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12881
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[1] V. Batra, A.A. Patkar, W.H. Berrettini, S.P. Weinstein, F.T. Leone The genetic determinants of smoking Chest, 123 (2003), pp. 1730-1739 [2] T. Arinami, H. Ishiguro, E.S. Onaivi Polymorphisms in genes involved in neurotransmission in relation to smoking Eur J Pharmacol, 410 (2000), pp. 215-226 [3] E.C. Johnstone, P. Yudkin, S.E. Griffiths, A. Fuller, M. Murphy, R. Walton The dopamine D2 receptor C32806T polymorphism (DRD2 Taq1A RFLP) exhibits no association with smoking behaviour in a healthy UK population Addict Biol, 9 (3–4) (2004), pp. 221-226 [4] G.N. Radwan, M. El-Setouhy, M.K. Mohamed, M.A. Hamid, S.A. Azem, et al. DRD2/ANKK1 TaqI polymorphism and smoking behavior of Egyptian male cigarette smokers Nicotine Tob Res, 9 (12) (2007), pp. 1325-1329 [5] J. Gelernter, H. Kranzler, S.L. Satel No association between D2 dopamine receptor (DRD2) alleles or haplotypes and cocaine dependence or severity of cocaine dependence in European- and African-Americans Biol Psychiatry, 45 (3) (1999), pp. 340-345 [6] A. Sieminska, K. Buczkowski, E. Jassem, M. Niedoszytko, E. Tkacz Influences of polymorphic variants of DRD2 and SLC6A3 genes, and their combinations on smoking in Polish population BMC Med Genet, 10 (2009), p. 92 [7] H. Ishikawa, T. Ohtsuki, H. Ishiguro, K. Yamakawa-Kobayashi, K. Endo, Y.L. Lin Association between serotonin transporter gene polymorphism and smoking among Japanese males Cancer Epidemiol Biomarkers Prev, 8 (1999), pp. 831-833 [8] N.I. Rozak, I. Ahmad, S.H. Gan, R. Abu Bakar Lack of association between the serotonin transporter (5-htt) and serotonin receptor (5-ht2a) gene polymorphisms with smoking behavior among malaysian malays Sci Pharm, 82 (3) (2014), pp. 631-642 [9] A. Sieminska, K. Buczkowski, E. Jassem, E. Tkacz Lack of association between serotonin transporter gene polymorphism 5-HTTLPR and smoking among Polish population: a case–control study BMC Med Genet, 9 (2008), p. 76 [10] M. Iordanidou, A. Tavridou, I. Petridis, S. Kyroglou, L. Kaklamanis, D. Christakidis Association of polymorphisms of the serotonergic system with smoking initiation in Caucasians Drug Alcohol Depend, 108 (2009), pp. 70-76 [11] Y. Feng, T. Niu, H. Xing, X. Xu, C. Chen, et al. A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men Am J Hum Genet, 75 (2004), pp. 112-121 [12] M.D. Li, J. Beuten, J.Z. Ma, T.J. Payne, X.Y. Lou, et al. Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence Hum Mol Genet, 14 (2005), pp. 1211-1219 [13] L.P. Breitling, N. Dahmen, K. Mittelstrass, D. Rujescu, J. Gallinat, et al. Association of nicotinic acetylcholine receptor subunit [alpha]4 polymorphisms with nicotine dependence in 5500 Germans Pharmacogenomics, 9 (2009), pp. 219-224 [14] C. Olsson, R. Anney, S. Forrest, G. Patton, C. Coffey, et al. Association between dependent smoking and a polymorphism in the tyrosine hydroxylase gene in a prospective population-based study of adolescent health Behav Genet, 34 (1) (2004), pp. 85-91 [15] S. Mizuno, H. Ito, N. Hamajima, A. Tamakoshi, K. Hirose, K. Tajima Association between smoking habits and tryptophan hydroxylase gene C218A polymorphism among the Japanese population J Epidemiol, 14 (3) (2004), pp. 94-99 [16] X. Yang, H. Chen, S. Li, Q. Wang, L. Pan, C. Jia Association between monoamine oxidase gene polymorphisms and smoking behavior: a meta-analysis Drug Alcohol Depend, 153 (2015), pp. 350-354 [17] J. Mutschler, E. Abbruzzese, C. von der Goltz, C. Dinter, A. Mobascher, et al. Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case–control study Nicotine Tob Res, 15 (7) (2013), pp. 1322-1327 [18] B. Karahalil, E. Coskun, E. Emerce ADRA2A polymorphism and smoking in a Turkish population Toxicol Ind Health, 24 (3) (2008), pp. 171-176 [19] M. Verhagen, M. Kleinjan, R.C. Engels A systematic review of the A118G (Asn40Asp) variant of OPRM1 in relation to smoking initiation, nicotine dependence and smoking cessation Pharmacogenomics, 13 (8) (2012), pp. 917-933 [20] M.J. Kreek, G. Bart, C. Lilly, K.S. LaForge, D.A. Nielsen Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments Pharmacol Rev, 57 (2005), pp. 1-26 [21] J.L. Galzi, J.P. Changeux Neuronal nicotinic receptors: molecular organization and regulations Neuropharmacology, 34 (1995), pp. 563-582 [22] A.R. Tapper, S.L. McKinney, R. Nashmi, J. Schwarz, P. Deshpande, C. Labarca, et al. Nicotine activation of alpha4∗ receptors: sufficient for reward, tolerance, and sensitization Science, 306 (2004), pp. 1029-1032 [23] O. Steinlein, S. Weiland, J. Stoodt, P. Propping Exon-intron structure of the human neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) Genomics, 32 (1996), pp. 289-294 [24] E.J. Pérez-Stable, B. Herrera, P. Jacob 3rd, N.L. Benowitz Nicotine metabolism and intake in black and white smokers JAMA, 280 (1998), pp. 152-156 [25] N.L. Benowitz, E.J. Perez-Stable, I. Fong, G. Modin, B. Herrera, P. Jacob 3rd Ethnic differences in N-glucuronidation of nicotine and cotinine J Pharmacol Exp Ther, 291 (1999), pp. 1196-1203 [26] R.F. Tyndale Genetics of alcohol and tobacco use in humans Ann Med, 35 (2003), pp. 94-121 [27] D. Von Ah, S. Ebert, A. Ngamvitroj, N. Park, D.H. Kang Factors related to cigarette smoking initiation and use among college students Tob Induc Dis, 3 (2005), pp. 1-5 [28] H.A. Anne Yee, C.G. Ng, A.R. Rusdi Validation of the Malay Version of Fagerstrom Test for Nicotine Dependence (FTND-M) Among a Group of Male Staffs in a University Hospital Malays J Psychiatry, 20 (1) (2011) [29] K. Fagerström Measuring degree of physical dependence to tobacco smoking with special reference to individualization of treatment Addict Behav, 3 (1978), pp. 235-241 [30] K.E. Hutchison, D.L. Allen, F.M. Filbey, C. Jepson, C. Lerman, N.L. Benowitz, et al. CHRNA4 and tobacco dependence: from gene regulation to treatment outcome Arch Gen Psychiatry, 64 (2007), pp. 1078-1086 [31] M.A. Ehringer, H.V. Clegg, A.C. Collins, R.P. Corley, T. Crowley, J.K. Hewitt, et al. Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine Am J Med Genet B Neuropsychiatr Genet, 144B (2007), pp. 596-604 [32] J.F. Etter, J.C. Hoda, N. Perroud, M. Munafò, C. Buresi, et al. Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence Addict Behav, 34 (2009), pp. 772-775 [33] T. Spruell, G. Colavita, T. Donegan, M. Egawhary, M. Hurley, et al. Association between nicotinic acetylcholine receptor single nucleotide polymorphisms and smoking cessation Nicot Toba Res, 14 (2012), pp. 993-997
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norman
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12881 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12881 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal image/jpeg inches 96 96 norman 53 53 723 1425 2016-03-08 11:12:45 1425x723 7188-01-FH02-FSSG-16-05421.jpg UniSZA Private Access α-4 subunit of nicotinic acetylcholine receptor polymorphisms exhibit no association with smoking behavior among Malay Males in Kelantan, Malaysia Egyptian Journal of Medical Human Genetics Background Smoking behavior is influenced by both genetic and environmental factors. Nicotine is the major addictive substance in cigarettes. Nicotinic acetylcholine receptors (nAChRs) are thought to play an important role in nicotine addiction of smokers. One of the genes, α-4 subunit of nicotinic acetylcholine receptor (CHRNA4) gene was reported to be associated with smoking behavior in many populations. Aim The aim of this study is to determine association between α-4 subunit of nicotinic acetylcholine receptor single nucleotide