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1860797448175222784
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INTELEK Repository
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Drugs - Real World Outcomes, doi:10.1007/s40801-015-0045-2
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Online Access
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https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072
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2024-08-27 13:50:08
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Restricted Document
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12754
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UniSZA
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1. International Conference on Harmonization-Efficacy. http:// www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatory Information/Guidances/UCM073087.pdf. 2. Kane-Gill SL, Kirisci L, Verrico MM, Rothschild JM. Analysis of risk factors for adverse drug events in critically ill patients. Crit Care Med. 2012;40(3):823. 3. Hepler CD, Strand LM. Opportunities and responsibilities in pharmaceutical care. Am J Hosp Pharm. 1990;47(3):533–43. 4. Field TS, Gurwitz JH, Harrold LR, Rothschild J, DeBellis KR, Seger AC, et al. Risk factors for adverse drug events among older adults in the ambulatory setting. J Am Geriatr Soc. 2004;52(8):1349–54. 5. Chen YC, Fan JS, Hsu TF, Chen MH, Huang HH, Cheng KW, et al. Detection of patients presenting with adverse drug events in the emergency department. Intern Med J. 2012;42(6):651–7. 6. Castro I, Guardiola JM, Tuneu L, Sala ML, Faus MJ, Mangues MA. Drug-related visits to the emergency department in a Spanish university hospital. Int J Clin Pharm. 2013;35(5): 727–35. 7. Wu C. Bell, Chaim M, Wodchis, Walter P. Incidence and economic burden of adverse drug reactions among elderly patients in Ontario Emergency Departments. Drug Saf. 2012;35(9):769–81. 8. Zed PJ, Abu-Laban RB, Balen RM, Loewen PS, Hohl CM, Brubacher JR, et al. Incidence, severity and preventability of medication-related visits to the emergency department: a prospective study. CMAJ. 2008;178(12):1563–9. 9. World Health Organisation. International Drug Monitoring: the role of a hospital. Technical Series No. 425. 1969; 426: 5–24. 10. Chen Wu CMB WPW. Incidence and economic burden of adverse drug reactions among elderly patients in Ontario Emergency Departments a retrospective study. Drug Saf. 2012;9:769–81. 11. Malaysia MoH. Health facts 2014. In: Center PDHI, editor. Putrajaya: Ministry of health Malaysia; 2014. p. 11–2. 12. Malaysia MoH. Guidelines for medication error reporting. In: Division PS, editor. 1 ed. Selangor Ministry of Health Malaysia; 2009. p. 30. 13. Zed PJ. Drug-related visits to the emergency department. J Pharm Prac. 2005;18(5):329–35. 14. Shah C, Ismail IM, Mohsin S. Ambulance response time and emergency medical dispatcher program: a study in Kelantan, Malaysia. 2008. 15. Queneau P, Trombert B, Carpentier F, Trinh-Duc A, Bannwarth B, Bouget J, editors. Adverse drug effects: a prospective study by Apnet performed in seven emergency care units in France: propositions for preventive measures. Ann Pharm Fr. 2005. 16. Hallas J, Harvald B, Worm J, Beck-Nielsen J, Gram L, Grodum E, et al. Drug related hospital admissions. Eur J Clin Pharmacol. 1993;45(3):199–203. 17. World Health Organisation. Report on Medication Adherence. World Health Organisation. Geneva. 2003; 4. http://www.who. int/chp/knowledge/publications/adherence_full_report.pdf. 18. Nelson KM, Talbert RL. Drug-related hospital admissions. Pharmacother. 1996;16(4):701–7. 19. Singh H, Kumar BN, Sinha T, Dulhani N. The incidence and nature of drug-related hospital admission: a 6-month observational study in a tertiary health care hospital. J Pharmacol Pharmacother. 