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1860797549066059776
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INTELEK Repository
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Online Access
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https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072
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2016-07-21 12:10:57
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Restricted Document
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13196
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UniSZA
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1. Mizoguchi H, Narita M, Wu H, Suzuki T, Nagase H, Tseng LF. Differential involvement of mu-opioid receptors in endomorphin-and beta-endorphin-induced G-protein activation in the mouse pons/medulla. Neuroscience 2000; 100:835-9. 2. Feng Y, He X, Yang Y, Chao D, Lazarus LH, Xia Y. Current research on opioid receptor function. Curr Drug Targets 2012;13:230-46. 3. Saidak Z, Blake-Palmer K, Hay DL, Northup JK, Glass M. Differential activation of G-proteins by mu-opioid receptor agonists. Br J Pharmacol 2006;147:671-80. 4. Zubieta JK, Smith YR, Bueller JA, Xu Y, Kilbourn MR, Jewett DM, et al. Regional mu opioid receptor regulation of sensory and affective dimensions of pain. Science 2001;293:311-5. 5. Young EE, Lariviere WR, Belfer I. Genetic basis of pain variability: recent advances. J Med Genet 2012;49:1-9. 6. Govoni S, Regazzi M, Ranzani GN. Pain and the pharmacogenetics at the fuzzy border between pain physiopathology and pain treatment. Eur J Pain Suppl 2008;2 Suppl 1:5-12. 7. Lind AL, Gordh TE. Research on genes predisposing for chronic pain: a challenge for pain researchers in scandinavia. Scandinavian J Pain 2009;1 Suppl 1:24-6. 8. Lötsch J, Geisslinger G, Tegeder I. Genetic modulation of the pharmacological treatment of pain. Pharmacol Ther 2009;124:168-84. 9. Miaskowski C. Understanding the genetic determinants of pain and pain management. Semin Oncol Nurs 2009;25(2, Suppl 1):1-7. 10. Kim DH, Schwartz CE. The genetics of pain: implications for evaluation and treatment of spinal disease. Spine J 2010;10:827-40. 11. Kasai S, Ikeda K. Pharmacogenomics of the human μ-opioid receptor. Pharmacogenomics 2011;12:1305-20. 12. Shipton EA. Pharmacogenomics in acute pain. Trends Anaesthesia Critical Care 2011;1:117-22. 13. Hagelberg N, Aalto S, Tuominen L, Pesonen U, Nagren K, Hietala J, et al. Striatal mu-opioid receptor availability predicts cold pressor pain-threshold in healthy human subjects. Neurosci Lett 2012;521:11-4. 14. Fillingim RB, Kaplan L, Staud R, Ness TJ, Glover TL, Campbell CM, et al. The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. J Pain 2005;6:159-67. 15. Lotsch J, Stuck B, Hummel T. The human μ-opioid receptor gene polymorphism 118A>G decreases cortical activation in response to specific nociceptive stimulation. Behav Neurosci 2006;120:1218-24. 16. Hastie BA, Riley JL, Kaplan L, Herrera DG, Campbell CM, Virtusio K, et al. Ethnicity interacts with the OPRM1 gene in experimental pain sensitivity. Pain 2012;153:1610-9. 17. Huang CJ, Liu HF, Su NY, Hsu YW, Yang CH, Chen CC, et al. Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*. Anaesthesia 2008;63:1288-95. 18. Chen AC, Dworkin SF, Haug J, Gehrig J. Human pain responsivity in a tonic pain model: psychological determinants. Pain 1989;37:143-60. 19. Compton P, Charuvastra VC, Ling W. Pain intolerance in opioid maintained former opiate addicts: effect of long-acting maintenance agent. Drug Alcohol Depend 2001;63:139-46. 