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1860797475136208896
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INTELEK Repository
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| collection |
Online Access
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https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072
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| date |
2016-02-24 09:23:29
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Restricted Document
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12871
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UniSZA
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Alam MS, Chopra N, Ali M, Niwa M. Oleanen and stigmasterol derivatives from Ambroma augusta. Phytochemistry, 1996; 41:1197-1200. Ata A, Mbong N, Iverson CD, Samarasekera R. Minor chemical constituents of Vitex pinnata. Natural product communications, 2009; 4:1. Barral-Netto M, Badaró R, Barral A, Almeida RP, Santos SB, Badaró F, Pedral-Sampaio D, Carvalho EM, Falcoff E, Falcoff R. Tumor Necrosis Factor (Cachectin) in Human Visceral Leishmaniasis. Journal of Infectious Diseases, 1991; 163:853-857. Burkill IH. 1966. A Dictionary of the Economic Products of the Malay Peninsula. Ministry of Agriculture Co-operatives: Kuala Lumpur 2280. Corner EJH. 1951. Wayside trees of Malaya. Singapore Govern: Singapore. de Kok R. The genus Vitex (Labiatae) in the flora Malesiana region, excluding New Guinea. Kew Bulletin, 2008; 63:17-40. Jacobs RT, Nare B, Phillips MA. State of the art in African trypanosome drug discovery. Current topics in medicinal chemistry, 2011; 11:1255. Kolak U, Hacibekıroğlu I, Öztürk M, Özgökçe F, Topçu G, Ulubelen A. Antioxidant and anticholinesterase constituents of Salvia poculata. Turkish Journal of Chemistry, 2009; 33. Li S, Lo C-Y, Ho C-T. Hydroxylated polymethoxyflavones and methylated flavonoids in sweet orange (Citrus sinensis) peel. Journal of agricultural and food chemistry, 2006; 54:4176-4185. Mahato SB, Kundu AP. 13C NMR Spectra of pentacyclic triterpenoids--a compilation and some salient features. Phytochemistry, 1994; 37:1517-1575. Malan E, Roux DG. Flavonoids from Distemonanthus benthamianus Baillon. Methoxylated flavones and inter-relationships of benthamianin, a [2]benzopyrano[4,3-b][1]benzopyran. Journal of the Chemical Society, Perkin Transactions 1, 1979:2696-2703. Marles RJ, Farnsworth NR. Antidiabetic plants and their active constituents. Phytomedicine, 1995; 2:137-189. Mukhtar M, Arshad M, Ahmad M, Pomerantz RJ, Wigdahl B, Parveen Z. Antiviral potentials of medicinal plants. Virus Research, 2008; 131:111-120. Nam N-H. Naturally occurring NF-せB inhibitors. Mini reviews in medicinal chemistry, 2006; 6:945-951. Okomo-Assoumou MC, Daulouede S, Lemesre J-L, N'ZilaMouanda A, Vincendeau P. Correlation of High Serum Levels of Tumor Necrosis Factor-g with Disease Severity in Human African trypanosomiasis. The American Journal of Tropical Medicine and Hygiene, 1995; 53:539-543. Ong H, Nordiana M. Malay ethno-medico botany in Machang, Kelantan, Malaysia. Fitoterapia, 1999; 70:502-513. Pezzuto JM. Plant-derived anticancer agents. Biochemical pharmacology, 1997; 53:121-133. Rhind SG, Sabiston BH, Shek PN, Buguet A, Muanga G, Stanghellini A, Dumas M, Radomski MW. Effect of Melarsoprol Treatment on Circulating IL-10 and TNF-g Levels in Human African Trypanosomiasis. Clinical Immunology and Immunopathology, 1997; 83:185-189. Rossi MH, Yoshida M, Soares Maia JG. 1997. Neolignans, styrylpyrones and flavonoids from an Aniba species. 1263-1269 p. Schmidt T, Khalid S, Romanha A, Alves T, Biavatti M, Brun R, Da Costa F, De Castro S, Ferreira V, De Lacerda M. The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-Part II. Curr. Med. Chem, 2012; 19:2176- 2228. Scuderi P, Lam K, Ryan K, Petersen E, Sterling K, Finley P, Ray CG, Slymen D, Salmon S. Raised serum levels of tumour necrosis factor in parasitic infections. The Lancet, 1986; 328:1364-1365. Shaffer N, Grau GE, Hedberg K, Davachi F, Lyamba B, Hightower AW, Breman JG, Nguyen-Dinh P. Tumor Necrosis Factor and Severe Malaria. Journal of Infectious Diseases, 1991; 163:96- 101. Simarro PP, Diarra A, Postigo JAR, Franco JR, Jannin JG. The human African trypanosomiasis control and surveillance programme of the World Health Organization 2000–2009: the way forward. PLoS neglected tropical diseases, 2011; 5:e1007. Suksamrarn A, Sommechai C. Ecdysteroids from Vitex pinnata. Phytochemistry, 1993; 32:303-306. Tasdemir D, Kaiser M, Brun R, Yardley V, Schmidt TJ, Tosun F, Rüedi P. Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. Antimicrobial agents and chemotherapy, 2006; 50:1352-1364. Viegelmann C, Parker J, Ooi T, Clements C, Abbott G, Young L, Kennedy J, Dobson A, Edrada-Ebel R. Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans. Marine Drugs, 2014; 12:2937-2952. WHO. 2013a. Sustaining the drive to overcome the global impact of neglected tropical diseases: second WHO report on neglected tropical diseases: summary. WHO. 2013b. Global tuberculosis report 2013. World Health Organization: Geneva, Switzerland.