2011;2(1):17. Drug-Related ED Visits in Malaysia 393 20. Drug information system [database on the Internet]. MIMS 2015. https://www.mims.com/home/index?aspxerrorpath=/Malaysia. Accessed 06 May 2015. 21. Naing L, Than W, Rusli B. Practical issues in calculating the sample size for prevalence studies. 2006. 22. Karuppannan M, Nee TK, Ali SM, Thong WK, Boardman H. The prevalence of adverse drug event-related admissions at a local hospital in Malaysia. Arch Pharm Pract. 2013;4(4):160. 23. Capuano A, Irpino A, Gallo M, Ferrante L, Illiano M, Rinaldi B, et al. Regional surveillance of emergency-department visits for outpatient adverse drug events. Eur J Clin Pharmacol. 2009;65(7):721–8. 24. Baena MI, Faus MJ, Fajardo PC, Luque FM, Sierra F, MartinezOlmos J, et al. Medicine-related problems resulting in emergency department visits. Eur J Clin Pharmacol. 2006;62(5):387–93. 25. Ramos Linares S, Dı´azRuiz P, Mesa Fumero J, et al. Incidence rate of adverse drug effects in a hospital emergency unit and its associated factors. J Farma. 2010;34(6):271–8. 26. Tafreshi MJ, Melby MJ, Kaback KR, Nord TC. Medication-related visits to the emergency department: a prospective study. Ann Pharmacother. 1999;33(12):1252–7. 27. Sikdar KC, Alaghehbandan R, MacDonald D, Barrett B, Collins KD, Donnan J, et al. Adverse drug events in adult patients leading to emergency department visits. Ann Pharmacother. 2010;44(4):641–9. 28. Juntti-Patinen L, Kuitunen T, Pere P, Neuvonen PJ. Drug-related visits to a District Hospital Emergency Room. Basic Clin Pharmacol Toxicol. 2006;98(2):212–7. 29. Trifiro` G, Calogero G, Ippolito FM, Cosentino M, Giuliani R, Conforti A, et al. Adverse drug events in emergency department population: a prospective Italian study. Pharmacoepidemiol Drug Saf. 2005;14(5):333–40. 30. Bednall R, McRobbie D, Hicks A. Identification of medicationrelated attendances at an A & E department. J Clin Pharm Ther. 2003;28(1):41–5. 31. Farooqui M, Noorizan A, Hassan Y, Azhar S, Ghazalli R. Drug related problems as a cause of admission to the medical wards of hospital Pulau Pinang. Malays J Pharm Sci. 2005;3(2):65–6. 32. Schneitman-McIntire O, Farnen TA, Gordon N, Chan J, Toy WA. Medication misadventures resulting in emergency department visits at and HMO medical center. Am J Health Syst Pharm. 1996;53(12):1416–22. 33. Olshaker JS, Barish RA, Naradzay JF, Jerrard DA, Safir E, Campbell L. Prescription noncompliance: contribution to emergency department visits and cost. Eur J Emerg Med. 1999;17(5):909–12. 34. De Paepe P, Petrovic M, Outtier L, Van Maele G, Buylaert W. Drug interactions and adverse drug reactions in the older patients admitted to the emergency department. Acta Clin Belg. 2013;68(1):15–21. 35. Zopf Y, Rabe C, Neubert A, Hahn EG, Dormann H. Risk factors associated with adverse drug reactions following hospital admission. Drug Saf. 2008;31(9):789–98. 36. Drici M-D, Cle´ment N. Is gender a risk factor for adverse drug reactions? Drug Saf. 2001;24(8):575–85. 37. Sarkar U, Lo´pez A, Maselli JH, Gonzales R. Adverse drug events in US adult ambulatory medical care. Health Serv Res. 2011;46(5):1517–33. 38. Cusack B, Nielson C, Vestal R. Geriatric clinical pharmacology and therapeutics. Avery’s Drug treatment 4th ed Auckland, New Zealand: Adis International. 1997: 173–223. 39. Salvo F, Miroddi M, Alibrandi A, Calapai F, Cafeo V, Mancari F, et al. Attitudes and opinion about adverse drug events of women living in a city of south Italy. Pharmacol. 2013;91(3–4):173–7. 40. Chrischilles E, Rubenstein L, Van Gilder R, Voelker M, Wright K, Wallace R. Risk factors for adverse drug events in older adults with mobility limitations in the community setting. J Am Soc Geriatr Dent. 2007;55(1):29–34. 