polymorphism (rs2236196 and rs2273502 loci) and smoking behavior among Malay Males. Methods The study was conducted in Malay smokers (n = 248) and non-smoking controls (n = 248). DNA was extracted from leucocytes and the two SNPs were determined by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The PCR product was digested with restriction enzymes AfeI and Sau96I, respectively. Results and conclusion We found that the AA genotype frequency for CHRNA4 rs2236196 polymorphism in the smoker group was 80.6% while in nonsmoker 77.0%. No mutation (GG genotype) was detected in both groups. The AG genotype for the smoker group was 19.4% while in the nonsmoker group 23.0%. There was no significant difference observed in the genotype (χ2 = 5.106, p = 0.078) and allele frequencies between both study groups. On the other hand, no mutation of CHRNA4 rs2273502 (TT genotype) was detected in the non-smoker group while the frequencies of genotype CC and heterozygous CT in non-smokers were 75.8% and 24.2%, respectively. In the smoker group, the frequencies were 73.4%, 2.0% and 24.6%, for TT, CC and CT, respectively. There was no significant difference observed in rs2273502 (χ2 = 5.16, p = 0.078) and smoking behavior of the subjects. In conclusion, the results revealed that CHRNA4 rs2273502 and rs2236196 gene polymorphisms are not statistically significantly associated with smoking behavior in our population. 17 1 Egyptian Society of Human Genetics Egyptian Society of Human Genetics 71-77 [1] V. Batra, A.A. Patkar, W.H. Berrettini, S.P. Weinstein, F.T. Leone The genetic determinants of smoking Chest, 123 (2003), pp. 1730-1739 [2] T. Arinami, H. Ishiguro, E.S. Onaivi Polymorphisms in genes involved in neurotransmission in relation to smoking Eur J Pharmacol, 410 (2000), pp. 215-226 [3] E.C. Johnstone, P. Yudkin, S.E. Griffiths, A. Fuller, M. Murphy, R. Walton The dopamine D2 receptor C32806T polymorphism (DRD2 Taq1A RFLP) exhibits no association with smoking behaviour in a healthy UK population Addict Biol, 9 (3–4) (2004), pp. 221-226 [4] G.N. Radwan, M. El-Setouhy, M.K. Mohamed, M.A. Hamid, S.A. Azem, et al. DRD2/ANKK1 TaqI polymorphism and smoking behavior of Egyptian male cigarette smokers Nicotine Tob Res, 9 (12) (2007), pp. 1325-1329 [5] J. Gelernter, H. Kranzler, S.L. Satel No association between D2 dopamine receptor (DRD2) alleles or haplotypes and cocaine dependence or severity of cocaine dependence in European- and African-Americans Biol Psychiatry, 45 (3) (1999), pp. 340-345 [6] A. Sieminska, K. Buczkowski, E. Jassem, M. Niedoszytko, E. Tkacz Influences of polymorphic variants of DRD2 and SLC6A3 genes, and their combinations on smoking in Polish population BMC Med Genet, 10 (2009), p. 92 [7] H. Ishikawa, T. Ohtsuki, H. Ishiguro, K. Yamakawa-Kobayashi, K. Endo, Y.L. Lin Association between serotonin transporter gene polymorphism and smoking among Japanese males Cancer Epidemiol Biomarkers Prev, 8 (1999), pp. 831-833 [8] N.I. Rozak, I. Ahmad, S.H. Gan, R. Abu Bakar Lack of association between the serotonin transporter (5-htt) and serotonin receptor (5-ht2a) gene polymorphisms with smoking behavior among malaysian malays Sci Pharm, 82 (3) (2014), pp. 631-642 [9] A. Sieminska, K. Buczkowski, E. Jassem, E. Tkacz Lack of association between serotonin transporter gene polymorphism 5-HTTLPR and smoking among Polish population: a case–control study BMC Med Genet, 9 (2008), p. 76 [10] M. Iordanidou, A. Tavridou, I. Petridis, S. Kyroglou, L. Kaklamanis, D. Christakidis Association of polymorphisms of the serotonergic system with smoking initiation in Caucasians Drug Alcohol Depend, 108 (2009), pp. 70-76 [11] Y. Feng, T. Niu, H. Xing, X. Xu, C. Chen, et al. A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men Am J Hum Genet, 75 (2004), pp. 112-121 [12] M.D. Li, J. Beuten, J.Z. Ma, T.J. Payne, X.Y. Lou, et al. Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence Hum Mol Genet, 14 (2005), pp. 1211-1219 [13] L.P. Breitling, N. Dahmen, K. Mittelstrass, D. Rujescu, J. Gallinat, et al. Association of nicotinic acetylcholine receptor subunit [alpha]4 polymorphisms with nicotine dependence in 5500 Germans Pharmacogenomics, 9 (2009), pp. 219-224 [14] C. Olsson, R. Anney, S. Forrest, G. Patton, C. Coffey, et al. Association between dependent smoking and a polymorphism in the tyrosine hydroxylase gene in a prospective population-based study of adolescent health Behav Genet, 34 (1) (2004), pp. 85-91 [15] S. Mizuno, H. Ito, N. Hamajima, A. Tamakoshi, K. Hirose, K. Tajima Association between smoking habits and tryptophan hydroxylase gene C218A polymorphism among the Japanese population J Epidemiol, 14 (3) (2004), pp. 94-99 [16] X. Yang, H. Chen, S. Li, Q. Wang, L. Pan, C. Jia Association between monoamine oxidase gene polymorphisms and smoking behavior: a meta-analysis Drug Alcohol Depend, 153 (2015), pp. 350-354 [17] J. Mutschler, E. Abbruzzese, C. von der Goltz, C. Dinter, A. Mobascher, et al. Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case–control study Nicotine Tob Res, 15 (7) (2013), pp. 1322-1327 [18] B. Karahalil, E. Coskun, E. Emerce ADRA2A polymorphism and smoking in a Turkish population Toxicol Ind Health, 24 (3) (2008), pp. 171-176 [19] M. Verhagen, M. Kleinjan, R.C. Engels A systematic review of the A118G (Asn40Asp) variant of OPRM1 in relation to smoking initiation, nicotine dependence and smoking cessation Pharmacogenomics, 13 (8) (2012), pp. 917-933 [20] M.J. Kreek, G. Bart, C. Lilly, K.S. LaForge, D.A. Nielsen Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments Pharmacol Rev, 57 (2005), pp. 1-26 [21] J.L. Galzi, J.P. Changeux Neuronal nicotinic receptors: molecular organization and regulations Neuropharmacology, 34 (1995), pp. 563-582 [22] A.R. Tapper, S.L. McKinney, R. Nashmi, J. Schwarz, P. Deshpande, C. Labarca, et al. Nicotine activation of alpha4∗ receptors: sufficient for reward, tolerance, and sensitization Science, 306 (2004), pp. 1029-1032 [23] O. Steinlein, S. Weiland, J. Stoodt, P. Propping Exon-intron structure of the human neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) Genomics, 32 (1996), pp. 289-294 [24] E.J. Pérez-Stable, B. Herrera, P. Jacob 3rd, N.L. Benowitz Nicotine metabolism and intake in black and white smokers JAMA, 280 (1998), pp. 152-156 [25] N.L. Benowitz, E.J. Perez-Stable, I. Fong, G. Modin, B. Herrera, P. Jacob 3rd Ethnic differences in N-glucuronidation of nicotine and cotinine J Pharmacol Exp Ther, 291 (1999), pp. 1196-1203 [26] R.F. Tyndale Genetics of alcohol and tobacco use in humans Ann Med, 35 (2003), pp. 94-121 [27] D. Von Ah, S. Ebert, A. Ngamvitroj, N. Park, D.H. Kang Factors related to cigarette smoking initiation and use among college students Tob Induc Dis, 3 (2005), pp. 1-5 [28] H.A. Anne Yee, C.G. Ng, A.R. Rusdi Validation of the Malay Version of Fagerstrom Test for Nicotine Dependence (FTND-M) Among a Group of Male Staffs in a University Hospital Malays J Psychiatry, 20 (1) (2011) [29] K. Fagerström Measuring degree of physical dependence to tobacco smoking with special reference to individualization of treatment Addict Behav, 3 (1978), pp. 235-241 [30] K.E. Hutchison, D.L. Allen, F.M. Filbey, C. Jepson, C. Lerman, N.L. Benowitz, et al. CHRNA4 and tobacco dependence: from gene regulation to treatment outcome Arch Gen Psychiatry, 64 (2007), pp. 1078-1086 [31] M.A. Ehringer, H.V. Clegg, A.C. Collins, R.P. Corley, T. Crowley, J.K. Hewitt, et al. Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine Am J Med Genet B Neuropsychiatr Genet, 144B (2007), pp. 596-604 [32] J.F. Etter, J.C. Hoda, N. Perroud, M. Munafò, C. Buresi, et al. Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence Addict Behav, 34 (2009), pp. 772-775 [33] T. Spruell, G. Colavita, T. Donegan, M. Egawhary, M. Hurley, et al. Association between nicotinic acetylcholine receptor single nucleotide polymorphisms and smoking cessation Nicot Toba Res, 14 (2012), pp. 993-997