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7178-01-FH02-FBIM-16-05379.jpg
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norman
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oai_dc
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https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12871
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12871 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12871 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal image/jpeg inches 96 96 norman 763 25 25 1425 2016-02-24 09:23:29 1425x763 7178-01-FH02-FBIM-16-05379.jpg UniSZA Private Access Anti-infective activities of secondary metabolites from Vitex pinnata Journal of Applied Pharmaceutical Science The phytochemical investigation of Vitex pinnata led to the isolation of a mixture of steroids く-sitosterol and stigmasterol (1a and 1b) and three known flavonoid identified as 5-hydroxy-3, 7, 4’-trimethoxyflavone (2), 5- hydroxy-7,4’-dimethoxy-flavone (3) and 5-hydroxy-3,3’,4’,7-tetramethoxyflavone (4). The structures of all isolated compounds were carried out by NMR and mass spectrometry. The isolated compounds were evaluated for their anti-infective activities against Trypanosoma brucei brucei and Mycobacterium marinum. Compound 1- 4 showed moderate antitrypanosomal activity with MIC values of 6.25たg/ml, 19.0, 21.0 and 17.0たM, respectively while no activity observed on anti-mycobacterial. This study is the first to report the presence of three flavones and their antitrypanosomal activity from V. pinnata. 6 1 Open Science Publishers LLP Inc. Open Science Publishers LLP Inc. 102-106 Alam MS, Chopra N, Ali M, Niwa M. Oleanen and stigmasterol derivatives from Ambroma augusta. Phytochemistry, 1996; 41:1197-1200. Ata A, Mbong N, Iverson CD, Samarasekera R. Minor chemical constituents of Vitex pinnata. Natural product communications, 2009; 4:1. Barral-Netto M, Badaró R, Barral A, Almeida RP, Santos SB, Badaró F, Pedral-Sampaio D, Carvalho EM, Falcoff E, Falcoff R. Tumor Necrosis Factor (Cachectin) in Human Visceral Leishmaniasis. Journal of Infectious Diseases, 1991; 163:853-857. Burkill IH. 1966. A Dictionary of the Economic Products of the Malay Peninsula. Ministry of Agriculture Co-operatives: Kuala Lumpur 2280. Corner EJH. 1951. Wayside trees of Malaya. Singapore Govern: Singapore. de Kok R. The genus Vitex (Labiatae) in the flora Malesiana region, excluding New Guinea. Kew Bulletin, 2008; 63:17-40. Jacobs RT, Nare B, Phillips MA. State of the art in African trypanosome drug discovery. Current topics in medicinal chemistry, 2011; 11:1255. Kolak U, Hacibekıroğlu I, Öztürk M, Özgökçe F, Topçu G, Ulubelen A. Antioxidant and anticholinesterase constituents of Salvia poculata. Turkish Journal of Chemistry, 2009; 33. Li S, Lo C-Y, Ho C-T. Hydroxylated polymethoxyflavones and methylated flavonoids in sweet orange (Citrus sinensis) peel. Journal of agricultural and food chemistry, 2006; 54:4176-4185. Mahato SB, Kundu AP. 13C NMR Spectra of pentacyclic triterpenoids--a compilation and some salient features. Phytochemistry, 1994; 37:1517-1575. Malan E, Roux DG. Flavonoids from Distemonanthus benthamianus Baillon. Methoxylated flavones and inter-relationships of benthamianin, a [2]benzopyrano[4,3-b][1]benzopyran. Journal of the Chemical Society, Perkin Transactions 1, 1979:2696-2703. Marles RJ, Farnsworth NR. Antidiabetic plants and their active constituents. Phytomedicine, 1995; 2:137-189. Mukhtar M, Arshad M, Ahmad M, Pomerantz RJ, Wigdahl B, Parveen Z. Antiviral potentials of medicinal plants. Virus Research, 2008; 131:111-120. Nam N-H. Naturally occurring NF-せB inhibitors. Mini reviews in medicinal chemistry, 2006; 6:945-951. Okomo-Assoumou MC, Daulouede S, Lemesre J-L, N'ZilaMouanda A, Vincendeau P. Correlation of High Serum Levels of Tumor Necrosis Factor-g with