Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort

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internalnotes 1. Caan BJ, Kwan ML, Hartzell G et al. Prediagnosis body mass index, post-diagnosis weight change, and prognosis among women with early stage breast cancer. Cancer Causes Control 2008;19:1319-1328. 2. Rock CL, Flatt SW, Newman V etal.Factors associated with weight gain in women after diagnosis of breast cancer. Women’s Healthy Eating and Living Study Group. J Am Diet Assoc 1999;99: 1212-1221. 3. Yong HY, Kandiah M, Zalilah MS et al. Pattern of weight changes in women with breast cancer. Asian Pac J Cancer Prev 2010;11:1535-1540. 4. Freedman RJ, Aziz N, Albanes D etal.Weight and body composition changes during and after adjuvant chemotherapy in women with breast cancer. J ClinEndocrinolMetab 2004;89:2248-2253. 5. Aslani A, Smith RC, Allen BJ et al. Changes in body composition during breast cancer chemotherapy with the CMF-regimen. Breast Cancer Res Treat 1999;57:285-290. 6. Del Rio G, Zironi S, Valeriani L et al. Weight gain in women with breast cancer treated with adjuvant cyclophosphamide, methotrexate and 5-fluorouracil. Analysis of resting energy expenditure and body composition. Breast Cancer Res Treat 2002;73:267-273. 7. Harvie MN, Campbell IT, Baildam A, Howell A. Energy balance in early breast cancer patients receiving adjuvant chemotherapy. Breast Cancer Res Treat 2004; 83:201-210. 8. Kutynec CL, McCargar L, Barr SI, Hislop TG: Energy balance in women with breast cancer during adjuvant treatment. J Am Diet Assoc 1999;99:1222-1227. 9. Yong HY, Zalilah MS, Kandiah M et al. Weight changes and lifestyle behaviours in women after breast cancer diagnosis: A crosssectional study. BMC Public Health2011;11:309. 10. Demark-Wahnefried W, Rock CL: Nutritionrelated issues for the breast cancer survivor. Semin Oncol 2003;30:789–798. 11. NurAishah MT, Cheng HY, Mohamed I: Suvival analysis of Malaysian women with breast cancer: Results from the University of Malaya Medical Centre. Asian Pac J Cancer Prev 2008;9:197-202. 12. Nor Idawaty I, Dahlui M, Aina EN, Al-Sadat N: Who are the breast cancer survivors in Malaysia?Asian Pac J Cancer Prev 2012;13:2213-2218. 13. Nor Aini A, Wan Rozita WM, Nor AsiahMet al. Survival rate of breast cancer patients in Malaysia: A population-based study. Asian Pac J Cancer Prev 2013;14:4591-4594. 14. Saquib N, Flatt SW, Natarajan L etal.Weight gain and recovery of pre-cancer weight after breast cancer treatments: evidence from the women’s healthy eating and living (WHEL) study. Breast Cancer Res Treat2007;105:177- 186. 15. WHO. Obesity: Preventing and managing the global epidemic. Geneva: World Health Organization Consultation on Obesity, 2000. 16. Demark-Wahnefried W, Hars V, Conaway MR, et al. Reduced rates of metabolism and decreased physical activity in breast cancer patients receiving adjuvant chemotherapy. Am JClinNutr1997;65:1495-1501. 17. Lankesterf KJ, Philips JE, Lawton PA.Weight gain during adjuvant and neoadjuvant chemotherapy for breast cancer: an audit of 100 women receiving FEC or CMF chemotherapy. ClinOncol 2002;14:64-67. 18. Hisham AN, Yip CH. Spectrum of breast cancer in Malaysian women: Overview. World J Surg 2003;27:921-923. 19. Hisham AN, Yip CH: Overview of breast cancer in Malaysian women: A problem with late diagnosis. Asian JSurg 2004;27:130-133. 20. Costa LJ, Varella PC, delGiglio A. Weight changes during chemotherapy for breast cancer. Sao Paulo Med J 2002;120:113-117. 21. Demark-Wahnefried W, Peterson BL, Winer EP, Marks L, Aziz N, Marcom PK, Blackwell K, Rimer BK: Changes in weight, body composition, and factors influencing energy balance among premenopausal breast cancer patients receiving adjuvant chemotherapy. JClinOncol2001;19:2381-2389. 22. TredanO, Bajard A, MeunierAetal.Body weight change in women receiving adjuvant chemotherapy for breast cancer: A French prospective study. ClinNutr2010;29:187-191. 23. Nissen MJ, Shapiro A, Swenson KK. Changes in weight and body composition in women receiving chemotherapy for breast cancer. Clin Breast Cancer 2011;11:52-60. 24. Harvie MN, Howell A, Thatcher N et al. Energy balance in patients with advanced NSCLC, metastatic melanoma and metastatic breast cancer receiving chemotherapy- a longitudinal study. British J Cancer 2005;92:673-680. 25. Lua PL, Noor Salihah Z, Mazlan N. Nutritional status and health-related quality of life of breast cancer patients on chemotherapy. Mal J Nutr 2012; 18: 173-184. 26. Grindel CG, Cahill CA, Walker M. Food intake of women with breast cancer during their first six moth of chemotherapy. OncolNurs Forum 1989;16:401-407. 27. Kroenke CH, Chen WY, Rosner B, Holmes MD. Weight, weight gain and survival after breast cancer diagnosis. J ClinOncol 2005;23:1370- 1378. 28. Thivat E, Therondel S, Lapirot O etal.Weight change during chemotherapy changes the prognosis in non-metastatic breast cancer for the worse. BMC Cancer 2010;10:648-656. 29. Han HS, Lee KW, Kim JH etal.Weight changes after adjuvant treatment in Korean women with early breast cancer. Breast Cancer Res Treat 2009;114:147-153. 30. NIH Consens Statement: Adjuvant Therapy for Breast Cancer 2000;17:1-35.