41. Hema NG, Bhuvana KB, Virupaksha HM. Critical assessment of adverse drug reactions to antitubercular drugs in a government teaching hospital. Intern J Basic Med Sci. 2013;5(5):60–7. 42. Al-Arifi M, Abu-Hashem H, Al-Meziny M, Said R, Aljadhey H. Emergency department visits and admissions due to drug related problems at Riyadh military hospital (RMH), Saudi Arabia. Saudi Pharm J. 2014;22(1):17–25. 43. Malhotra S, Karan R, Pandhi P, Jain S. Drug related medical emergencies in the elderly: role of adverse drug reactions and non-compliance. Postgrad Med J. 2001;77(913):703–7. 44. Heaton PC, Tundia NL, Luder HR. US emergency departments visits resulting from poor medication adherence: 2005–07. JAPhA. 2012;53(5):513–9. 45. Ir MD, Johari Dato MohdGhazali R, Hazilah Abd Manaf N, Hassan Asaari Abdullah A, Abu Bakar A, Salikin F, et al. Hospital waiting time: the forgotten premise of healthcare service delivery? Int J Health Care Qual Assur. 2011;24(7):506–22. 46. Hazilah Abd Manaf N, Siew Nooi P. Patient satisfaction as an indicator of service quality in Malaysian public hospitals. Asian J Qual. 2009;10(1):77–87. 47. Lewis A. Non-compliance: a $100 billion problem. Remington Report. 1997;5(4):14–5. 48. Peterson AMTLFR. Meta-analysis of trials of interventions to improve medication adherence. Am J Health Syst Pharm. 2003;60(7):657–65. 49. Phei Ching L, Kelvin L. Evaluation of a pharmacist-managed diabetes medication therapy adherence clinic. Pharm Pract. 2010;8(4):250–4. 50. Lee JK, Grace KA, Taylor AJ. Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol: a randomized controlled trial. JAMA. 2006;296(21):2563–71. 51. Brennan TA, Dollear TJ, Hu M, Matlin OS, Shrank WH, Choudhry NK, et al. An integrated pharmacy-based program improved medication prescription and adherence rates in diabetes patients. Health Aff. 2012;31(1):120–9. 52. Winterstein AG, Sauer BC, Hepler CD, Poole C. Preventable drug-related hospital admissions. Ann Pharmacother. 2002;36(7–8):1238–48. 53. Mayasia MoH. Guidelines for medication error reporting.. In: Division PS, editor. Selangor: Pharmaceutical Services Division; 2009. p. 30. 54. Aziz Z, Siang TC, Badarudin NS. Reporting of adverse drug reactions: predictors of under-reporting in Malaysia. Pharmacoepidemiol Drug Saf. 2007;16(2):223–8. 55. IDF. Diabetes in Malaysia-2014. In: Malaysia. Brussels. 2014. http://www.idf.org/membership/wp/malaysia. Accessed 9 may 2015. 56. Amal N, Paramesarvathy R, Tee G, Gurpreet K, Karuthan C. Prevalence of Chronic Illness and Health Seeking Behaviour in Malaysian Population: results from the Third National Health Morbidity Survey (NHMS III) 2006. Med J Malaysia. 2011;66(1):36–41. 57. WMW B. National Launching of the ‘‘Clinical Practice Guidelines: Management of Type 2 Diabetes Mellitus. In: Society MEM, editor. 4 ed. Kuala Lumpur: Malaysian Endocrine and Metabolic Society; 2009. 58. MEaM. Practical guide to insulin therapy in Type 2 Diabetes Mellitus. In: Society MEaM, editor. Kuala Lumpur: Malaysian Endocrine and Metabolic Society; 2011. 59. Rashed AN, Neubert A, Alhamdan H, Tomlin S, Alazmi A, AlShaikh A, et al. Drug-related problems found in children attending an emergency department in Saudi Arabia and in the United Kingdom. Inter J Clin Pharm. 2013;35(3):327–31. 394 A. I. Jatau et al. 60. Kohn LT, Corrigan JM, Donaldson MS. To err is human: building a Safer Health System. Washington: National Academies Press; 2000. 61. Smith KM, McAdams JW, Frenia ML, Todd MW. Drug-related problems in emergency department patients. AJHP. 1997;54(3):295. 62. Dennehy CE, Kishi DT, Louie C. Drug-related illness in emergency department patients. Am J Health Syst Pharm. 1996;53(12):1422–6. 63. Koh MJ, Tay YK. Stevens-Johnson syndrome and toxic epidermal necrolysis in Asian children. J Am Acad Dermatol. 