20. Zahari Z, Lee CS, Tan SC, Mohamad N, Lee YY, Ismail R. Relationship between cold pressor pain-sensitivity and sleep quality in opioid-dependent males on methadone treatment. Peer J 2015;3:e839. 21. Wolf S, Hardy JD. Studies on pain. Observations on pain due to local cooling and on factors involved in the “cold pressor” effect. J Clin Invest 1941;20:521-33. 22. Harris G, Rollman GB. The validity of experimental pain measures. Pain 1983;17:369-76. 23. Glynn CJ, Lloyd JW. The diurnal variation in perception of pain. Proc R Soc Med 1976;69:369-72. 24. Mohamed Nazar NI. Therapeutic drug monitoring in methadone maintenance therapy (mmt): an evaluation of genetic factors influencing clinical outcomes and serum concentrations of methadone: Ph. D Thesis, Universiti Sains Malaysia; 2013. 25. Cohen J. A power primer. Psychol Bull 1992;112:155-9. 26. Belfer I, Segall SK, Lariviere WR, Smith SB, Dai F, Slade GG, et al. Pain modality-and sex-specific effects of COMT genetic functional variants. Pain 2013;154:1368-76. 27. Tan EC, Tan CH, Karupathivan U, Yap EP. Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations. Neuroreport 2003;14:569-72. 28. Zhang W, Chang YZ, Kan QC, Zhang LR, Lu H, Chu QJ, et al. Association of human μ-opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecological patients. Anaesthesia 2010;65:130-5. 29. Fukuda K, Hayashida M, Ide S, Saita N, Kokita Y, Kasai S, et al. Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery. Pain 2009;147:194-201. 30. Tan EC, Lim EC, Teo YY, Lim Y, Law HY, Sia AT. Ethnicity and OPRM variant independently predict pain perception and patient-controlled analgesia usage for post-operative pain. Mol Pain 2009;5:32. 31. Bond C, LaForge KS, Tian M, Melia D, Zhang S, Borg L, et al. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci U S A 1998;95:9608-13. 32. Beyer A, Koch T, Schroder H, Schulz S, Hollt V. Effect of the A118G polymorphism on binding affinity, potency and agonist mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor. J Neurochem 2004;89:553-60. 33. Zhang Y, Wang D, Johnson AD, Papp AC, Sadee W. Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. J Biol Chem 2005;280:32618-24. 34. Muralidharan A, Smith MT. Pain, analgesia and genetics. J Pharm Pharmacol 2011;63:1387-400. 35. Fillingim RB, Maixner W. Gender differences in the responses to noxious stimuli. Pain Forum 1995;4:209-21. 36. Alabas OA, Tashani OA, Tabasam G, Johnson MI. Gender role affects experimental pain responses: a systematic review with meta-analysis. Eur J Pain 2012;16:1211-23. 37. Fillingim RB, King CD, Ribeiro-Dasilva MC, Rahim-Williams B, Riley JL. Sex, gender, and pain: a review of recent clinical and experimental findings. J Pain 2009;10:447-85. 38. Racine M, Tousignant-Laflamme Y, Kloda LA, Dion D, Dupuis G, Choiniere M. A systematic literature review of 10 y of research on sex/gender and experimental pain perception-part 1:are there really differences between women and men? Pain 2012;153:602-18. 39. Angst MS, Phillips NG, Drover DR, Tingle M, Ray A, Swan GE, et al. Pain sensitivity and opioid analgesia: a pharmacogenomic twin study. Pain 2012;153:1397-409. 40. Shavers VL, Bakos A, Sheppard VB. Race, ethnicity, and pain among the U. S. adult population. J Health Care Poor Underserved 2010;21:177-220. 41. Edwards CL, Fillingim RB, Keefe F. Race, ethnicity and pain. Pain 2001;94:133-7. 42. Carter LE, McNeil DW, Vowles KE, Sorrell JT, Turk CL, Ries BJ, et al. Effects of emotion on pain reports, tolerance and physiology. Pain Res Manag 2002;7:21-30.