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spelling 13117 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=13117 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal image/jpeg inches 767 96 96 norman 1427x767 1427 09 09 2016-06-23 13:01:40 7427-01-FH02-FSK-16-06113.jpg UniSZA Private Access Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort Malaysian Journal of Public Health Medicine A concern in breast cancer involves changes in weight which may adversely affect the prognosis of patients. This study intended to evaluate weight changed uring chemotherapy and its association with prognostic outcome measured as event-free survival (EFS)among breast cancer patients. A total of63 women diagnosed with breast cancer and have been treated by anthracycline-based chemotherapy between 2005 and 2011were included. A weight change (WC) was calculated based on relative percentage of weight changes from baseline to post-chemotherapy and categorized into either weight change (WC >5%) or stable (±5% WC). Survival probabilities were estimated using the Kaplan-Meier (SPSS 20). Upon treatment completion, 42.9% of the women experienced weight changes. A small weight reduction was observed (61.1 ± 11.6kg to 60.2 ± 11.9kg; -0.8 ± 4.0kg; p=0.106). The median EFS of women who experienced weight change was shorter (median 61.0 months) compared to those who maintained their weight (median 89.0 months) (p=0.044). In this study, weight changes during breast cancer chemotherapy were associated with poorer prognosis in comparison to women who maintained their weight. 16 1 Malaysian Public Health Physicians Association Malaysian Public Health Physicians Association 129-136 1. Caan BJ, Kwan ML, Hartzell G et al. Prediagnosis body mass index, post-diagnosis weight change, and prognosis among women with early stage breast cancer. Cancer Causes Control 2008;19:1319-1328. 2. Rock CL, Flatt SW, Newman V etal.Factors associated with weight gain in women after diagnosis of breast cancer. Women’s Healthy Eating and Living Study Group. J Am Diet Assoc 1999;99: 1212-1221. 3. Yong HY, Kandiah M, Zalilah MS et al. Pattern of weight changes in women with breast cancer. Asian Pac J Cancer Prev 2010;11:1535-1540. 4. Freedman RJ, Aziz N, Albanes D etal.Weight and body composition changes during and after adjuvant chemotherapy in women with breast cancer. J ClinEndocrinolMetab 2004;89:2248-2253. 5. Aslani A, Smith RC, Allen BJ et al. Changes in body composition during breast cancer chemotherapy with the CMF-regimen. Breast Cancer Res Treat 1999;57:285-290. 6. Del Rio G, Zironi S, Valeriani L et al. Weight gain in women with breast cancer treated with adjuvant cyclophosphamide, methotrexate and 5-fluorouracil. Analysis of resting energy expenditure and body composition. Breast Cancer Res Treat 2002;73:267-273. 7. Harvie MN, Campbell IT, Baildam A, Howell A. Energy balance in early breast cancer patients receiving adjuvant chemotherapy. Breast Cancer Res Treat 2004; 83:201-210. 8. Kutynec CL, McCargar L, Barr SI, Hislop TG: Energy balance in women with breast cancer during adjuvant treatment. J Am Diet Assoc 1999;99:1222-1227. 9. Yong HY, Zalilah MS, Kandiah M et al. Weight changes and lifestyle behaviours in women after breast cancer diagnosis: A crosssectional study. BMC Public Health2011;11:309. 10. Demark-Wahnefried W, Rock CL: Nutritionrelated issues for the breast cancer survivor. Semin Oncol 2003;30:789–798. 11. NurAishah MT, Cheng HY, Mohamed I: Suvival analysis of Malaysian women with breast cancer: Results from the University of Malaya Medical Centre. Asian Pac J Cancer Prev 2008;9:197-202. 12. Nor Idawaty I, Dahlui M, Aina EN, Al-Sadat N: Who are the breast cancer survivors in Malaysia?Asian Pac J Cancer Prev 2012;13:2213-2218. 13. Nor Aini A, Wan Rozita WM, Nor AsiahMet al. Survival rate of breast cancer patients in Malaysia: A population-based study. Asian Pac J Cancer Prev 2013;14:4591-4594. 14. Saquib N, Flatt SW, Natarajan L etal.Weight gain and recovery of pre-cancer weight after breast cancer treatments: evidence from the women’s healthy eating and living (WHEL) study. Breast Cancer Res Treat2007;105:177- 186. 15. WHO. Obesity: Preventing and managing the global epidemic. Geneva: World Health Organization Consultation on Obesity, 2000. 