2010;62(1):54–60. 64. Hohl CM, Zed PJ, Brubacher JR, Abu-Laban RB, Loewen PS, Purssell RA. Do emergency physicians attribute drug-related emergency department visits to medication-related problems? Ann Emerg Med. 2010;55(6):493–502. 65. Stoukides C, D’agostino P, Kaufman M. Adverse drug reaction surveillance in an emergency room. AJHP. 1993;50(4):712–4. 66. Prince B, Goetz C, Rihn T, Olsky M. Drug-related emergency department visits and hospital admissions. Am J Health Syst Pharm. 1992;49(7):1696–700. 67. Sekhar MS, Mary CA, Anju P, Hamsa NA. Study on drug related hospital admissions in a tertiary care hospital in South India. Saudi Pharm J. 2011;19(4):273–8. 68. Alghamdy MS, Randhawa MA, Al-Wahhas MH, Al-Jumaan MA. Admissions for drug-related problems at the Emergency Department of a University Hospital in the Kingdom of Saudi Arabia. J Family Community Med. 2015;22(1):44. 69. Jayarama N, Shiju K, Prabahakar K. Adverse drug reactions in adults leading to emergency department visits. Int J Pharm Pharm Sci. 2012;4:642–6. 70. Olivier P, Bertrand L, Tubery M, Lauque D, Montastruc J-L, Lapeyre-Mestre M. Hospitalizations because of adverse drug reactions in elderly patients admitted through the emergency department. Drugs Aging. 2009;26(6):475–82.
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7061-01-FH02-FP-16-05232.pdf
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Abubakar Ibrahim Jatau
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oai_dc
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https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12754
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12754 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12754 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal application/pdf Adobe Acrobat Pro DC 20 Paper Capture Plug-in with ClearScan 10 1.6 Abubakar Ibrahim Jatau 2024-08-27 13:50:08 Drugs - Real World Outcomes, doi:10.1007/s40801-015-0045-2 Drugs - Real World Outcomes doi:10.1007/s40801-015-0045-2 7061-01-FH02-FP-16-05232.pdf UniSZA Private Access Prevalence of Drug-Related Emergency Department Visits at a Teaching Hospital in Malaysia Drugs - Real World Outcomes Background Data on the prevalence of adverse drug event (ADE)-related emergency department (ED) visits in developing countries are limited. Malaysia is located in South-East Asia, and, to our knowledge, no information exists on ADE-related ED visits. Objective The objective of this study was to determine the prevalence, preventability, severity, and outcome of drug-related ED visits. Methodology A cross-sectional study was conducted in consenting patients who visited the ED of Hospital Universiti Sains Malaysia over a 6-week period. The ED physician on duty determined whether or not the visit was drug related according to set criteria. Other relevant information was extracted from the patient’s medical folder by a clinical pharmacist. Results Of the 434 consenting patients, 133 (30.6 %; 95 % confidence interval [CI] 26–35 %) visits were determined to be ADE related; 55.5 % were considered preventable, 11.3 % possibly preventable, and 33.1 % not preventable. Severity was classed as mild in 1.5 %, moderate in 67.7 %, and severe in 30.8 %. The most common ADEs reported were drug therapeutic failure (55.6 %) and adverse drug reactions (32.3 %). The most frequently implicated drugs were antidiabetics (n = 31; 23.3 %), antihypertensives (n = 28; 21.1 %), antibiotics (n = 13; 9.8 %), and antiasthmatics (n = 11; 8.3 %). A total of 93 patients (69.9 %) were admitted to the ED for observation, 25 (18.8 %) were discharged immediately after consultation, and 15 (11.3 %) were admitted to the ward through the ED. Conclusion The prevalence of ADE-related ED visits was high; more than one-half of the events were considered preventable and one-third was classed as severe. As such, preventive measures will minimize future occurrences and increase patient safety. 