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1860797475612262400
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INTELEK Repository
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Online Access
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https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072
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| date |
2016-03-01 14:37:34
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Restricted Document
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12877
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UniSZA
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[1] Kent TH, Hart MN. Appleton-Century Crofts, New York. [2] Allen A, Flemstrom G, Garner A and Kivilaakso E. Physiol Rev, 1993, 73: 823-857. [3] Belaiche, J; Burette, A; De Vos, M; Louis, E; Huybrechts, M; Deltenre, M; Belgian Acta gastro-enterologica Belgica, 2002, 65: 65-73. [4] Chan, F K; Leung, W K. The Lancet, 2002, 360: 933-941. [5] Croft DN, J. Digestive Dis. 1977, 22: 383-386. [6] Nguelefack TB, Watcho P, Wansi SL, Nguelta MM, Ngamga D, Tane P, Kamanyi A African Journal of Traditional Complementary and Alternative Medicines, 2005, 2, 233–237. [7] Salih BA, Abasiyanik MF, Bayyurt N, Sander E. World J Gastroenterol. 2007, 13(23):3245-3248. [8] Sanyal RK, Das PK, Sinha S, Sinha YK. J Pharm Pharmacol. 1961, 13:318-319. [9] Sanyal AK, Gupta KK, Chowdhury NK. J Pharm Pharmacol. 1963. 15:283-284. [10] Sanyal AK, Gupta KK, Chawdhury NK . Arch Int Pharmacodyn, 1964. 149:393-400. [11] Sanyal AK, Banerjee CR, Das PK. Arch Int Pharmacodyn. 1965. 155:244-8. [12] Goel RK, Sairam K, Rao CV. Indian J Exp Biol. 2001. 39(7):719-722. [13] Vadivelan R, Elango K, Suresh B, Ramesh BR. Anc Sci Life. 2006. 25(3-4):67-70. [14] Imam MZ, Akter, S. Journal of Applied Pharmaceutical Science. 2011. 01 (05):14-20. [15] Choi J, Shin KM, Park HJ, Jung HJ, Kim HJ, Lee YS, Rew JH, Lee KT. Planta Med. 2004. 70(11):1027-1032. [16] Nakazawa T, Yasuda T, Ohsawa K. J. Pharm. Pharmacol.2003. 55: 1583-1591. [17] Eleni HP, Paula MF, Supriya K. Am. J. Physiol. Cell Physiol. 2004. 286:239-246. [18] Nour-Eddine E, Kollmann A, Khlifi S, Ducrot PH. Food Sci. Technol, 2007. 40: 1246-1252. [19] Niu HS, Liu IM, Cheng JT, Lin CL, Hsu FL. Planta Med. 2008. 74(2):109-113. [20] Wan Z, Jiang SC, Zhu Y. Medica Res. 2010. 21: 752-753. [21] Cho JY, Nam KH, Kim AR, Park J, Yoo ES, Baik KU, Yu YH, Park MH. J Pharm Pharmacol. 2001. 53(9):1287-1294. [22] Park HJ, Lee MS, Lee KT, Sohn IC, Han YN and Miyamoto KI. Chemical and Pharmacological Bulletin. 1999. 47: 1029-1031. [23] Kim DH, Lee KT, Bae EA, Han MJ and Park HJ. Archives of Pharmaceutical Research. 1999. 22: 30-34. [24] Lanza AMD, Martinez MJA, Matellano LF, Carretero CR, Castillo LV, Sen AMS and Benito PB. Planta Medica. 2001. 67: 219-223. [25] Büyükokuroglu, M E; Taysi, S; Polat, F; Göçer, F. Pharmacological Research. 2002. 45: 421-425. [26] Süleyman, H; Akçay, F; Altinkaynak, K. Pharmacological Research. 2002. 45: 155-158. [27] Shay H, Komarov SA, Fels SS, Mereanze D, Gruentein M and Siplet H. Gastroenterol. 1945. 5: 43-61. [28] Tan PV, Nditafon NG, Yewah MP, Dimo T and Ayafor FJ. J Ethnopharmacol. 1996. 