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1860797440331874304
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INTELEK Repository
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| collection |
Online Access
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https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072
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| date |
2024-08-27 13:22:51
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| format |
Restricted Document
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12724
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UniSZA
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[1] American Cancer Society. (2011). American Cancer Society INC., 1(34). [2] Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., & Thun, M. J. (2009). CA Cancer J Clin, 59, 1–25. doi:10.1002/caac.20073.Available [3] Stewart, B. W., & Wild, C. P. (2014). World Cancer Report 2014. World Health Organization: Geneva (p. 953). doi:9283204298. [4] Henderson MM. Cancer, 1995,76; 2053-8. [5] Howe GR, T Hirohata, TG Hislop, JMIscovich, JM Yuan, K Katsouyanni. J Natl Cancer Inst., 1990, 82:561-9. [6] Bhadoria AS, U Kapil, N Sareen. P Singh. A case-control study in tertiary care hospitals of North India., 2015. [7] Pisani, P., Parkin, D. M., Bray, F., &Ferlay, J. (1999). International journal of cancer, 83(1), 18-29. [8] Smith, R. A., Cokkinides, V., Brooks, D., Saslow, D., & Brawley, O. W. (2010). CCA: A Cancer Journal for Clinicians, 60, 99–119. doi:10.3322/caac.20063.Available [9] Lee, V., Cohen, S. R., Edgar, L., Laizner, A. M., & Gagnon, A. J. (2006). Social science & medicine,62(12), 3133-3145. [10] Abenavoli, L., Bardazzi, G., Cracolici, F., Quaranta, C., Santini, G., Graziosi, S., … Addolorato, G. (2008). Fitoterapia, 79(2), 142–7. doi:10.1016/j.fitote.2007.11.016. [11] Bharti, A. C., Takada, Y., & Aggarwal, B. B. (2004). Journal of Immunology (Baltimore, Md. : 1950), 172, 5940–5947. doi:10.4049/jimmunol.172.10.5940. [12] Shah, U., Shah, R., Acharya, S., & Acharya, N. (2013). Novel anticancer agents from plant sources. Chinese Journal of Natural Medicines, 11, 16–23. doi:10.1016/S1875-5364(13)60002-3 Shrififar F., Yassa N., Shafiee A. (2003) Iran. J.Plant Res., 2, 235-239. [13] Liu, R. H. (2004). The Journal of Nutrition, 134, 3479S–3485S. doi:134/12/3479S [pii] [14] Bagheri SM; L Keyhani; M Heydari; MH Dashti. J Ayurveda Integr Med., 2015, 6(1),19-23 [15] US Department of Agriculture, Agricultural Research Services, USDA Nutrient Data base for Standard Reference, Release 15, 2002 Nutrient DataLaboratoryHomePage,/http://www.nal.usda.gov/fnic/foodcompS. [16] Mawa, S., Husain, K., &Jantan, I. (2013). Ficus carica L.(Moraceae): phytochemistry, traditional uses and biological activities. Evidence-Based Complementary and Alternative Medicine, 2013. [17] Wang G, Wang H, Song Y, Jai C, Wang Z and Zu H. Studies on anti-HSV effect of Ficus carica leaves.(2004) 27: 754-756. [18] Stepek G, Buttle DJ, Duce IR, Lowe A and Beheneke, JM. In-vitroParasitol.( 2005) 130: 203-211. [19] Agabeili RA, Kasimova TE and Alekperov UK. Tsitol Genet. (2004) 38:40-45. [20] Rubnov S, Kashman Y, Rabinowitz R, Schlesinger M and Mechoulam R. J. Nat. Prod (2001) 64: 993-996. [21] Perez C, Canal JR and Torres MD. Acta Diabetol(2003) 40: 3-8. [22] Garcia-Solis, P., Yahia, E. M., Morales-Tlalpan, V., & Diaz-Munoz, M. (2009). International Journal of Food Sciences and Nutrition, 60, 1–15. doi:10.1080/09637480802312922. [23] Khodarahmi, G. A., Ghasemi, N., Hassanzadeh, F., & Safaie, M. (2011). Iranian Journal of