2021_The Expression of SOX2 Protein and Its Association With Clinicopathological Factors in Invasive Breast Cancer: A Hospital-Based Study
| Format: | General Document |
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| collectionurl | https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection3 |
| copyright | Copyright©PWB2025 |
| country | Malaysia |
| date | 2021-07-11 |
| format | General Document |
| id | 15526 |
| institution | UniSZA |
| internalnotes | Sila masukkan subject wajib Dissertations, Academic. Terima kasih... |
| originalfilename | 15526_7789ebff728e243.pdf |
| person | Nik Armiza Binti Mat Rashid |
| recordtype | oai_dc |
| resourceurl | https://intelek.unisza.edu.my/intelek/pages/view.php?ref=15526 |
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| spelling | 15526 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=15526 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection3 General Document Malaysia Library Staff (Top Management) Library Staff (Management) Library Staff (Support) Terengganu Faculty of Medicine English application/pdf 1.5 Server storage Scanned document Universiti Sultan Zainal Abidin UniSZA Private Access Universiti Sultan Zainal Abidin SAMBox 2.3.4; modified using iTextSharp™ 5.5.10 ©2000-2016 iText Group NV (AGPL-version) 159 2021-07-11 15526_7789ebff728e243.pdf 2021_The Expression of SOX2 Protein and Its Association With Clinicopathological Factors in Invasive Breast Cancer: A Hospital-Based Study Copyright©PWB2025 Nik Armiza Binti Mat Rashid Breast cancer is the fifth leading cause of cancer-related deaths among women, accounting for 571 000 deaths worldwide. In Malaysia, breast cancer is the leading cause of cancer deaths among women, accounting for 32.1% of the total cancer cases. In Asia, there has been a sharp increase in cases of breast cancer detected in recent years over cases of cervical cancer. The SOX2 protein has the ability to regenerate cancer stem cells that are responsible for the growth of many types of cancer including breast cancer. The SOX2 protein is identified to play a role in the tumorigenesis of breast cancer. Therefore, it has the potential to be studied as a tumour marker and for a target of immunotherapy. However, there was a limited study on the association between SOX2 protein and the clinicopathological factors of invasive breast cancer among Malaysian populations. The purpose of this study was to identify the association between the expression of SOX2 protein and the clinicopathological factors of invasive breast cancer cases in Hospital Sultanah Nur Zahirah, Kuala Terengganu. One hundred archived paraffin blocks samples of invasive breast carcinomas were evaluated for the expression of SOX2 protein by using immunohistochemistry. The positive cases for SOX2 protein expression were then confirmed by Fluorescence In-Situ Hybridisation for the SOX2 amplification status. The association between SOX2 protein expression and the results of the clinicopathological factors were analysed using Fisher Exact bioinformatic analysis. The P-values less than 0.05 were considered as statistically significant. The expression of SOX2 protein was detected in 6.0% of invasive breast carcinomas. The protein expression showed a positive association with tumour recurrence, tumour size and lymphovascular invasion. Furthermore, SOX2 protein expression was associated with a greater number of lymph nodes metastasis. However, SOX2 expression was not associated with tumour grade, ER positivity, PR positivity and HER2 protein overexpression. SOX2 may be used as a prognostic marker of invasive breast carcinoma. Further studies need to be designed to elucidate its role in the management of invasive breast carcinoma. Breast cancer—Molecular aspects Dissertations, Academic Sila masukkan subject wajib Dissertations, Academic. Terima kasih... Breast Cancer Biomarkers Invasive Breast Carcinoma Immunohistochemistry In Cancer Thesis |
| spellingShingle | 2021_The Expression of SOX2 Protein and Its Association With Clinicopathological Factors in Invasive Breast Cancer: A Hospital-Based Study |
| state | Terengganu |
| subject | Breast cancer—Molecular aspects Dissertations, Academic |
| summary | Breast cancer is the fifth leading cause of cancer-related deaths among women, accounting for 571 000 deaths worldwide. In Malaysia, breast cancer is the leading cause of cancer deaths among women, accounting for 32.1% of the total cancer cases. In Asia, there has been a sharp increase in cases of breast cancer detected in recent years over cases of cervical cancer. The SOX2 protein has the ability to regenerate cancer stem cells that are responsible for the growth of many types of cancer including breast cancer. The SOX2 protein is identified to play a role in the tumorigenesis of breast cancer. Therefore, it has the potential to be studied as a tumour marker and for a target of immunotherapy. However, there was a limited study on the association between SOX2 protein and the clinicopathological factors of invasive breast cancer among Malaysian populations. The purpose of this study was to identify the association between the expression of SOX2 protein and the clinicopathological factors of invasive breast cancer cases in Hospital Sultanah Nur Zahirah, Kuala Terengganu. One hundred archived paraffin blocks samples of invasive breast carcinomas were evaluated for the expression of SOX2 protein by using immunohistochemistry. The positive cases for SOX2 protein expression were then confirmed by Fluorescence In-Situ Hybridisation for the SOX2 amplification status. The association between SOX2 protein expression and the results of the clinicopathological factors were analysed using Fisher Exact bioinformatic analysis. The P-values less than 0.05 were considered as statistically significant. The expression of SOX2 protein was detected in 6.0% of invasive breast carcinomas. The protein expression showed a positive association with tumour recurrence, tumour size and lymphovascular invasion. Furthermore, SOX2 protein expression was associated with a greater number of lymph nodes metastasis. However, SOX2 expression was not associated with tumour grade, ER positivity, PR positivity and HER2 protein overexpression. SOX2 may be used as a prognostic marker of invasive breast carcinoma. Further studies need to be designed to elucidate its role in the management of invasive breast carcinoma. |
| title | 2021_The Expression of SOX2 Protein and Its Association With Clinicopathological Factors in Invasive Breast Cancer: A Hospital-Based Study |
| title_full | 2021_The Expression of SOX2 Protein and Its Association With Clinicopathological Factors in Invasive Breast Cancer: A Hospital-Based Study |
| title_fullStr | 2021_The Expression of SOX2 Protein and Its Association With Clinicopathological Factors in Invasive Breast Cancer: A Hospital-Based Study |
| title_full_unstemmed | 2021_The Expression of SOX2 Protein and Its Association With Clinicopathological Factors in Invasive Breast Cancer: A Hospital-Based Study |
| title_short | 2021_The Expression of SOX2 Protein and Its Association With Clinicopathological Factors in Invasive Breast Cancer: A Hospital-Based Study |
| title_sort | 2021_the expression of sox2 protein and its association with clinicopathological factors in invasive breast cancer: a hospital-based study |