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7505-01-FH02-FP-16-06201.jpg
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norman
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oai_dc
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https://intelek.unisza.edu.my/intelek/pages/view.php?ref=13196
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13196 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=13196 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal image/jpeg inches 96 96 norman 1426 772 23 23 2016-07-21 12:10:57 1426x772 7505-01-FH02-FP-16-06201.jpg UniSZA Private Access 118A>G and IVS2+691G>C polymorphisms of OPRM1 gene have no influence on cold-pain sensitivity among healthy opioid-naive malay males International Journal of Pharmacy and Pharmaceutical Sciences Objective: Common polymorphisms of the mu-type opioid receptor (OPRM1) including 118A>G and IVS2+691G>C may affect experimental pain responses in healthy subjects, and the effect could be ethnic-dependent. The aim of this study was to investigate the influence of these OPRM1 polymorphisms on cold-pressor pain responses among healthy opioid-naive Malay males. Methods: Pain-threshold, pain-tolerance, and pain-intensity in response to the cold pressor test (CPT) were measured in healthy opioid-naive Malay males. DNA was extracted from the collected venous blood before PCR-genotyping. Repeated measure analysis of variance (RM-ANOVA) was used to compare CPT responses and OPRM1 polymorphisms (118A>G and IVS2+691G>C) according to their genotypes and allelic additive models, genotype dominant and recessive models, haplotypes, and diplotypes. Results: A total of 152 participants were recruited. Both 118A>G and IVS2+691G>C polymorphisms were not associated with cold-pressor pain threshold, pain-tolerance and pain-intensity despite using genotypes and allelic additive models and genotype dominant and recessive models (all p>0.05). Likewise, there were no significant associations between haplotypes and diplotypes for the 118A>G and IVS2+691G>C polymorphisms and the three cold-pain responses (all p>0.05). Conclusion: The common OPRM1 polymorphisms (i.e., 118A>G and IVS2+691G>C), are not associated with cold-pressor pain responses in healthy opioid-naive Malay males. However, this may be unique for this particular ethnicity. Other polymorphisms may be more relevant for this population, and this should be further investigated. 8 7 Innovare Academics Sciences Pvt. Ltd Innovare Academics Sciences Pvt. Ltd 73-80 1. Mizoguchi H, Narita M, Wu H, Suzuki T, Nagase H, Tseng LF. Differential involvement of mu-opioid receptors in endomorphin-and beta-endorphin-induced G-protein activation in the mouse pons/medulla. Neuroscience 2000; 100:835-9. 2. Feng Y, He X, Yang Y, Chao D, Lazarus LH, Xia Y. Current research on opioid receptor function. Curr Drug Targets 2012;13:230-46. 3. Saidak Z, Blake-Palmer K, Hay DL, Northup JK, Glass M. Differential activation of G-proteins by mu-opioid receptor agonists. Br J Pharmacol 2006;147:671-80. 4. Zubieta JK, Smith YR, Bueller JA, Xu Y, Kilbourn MR, Jewett DM, et al. Regional mu opioid receptor regulation of sensory and affective dimensions of pain. Science 2001;293:311-5. 5. Young EE, Lariviere WR, Belfer I. Genetic basis of pain variability: recent advances. J Med Genet 2012;49:1-9. 6. Govoni S, Regazzi M, Ranzani GN. Pain and the pharmacogenetics at the fuzzy border between pain physiopathology and pain treatment. Eur J Pain Suppl 2008;2 Suppl 1:5-12. 7. Lind AL, Gordh TE. Research on genes predisposing for chronic pain: a challenge for pain researchers in scandinavia. Scandinavian J Pain 2009;1 Suppl 1:24-6. 8. Lötsch J, Geisslinger G, Tegeder I. Genetic modulation of the pharmacological treatment of pain. Pharmacol Ther 2009;124:168-84. 9. Miaskowski C. Understanding the genetic determinants of pain and pain management. Semin Oncol Nurs 2009;25(2, Suppl 1):1-7. 10. Kim DH, Schwartz CE. The genetics of pain: implications for evaluation and treatment of spinal disease. Spine J 2010;10:827-40. 