54, 139-142. [29] Gordon, K and P. Bradburg. Churchill Livingston, Newyork. 1990. pp: 61-80. [30] Mani, F; Damasceno, H C; Novelli, E L; Martins, E A; Sforcin, J M. Journal of Ethnopharmacology. 2006. 105: 95-98. [31] Choi J1, Shin KM, Park HJ, Jung HJ, Kim HJ, Lee YS, Rew JH, Lee KT. Planta Med. 2004. Nov; 70(11):1027-32. [32] S. Iyyam Pillai, M. Kandaswamy, and S. Subramanian. Journal of ApiProduct and ApiMedical Science. 2010. 2 (1): 21 - 28. [33] De Barros, M P; Sousa, J P; Bastos, J K; De Andrade, S F. Journal of Ethnopharmacology. 2007. 110: 567-571. [34] Miller, T A; Henagan, J M. Digestive Diseases and Sciences. 1984. 29: 141-149. [35] Pihan, G; Regillo, C; Szabo, S. Digestive Diseases and Sciences. 1987. 32: 1395-1401. [36] Puurunen, J; Huttunen, P; Hirvonen, J. Acta Pharmacology and Toxicology (Copenh). 1980. 47: 321-327. [37] Wallace J.L. Am J Med. 2001. 110:19 -23. [38] Rainsford, K D. Agents and Actions. 1987. 21: 316-319. [39] Martin MJ, Motilva V, Alarcon de la Lastra C. Phytotherapy Res. 1993;7:150–3. [40] Goel RK, Bhattacharya SK. Indian J Exp Biol. 1991. Aug; 29(8):701-14. [41] C.Sumathy and Dr.N.Vijayakumar. World Journal of Pharmaceutical Research. 2015. Volume 4, Issue 5, 832-846.
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norman
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oai_dc
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12877 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12877 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal image/jpeg inches 96 96 norman 1417 768 87 87 2016-03-01 14:37:34 1417x768 7184-01-FH02-FP-16-05391.jpg UniSZA Private Access Invivo gastric antiulcer activity of syringin (phenyl propanoid glucoside) studied in different ulcer induced experimental rat models Der Pharmacia Lettre Most of the currently available oral antiulcer drugs for the treatment of peptic ulcer provoke detrimental adversative effects. Hence, the exploration for plant-derived products for the treatment of ulcer continues. Syringin, a phenylpropanoid glucoside found in the tepals of Musa Paradisiaca, has many biological properties, including as an antioxidant, immunomodulatory and antidiabetic agent. The preventive and curative effects of syringin for ulcers were evaluated using models of acute gastric lesions induced by ethanol and indomethacin in rats. Moreover, the effects of ethanolic extract of syringin on gastric content volume, total acidity and pH, using the pylorus ligated model were also evaluated. Animals pretreated with syringin extract showed a significant reduction in lesion index in both ethanol and indomethacin induced ulcer models in a dose dependent manner when compared to the control group. Similarly, post-treatment with syringin (50 mg/kg body weight) for a period of 15 days revealed a statistically significant improvement in the ulcer healing process (p <0.05). In the pylorus ligated model, it was observed that the syringin displayed an antisecretory activity, which led to a significant reduction in the gastric juice volume, total acidity and pH. These findings indicate that syringin displays both ulcer preventive and ulcer curative properties and provides a scientific rationale for the use of syringin in the traditional medicinal system. 