2024_A Digital Therapy for Diabetes Prevention Among High-Risk Individuals: A Randomised Controlled Trial of Malaysia Diabetes Prevention Programme (MyDiPP)
| Format: | General Document |
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| _version_ | 1860798067700137984 |
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| building | INTELEK Repository |
| collection | Online Access |
| collectionurl | https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection3 |
| copyright | Copyright©PWB2025 |
| country | Malaysia |
| date | 2024-07-21 |
| format | General Document |
| id | 15740 |
| institution | UniSZA |
| internalnotes | Sila masukkan subject wajib Dissertations, Academic. Terima kasih... |
| originalfilename | A DIGITAL THERAPY FOR DIABETES PREVENTION AMONG HIGH-RISK INDIVIDUALS_ A RANDOMISED CONTROLLED TRIAL OF MALAYSIA DIABETES PREVENTION PROGRAMME (MyDiPP) (PHD_2024).pdf |
| person | Nurul Fatihah Binti Mohd Fauzi |
| recordtype | oai_dc |
| resourceurl | https://intelek.unisza.edu.my/intelek/pages/view.php?ref=15740 |
| sourcemedia | Server storage Scanned document |
| spelling | 15740 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=15740 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection3 General Document Malaysia Library Staff (Top Management) Library Staff (Management) Library Staff (Support) Terengganu Faculty of Health Sciences English application/pdf 1.5 Server storage Scanned document Universiti Sultan Zainal Abidin UniSZA Private Access UNIVERSITI SULTAN ZAINAL ABIDIN SAMBox 3.0.10; modified using iTextSharp™ 5.5.10 ©2000-2016 iText Group NV (AGPL-version) Copyright©PWB2025 657 A DIGITAL THERAPY FOR DIABETES PREVENTION AMONG HIGH-RISK INDIVIDUALS_ A RANDOMISED CONTROLLED TRIAL OF MALAYSIA DIABETES PREVENTION PROGRAMME (MyDiPP) (PHD_2024).pdf 2024_A Digital Therapy for Diabetes Prevention Among High-Risk Individuals: A Randomised Controlled Trial of Malaysia Diabetes Prevention Programme (MyDiPP) Nurul Fatihah Binti Mohd Fauzi 2024-07-21 Diabetes—Prevention & control Lifestyle interventions can reduce the risk of type 2 diabetes mellitus (T2DM) in high risk adults. The Diabetes Prevention Program (DPP) discovered that weight loss through diet and exercise reduces this risk. However, implementing and maintaining the DPP face challenges. Therefore, several interventions have combined human coaching with technology, known as “digital therapy”. Based on digital DPP's success in reducing T2DM risk, this present study aims to examine the efficacy of the Malaysia Diabetes Prevention Programme (MyDiPP) mobile app among high-risk adults of developing T2DM. This study had two phases. Phase I was a cross-sectional study, involved developing the MyDiPP module and mobile app, assessing content validity among four experts, and conducting a pilot usability test on 10 high-risk adults for T2DM (American Diabetes Association Diabetes Risk Score ≥ 5, or HbA1c of 5.6-6.2%). Phase II was a randomised controlled trial (RCT) assessing the effectiveness of the MyDiPP mobile app in high-risk adults for T2DM aged 18-65 with a BMI ≥ 23 kg/m2 that were randomly assigned to either the intervention or control group for 12 months. The primary outcomes were changes in body weight and HbA1c levels, meanwhile, the secondary outcomes were changes in physical activity levels, dietary intake, and health related quality of life (HRQoL) measured within groups from 0-6 months and 0-12 months as well as between groups at the six- and 12-month time points. The secondary outcomes were assessed through the International Physical Activity Questionnaire (IPAQ) Short Form, 24-hours diet recall, and SF-36 health survey questionnaire, respectively. Each outcome was measured at baseline, 6 and 12 months, where the changes within and between groups over time were measured using repeated measure ANCOVA. For Phase I, the content validity index for each item (I-CVI) in the module met the cut-off score of 1.00, and the MyDiPP mobile app met usability requirements. For Phase II, analysis of the primary outcomes found significant differences in weight changes between groups at the six months (intervention: -0.87 kg vs control: 1.41 kg, p=0.014) and 12 months (intervention: -0.56 kg vs control: 1.53 kg, p=0.042) intervention, whereas, there was no significant difference in HbA1c changes between groups at six months (intervention: -0.05% vs control: 0.07%, p=0.108) and 12 months (intervention: 0.11% vs control: 0.13%, p=0.841) intervention. For secondary outcomes, no significant differences were observed between groups for changes in physical activity level, dietary intake, and HRQoL at six- and 12-month intervention. Similarly, there were no significant differences within each group for weight, HbA1C, physical activity level, and dietary intake at any point measured. However, the intervention group showed notable improvements in HRQoL domains, like role emotion (RE) (p=0.001) and mental component summary (MCS) (p=0.015), over the 0-6-month time interval. Collectively, these results suggest that the MyDiPP mobile app can help high-risk adults reduce body weight and produce improvements in several HRQoL domains. These findings reassure policymakers about the reliability and effectiveness of digital DPP for diabetes prevention, but further studies are warranted to determine if better results can be achieved in larger trials. Dissertations, Academic Sila masukkan subject wajib Dissertations, Academic. Terima kasih... Digital Therapy For Diabetes Prevention Mobile Health (mHealth) Interventions Randomized Controlled Trial (RCT) in Diabetes Thesis |