11. Kasai S, Ikeda K. Pharmacogenomics of the human μ-opioid receptor. Pharmacogenomics 2011;12:1305-20. 12. Shipton EA. Pharmacogenomics in acute pain. Trends Anaesthesia Critical Care 2011;1:117-22. 13. Hagelberg N, Aalto S, Tuominen L, Pesonen U, Nagren K, Hietala J, et al. Striatal mu-opioid receptor availability predicts cold pressor pain-threshold in healthy human subjects. Neurosci Lett 2012;521:11-4. 14. Fillingim RB, Kaplan L, Staud R, Ness TJ, Glover TL, Campbell CM, et al. The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. J Pain 2005;6:159-67. 15. Lotsch J, Stuck B, Hummel T. The human μ-opioid receptor gene polymorphism 118A>G decreases cortical activation in response to specific nociceptive stimulation. Behav Neurosci 2006;120:1218-24. 16. Hastie BA, Riley JL, Kaplan L, Herrera DG, Campbell CM, Virtusio K, et al. Ethnicity interacts with the OPRM1 gene in experimental pain sensitivity. Pain 2012;153:1610-9. 17. Huang CJ, Liu HF, Su NY, Hsu YW, Yang CH, Chen CC, et al. Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*. Anaesthesia 2008;63:1288-95. 18. Chen AC, Dworkin SF, Haug J, Gehrig J. Human pain responsivity in a tonic pain model: psychological determinants. Pain 1989;37:143-60. 19. Compton P, Charuvastra VC, Ling W. Pain intolerance in opioid maintained former opiate addicts: effect of long-acting maintenance agent. Drug Alcohol Depend 2001;63:139-46. 20. Zahari Z, Lee CS, Tan SC, Mohamad N, Lee YY, Ismail R. Relationship between cold pressor pain-sensitivity and sleep quality in opioid-dependent males on methadone treatment. Peer J 2015;3:e839. 21. Wolf S, Hardy JD. Studies on pain. Observations on pain due to local cooling and on factors involved in the “cold pressor” effect. J Clin Invest 1941;20:521-33. 22. Harris G, Rollman GB. The validity of experimental pain measures. Pain 1983;17:369-76. 23. Glynn CJ, Lloyd JW. The diurnal variation in perception of pain. Proc R Soc Med 1976;69:369-72. 24. Mohamed Nazar NI. Therapeutic drug monitoring in methadone maintenance therapy (mmt): an evaluation of genetic factors influencing clinical outcomes and serum concentrations of methadone: Ph. D Thesis, Universiti Sains Malaysia; 2013. 25. Cohen J. A power primer. Psychol Bull 1992;112:155-9. 26. Belfer I, Segall SK, Lariviere WR, Smith SB, Dai F, Slade GG, et al. Pain modality-and sex-specific effects of COMT genetic functional variants. Pain 2013;154:1368-76. 27. Tan EC, Tan CH, Karupathivan U, Yap EP. Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations. Neuroreport 2003;14:569-72. 28. Zhang W, Chang YZ, Kan QC, Zhang LR, Lu H, Chu QJ, et al. Association of human μ-opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecological patients. Anaesthesia 2010;65:130-5. 29. Fukuda K, Hayashida M, Ide S, Saita N, Kokita Y, Kasai S, et al. Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery. Pain 2009;147:194-201. 30. Tan EC, Lim EC, Teo YY, Lim Y, Law HY, Sia AT. Ethnicity and OPRM variant independently predict pain perception and patient-controlled analgesia usage for post-operative pain. Mol Pain 2009;5:32. 31. Bond C, LaForge KS, Tian M, Melia D, Zhang S, Borg L, et al. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci U S A 1998;95:9608-13. 32. Beyer A, Koch T, Schroder H, Schulz S, Hollt V. Effect of the A118G polymorphism on binding affinity, potency and agonist mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor. J Neurochem 2004;89:553-60. 33. Zhang Y, Wang D, Johnson AD, Papp AC, Sadee W. Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. J Biol Chem 2005;280:32618-24. 34. Muralidharan A, Smith MT. Pain, analgesia and genetics. J Pharm Pharmacol 2011;63:1387-400. 35. Fillingim RB, Maixner W. Gender differences in the responses to noxious stimuli. Pain Forum 1995;4:209-21. 36. Alabas OA, Tashani OA, Tabasam G, Johnson MI. Gender role affects experimental pain responses: a systematic review with meta-analysis. Eur J Pain 2012;16:1211-23. 