Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus F.M. Jarrett
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| caption | One of the most promising plants in biological screening test results of thirteen Artocarpus species was Artocarpus obtusus FM Jarrett and detailed phytochemical investigation of powdered dried bark of the plant has led to the isolation and identification of three xanthones; pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2) and pyranocycloartobiloxanthone B (3). These compounds were screened for antioxidant, antimicrobial and tyrosinase inhibitory activities. Pyranocycloartobiloxanthone A (1) exhibited a strong free radical scavenger towards DPPH free radicals with IC50 value of 2 µg/mL with prominent discoloration observed in comparison with standard ascorbic acid, α-tocopherol and quercetin, The compound also exhibited antibacterial activity against methicillin resistant Staphylococcus aureus (ATCC3359) and Bacillus subtilis (clinically isolated) with inhibition zone of 20 and 12 mm, respectively. However the other two xanthones were found to be inactive. For the tyrosinase inhibitory activity, again compound (1) displayed strong activity comparable with the standard kojic acid. |
| collection | Online Access |
| collectionurl | https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 |
| date | 2024-08-26 15:43:11 |
| format | Restricted Document |
| id | 14524 |
| institution | UniSZA |
| originalfilename | 2451-01-FH02-FPBSM-14-00519.pdf |
| person | Mohd Aspollah Sukari Najihah Mohd. Hashim Mawardi Rahmani Gwendoline Cheng Lian Ee Maizatulakmal Yahayu Muhamad Aizat Mohd Amin Abd Manaf Ali Rusea Go |
| recordtype | oai_dc |
| resourceurl | https://intelek.unisza.edu.my/intelek/pages/view.php?ref=14524 |
| spelling | 14524 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=14524 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal application/pdf Adobe Acrobat Pro DC 20 Paper Capture Plug-in with ClearScan 13 1.6 Mohd Aspollah Sukari Najihah Mohd. Hashim Mawardi Rahmani Gwendoline Cheng Lian Ee Maizatulakmal Yahayu Muhamad Aizat Mohd Amin Abd Manaf Ali Rusea Go 2024-08-26 15:43:11 One of the most promising plants in biological screening test results of thirteen Artocarpus species was Artocarpus obtusus FM Jarrett and detailed phytochemical investigation of powdered dried bark of the plant has led to the isolation and identification of three xanthones; pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2) and pyranocycloartobiloxanthone B (3). These compounds were screened for antioxidant, antimicrobial and tyrosinase inhibitory activities. Pyranocycloartobiloxanthone A (1) exhibited a strong free radical scavenger towards DPPH free radicals with IC50 value of 2 µg/mL with prominent discoloration observed in comparison with standard ascorbic acid, α-tocopherol and quercetin, The compound also exhibited antibacterial activity against methicillin resistant Staphylococcus aureus (ATCC3359) and Bacillus subtilis (clinically isolated) with inhibition zone of 20 and 12 mm, respectively. However the other two xanthones were found to be inactive. For the tyrosinase inhibitory activity, again compound (1) displayed strong activity comparable with the standard kojic acid. One of the most promising plants in biological screening test results of thirteen Artocarpus species was Artocarpus obtusus FM Jarrett and detailed phytochemical investigation of powdered dried bark of the plant has led to the isolation and identification of three xanthones; pyranocycloartobiloxanthone A (1) dihydroartoindonesianin C (2) and pyranocycloartobiloxanthone B (3). These compounds were screened for antioxidant antimicrobial and tyrosinase inhibitory activities. Pyranocycloartobiloxanthone A (1) exhibited a strong free radical scavenger towards DPPH free radicals with IC50 value of 2 µg/mL with prominent discoloration observed in comparison with standard ascorbic acid α-tocopherol and quercetin The compound also exhibited antibacterial activity against methicillin resistant Staphylococcus aureus (ATCC3359) and Bacillus subtilis (clinically isolated) with inhibition zone of 20 and 12 mm respectively. However the other two xanthones were found to be inactive. For the tyrosinase inhibitory activity again compound (1) displayed strong activity comparable with the standard kojic acid. 2451-01-FH02-FPBSM-14-00519.pdf UniSZA Private Access Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus F.M. Jarrett Molecules One of the most promising plants in biological screening test results of thirteen Artocarpus species was Artocarpus obtusus FM Jarrett and detailed phytochemical investigation of powdered dried bark of the plant has led to the isolation and identification of three xanthones; pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2) and pyranocycloartobiloxanthone B (3). These compounds were screened for antioxidant, antimicrobial and tyrosinase inhibitory activities. Pyranocycloartobiloxanthone A (1) exhibited a strong free radical scavenger towards DPPH free radicals with IC50 value of 2 µg/mL with prominent discoloration observed in comparison with standard ascorbic acid, α-tocopherol and quercetin, The compound also exhibited antibacterial activity against methicillin resistant Staphylococcus aureus (ATCC3359) and Bacillus subtilis (clinically isolated) with inhibition zone of 20 and 12 mm, respectively. However the other two xanthones were found to be inactive. For the tyrosinase inhibitory activity, again compound (1) displayed strong activity comparable with the standard kojic acid 6071-6082 |
| spellingShingle | Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus F.M. Jarrett |
| subject | One of the most promising plants in biological screening test results of thirteen Artocarpus species was Artocarpus obtusus FM Jarrett and detailed phytochemical investigation of powdered dried bark of the plant has led to the isolation and identification of three xanthones; pyranocycloartobiloxanthone A (1) dihydroartoindonesianin C (2) and pyranocycloartobiloxanthone B (3). These compounds were screened for antioxidant antimicrobial and tyrosinase inhibitory activities. Pyranocycloartobiloxanthone A (1) exhibited a strong free radical scavenger towards DPPH free radicals with IC50 value of 2 µg/mL with prominent discoloration observed in comparison with standard ascorbic acid α-tocopherol and quercetin The compound also exhibited antibacterial activity against methicillin resistant Staphylococcus aureus (ATCC3359) and Bacillus subtilis (clinically isolated) with inhibition zone of 20 and 12 mm respectively. However the other two xanthones were found to be inactive. For the tyrosinase inhibitory activity again compound (1) displayed strong activity comparable with the standard kojic acid. |
| summary | One of the most promising plants in biological screening test results of thirteen Artocarpus species was Artocarpus obtusus FM Jarrett and detailed phytochemical investigation of powdered dried bark of the plant has led to the isolation and identification of three xanthones; pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2) and pyranocycloartobiloxanthone B (3). These compounds were screened for antioxidant, antimicrobial and tyrosinase inhibitory activities. Pyranocycloartobiloxanthone A (1) exhibited a strong free radical scavenger towards DPPH free radicals with IC50 value of 2 µg/mL with prominent discoloration observed in comparison with standard ascorbic acid, α-tocopherol and quercetin, The compound also exhibited antibacterial activity against methicillin resistant Staphylococcus aureus (ATCC3359) and Bacillus subtilis (clinically isolated) with inhibition zone of 20 and 12 mm, respectively. However the other two xanthones were found to be inactive. For the tyrosinase inhibitory activity, again compound (1) displayed strong activity comparable with the standard kojic acid |
| title | Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus F.M. Jarrett |
| title_full | Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus F.M. Jarrett |
| title_fullStr | Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus F.M. Jarrett |
| title_full_unstemmed | Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus F.M. Jarrett |
| title_short | Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus F.M. Jarrett |
| title_sort | antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus f.m. jarrett |