Pharmaceutical Research, 10, 273–277. [24] Hashemi, S. a, Abediankenari, S., Ghasemi, M., Azadbakht, M., Yousefzadeh, Y., & Dehpour, a a. (2011). The Iranian Red Crescent Medical Journal, 13, 272–5. Retrieved from [25] http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3371962&tool=pmcentrez&rendertype=abstract [26] Adel Mohdaly. A., Sarhan, M. A., Smetanska, I. and Mahmoud, A. (2010), J. Sci. Food Agric., 90: 218–226. doi: 10.1002/jsfa.3796 [27] Lope Pihie, A. H., Zakaria, Z. A., & Othman, F. (2012). Evidence-Based Complementary and Alternative Medicine, 2012. [28] Gomes de Melo, J., de Sousa Araújo, T. A., ThijanNobre de Almeida e Castro, V., Lyra de Vasconcelos Cabral, D., Do Desterro Rodrigues, M., Carneiro do Nascimento, S., ... & De Albuquerque, U. P. (2010). Molecules, 15(12), 8534-8542. [29 ]Mosmann, T. (1983). Journal of Immunological Methods, 65, 55–63. doi:10.1016/0022-1759(83)90303-4 [30] Mello Filho, A. C., Hoffmann, M. E., & Meneghini, R. (1984). The Biochemical Journal, 218, 273–275.
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7031-01-FH02-FP-16-04864.pdf
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| person |
Hamendra ji
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| recordtype |
oai_dc
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| resourceurl |
https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12724
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| spelling |
12724 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12724 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal application/pdf Adobe Acrobat Pro DC 20 Paper Capture Plug-in with ClearScan 8 1.6 Hamendra ji 2024-08-27 13:22:51 7031-01-FH02-FP-16-04864.pdf UniSZA Private Access Non-toxic antiproliferative effect of Ficus carica fruit extracts on estrogen receptor positive breast cancer cell (MCF-7) Journal of Chemical and Pharmaceutical Research Cancer is one of many diseases of global concern due to its high mortality rate with various therapeutic options but most of them are toxic and this compelled many cancer patients to seek alternative and complementary method for treatment. Plants have been recognised as alternative source of remedy for various ailments as they contain many bioactive compounds. The objective of this study was therefore to determine the antiproliferative activity and nontoxic effect of dried preserved fruit extracts of Ficus carica on estrogen/progesterone receptor positive breast cancer cell (MCF-7) and mouse epithelial cell (3T3). The ethyl acetate, ethanol and hexane extracts were prepared by maceration and then concentrated under vacuum at 40oC by rotary evaporator to get the crude extracts. The antiproliferative effect of the extracts was determined using microtitration colorimetric method of 3(4, 5 diphenylmethyl thiazol-2-yl)-2, 5 diphenyltetrazolium bromide assay. The ethyl acetate has low extract yield compared to ethanol and hexane extracts. The ethyl acetate extract was found to have strong and significant antiproliferative activity against estrogen/progesterone receptor positive breast cancer cells (MCF-7) with IC50 value of 9.8µg/mL, whereas the ethanol and hexane extracts showed weak antiproliferative activity. Interestingly, all the extracts have non-toxic effect on 3T3 cell line. These finding suggest that crude extracts of Ficus carica fruit have antiproliferative effect on the estrogen/progesterone receptor positive breast cancer cells. These may be attributed to the bioactive compound present in the crude extracts. The study also suggests a promising chemoprotective potential of Ficus carica fruit extracts on estrogen/progesterone receptor positive breast cancer cells. Further studies are required to isolate the bioactive compounds of the fruit extracts and establish their mechanism of actions. 