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1860797453521911808
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INTELEK Repository
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Online Access
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| collectionurl |
https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072
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| date |
2016-03-21 09:24:34
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| format |
Restricted Document
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| id |
12776
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UniSZA
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7083-01-FH02-FP-16-05527.jpg
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| person |
norman
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| recordtype |
oai_dc
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https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12776
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| spelling |
12776 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12776 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal image/jpeg inches 96 96 norman 774 17 17 2016-03-21 09:24:34 1326x774 1326 7083-01-FH02-FP-16-05527.jpg UniSZA Private Access No Association of Polymorphisms in the Dopamine Receptor D2 (DRD2) Gene with Cold Pressor Pain Sensitivity among Healthy Malay Males PUBLIC HEALTH GENOMICS Objective: To examine the effects of variations of loci in the dopamine receptor D2 (DRD2) gene on cold pressor pain responses among healthy Malay males. Material and Methods: Healthy Malay males (n = 152) from a local population signed an informed-consent and participated in this study. Their cold pressor test (CPT) responses (pain threshold, pain tolerance and pain intensity) were assessed at 0 hour, and at 2, 4, 8, 12, and 24 hours after the first CPT. DNA was extracted from whole blood and subjected to PCR-genotyping for eight DRD2 polymorphisms (Val96Ala, Leu141Leu, Val154Ile, Pro310Ser, Ser311Cys, TaqI A, −141C Ins/Del and A-241G). The differences of CPT responses between the DRD2 polymorphisms were analysed using repeated measure ANOVA (RM-ANOVA). Results: Val96Ala, Leu141Leu, Val154Ile and Pro310Ser polymorphisms were not detected in any subject. There were no significant differences in pain responses (pain threshold, tolerance and intensity) between Ser311Cys, TaqI A, −141C Ins/Del and A-241G polymorphisms of DRD2 gene. Conclusion: DRD2 polymorphisms do not have impact on cold pressor pain threshold, pain tolerance and pain intensity. The present results also do not support the notion that DRD2 polymorphisms play a major role in cold pressor pain sensitivity. 18 30-31
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| spellingShingle |
No Association of Polymorphisms in the Dopamine Receptor D2 (DRD2) Gene with Cold Pressor Pain Sensitivity among Healthy Malay Males
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| summary |
Objective: To examine the effects of variations of loci in the dopamine receptor D2 (DRD2) gene on cold pressor pain responses among healthy Malay males. Material and Methods: Healthy Malay males (n = 152) from a local population signed an informed-consent and participated in this study. Their cold pressor test (CPT) responses (pain threshold, pain tolerance and pain intensity) were assessed at 0 hour, and at 2, 4, 8, 12, and 24 hours after the first CPT. DNA was extracted from whole blood and subjected to PCR-genotyping for eight DRD2 polymorphisms (Val96Ala, Leu141Leu, Val154Ile, Pro310Ser, Ser311Cys, TaqI A, −141C Ins/Del and A-241G). The differences of CPT responses between the DRD2 polymorphisms were analysed using repeated measure ANOVA (RM-ANOVA). Results: Val96Ala, Leu141Leu, Val154Ile and Pro310Ser polymorphisms were not detected in any subject. There were no significant differences in pain responses (pain threshold, tolerance and intensity) between Ser311Cys, TaqI A, −141C Ins/Del and A-241G polymorphisms of DRD2 gene. Conclusion: DRD2 polymorphisms do not have impact on cold pressor pain threshold, pain tolerance and pain intensity. The present results also do not support the notion that DRD2 polymorphisms play a major role in cold pressor pain sensitivity.
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| title |
No Association of Polymorphisms in the Dopamine Receptor D2 (DRD2) Gene with Cold Pressor Pain Sensitivity among Healthy Malay Males
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| title_full |
No Association of Polymorphisms in the Dopamine Receptor D2 (DRD2) Gene with Cold Pressor Pain Sensitivity among Healthy Malay Males
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| title_fullStr |
No Association of Polymorphisms in the Dopamine Receptor D2 (DRD2) Gene with Cold Pressor Pain Sensitivity among Healthy Malay Males
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| title_full_unstemmed |
No Association of Polymorphisms in the Dopamine Receptor D2 (DRD2) Gene with Cold Pressor Pain Sensitivity among Healthy Malay Males
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| title_short |
No Association of Polymorphisms in the Dopamine Receptor D2 (DRD2) Gene with Cold Pressor Pain Sensitivity among Healthy Malay Males
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| title_sort |
no association of polymorphisms in the dopamine receptor d2 (drd2) gene with cold pressor pain sensitivity among healthy malay males
|