8 1 Scholars Research Library Scholars Research Library 121-128 [1] Kent TH, Hart MN. Appleton-Century Crofts, New York. [2] Allen A, Flemstrom G, Garner A and Kivilaakso E. Physiol Rev, 1993, 73: 823-857. [3] Belaiche, J; Burette, A; De Vos, M; Louis, E; Huybrechts, M; Deltenre, M; Belgian Acta gastro-enterologica Belgica, 2002, 65: 65-73. [4] Chan, F K; Leung, W K. The Lancet, 2002, 360: 933-941. [5] Croft DN, J. Digestive Dis. 1977, 22: 383-386. [6] Nguelefack TB, Watcho P, Wansi SL, Nguelta MM, Ngamga D, Tane P, Kamanyi A African Journal of Traditional Complementary and Alternative Medicines, 2005, 2, 233–237. [7] Salih BA, Abasiyanik MF, Bayyurt N, Sander E. World J Gastroenterol. 2007, 13(23):3245-3248. [8] Sanyal RK, Das PK, Sinha S, Sinha YK. J Pharm Pharmacol. 1961, 13:318-319. [9] Sanyal AK, Gupta KK, Chowdhury NK. J Pharm Pharmacol. 1963. 15:283-284. [10] Sanyal AK, Gupta KK, Chawdhury NK . Arch Int Pharmacodyn, 1964. 149:393-400. [11] Sanyal AK, Banerjee CR, Das PK. Arch Int Pharmacodyn. 1965. 155:244-8. [12] Goel RK, Sairam K, Rao CV. Indian J Exp Biol. 2001. 39(7):719-722. [13] Vadivelan R, Elango K, Suresh B, Ramesh BR. Anc Sci Life. 2006. 25(3-4):67-70. [14] Imam MZ, Akter, S. Journal of Applied Pharmaceutical Science. 2011. 01 (05):14-20. [15] Choi J, Shin KM, Park HJ, Jung HJ, Kim HJ, Lee YS, Rew JH, Lee KT. Planta Med. 2004. 70(11):1027-1032. [16] Nakazawa T, Yasuda T, Ohsawa K. J. Pharm. Pharmacol.2003. 55: 1583-1591. [17] Eleni HP, Paula MF, Supriya K. Am. J. Physiol. Cell Physiol. 2004. 286:239-246. [18] Nour-Eddine E, Kollmann A, Khlifi S, Ducrot PH. Food Sci. Technol, 2007. 40: 1246-1252. [19] Niu HS, Liu IM, Cheng JT, Lin CL, Hsu FL. Planta Med. 2008. 74(2):109-113. [20] Wan Z, Jiang SC, Zhu Y. Medica Res. 2010. 21: 752-753. [21] Cho JY, Nam KH, Kim AR, Park J, Yoo ES, Baik KU, Yu YH, Park MH. J Pharm Pharmacol. 2001. 53(9):1287-1294. [22] Park HJ, Lee MS, Lee KT, Sohn IC, Han YN and Miyamoto KI. Chemical and Pharmacological Bulletin. 1999. 47: 1029-1031. [23] Kim DH, Lee KT, Bae EA, Han MJ and Park HJ. Archives of Pharmaceutical Research. 1999. 22: 30-34. [24] Lanza AMD, Martinez MJA, Matellano LF, Carretero CR, Castillo LV, Sen AMS and Benito PB. Planta Medica. 2001. 67: 219-223. [25] Büyükokuroglu, M E; Taysi, S; Polat, F; Göçer, F. Pharmacological Research. 2002. 45: 421-425. [26] Süleyman, H; Akçay, F; Altinkaynak, K. Pharmacological Research. 2002. 45: 155-158. [27] Shay H, Komarov SA, Fels SS, Mereanze D, Gruentein M and Siplet H. Gastroenterol. 1945. 5: 43-61. [28] Tan PV, Nditafon NG, Yewah MP, Dimo T and Ayafor FJ. J Ethnopharmacol. 1996. 54, 139-142. [29] Gordon, K and P. Bradburg. Churchill Livingston, Newyork. 1990. pp: 61-80. [30] Mani, F; Damasceno, H C; Novelli, E L; Martins, E A; Sforcin, J M. Journal of Ethnopharmacology. 2006. 105: 95-98. [31] Choi J1, Shin KM, Park HJ, Jung HJ, Kim HJ, Lee YS, Rew JH, Lee KT. Planta Med. 2004. Nov; 70(11):1027-32. [32] S. Iyyam Pillai, M. Kandaswamy, and S. Subramanian. Journal of ApiProduct and ApiMedical Science. 2010. 2 (1): 21 - 28. [33] De Barros, M P; Sousa, J P; Bastos, J K; De Andrade, S F. Journal of Ethnopharmacology. 2007. 110: 567-571. [34] Miller, T A; Henagan, J M. Digestive Diseases and Sciences. 