2 4 387-395 1. International Conference on Harmonization-Efficacy. http:// www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatory Information/Guidances/UCM073087.pdf. 2. Kane-Gill SL, Kirisci L, Verrico MM, Rothschild JM. Analysis of risk factors for adverse drug events in critically ill patients. Crit Care Med. 2012;40(3):823. 3. Hepler CD, Strand LM. Opportunities and responsibilities in pharmaceutical care. Am J Hosp Pharm. 1990;47(3):533–43. 4. Field TS, Gurwitz JH, Harrold LR, Rothschild J, DeBellis KR, Seger AC, et al. Risk factors for adverse drug events among older adults in the ambulatory setting. J Am Geriatr Soc. 2004;52(8):1349–54. 5. Chen YC, Fan JS, Hsu TF, Chen MH, Huang HH, Cheng KW, et al. Detection of patients presenting with adverse drug events in the emergency department. Intern Med J. 2012;42(6):651–7. 6. Castro I, Guardiola JM, Tuneu L, Sala ML, Faus MJ, Mangues MA. Drug-related visits to the emergency department in a Spanish university hospital. Int J Clin Pharm. 2013;35(5): 727–35. 7. Wu C. Bell, Chaim M, Wodchis, Walter P. Incidence and economic burden of adverse drug reactions among elderly patients in Ontario Emergency Departments. Drug Saf. 2012;35(9):769–81. 8. Zed PJ, Abu-Laban RB, Balen RM, Loewen PS, Hohl CM, Brubacher JR, et al. Incidence, severity and preventability of medication-related visits to the emergency department: a prospective study. CMAJ. 2008;178(12):1563–9. 9. World Health Organisation. International Drug Monitoring: the role of a hospital. Technical Series No. 425. 1969; 426: 5–24. 10. Chen Wu CMB WPW. Incidence and economic burden of adverse drug reactions among elderly patients in Ontario Emergency Departments a retrospective study. Drug Saf. 2012;9:769–81. 11. Malaysia MoH. Health facts 2014. In: Center PDHI, editor. Putrajaya: Ministry of health Malaysia; 2014. p. 11–2. 12. Malaysia MoH. Guidelines for medication error reporting. In: Division PS, editor. 1 ed. Selangor Ministry of Health Malaysia; 2009. p. 30. 13. Zed PJ. Drug-related visits to the emergency department. J Pharm Prac. 2005;18(5):329–35. 14. Shah C, Ismail IM, Mohsin S. Ambulance response time and emergency medical dispatcher program: a study in Kelantan, Malaysia. 2008. 15. Queneau P, Trombert B, Carpentier F, Trinh-Duc A, Bannwarth B, Bouget J, editors. Adverse drug effects: a prospective study by Apnet performed in seven emergency care units in France: propositions for preventive measures. Ann Pharm Fr. 2005. 16. Hallas J, Harvald B, Worm J, Beck-Nielsen J, Gram L, Grodum E, et al. Drug related hospital admissions. Eur J Clin Pharmacol. 1993;45(3):199–203. 17. World Health Organisation. Report on Medication Adherence. World Health Organisation. Geneva. 2003; 4. http://www.who. int/chp/knowledge/publications/adherence_full_report.pdf. 18. Nelson KM, Talbert RL. Drug-related hospital admissions. Pharmacother. 1996;16(4):701–7. 19. Singh H, Kumar BN, Sinha T, Dulhani N. The incidence and nature of drug-related hospital admission: a 6-month observational study in a tertiary health care hospital. J Pharmacol Pharmacother. 2011;2(1):17. Drug-Related ED Visits in Malaysia 393 20. Drug information system [database on the Internet]. MIMS 2015. https://www.mims.com/home/index?aspxerrorpath=/Malaysia. Accessed 06 May 2015. 21. Naing L, Than W, Rusli B. Practical issues in calculating the sample size for prevalence studies. 2006. 22. Karuppannan M, Nee TK, Ali SM, Thong WK, Boardman H. The prevalence of adverse drug event-related admissions at a local hospital in Malaysia. Arch Pharm Pract. 2013;4(4):160. 