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1860797546256924672
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INTELEK Repository
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Online Access
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https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072
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| date |
2021-09-20 18:14:44
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Restricted Document
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13183
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UniSZA
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7492-01-FH02-FSK-21-56420.pdf
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S
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oai_dc
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https://intelek.unisza.edu.my/intelek/pages/view.php?ref=13183
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13183 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=13183 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal application/pdf 9 1.6 Adobe Acrobat Pro DC 20 Paper Capture Plug-in S 2021-09-20 18:14:44 7492-01-FH02-FSK-21-56420.pdf UniSZA Private Access Goat’s Milk as a Potential Anti-proliferative against Colon Cancer Cell Lines Journal of Pharmaceutical Research International Aim: To investigate anti-proliferative effect of fresh and pasteurized goat milk against colon cancer cell lines (HT-29, HCT-116, CT-26). Study Design: Experimental study. Place and Duration of Study: Central Laboratory, Tissue Culture Laboratory, Universiti Sultan Zainal Abidin, Terengganu between January 2020 and April 2020. Methodology: Samples comprised of two types goat milk, which were fresh and pasteurized in powder form. The samples were analysed for the anti-proliferative effect by MTT assay, and IC50 value was determined. Then, cell apoptotic changes were observed by light inverted microscope by 24, 48 and 72 hours. Results: Experimental data showed that the fresh sample produce the highest yield (9.40%) than the pasteurized sample (7.17%). The fresh sample yielded the most potent cytotoxic value (0.28 ± 0.03), followed by pasteurized sample with value IC50 0.32 ± 0.02 against HCT-116 cells. Then, the anti-proliferative effect was observed on cell apoptotic changes by reduction of cell volume, cell densed, and presence of fragmentation and apoptotic bodies at 24, 48 and 72 hours treatment. Conclusion: In conclusion, the fresh sample of goat milk yielded the potent anti-proliferative effect than pasteurized sample 33 44A 493-501
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Goat’s Milk as a Potential Anti-proliferative against Colon Cancer Cell Lines
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| summary |
Aim: To investigate anti-proliferative effect of fresh and pasteurized goat milk against colon cancer cell lines (HT-29, HCT-116, CT-26). Study Design: Experimental study. Place and Duration of Study: Central Laboratory, Tissue Culture Laboratory, Universiti Sultan Zainal Abidin, Terengganu between January 2020 and April 2020. Methodology: Samples comprised of two types goat milk, which were fresh and pasteurized in powder form. The samples were analysed for the anti-proliferative effect by MTT assay, and IC50 value was determined. Then, cell apoptotic changes were observed by light inverted microscope by 24, 48 and 72 hours. Results: Experimental data showed that the fresh sample produce the highest yield (9.40%) than the pasteurized sample (7.17%). The fresh sample yielded the most potent cytotoxic value (0.28 ± 0.03), followed by pasteurized sample with value IC50 0.32 ± 0.02 against HCT-116 cells. Then, the anti-proliferative effect was observed on cell apoptotic changes by reduction of cell volume, cell densed, and presence of fragmentation and apoptotic bodies at 24, 48 and 72 hours treatment. Conclusion: In conclusion, the fresh sample of goat milk yielded the potent anti-proliferative effect than pasteurized sample
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| title |
Goat’s Milk as a Potential Anti-proliferative against Colon Cancer Cell Lines
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| title_full |
Goat’s Milk as a Potential Anti-proliferative against Colon Cancer Cell Lines
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| title_fullStr |
Goat’s Milk as a Potential Anti-proliferative against Colon Cancer Cell Lines
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| title_full_unstemmed |
Goat’s Milk as a Potential Anti-proliferative against Colon Cancer Cell Lines
|
| title_short |
Goat’s Milk as a Potential Anti-proliferative against Colon Cancer Cell Lines
|
| title_sort |
goat’s milk as a potential anti-proliferative against colon cancer cell lines
|