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1860797483483922432
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INTELEK Repository
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Online Access
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https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072
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2016-04-27 10:45:08
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Restricted Document
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12918
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UniSZA
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[1] Song, G., & Mao, Y. B. Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosis-related protein expression, 2005; 38, 1791–1798. [2] Labianca R., Beretta G., Gatta G. et al.. Colon cancer. Critical Reviews in Oncology/Hematology,2004; 51: 145-170 [3] Scheck, A. C., Shapiro, J. R., Coons, S. W., Norman, S. A. and Johnson, P. C. Biological and molecular analysis of a low-grade recurrence of a glioblastoma multiforme. Clinical Cancer Research : An Official Journal of the American Association for Cancer Research. 1996; 2 (1). Pp 187–99. [4] Buchanan, D. R., White, J. D., O’Mara, A. M.. Kelaghan, J. W., Smith, W. B. and Minasian, L. M. Research-design issues in cancer-symptom-management trials using complementary and alternative medicine: lessons from the National Cancer Institute Community Clinical Oncology Program experience. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 2005; 23 (27). Pp 6682–9. [5] Richardson, M. A., Sanders, T., Palmer, J. L., Greisinger, A. and Singletary, S. E. Complementary/Alternative Medicine Use in a Comprehensive Cancer Center and the Implications for Oncology. J. Clin. Oncol..2000; 18 (13). Pp 2505–2514. [6] Mohd Adzim Khalili R., Norhayati A. H., Rokiah M. Y., Asmah R., Siti M. M. & Manaf A. A. Determination of radical scavenging Activity and Vitamin A, C and E in organically grown Red Pitaya (Hylocereus sp.). International Food Research Journal 2010; 17: 405-409 [7] Abdulnabi, A. A., Emhemed, A. H, Hussein, G. D. and Biacs, P. A. Determination of antioxidant vitamin in tomatoes. Food Chemistry 1997; 60: 207-212 [8] Esmaeilbeig M., Kouhpayeh S. A., & Amirghofran Z. An Investigation of the Growth Inhibitory Capacity of Several Medicinal Plants From Iran on Tumor Cell Lines. Iran J Cancer Preven. 2015; 8(5): e4032 [9] Encalada M. A., Hoyos K. M., Rehecho S., Berasategi I., Ciriano M. G. D., Ansorena D., Astiasarán I., Navarro-Blasco I., Cavero R. Y., & Calvo M. I. Anti-proliferative Effect of Melissa officinalis on Human Colon Cancer Cell Line. Plant Foods Hum Nutr 2011; 66:328–334 [10] Yapp D. T. T. & Yap . Lansium domesticum: skin and leaf extracts of this fruit tree interrupt the lifecycle of Plasmodium falciparum, and are active towards a chloroquine-resistant strain of the parasite (T9) in vitro. Journal of Ethnopharmacology: 2003; 85 (1) 145–150 [11] Morton J. Fruits of Warm Climates. J.F.M., Miami, 1987. 201 [12] Mabberley D. J. Jupiter Botanicus. Robert Brown of the British Museum. – Braunschweig. 1985 [13] Hanum, L., & Kasiamdari, R. S. The Phylogenetic Relationship Among Varieties of Lansium domesticum Correa Based on ITS rDNA Sequences, 2013; 18(2), 123–132. [14] Mitsuoka, T.,Beneficial microbial aspects (probiotics). proc. International Dairy Congress. 1990; 2:1226-1237, Montreal,Oct.8-12. [15] Manosroi A., Jantrawut P., Sainakham M., Manosroi W. & Manosroi J. Anticancer ativities of te extract from Longkong (Lansium Domesticum) youang fruits. Pharmaceutical Biology; 2012; 50(11): 1397-1407 [16] Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods. 1983; 65 (1-2). 