23. Capuano A, Irpino A, Gallo M, Ferrante L, Illiano M, Rinaldi B, et al. Regional surveillance of emergency-department visits for outpatient adverse drug events. Eur J Clin Pharmacol. 2009;65(7):721–8. 24. Baena MI, Faus MJ, Fajardo PC, Luque FM, Sierra F, MartinezOlmos J, et al. Medicine-related problems resulting in emergency department visits. Eur J Clin Pharmacol. 2006;62(5):387–93. 25. Ramos Linares S, Dı´azRuiz P, Mesa Fumero J, et al. Incidence rate of adverse drug effects in a hospital emergency unit and its associated factors. J Farma. 2010;34(6):271–8. 26. Tafreshi MJ, Melby MJ, Kaback KR, Nord TC. Medication-related visits to the emergency department: a prospective study. Ann Pharmacother. 1999;33(12):1252–7. 27. Sikdar KC, Alaghehbandan R, MacDonald D, Barrett B, Collins KD, Donnan J, et al. Adverse drug events in adult patients leading to emergency department visits. Ann Pharmacother. 2010;44(4):641–9. 28. Juntti-Patinen L, Kuitunen T, Pere P, Neuvonen PJ. Drug-related visits to a District Hospital Emergency Room. Basic Clin Pharmacol Toxicol. 2006;98(2):212–7. 29. Trifiro` G, Calogero G, Ippolito FM, Cosentino M, Giuliani R, Conforti A, et al. Adverse drug events in emergency department population: a prospective Italian study. Pharmacoepidemiol Drug Saf. 2005;14(5):333–40. 30. Bednall R, McRobbie D, Hicks A. Identification of medicationrelated attendances at an A & E department. J Clin Pharm Ther. 2003;28(1):41–5. 31. Farooqui M, Noorizan A, Hassan Y, Azhar S, Ghazalli R. Drug related problems as a cause of admission to the medical wards of hospital Pulau Pinang. Malays J Pharm Sci. 2005;3(2):65–6. 32. Schneitman-McIntire O, Farnen TA, Gordon N, Chan J, Toy WA. Medication misadventures resulting in emergency department visits at and HMO medical center. Am J Health Syst Pharm. 1996;53(12):1416–22. 33. Olshaker JS, Barish RA, Naradzay JF, Jerrard DA, Safir E, Campbell L. Prescription noncompliance: contribution to emergency department visits and cost. Eur J Emerg Med. 1999;17(5):909–12. 34. De Paepe P, Petrovic M, Outtier L, Van Maele G, Buylaert W. Drug interactions and adverse drug reactions in the older patients admitted to the emergency department. Acta Clin Belg. 2013;68(1):15–21. 35. Zopf Y, Rabe C, Neubert A, Hahn EG, Dormann H. Risk factors associated with adverse drug reactions following hospital admission. Drug Saf. 2008;31(9):789–98. 36. Drici M-D, Cle´ment N. Is gender a risk factor for adverse drug reactions? Drug Saf. 2001;24(8):575–85. 37. Sarkar U, Lo´pez A, Maselli JH, Gonzales R. Adverse drug events in US adult ambulatory medical care. Health Serv Res. 2011;46(5):1517–33. 38. Cusack B, Nielson C, Vestal R. Geriatric clinical pharmacology and therapeutics. Avery’s Drug treatment 4th ed Auckland, New Zealand: Adis International. 1997: 173–223. 39. Salvo F, Miroddi M, Alibrandi A, Calapai F, Cafeo V, Mancari F, et al. Attitudes and opinion about adverse drug events of women living in a city of south Italy. Pharmacol. 2013;91(3–4):173–7. 40. Chrischilles E, Rubenstein L, Van Gilder R, Voelker M, Wright K, Wallace R. Risk factors for adverse drug events in older adults with mobility limitations in the community setting. J Am Soc Geriatr Dent. 2007;55(1):29–34. 41. Hema NG, Bhuvana KB, Virupaksha HM. Critical assessment of adverse drug reactions to antitubercular drugs in a government teaching hospital. Intern J Basic Med Sci. 2013;5(5):60–7. 42. Al-Arifi M, Abu-Hashem H, Al-Meziny M, Said R, Aljadhey H. Emergency department visits and admissions due to drug related problems at Riyadh military hospital (RMH), Saudi Arabia. Saudi Pharm J. 2014;22(1):17–25. 43. Malhotra S, Karan R, Pandhi P, Jain S. Drug related medical emergencies in the elderly: role of adverse drug reactions and non-compliance. Postgrad Med J. 2001;77(913):703–7. 