Disease Severity in Human African trypanosomiasis. The American Journal of Tropical Medicine and Hygiene, 1995; 53:539-543. Ong H, Nordiana M. Malay ethno-medico botany in Machang, Kelantan, Malaysia. Fitoterapia, 1999; 70:502-513. Pezzuto JM. Plant-derived anticancer agents. Biochemical pharmacology, 1997; 53:121-133. Rhind SG, Sabiston BH, Shek PN, Buguet A, Muanga G, Stanghellini A, Dumas M, Radomski MW. Effect of Melarsoprol Treatment on Circulating IL-10 and TNF-g Levels in Human African Trypanosomiasis. Clinical Immunology and Immunopathology, 1997; 83:185-189. Rossi MH, Yoshida M, Soares Maia JG. 1997. Neolignans, styrylpyrones and flavonoids from an Aniba species. 1263-1269 p. Schmidt T, Khalid S, Romanha A, Alves T, Biavatti M, Brun R, Da Costa F, De Castro S, Ferreira V, De Lacerda M. The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-Part II. Curr. Med. Chem, 2012; 19:2176- 2228. Scuderi P, Lam K, Ryan K, Petersen E, Sterling K, Finley P, Ray CG, Slymen D, Salmon S. Raised serum levels of tumour necrosis factor in parasitic infections. The Lancet, 1986; 328:1364-1365. Shaffer N, Grau GE, Hedberg K, Davachi F, Lyamba B, Hightower AW, Breman JG, Nguyen-Dinh P. Tumor Necrosis Factor and Severe Malaria. Journal of Infectious Diseases, 1991; 163:96- 101. Simarro PP, Diarra A, Postigo JAR, Franco JR, Jannin JG. The human African trypanosomiasis control and surveillance programme of the World Health Organization 2000–2009: the way forward. PLoS neglected tropical diseases, 2011; 5:e1007. Suksamrarn A, Sommechai C. Ecdysteroids from Vitex pinnata. Phytochemistry, 1993; 32:303-306. Tasdemir D, Kaiser M, Brun R, Yardley V, Schmidt TJ, Tosun F, Rüedi P. Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. Antimicrobial agents and chemotherapy, 2006; 50:1352-1364. Viegelmann C, Parker J, Ooi T, Clements C, Abbott G, Young L, Kennedy J, Dobson A, Edrada-Ebel R. Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans. Marine Drugs, 2014; 12:2937-2952. WHO. 2013a. Sustaining the drive to overcome the global impact of neglected tropical diseases: second WHO report on neglected tropical diseases: summary. WHO. 2013b. Global tuberculosis report 2013. World Health Organization: Geneva, Switzerland.
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| spellingShingle |
Anti-infective activities of secondary metabolites from Vitex pinnata
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| summary |
The phytochemical investigation of Vitex pinnata led to the isolation of a mixture of steroids く-sitosterol and stigmasterol (1a and 1b) and three known flavonoid identified as 5-hydroxy-3, 7, 4’-trimethoxyflavone (2), 5- hydroxy-7,4’-dimethoxy-flavone (3) and 5-hydroxy-3,3’,4’,7-tetramethoxyflavone (4). The structures of all isolated compounds were carried out by NMR and mass spectrometry. The isolated compounds were evaluated for their anti-infective activities against Trypanosoma brucei brucei and Mycobacterium marinum. Compound 1- 4 showed moderate antitrypanosomal activity with MIC values of 6.25たg/ml, 19.0, 21.0 and 17.0たM, respectively while no activity observed on anti-mycobacterial. This study is the first to report the presence of three flavones and their antitrypanosomal activity from V. pinnata.
|
| title |
Anti-infective activities of secondary metabolites from Vitex pinnata
|
| title_full |
Anti-infective activities of secondary metabolites from Vitex pinnata
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| title_fullStr |
Anti-infective activities of secondary metabolites from Vitex pinnata
|
| title_full_unstemmed |
Anti-infective activities of secondary metabolites from Vitex pinnata
|
| title_short |
Anti-infective activities of secondary metabolites from Vitex pinnata
|
| title_sort |
anti-infective activities of secondary metabolites from vitex pinnata
|