16. Demark-Wahnefried W, Hars V, Conaway MR, et al. Reduced rates of metabolism and decreased physical activity in breast cancer patients receiving adjuvant chemotherapy. Am JClinNutr1997;65:1495-1501. 17. Lankesterf KJ, Philips JE, Lawton PA.Weight gain during adjuvant and neoadjuvant chemotherapy for breast cancer: an audit of 100 women receiving FEC or CMF chemotherapy. ClinOncol 2002;14:64-67. 18. Hisham AN, Yip CH. Spectrum of breast cancer in Malaysian women: Overview. World J Surg 2003;27:921-923. 19. Hisham AN, Yip CH: Overview of breast cancer in Malaysian women: A problem with late diagnosis. Asian JSurg 2004;27:130-133. 20. Costa LJ, Varella PC, delGiglio A. Weight changes during chemotherapy for breast cancer. Sao Paulo Med J 2002;120:113-117. 21. Demark-Wahnefried W, Peterson BL, Winer EP, Marks L, Aziz N, Marcom PK, Blackwell K, Rimer BK: Changes in weight, body composition, and factors influencing energy balance among premenopausal breast cancer patients receiving adjuvant chemotherapy. JClinOncol2001;19:2381-2389. 22. TredanO, Bajard A, MeunierAetal.Body weight change in women receiving adjuvant chemotherapy for breast cancer: A French prospective study. ClinNutr2010;29:187-191. 23. Nissen MJ, Shapiro A, Swenson KK. Changes in weight and body composition in women receiving chemotherapy for breast cancer. Clin Breast Cancer 2011;11:52-60. 24. Harvie MN, Howell A, Thatcher N et al. Energy balance in patients with advanced NSCLC, metastatic melanoma and metastatic breast cancer receiving chemotherapy- a longitudinal study. British J Cancer 2005;92:673-680. 25. Lua PL, Noor Salihah Z, Mazlan N. Nutritional status and health-related quality of life of breast cancer patients on chemotherapy. Mal J Nutr 2012; 18: 173-184. 26. Grindel CG, Cahill CA, Walker M. Food intake of women with breast cancer during their first six moth of chemotherapy. OncolNurs Forum 1989;16:401-407. 27. Kroenke CH, Chen WY, Rosner B, Holmes MD. Weight, weight gain and survival after breast cancer diagnosis. J ClinOncol 2005;23:1370- 1378. 28. Thivat E, Therondel S, Lapirot O etal.Weight change during chemotherapy changes the prognosis in non-metastatic breast cancer for the worse. BMC Cancer 2010;10:648-656. 29. Han HS, Lee KW, Kim JH etal.Weight changes after adjuvant treatment in Korean women with early breast cancer. Breast Cancer Res Treat 2009;114:147-153. 30. NIH Consens Statement: Adjuvant Therapy for Breast Cancer 2000;17:1-35.
spellingShingle Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort
summary A concern in breast cancer involves changes in weight which may adversely affect the prognosis of patients. This study intended to evaluate weight changed uring chemotherapy and its association with prognostic outcome measured as event-free survival (EFS)among breast cancer patients. A total of63 women diagnosed with breast cancer and have been treated by anthracycline-based chemotherapy between 2005 and 2011were included. A weight change (WC) was calculated based on relative percentage of weight changes from baseline to post-chemotherapy and categorized into either weight change (WC >5%) or stable (±5% WC). Survival probabilities were estimated using the Kaplan-Meier (SPSS 20). Upon treatment completion, 42.9% of the women experienced weight changes. A small weight reduction was observed (61.1 ± 11.6kg to 60.2 ± 11.9kg; -0.8 ± 4.0kg; p=0.106). The median EFS of women who experienced weight change was shorter (median 61.0 months) compared to those who maintained their weight (median 89.0 months) (p=0.044). In this study, weight changes during breast cancer chemotherapy were associated with poorer prognosis in comparison to women who maintained their weight.
title Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort
title_full Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort
title_fullStr Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort
title_full_unstemmed Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort
title_short Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort
title_sort weight changes during chemotherapy and prognostic outcome in breast cancer: a preliminary assessment in single centre cohort