7 10 815-821 [1] American Cancer Society. (2011). American Cancer Society INC., 1(34). [2] Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., & Thun, M. J. (2009). CA Cancer J Clin, 59, 1–25. doi:10.1002/caac.20073.Available [3] Stewart, B. W., & Wild, C. P. (2014). World Cancer Report 2014. World Health Organization: Geneva (p. 953). doi:9283204298. [4] Henderson MM. Cancer, 1995,76; 2053-8. [5] Howe GR, T Hirohata, TG Hislop, JMIscovich, JM Yuan, K Katsouyanni. J Natl Cancer Inst., 1990, 82:561-9. [6] Bhadoria AS, U Kapil, N Sareen. P Singh. A case-control study in tertiary care hospitals of North India., 2015. [7] Pisani, P., Parkin, D. M., Bray, F., &Ferlay, J. (1999). International journal of cancer, 83(1), 18-29. [8] Smith, R. A., Cokkinides, V., Brooks, D., Saslow, D., & Brawley, O. W. (2010). CCA: A Cancer Journal for Clinicians, 60, 99–119. doi:10.3322/caac.20063.Available [9] Lee, V., Cohen, S. R., Edgar, L., Laizner, A. M., & Gagnon, A. J. (2006). Social science & medicine,62(12), 3133-3145. [10] Abenavoli, L., Bardazzi, G., Cracolici, F., Quaranta, C., Santini, G., Graziosi, S., … Addolorato, G. (2008). Fitoterapia, 79(2), 142–7. doi:10.1016/j.fitote.2007.11.016. [11] Bharti, A. C., Takada, Y., & Aggarwal, B. B. (2004). Journal of Immunology (Baltimore, Md. : 1950), 172, 5940–5947. doi:10.4049/jimmunol.172.10.5940. [12] Shah, U., Shah, R., Acharya, S., & Acharya, N. (2013). Novel anticancer agents from plant sources. Chinese Journal of Natural Medicines, 11, 16–23. doi:10.1016/S1875-5364(13)60002-3 Shrififar F., Yassa N., Shafiee A. (2003) Iran. J.Plant Res., 2, 235-239. [13] Liu, R. H. (2004). The Journal of Nutrition, 134, 3479S–3485S. doi:134/12/3479S [pii] [14] Bagheri SM; L Keyhani; M Heydari; MH Dashti. J Ayurveda Integr Med., 2015, 6(1),19-23 [15] US Department of Agriculture, Agricultural Research Services, USDA Nutrient Data base for Standard Reference, Release 15, 2002 Nutrient DataLaboratoryHomePage,/http://www.nal.usda.gov/fnic/foodcompS. [16] Mawa, S., Husain, K., &Jantan, I. (2013). Ficus carica L.(Moraceae): phytochemistry, traditional uses and biological activities. Evidence-Based Complementary and Alternative Medicine, 2013. [17] Wang G, Wang H, Song Y, Jai C, Wang Z and Zu H. Studies on anti-HSV effect of Ficus carica leaves.(2004) 27: 754-756. [18] Stepek G, Buttle DJ, Duce IR, Lowe A and Beheneke, JM. In-vitroParasitol.( 2005) 130: 203-211. [19] Agabeili RA, Kasimova TE and Alekperov UK. Tsitol Genet. (2004) 38:40-45. [20] Rubnov S, Kashman Y, Rabinowitz R, Schlesinger M and Mechoulam R. J. Nat. Prod (2001) 64: 993-996. [21] Perez C, Canal JR and Torres MD. Acta Diabetol(2003) 40: 3-8. [22] Garcia-Solis, P., Yahia, E. M., Morales-Tlalpan, V., & Diaz-Munoz, M. (2009). International Journal of Food Sciences and Nutrition, 60, 1–15. doi:10.1080/09637480802312922. [23] Khodarahmi, G. A., Ghasemi, N., Hassanzadeh, F., & Safaie, M. (2011). Iranian Journal of Pharmaceutical Research, 10, 273–277. [24] Hashemi, S. a, Abediankenari, S., Ghasemi, M., Azadbakht, M., Yousefzadeh, Y., & Dehpour, a a. (2011). The Iranian Red Crescent Medical Journal, 13, 272–5. Retrieved from [25] http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3371962&tool=pmcentrez&rendertype=abstract [26] Adel Mohdaly. A., Sarhan, M. A., Smetanska, I. and Mahmoud, A. (2010), J. Sci. Food Agric., 90: 218–226. doi: 10.1002/jsfa.3796 [27] Lope Pihie, A. H., Zakaria, Z. A., & Othman, F. (2012). Evidence-Based Complementary and Alternative Medicine, 2012. [28] Gomes de Melo, J., de Sousa Araújo, T. A., ThijanNobre de Almeida e Castro, V., Lyra de Vasconcelos Cabral, D., Do Desterro Rodrigues, M., Carneiro do Nascimento, S., ... & De Albuquerque, U. P. (2010). Molecules, 15(12), 8534-8542. [29 ]Mosmann, T. (1983). Journal of Immunological Methods, 65, 55–63. doi:10.1016/0022-1759(83)90303-4 [30] Mello Filho, A. C., Hoffmann, M. E., & Meneghini, R. (1984). The Biochemical Journal, 218, 273–275.
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| spellingShingle |
Non-toxic antiproliferative effect of Ficus carica fruit extracts on estrogen receptor positive breast cancer cell (MCF-7)
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| summary |
Cancer is one of many diseases of global concern due to its high mortality rate with various therapeutic options but most of them are toxic and this compelled many cancer patients to seek alternative and complementary method for treatment. Plants have been recognised as alternative source of remedy for various ailments as they contain many bioactive compounds. The objective of this study was therefore to determine the antiproliferative activity and nontoxic effect of dried preserved fruit extracts of Ficus carica on estrogen/progesterone receptor positive breast cancer cell (MCF-7) and mouse epithelial cell (3T3). The ethyl acetate, ethanol and hexane extracts were prepared by maceration and then concentrated under vacuum at 40oC by rotary evaporator to get the crude extracts. The antiproliferative effect of the extracts was determined using microtitration colorimetric method of 3(4, 5 diphenylmethyl thiazol-2-yl)-2, 5 diphenyltetrazolium bromide assay. The ethyl acetate has low extract yield compared to ethanol and hexane extracts. The ethyl acetate extract was found to have strong and significant antiproliferative activity against estrogen/progesterone receptor positive breast cancer cells (MCF-7) with IC50 value of 9.8µg/mL, whereas the ethanol and hexane extracts showed weak antiproliferative activity. Interestingly, all the extracts have non-toxic effect on 3T3 cell line. These finding suggest that crude extracts of Ficus carica fruit have antiproliferative effect on the estrogen/progesterone receptor positive breast cancer cells. These may be attributed to the bioactive compound present in the crude extracts. The study also suggests a promising chemoprotective potential of Ficus carica fruit extracts on estrogen/progesterone receptor positive breast cancer cells. Further studies are required to isolate the bioactive compounds of the fruit extracts and establish their mechanism of actions.
|
| title |
Non-toxic antiproliferative effect of Ficus carica fruit extracts on estrogen receptor positive breast cancer cell (MCF-7)
|
| title_full |
Non-toxic antiproliferative effect of Ficus carica fruit extracts on estrogen receptor positive breast cancer cell (MCF-7)
|
| title_fullStr |
Non-toxic antiproliferative effect of Ficus carica fruit extracts on estrogen receptor positive breast cancer cell (MCF-7)
|
| title_full_unstemmed |
Non-toxic antiproliferative effect of Ficus carica fruit extracts on estrogen receptor positive breast cancer cell (MCF-7)
|
| title_short |
Non-toxic antiproliferative effect of Ficus carica fruit extracts on estrogen receptor positive breast cancer cell (MCF-7)
|
| title_sort |
non-toxic antiproliferative effect of ficus carica fruit extracts on estrogen receptor positive breast cancer cell (mcf-7)
|