55–63. [17] Mohd Adzim Khalili, Rohin, K., Naim, R., Baig, A., Sultan, U., Abidin, Z. … Abidin, Z. Study On Antioxidant Capacity And Anticancer Activity Of Bismillah Leaf ( Vernonia Amygdalina )., 2014 [18] Mohd Adzim Khalili Rohin, Norhayati Abd Hadi, Rochman Naim, Atif Amin Baig, Khairil Mahmud: Study On Antioxidant Capacity And Anticancer Activity Of Bismillah Leaf (Vernonia Amygdalina). World Journal of Pharmaceutical Research 09/2014; 3(6):14-29. [19] Mohd Adzim Khalili R, Che Abdullah A.B, And Abdul Manaf A: Total Antioxidant Activity, Total Phenolic Content And Radical Scavenging Activity Both Flesh And Peel Of Red Pitaya, White Pitaya And Papaya. International Journal of Pharmacy and Pharmaceutical Sciences 04/2012; Vol 4,(Issue 2):113-122. [20] Mohd Adzim Khalili R, Norhayati AH, Rokiah MY, Asmah R, Siti Muskinah M, Abdul Manaf A: Determination of radical scavenging activity and Vitamin A, C and E in organically grown Red Pitaya (Hylocereus sp.). International Food Research Journal 06/2010; Volume 17.(Issue 2.-ISSN 22317546):405-409. [21] Geran, R. I., Greenberg, H. M., McDonald, M. and Abbott, B. J. Protocols for screening chemical agents and natural products against animal tumours and other biological systems. Cancer Chemoth Rep. 1972; 33. Pp 1-17. [22] American Cancer Society (2014). Colorectal Cancer. Retrieved from http://www.cancer.org/cancer/colonandrectumcancer/detailedguide/colorectal-cancer-what-iscolorectal-cancer [23] Warburg O., Wind F. & Negelein E. The metabolism of tumors in the body. J Gen Physiol; 1927; 8:519– 530. [24] Annibaldi A. and Widmann C. Glucose metabolism in cancer cells. Curr Opin Clin Nutr Metab Care 2010; 13:466–470.
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norman
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12918 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12918 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal image/jpeg inches 96 96 norman 1421 17 17 770 2016-04-27 10:45:08 1421x770 7225-01-FH02-FSK-16-05741.jpg UniSZA Private Access Anti-proliferative effect of duku (Lansium Domesticum Corr) extracts on human colorectal adenocarcinoma cell lines Research Journal of Pharmaceutical, Biological and Chemical Sciences In the treatment or prevention of cancer, fruits and plants have a high content of natural antioxidants and the potential to protect humans against cancer. The duku fruit or Lansium Domesticum Corr, is rich in bioactive compounds and nutrients which important to health benefits. The purpose of this study is to screen possible anticancer activity of various extracts and fractions of duku fruit extracts that inhibit the proliferation of human colorectal adenocarcinoma (HT29). The duku fruit extract process involved three different solvents (methanol, ethanol and ethyl acetate). The human colorectal adenocarcinoma cell line was treated with concentration methanol, ethanol and ethyl acetate extracts (0-60μg/ml) from the duku fruit. The anti-proliferative activities of human colon adenocarcinoma cell line treated with duku fruit extracts were determined using MTT Assays (570nm). This study found that only the methanol extract had inhibited the proliferation activity of cancer cell lines. The degree of inhibited proliferation is defined as a concentration that reduced the number of cells to 50% compared to the untreated sample (IC50). Methanol extract inhibited the proliferative HT-29 cell lines at concentration of 6.8 μg/ml. Methanol extract from the duku fruit was found to be more successful in inhibiting HT29 cell proliferation compared to the Ethanol and Ethyl Acetate extracts. 