44. Heaton PC, Tundia NL, Luder HR. US emergency departments visits resulting from poor medication adherence: 2005–07. JAPhA. 2012;53(5):513–9. 45. Ir MD, Johari Dato MohdGhazali R, Hazilah Abd Manaf N, Hassan Asaari Abdullah A, Abu Bakar A, Salikin F, et al. Hospital waiting time: the forgotten premise of healthcare service delivery? Int J Health Care Qual Assur. 2011;24(7):506–22. 46. Hazilah Abd Manaf N, Siew Nooi P. Patient satisfaction as an indicator of service quality in Malaysian public hospitals. Asian J Qual. 2009;10(1):77–87. 47. Lewis A. Non-compliance: a $100 billion problem. Remington Report. 1997;5(4):14–5. 48. Peterson AMTLFR. Meta-analysis of trials of interventions to improve medication adherence. Am J Health Syst Pharm. 2003;60(7):657–65. 49. Phei Ching L, Kelvin L. Evaluation of a pharmacist-managed diabetes medication therapy adherence clinic. Pharm Pract. 2010;8(4):250–4. 50. Lee JK, Grace KA, Taylor AJ. Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol: a randomized controlled trial. JAMA. 2006;296(21):2563–71. 51. Brennan TA, Dollear TJ, Hu M, Matlin OS, Shrank WH, Choudhry NK, et al. An integrated pharmacy-based program improved medication prescription and adherence rates in diabetes patients. Health Aff. 2012;31(1):120–9. 52. Winterstein AG, Sauer BC, Hepler CD, Poole C. Preventable drug-related hospital admissions. Ann Pharmacother. 2002;36(7–8):1238–48. 53. Mayasia MoH. Guidelines for medication error reporting.. In: Division PS, editor. Selangor: Pharmaceutical Services Division; 2009. p. 30. 54. Aziz Z, Siang TC, Badarudin NS. Reporting of adverse drug reactions: predictors of under-reporting in Malaysia. Pharmacoepidemiol Drug Saf. 2007;16(2):223–8. 55. IDF. Diabetes in Malaysia-2014. In: Malaysia. Brussels. 2014. http://www.idf.org/membership/wp/malaysia. Accessed 9 may 2015. 56. Amal N, Paramesarvathy R, Tee G, Gurpreet K, Karuthan C. Prevalence of Chronic Illness and Health Seeking Behaviour in Malaysian Population: results from the Third National Health Morbidity Survey (NHMS III) 2006. Med J Malaysia. 2011;66(1):36–41. 57. WMW B. National Launching of the ‘‘Clinical Practice Guidelines: Management of Type 2 Diabetes Mellitus. In: Society MEM, editor. 4 ed. Kuala Lumpur: Malaysian Endocrine and Metabolic Society; 2009. 58. MEaM. Practical guide to insulin therapy in Type 2 Diabetes Mellitus. In: Society MEaM, editor. Kuala Lumpur: Malaysian Endocrine and Metabolic Society; 2011. 59. Rashed AN, Neubert A, Alhamdan H, Tomlin S, Alazmi A, AlShaikh A, et al. Drug-related problems found in children attending an emergency department in Saudi Arabia and in the United Kingdom. Inter J Clin Pharm. 2013;35(3):327–31. 394 A. I. Jatau et al. 60. Kohn LT, Corrigan JM, Donaldson MS. To err is human: building a Safer Health System. Washington: National Academies Press; 2000. 61. Smith KM, McAdams JW, Frenia ML, Todd MW. Drug-related problems in emergency department patients. AJHP. 1997;54(3):295. 62. Dennehy CE, Kishi DT, Louie C. Drug-related illness in emergency department patients. Am J Health Syst Pharm. 1996;53(12):1422–6. 63. Koh MJ, Tay YK. Stevens-Johnson syndrome and toxic epidermal necrolysis in Asian children. J Am Acad Dermatol. 2010;62(1):54–60. 64. Hohl CM, Zed PJ, Brubacher JR, Abu-Laban RB, Loewen PS, Purssell RA. Do emergency physicians attribute drug-related emergency department visits to medication-related problems? Ann Emerg Med. 2010;55(6):493–502. 65. Stoukides C, D’agostino P, Kaufman M. Adverse drug reaction surveillance in an emergency room. AJHP. 1993;50(4):712–4. 66. Prince B, Goetz C, Rihn T, Olsky M. Drug-related emergency department visits and hospital admissions. Am J Health Syst Pharm. 1992;49(7):1696–700. 