2019_Dietary Patterns and Their Relationship with Adiponectin, Leptin and Health-Related Quality of Life Among Breast Cancer Survivors
| Format: | General Document |
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| collectionurl | https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection3 |
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| country | Malaysia |
| date | 2019-10-02 |
| format | General Document |
| id | 15784 |
| institution | UniSZA |
| internalnotes | Sila masukkan subject wajib Dissertations, Academic. Terima kasih... |
| originalfilename | 15784_e41aa7251fd9e55.pdf |
| person | Nor Syamimi Binti Zakarai |
| recordtype | oai_dc |
| resourceurl | https://intelek.unisza.edu.my/intelek/pages/view.php?ref=15784 |
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| spelling | 15784 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=15784 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection3 General Document Malaysia Library Staff (Top Management) Library Staff (Management) Library Staff (Support) Terengganu Faculty of Health Sciences English application/pdf 1.5 211 Server storage Scanned document Universiti Sultan Zainal Abidin UniSZA Private Access UNIVERSITI SULTAN ZAINAL ABIDIN SAMBox 2.3.4; modified using iTextSharp™ 5.5.10 ©2000-2016 iText Group NV (AGPL-version) Copyright©PWB2025 2019-10-02 15784_e41aa7251fd9e55.pdf 2019_Dietary Patterns and Their Relationship with Adiponectin, Leptin and Health-Related Quality of Life Among Breast Cancer Survivors Nor Syamimi Binti Zakarai Dietary patterns—Health aspects Biologically active adipokines such as adiponectin and leptin, and health-related quality of life (HRQoL) are gaining recognition in breast cancer research as modifiable risk factors. Consuming a healthy diet which could favourably modify circulating adipokines concentration and improve HRQoL may be paramount to increase cancer survival. Therefore, it is crucial to discover dietary patterns that have an effect on these adipokines and HRQoL among growing population of breast cancer survivors. Cross-sectional data were collected for 128 breast cancer survivors, aged 37 to 72 years who recruited by using purposive sampling method at two main government hospitals in Kelantan (n=67) and Terengganu (n=61). Serum concentration of high molecular weight (HMW) adiponectin and leptin were measured using an enzyme-linked immunosorbent assay (ELISA). The validated European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and Breast Cancer Supplementary Measure (EORTC QLQ-BR23) were used to measure HRQoL of breast cancer survivors. Dietary intake was assessed by using food frequency questionnaire (FFQ). Reduced rank regression (RRR) method was used to analyse three dietary patterns that explain three set of different response variables hypothesised to be associated with breast cancer survivors i.e. DP-1: dietary energy density, percentage energy from saturated fatty acid (SFA) and dietary fibre; DP-2: percentage energy from sugar and SFA and dietary fibre; DP-3: percentage energy from carbohydrate and dietary fibre. The relationship of the z-scores for each DP and key foods with HMW adiponectin, leptin and HRQoL were examined using multiple linear regressions by adjusting for age, BMI, cancer stage, duration since diagnosed, education level and occupation. Majority of the respondents were Malay (94.5%) with a mean BMI of 27.7 ± 5.03 kg/m². The mean daily intake of energy was 1697 ± 336 kcal/day, protein was 69.4 ± 16.1 g/day (16.5% of energy), carbohydrate was 235.6 ± 58.1 g/day (55.3% of energy) and fat was 53.1 ± 12.5 g/day (28.2% of energy). Overall, breast cancer survivors in this study had an adequate daily intake in which almost all macronutrients and most of the micronutrients intake had met Malaysian Recommended Nutrient Intakes (RNI). The ‘energy-dense, high-SFA and low-fibre’ dietary pattern extracted from DP-1 was negatively associated with HMW adiponectin (β=-0.410, p=0.043). Whereas green leafy vegetables (β=-0.079, p=0.032) and fruit-based vegetables (β=-0.046, p=0.023) were negatively associated with leptin concentration. Although none of DP showed significant relationship with HRQoL, but sugar sweetened drink (β= 0.008, p=0.048) and green leafy vegetables (β=0.040, p=0.012) were positively associated with symptoms score of EORTC QLQ-C30. Similarly, fat-based spread (β=0.411, p=0.021), total vegetables (β=0.041, p=0.002) and green leafy vegetables (β=0.057, p<0.001) had significant positive association with symptoms scores of EORTC QLQ-BR23. In conclusion, ‘Energy-dense, high-SFA and low-fibre’ dietary pattern is an unhealthy dietary pattern and unfavourable for HMW adiponectin concentration but not for leptin and HRQoL. These findings could serve as a basis in developing specific preventive strategies that are tailored to the growing population of breast cancer survivors. Dissertations, Academic Sila masukkan subject wajib Dissertations, Academic. Terima kasih... Nutritional Influence On Post-Cancer Health Diet And Hormone Regulation in Breast Cancer Survivors Adiponectin And Leptin Levels in Cancer Recovery Thesis |