37. Fillingim RB, King CD, Ribeiro-Dasilva MC, Rahim-Williams B, Riley JL. Sex, gender, and pain: a review of recent clinical and experimental findings. J Pain 2009;10:447-85. 38. Racine M, Tousignant-Laflamme Y, Kloda LA, Dion D, Dupuis G, Choiniere M. A systematic literature review of 10 y of research on sex/gender and experimental pain perception-part 1:are there really differences between women and men? Pain 2012;153:602-18. 39. Angst MS, Phillips NG, Drover DR, Tingle M, Ray A, Swan GE, et al. Pain sensitivity and opioid analgesia: a pharmacogenomic twin study. Pain 2012;153:1397-409. 40. Shavers VL, Bakos A, Sheppard VB. Race, ethnicity, and pain among the U. S. adult population. J Health Care Poor Underserved 2010;21:177-220. 41. Edwards CL, Fillingim RB, Keefe F. Race, ethnicity and pain. Pain 2001;94:133-7. 42. Carter LE, McNeil DW, Vowles KE, Sorrell JT, Turk CL, Ries BJ, et al. Effects of emotion on pain reports, tolerance and physiology. Pain Res Manag 2002;7:21-30.
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| spellingShingle |
118A>G and IVS2+691G>C polymorphisms of OPRM1 gene have no influence on cold-pain sensitivity among healthy opioid-naive malay males
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| summary |
Objective: Common polymorphisms of the mu-type opioid receptor (OPRM1) including 118A>G and IVS2+691G>C may affect experimental pain responses in healthy subjects, and the effect could be ethnic-dependent. The aim of this study was to investigate the influence of these OPRM1 polymorphisms on cold-pressor pain responses among healthy opioid-naive Malay males. Methods: Pain-threshold, pain-tolerance, and pain-intensity in response to the cold pressor test (CPT) were measured in healthy opioid-naive Malay males. DNA was extracted from the collected venous blood before PCR-genotyping. Repeated measure analysis of variance (RM-ANOVA) was used to compare CPT responses and OPRM1 polymorphisms (118A>G and IVS2+691G>C) according to their genotypes and allelic additive models, genotype dominant and recessive models, haplotypes, and diplotypes. Results: A total of 152 participants were recruited. Both 118A>G and IVS2+691G>C polymorphisms were not associated with cold-pressor pain threshold, pain-tolerance and pain-intensity despite using genotypes and allelic additive models and genotype dominant and recessive models (all p>0.05). Likewise, there were no significant associations between haplotypes and diplotypes for the 118A>G and IVS2+691G>C polymorphisms and the three cold-pain responses (all p>0.05). Conclusion: The common OPRM1 polymorphisms (i.e., 118A>G and IVS2+691G>C), are not associated with cold-pressor pain responses in healthy opioid-naive Malay males. However, this may be unique for this particular ethnicity. Other polymorphisms may be more relevant for this population, and this should be further investigated.
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| title |
118A>G and IVS2+691G>C polymorphisms of OPRM1 gene have no influence on cold-pain sensitivity among healthy opioid-naive malay males
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| title_full |
118A>G and IVS2+691G>C polymorphisms of OPRM1 gene have no influence on cold-pain sensitivity among healthy opioid-naive malay males
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| title_fullStr |
118A>G and IVS2+691G>C polymorphisms of OPRM1 gene have no influence on cold-pain sensitivity among healthy opioid-naive malay males
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| title_full_unstemmed |
118A>G and IVS2+691G>C polymorphisms of OPRM1 gene have no influence on cold-pain sensitivity among healthy opioid-naive malay males
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| title_short |
118A>G and IVS2+691G>C polymorphisms of OPRM1 gene have no influence on cold-pain sensitivity among healthy opioid-naive malay males
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| title_sort |
118a>g and ivs2+691g>c polymorphisms of oprm1 gene have no influence on cold-pain sensitivity among healthy opioid-naive malay males
|