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α-4 subunit of nicotinic acetylcholine receptor polymorphisms exhibit no association with smoking behavior among Malay Males in Kelantan, Malaysia
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| summary |
Background Smoking behavior is influenced by both genetic and environmental factors. Nicotine is the major addictive substance in cigarettes. Nicotinic acetylcholine receptors (nAChRs) are thought to play an important role in nicotine addiction of smokers. One of the genes, α-4 subunit of nicotinic acetylcholine receptor (CHRNA4) gene was reported to be associated with smoking behavior in many populations. Aim The aim of this study is to determine association between α-4 subunit of nicotinic acetylcholine receptor single nucleotide polymorphism (rs2236196 and rs2273502 loci) and smoking behavior among Malay Males. Methods The study was conducted in Malay smokers (n = 248) and non-smoking controls (n = 248). DNA was extracted from leucocytes and the two SNPs were determined by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The PCR product was digested with restriction enzymes AfeI and Sau96I, respectively. Results and conclusion We found that the AA genotype frequency for CHRNA4 rs2236196 polymorphism in the smoker group was 80.6% while in nonsmoker 77.0%. No mutation (GG genotype) was detected in both groups. The AG genotype for the smoker group was 19.4% while in the nonsmoker group 23.0%. There was no significant difference observed in the genotype (χ2 = 5.106, p = 0.078) and allele frequencies between both study groups. On the other hand, no mutation of CHRNA4 rs2273502 (TT genotype) was detected in the non-smoker group while the frequencies of genotype CC and heterozygous CT in non-smokers were 75.8% and 24.2%, respectively. In the smoker group, the frequencies were 73.4%, 2.0% and 24.6%, for TT, CC and CT, respectively. There was no significant difference observed in rs2273502 (χ2 = 5.16, p = 0.078) and smoking behavior of the subjects. In conclusion, the results revealed that CHRNA4 rs2273502 and rs2236196 gene polymorphisms are not statistically significantly associated with smoking behavior in our population.
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| title |
α-4 subunit of nicotinic acetylcholine receptor polymorphisms exhibit no association with smoking behavior among Malay Males in Kelantan, Malaysia
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| title_full |
α-4 subunit of nicotinic acetylcholine receptor polymorphisms exhibit no association with smoking behavior among Malay Males in Kelantan, Malaysia
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| title_fullStr |
α-4 subunit of nicotinic acetylcholine receptor polymorphisms exhibit no association with smoking behavior among Malay Males in Kelantan, Malaysia
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| title_full_unstemmed |
α-4 subunit of nicotinic acetylcholine receptor polymorphisms exhibit no association with smoking behavior among Malay Males in Kelantan, Malaysia
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| title_short |
α-4 subunit of nicotinic acetylcholine receptor polymorphisms exhibit no association with smoking behavior among Malay Males in Kelantan, Malaysia
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| title_sort |
α-4 subunit of nicotinic acetylcholine receptor polymorphisms exhibit no association with smoking behavior among malay males in kelantan, malaysia
|