| spellingShingle | 2019_Dietary Patterns and Their Relationship with Adiponectin, Leptin and Health-Related Quality of Life Among Breast Cancer Survivors |
| state | Terengganu |
| subject | Dietary patterns—Health aspects Dissertations, Academic |
| summary | Biologically active adipokines such as adiponectin and leptin, and health-related quality of life (HRQoL) are gaining recognition in breast cancer research as modifiable risk factors. Consuming a healthy diet which could favourably modify circulating adipokines concentration and improve HRQoL may be paramount to increase cancer survival. Therefore, it is crucial to discover dietary patterns that have an effect on these adipokines and HRQoL among growing population of breast cancer survivors. Cross-sectional data were collected for 128 breast cancer survivors, aged 37 to 72 years who recruited by using purposive sampling method at two main government hospitals in Kelantan (n=67) and Terengganu (n=61). Serum concentration of high molecular weight (HMW) adiponectin and leptin were measured using an enzyme-linked immunosorbent assay (ELISA). The validated European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and Breast Cancer Supplementary Measure (EORTC QLQ-BR23) were used to measure HRQoL of breast cancer survivors. Dietary intake was assessed by using food frequency questionnaire (FFQ). Reduced rank regression (RRR) method was used to analyse three dietary patterns that explain three set of different response variables hypothesised to be associated with breast cancer survivors i.e. DP-1: dietary energy density, percentage energy from saturated fatty acid (SFA) and dietary fibre; DP-2: percentage energy from sugar and SFA and dietary fibre; DP-3: percentage energy from carbohydrate and dietary fibre. The relationship of the z-scores for each DP and key foods with HMW adiponectin, leptin and HRQoL were examined using multiple linear regressions by adjusting for age, BMI, cancer stage, duration since diagnosed, education level and occupation. Majority of the respondents were Malay (94.5%) with a mean BMI of 27.7 ± 5.03 kg/m². The mean daily intake of energy was 1697 ± 336 kcal/day, protein was 69.4 ± 16.1 g/day (16.5% of energy), carbohydrate was 235.6 ± 58.1 g/day (55.3% of energy) and fat was 53.1 ± 12.5 g/day (28.2% of energy). Overall, breast cancer survivors in this study had an adequate daily intake in which almost all macronutrients and most of the micronutrients intake had met Malaysian Recommended Nutrient Intakes (RNI). The ‘energy-dense, high-SFA and low-fibre’ dietary pattern extracted from DP-1 was negatively associated with HMW adiponectin (β=-0.410, p=0.043). Whereas green leafy vegetables (β=-0.079, p=0.032) and fruit-based vegetables (β=-0.046, p=0.023) were negatively associated with leptin concentration. Although none of DP showed significant relationship with HRQoL, but sugar sweetened drink (β= 0.008, p=0.048) and green leafy vegetables (β=0.040, p=0.012) were positively associated with symptoms score of EORTC QLQ-C30. Similarly, fat-based spread (β=0.411, p=0.021), total vegetables (β=0.041, p=0.002) and green leafy vegetables (β=0.057, p<0.001) had significant positive association with symptoms scores of EORTC QLQ-BR23. In conclusion, ‘Energy-dense, high-SFA and low-fibre’ dietary pattern is an unhealthy dietary pattern and unfavourable for HMW adiponectin concentration but not for leptin and HRQoL. These findings could serve as a basis in developing specific preventive strategies that are tailored to the growing population of breast cancer survivors. |
| title | 2019_Dietary Patterns and Their Relationship with Adiponectin, Leptin and Health-Related Quality of Life Among Breast Cancer Survivors |
| title_full | 2019_Dietary Patterns and Their Relationship with Adiponectin, Leptin and Health-Related Quality of Life Among Breast Cancer Survivors |
| title_fullStr | 2019_Dietary Patterns and Their Relationship with Adiponectin, Leptin and Health-Related Quality of Life Among Breast Cancer Survivors |
| title_full_unstemmed | 2019_Dietary Patterns and Their Relationship with Adiponectin, Leptin and Health-Related Quality of Life Among Breast Cancer Survivors |
| title_short | 2019_Dietary Patterns and Their Relationship with Adiponectin, Leptin and Health-Related Quality of Life Among Breast Cancer Survivors |
| title_sort | 2019_dietary patterns and their relationship with adiponectin, leptin and health-related quality of life among breast cancer survivors |