPSS) version 23 software for descriptive and inference analysis, including t-tests, correlations, and regression. Result: The findings showed that 53.7% of adolescents met the daily recommended intake of two servings of fruits, and was significantly higher proportion in urban group. The most preferred fruit eaten was banana. There was a significant difference in the level of CREB and BDNF between adolescents from urban and rural schools. The BDNF level is positively correlated with fruit intake and significantly higher in adolescents who consume more than two servings of fruits per day, while the CREB protein level is negatively correlated with fruit intake. This study also revealed that BDNF was significantly associated with papaya, watermelon, folate, thiamine, and iron. While banana, vitamin A, and folate were found to have a significant association with CREB. Conclusion: The study showed that consuming an adequate serving of fruits can significantly contribute to the protein levels of BDNF and CREB in adolescents in Terengganu, especially in terms of types of fruits, vitamin and mineral intake. There was difference in the amount and type of fruit consumed by adolescents living in rural and urban areas. The findings could potentially serve as preliminary data for future studies on the neuroprotective effects of fruits and, thus, develop better intervention strategies to increase fruit intake among adolescents and prevent cognitive impairment in later life. Dissertations, Academic Sila masukkan subject wajib Dissertations, Academic. Terima kasih... Dietary Fruit Intake And Brain Health bdnf Protein Levels And Nutrition CREB Signaling And Cognitive Function Thesis |
| spellingShingle | 2024_The Relationship Between Dietary Fruit Intake, Camp Response Element-Binding (CREB) and Brain Derived Neurotrophic Factor (BDNF) Protein Levels Among Adolescents in Rural and Urban Terengganu |
| state | Terengganu |
| subject | Dietary habits—Adolescents Dissertations, Academic |
| summary | Introduction: The declining trend in the adequacy of fruit intake among adolescents in Malaysia from 2012 to 2017 has been a cause for concern. Eating at least two servings of fruits daily helps to prevent micronutrient deficiencies, protects against diseases, cancers, and cognitive disorders, and is necessary for the maintenance of normal cognitive functions. The levels of cAMP Response Element-Binding (CREB) and Brain Derived Neurotrophic Factor (BDNF) protein could play a crucial role in neurogenesis and cognitive function. However, little is known about the effects of fruit consumption on CREB and BDNF protein levels among Malaysian adolescents. Therefore, this study aimed to determine the relationship between the types of fruit, serving intake, and nutrients consumed by adolescents in urban and rural Terengganu and their CREB and BDNF protein levels. Methodology: In this cross-sectional study, face-to-face interviews regarding fruit intake assessment were conducted using a validated MyUM Adolescent food frequency questionnaire after fasting blood sample collection among 352 students, aged 14 and 16 years old, from selected eleven secondary schools in Kuala Terengganu, Marang, and Hulu Terengganu districts consisting of rural and urban areas by using multistage random sampling techniques. Serum analyses using an ELISA method were done for CREB and BDNF levels. Data were analysed using Statistical Package for the Social Sciences (SPSS) version 23 software for descriptive and inference analysis, including t-tests, correlations, and regression. Result: The findings showed that 53.7% of adolescents met the daily recommended intake of two servings of fruits, and was significantly higher proportion in urban group. The most preferred fruit eaten was banana. There was a significant difference in the level of CREB and BDNF between adolescents from urban and rural schools. The BDNF level is positively correlated with fruit intake and significantly higher in adolescents who consume more than two servings of fruits per day, while the CREB protein level is negatively correlated with fruit intake. This study also revealed that BDNF was significantly associated with papaya, watermelon, folate, thiamine, and iron. While banana, vitamin A, and folate were found to have a significant association with CREB. Conclusion: The study showed that consuming an adequate serving of fruits can significantly contribute to the protein levels of BDNF and CREB in adolescents in Terengganu, especially in terms of types of fruits, vitamin and mineral intake. There was difference in the amount and type of fruit consumed by adolescents living in rural and urban areas. The findings could potentially serve as preliminary data for future studies on the neuroprotective effects of fruits and, thus, develop better intervention strategies to increase fruit intake among adolescents and prevent cognitive impairment in later life. |
| title | 2024_The Relationship Between Dietary Fruit Intake, Camp Response Element-Binding (CREB) and Brain Derived Neurotrophic Factor (BDNF) Protein Levels Among Adolescents in Rural and Urban Terengganu |
| title_full | 2024_The Relationship Between Dietary Fruit Intake, Camp Response Element-Binding (CREB) and Brain Derived Neurotrophic Factor (BDNF) Protein Levels Among Adolescents in Rural and Urban Terengganu |
| title_fullStr | 2024_The Relationship Between Dietary Fruit Intake, Camp Response Element-Binding (CREB) and Brain Derived Neurotrophic Factor (BDNF) Protein Levels Among Adolescents in Rural and Urban Terengganu |
| title_full_unstemmed | 2024_The Relationship Between Dietary Fruit Intake, Camp Response Element-Binding (CREB) and Brain Derived Neurotrophic Factor (BDNF) Protein Levels Among Adolescents in Rural and Urban Terengganu |
| title_short | 2024_The Relationship Between Dietary Fruit Intake, Camp Response Element-Binding (CREB) and Brain Derived Neurotrophic Factor (BDNF) Protein Levels Among Adolescents in Rural and Urban Terengganu |
| title_sort | 2024_the relationship between dietary fruit intake, camp response element-binding (creb) and brain derived neurotrophic factor (bdnf) protein levels among adolescents in rural and urban terengganu |