7 2 Research Journal of Pharmaceutical, Biological and Chemical Sciences Research Journal of Pharmaceutical, Biological and Chemical Sciences 1078-1083 [1] Song, G., & Mao, Y. B. Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosis-related protein expression, 2005; 38, 1791–1798. [2] Labianca R., Beretta G., Gatta G. et al.. Colon cancer. Critical Reviews in Oncology/Hematology,2004; 51: 145-170 [3] Scheck, A. C., Shapiro, J. R., Coons, S. W., Norman, S. A. and Johnson, P. C. Biological and molecular analysis of a low-grade recurrence of a glioblastoma multiforme. Clinical Cancer Research : An Official Journal of the American Association for Cancer Research. 1996; 2 (1). Pp 187–99. [4] Buchanan, D. R., White, J. D., O’Mara, A. M.. Kelaghan, J. W., Smith, W. B. and Minasian, L. M. Research-design issues in cancer-symptom-management trials using complementary and alternative medicine: lessons from the National Cancer Institute Community Clinical Oncology Program experience. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 2005; 23 (27). Pp 6682–9. [5] Richardson, M. A., Sanders, T., Palmer, J. L., Greisinger, A. and Singletary, S. E. Complementary/Alternative Medicine Use in a Comprehensive Cancer Center and the Implications for Oncology. J. Clin. Oncol..2000; 18 (13). Pp 2505–2514. [6] Mohd Adzim Khalili R., Norhayati A. H., Rokiah M. Y., Asmah R., Siti M. M. & Manaf A. A. Determination of radical scavenging Activity and Vitamin A, C and E in organically grown Red Pitaya (Hylocereus sp.). International Food Research Journal 2010; 17: 405-409 [7] Abdulnabi, A. A., Emhemed, A. H, Hussein, G. D. and Biacs, P. A. Determination of antioxidant vitamin in tomatoes. Food Chemistry 1997; 60: 207-212 [8] Esmaeilbeig M., Kouhpayeh S. A., & Amirghofran Z. An Investigation of the Growth Inhibitory Capacity of Several Medicinal Plants From Iran on Tumor Cell Lines. Iran J Cancer Preven. 2015; 8(5): e4032 [9] Encalada M. A., Hoyos K. M., Rehecho S., Berasategi I., Ciriano M. G. D., Ansorena D., Astiasarán I., Navarro-Blasco I., Cavero R. Y., & Calvo M. I. Anti-proliferative Effect of Melissa officinalis on Human Colon Cancer Cell Line. Plant Foods Hum Nutr 2011; 66:328–334 [10] Yapp D. T. T. & Yap . Lansium domesticum: skin and leaf extracts of this fruit tree interrupt the lifecycle of Plasmodium falciparum, and are active towards a chloroquine-resistant strain of the parasite (T9) in vitro. Journal of Ethnopharmacology: 2003; 85 (1) 145–150 [11] Morton J. Fruits of Warm Climates. J.F.M., Miami, 1987. 201 [12] Mabberley D. J. Jupiter Botanicus. Robert Brown of the British Museum. – Braunschweig. 1985 [13] Hanum, L., & Kasiamdari, R. S. The Phylogenetic Relationship Among Varieties of Lansium domesticum Correa Based on ITS rDNA Sequences, 2013; 18(2), 123–132. [14] Mitsuoka, T.,Beneficial microbial aspects (probiotics). proc. International Dairy Congress. 1990; 2:1226-1237, Montreal,Oct.8-12. [15] Manosroi A., Jantrawut P., Sainakham M., Manosroi W. & Manosroi J. Anticancer ativities of te extract from Longkong (Lansium Domesticum) youang fruits. Pharmaceutical Biology; 2012; 50(11): 1397-1407 [16] Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods. 1983; 65 (1-2). 