67. Sekhar MS, Mary CA, Anju P, Hamsa NA. Study on drug related hospital admissions in a tertiary care hospital in South India. Saudi Pharm J. 2011;19(4):273–8. 68. Alghamdy MS, Randhawa MA, Al-Wahhas MH, Al-Jumaan MA. Admissions for drug-related problems at the Emergency Department of a University Hospital in the Kingdom of Saudi Arabia. J Family Community Med. 2015;22(1):44. 69. Jayarama N, Shiju K, Prabahakar K. Adverse drug reactions in adults leading to emergency department visits. Int J Pharm Pharm Sci. 2012;4:642–6. 70. Olivier P, Bertrand L, Tubery M, Lauque D, Montastruc J-L, Lapeyre-Mestre M. Hospitalizations because of adverse drug reactions in elderly patients admitted through the emergency department. Drugs Aging. 2009;26(6):475–82.
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Prevalence of Drug-Related Emergency Department Visits at a Teaching Hospital in Malaysia
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Drugs - Real World Outcomes
doi:10.1007/s40801-015-0045-2
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| summary |
Background Data on the prevalence of adverse drug event (ADE)-related emergency department (ED) visits in developing countries are limited. Malaysia is located in South-East Asia, and, to our knowledge, no information exists on ADE-related ED visits. Objective The objective of this study was to determine the prevalence, preventability, severity, and outcome of drug-related ED visits. Methodology A cross-sectional study was conducted in consenting patients who visited the ED of Hospital Universiti Sains Malaysia over a 6-week period. The ED physician on duty determined whether or not the visit was drug related according to set criteria. Other relevant information was extracted from the patient’s medical folder by a clinical pharmacist. Results Of the 434 consenting patients, 133 (30.6 %; 95 % confidence interval [CI] 26–35 %) visits were determined to be ADE related; 55.5 % were considered preventable, 11.3 % possibly preventable, and 33.1 % not preventable. Severity was classed as mild in 1.5 %, moderate in 67.7 %, and severe in 30.8 %. The most common ADEs reported were drug therapeutic failure (55.6 %) and adverse drug reactions (32.3 %). The most frequently implicated drugs were antidiabetics (n = 31; 23.3 %), antihypertensives (n = 28; 21.1 %), antibiotics (n = 13; 9.8 %), and antiasthmatics (n = 11; 8.3 %). A total of 93 patients (69.9 %) were admitted to the ED for observation, 25 (18.8 %) were discharged immediately after consultation, and 15 (11.3 %) were admitted to the ward through the ED. Conclusion The prevalence of ADE-related ED visits was high; more than one-half of the events were considered preventable and one-third was classed as severe. As such, preventive measures will minimize future occurrences and increase patient safety.
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| title |
Prevalence of Drug-Related Emergency Department Visits at a Teaching Hospital in Malaysia
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| title_full |
Prevalence of Drug-Related Emergency Department Visits at a Teaching Hospital in Malaysia
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| title_fullStr |
Prevalence of Drug-Related Emergency Department Visits at a Teaching Hospital in Malaysia
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| title_full_unstemmed |
Prevalence of Drug-Related Emergency Department Visits at a Teaching Hospital in Malaysia
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| title_short |
Prevalence of Drug-Related Emergency Department Visits at a Teaching Hospital in Malaysia
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| title_sort |
prevalence of drug-related emergency department visits at a teaching hospital in malaysia
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