| spellingShingle | 2024_A Digital Therapy for Diabetes Prevention Among High-Risk Individuals: A Randomised Controlled Trial of Malaysia Diabetes Prevention Programme (MyDiPP) |
| state | Terengganu |
| subject | Diabetes—Prevention & control Dissertations, Academic |
| summary | Lifestyle interventions can reduce the risk of type 2 diabetes mellitus (T2DM) in high risk adults. The Diabetes Prevention Program (DPP) discovered that weight loss through diet and exercise reduces this risk. However, implementing and maintaining the DPP face challenges. Therefore, several interventions have combined human coaching with technology, known as “digital therapy”. Based on digital DPP's success in reducing T2DM risk, this present study aims to examine the efficacy of the Malaysia Diabetes Prevention Programme (MyDiPP) mobile app among high-risk adults of developing T2DM. This study had two phases. Phase I was a cross-sectional study, involved developing the MyDiPP module and mobile app, assessing content validity among four experts, and conducting a pilot usability test on 10 high-risk adults for T2DM (American Diabetes Association Diabetes Risk Score ≥ 5, or HbA1c of 5.6-6.2%). Phase II was a randomised controlled trial (RCT) assessing the effectiveness of the MyDiPP mobile app in high-risk adults for T2DM aged 18-65 with a BMI ≥ 23 kg/m2 that were randomly assigned to either the intervention or control group for 12 months. The primary outcomes were changes in body weight and HbA1c levels, meanwhile, the secondary outcomes were changes in physical activity levels, dietary intake, and health related quality of life (HRQoL) measured within groups from 0-6 months and 0-12 months as well as between groups at the six- and 12-month time points. The secondary outcomes were assessed through the International Physical Activity Questionnaire (IPAQ) Short Form, 24-hours diet recall, and SF-36 health survey questionnaire, respectively. Each outcome was measured at baseline, 6 and 12 months, where the changes within and between groups over time were measured using repeated measure ANCOVA. For Phase I, the content validity index for each item (I-CVI) in the module met the cut-off score of 1.00, and the MyDiPP mobile app met usability requirements. For Phase II, analysis of the primary outcomes found significant differences in weight changes between groups at the six months (intervention: -0.87 kg vs control: 1.41 kg, p=0.014) and 12 months (intervention: -0.56 kg vs control: 1.53 kg, p=0.042) intervention, whereas, there was no significant difference in HbA1c changes between groups at six months (intervention: -0.05% vs control: 0.07%, p=0.108) and 12 months (intervention: 0.11% vs control: 0.13%, p=0.841) intervention. For secondary outcomes, no significant differences were observed between groups for changes in physical activity level, dietary intake, and HRQoL at six- and 12-month intervention. Similarly, there were no significant differences within each group for weight, HbA1C, physical activity level, and dietary intake at any point measured. However, the intervention group showed notable improvements in HRQoL domains, like role emotion (RE) (p=0.001) and mental component summary (MCS) (p=0.015), over the 0-6-month time interval. Collectively, these results suggest that the MyDiPP mobile app can help high-risk adults reduce body weight and produce improvements in several HRQoL domains. These findings reassure policymakers about the reliability and effectiveness of digital DPP for diabetes prevention, but further studies are warranted to determine if better results can be achieved in larger trials. |
| title | 2024_A Digital Therapy for Diabetes Prevention Among High-Risk Individuals: A Randomised Controlled Trial of Malaysia Diabetes Prevention Programme (MyDiPP) |
| title_full | 2024_A Digital Therapy for Diabetes Prevention Among High-Risk Individuals: A Randomised Controlled Trial of Malaysia Diabetes Prevention Programme (MyDiPP) |
| title_fullStr | 2024_A Digital Therapy for Diabetes Prevention Among High-Risk Individuals: A Randomised Controlled Trial of Malaysia Diabetes Prevention Programme (MyDiPP) |
| title_full_unstemmed | 2024_A Digital Therapy for Diabetes Prevention Among High-Risk Individuals: A Randomised Controlled Trial of Malaysia Diabetes Prevention Programme (MyDiPP) |
| title_short | 2024_A Digital Therapy for Diabetes Prevention Among High-Risk Individuals: A Randomised Controlled Trial of Malaysia Diabetes Prevention Programme (MyDiPP) |
| title_sort | 2024_a digital therapy for diabetes prevention among high-risk individuals: a randomised controlled trial of malaysia diabetes prevention programme (mydipp) |