55–63. [17] Mohd Adzim Khalili, Rohin, K., Naim, R., Baig, A., Sultan, U., Abidin, Z. … Abidin, Z. Study On Antioxidant Capacity And Anticancer Activity Of Bismillah Leaf ( Vernonia Amygdalina )., 2014 [18] Mohd Adzim Khalili Rohin, Norhayati Abd Hadi, Rochman Naim, Atif Amin Baig, Khairil Mahmud: Study On Antioxidant Capacity And Anticancer Activity Of Bismillah Leaf (Vernonia Amygdalina). World Journal of Pharmaceutical Research 09/2014; 3(6):14-29. [19] Mohd Adzim Khalili R, Che Abdullah A.B, And Abdul Manaf A: Total Antioxidant Activity, Total Phenolic Content And Radical Scavenging Activity Both Flesh And Peel Of Red Pitaya, White Pitaya And Papaya. International Journal of Pharmacy and Pharmaceutical Sciences 04/2012; Vol 4,(Issue 2):113-122. [20] Mohd Adzim Khalili R, Norhayati AH, Rokiah MY, Asmah R, Siti Muskinah M, Abdul Manaf A: Determination of radical scavenging activity and Vitamin A, C and E in organically grown Red Pitaya (Hylocereus sp.). International Food Research Journal 06/2010; Volume 17.(Issue 2.-ISSN 22317546):405-409. [21] Geran, R. I., Greenberg, H. M., McDonald, M. and Abbott, B. J. Protocols for screening chemical agents and natural products against animal tumours and other biological systems. Cancer Chemoth Rep. 1972; 33. Pp 1-17. [22] American Cancer Society (2014). Colorectal Cancer. Retrieved from http://www.cancer.org/cancer/colonandrectumcancer/detailedguide/colorectal-cancer-what-iscolorectal-cancer [23] Warburg O., Wind F. & Negelein E. The metabolism of tumors in the body. J Gen Physiol; 1927; 8:519– 530. [24] Annibaldi A. and Widmann C. Glucose metabolism in cancer cells. Curr Opin Clin Nutr Metab Care 2010; 13:466–470.
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| spellingShingle |
Anti-proliferative effect of duku (Lansium Domesticum Corr) extracts on human colorectal adenocarcinoma cell lines
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| summary |
In the treatment or prevention of cancer, fruits and plants have a high content of natural antioxidants and the potential to protect humans against cancer. The duku fruit or Lansium Domesticum Corr, is rich in bioactive compounds and nutrients which important to health benefits. The purpose of this study is to screen possible anticancer activity of various extracts and fractions of duku fruit extracts that inhibit the proliferation of human colorectal adenocarcinoma (HT29). The duku fruit extract process involved three different solvents (methanol, ethanol and ethyl acetate). The human colorectal adenocarcinoma cell line was treated with concentration methanol, ethanol and ethyl acetate extracts (0-60μg/ml) from the duku fruit. The anti-proliferative activities of human colon adenocarcinoma cell line treated with duku fruit extracts were determined using MTT Assays (570nm). This study found that only the methanol extract had inhibited the proliferation activity of cancer cell lines. The degree of inhibited proliferation is defined as a concentration that reduced the number of cells to 50% compared to the untreated sample (IC50). Methanol extract inhibited the proliferative HT-29 cell lines at concentration of 6.8 μg/ml. Methanol extract from the duku fruit was found to be more successful in inhibiting HT29 cell proliferation compared to the Ethanol and Ethyl Acetate extracts.
|
| title |
Anti-proliferative effect of duku (Lansium Domesticum Corr) extracts on human colorectal adenocarcinoma cell lines
|
| title_full |
Anti-proliferative effect of duku (Lansium Domesticum Corr) extracts on human colorectal adenocarcinoma cell lines
|
| title_fullStr |
Anti-proliferative effect of duku (Lansium Domesticum Corr) extracts on human colorectal adenocarcinoma cell lines
|
| title_full_unstemmed |
Anti-proliferative effect of duku (Lansium Domesticum Corr) extracts on human colorectal adenocarcinoma cell lines
|
| title_short |
Anti-proliferative effect of duku (Lansium Domesticum Corr) extracts on human colorectal adenocarcinoma cell lines
|
| title_sort |
anti-proliferative effect of duku (lansium domesticum corr) extracts on human colorectal adenocarcinoma cell lines
|