1984. 29: 141-149. [35] Pihan, G; Regillo, C; Szabo, S. Digestive Diseases and Sciences. 1987. 32: 1395-1401. [36] Puurunen, J; Huttunen, P; Hirvonen, J. Acta Pharmacology and Toxicology (Copenh). 1980. 47: 321-327. [37] Wallace J.L. Am J Med. 2001. 110:19 -23. [38] Rainsford, K D. Agents and Actions. 1987. 21: 316-319. [39] Martin MJ, Motilva V, Alarcon de la Lastra C. Phytotherapy Res. 1993;7:150–3. [40] Goel RK, Bhattacharya SK. Indian J Exp Biol. 1991. Aug; 29(8):701-14. [41] C.Sumathy and Dr.N.Vijayakumar. World Journal of Pharmaceutical Research. 2015. Volume 4, Issue 5, 832-846.
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| spellingShingle |
Invivo gastric antiulcer activity of syringin (phenyl propanoid glucoside) studied in different ulcer induced experimental rat models
|
| summary |
Most of the currently available oral antiulcer drugs for the treatment of peptic ulcer provoke detrimental adversative effects. Hence, the exploration for plant-derived products for the treatment of ulcer continues. Syringin, a phenylpropanoid glucoside found in the tepals of Musa Paradisiaca, has many biological properties, including as an antioxidant, immunomodulatory and antidiabetic agent. The preventive and curative effects of syringin for ulcers were evaluated using models of acute gastric lesions induced by ethanol and indomethacin in rats. Moreover, the effects of ethanolic extract of syringin on gastric content volume, total acidity and pH, using the pylorus ligated model were also evaluated. Animals pretreated with syringin extract showed a significant reduction in lesion index in both ethanol and indomethacin induced ulcer models in a dose dependent manner when compared to the control group. Similarly, post-treatment with syringin (50 mg/kg body weight) for a period of 15 days revealed a statistically significant improvement in the ulcer healing process (p <0.05). In the pylorus ligated model, it was observed that the syringin displayed an antisecretory activity, which led to a significant reduction in the gastric juice volume, total acidity and pH. These findings indicate that syringin displays both ulcer preventive and ulcer curative properties and provides a scientific rationale for the use of syringin in the traditional medicinal system.
|
| title |
Invivo gastric antiulcer activity of syringin (phenyl propanoid glucoside) studied in different ulcer induced experimental rat models
|
| title_full |
Invivo gastric antiulcer activity of syringin (phenyl propanoid glucoside) studied in different ulcer induced experimental rat models
|
| title_fullStr |
Invivo gastric antiulcer activity of syringin (phenyl propanoid glucoside) studied in different ulcer induced experimental rat models
|
| title_full_unstemmed |
Invivo gastric antiulcer activity of syringin (phenyl propanoid glucoside) studied in different ulcer induced experimental rat models
|
| title_short |
Invivo gastric antiulcer activity of syringin (phenyl propanoid glucoside) studied in different ulcer induced experimental rat models
|
| title_sort |
invivo gastric antiulcer activity of syringin (phenyl propanoid glucoside) studied in different ulcer induced experimental rat models
|