Analgesic effect of honey bioactive compounds and its role in reducing morphine tolerance

Analgesic effect of honey bioactive compounds and its role in reducing morphine tolerance

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internalnotes Abd. Aziz CB, Ahmad R, Mohamed M, Wan Yusof WN. The effects of Tualang honey intake during prenatal stress on pain responses in the rat offsprings. European Journal of Integrative Medicine, 2013;5:326- 331. Abdel-Zaher AO, Abdel-Rahman MS, Elwasei FM. Blockade of nitric oxideoverproduction and oxidative stress by Nigella sativa oil attenuates morphine-induced tolerance and dependence in mice. Neurochem. Res. 2010;35:1557–1565. Ahmed J, Prabhu ST, Raghavan GSV, Ngadi M. Physicochemocal, rheological, calorimetric and dielectric behavior of selected Indian honey. J Food Eng, 2007;29:1207-13. Alvarez-Suarez JM, Giampieri F, Battino M. Honey as a source of dietary antioxidants:Structures, bioavailability and evidence of protective effects against human chronic diseases. Curr Med Chem, 2013;20(5):621–638. Alzubier AA, Okechukwu PN. 2011. Investigation of antiinflammatory, antipyretic and analgesic effect of yemeni sidr honey. International Scholarly and Scientific Research and Innovation, 2011; 5(8):41-46. Backhouse N, Delporte C, Apablaza C, Farias M, Goity L, Arrau S, et al. Analgesic activity of Buddleja globosa (matico) in several models of pain. J Ethnopharmacol, 2008;119:160-5. Bannon AW, Malmberg AB, Models of nociception: hot plate, tail flick, and formalin tests in rodents. Curr. Protoc. Neurosci, 2007;41: 891-896. Berrocoso E, Sanchez-Blazquez P, Garzon J,Mico, JA. Opiates as Antidepressants. Current Pharmaceutical Design. 2009;15:1612-1622. Boroumand , Zamani MM, Saeedi M, Rouhbakhshfar O, Motlagh SRH, Moghaddam FA. Post tonsillectomy pain: can honey reduce the analgesic requirements?. Anesthesiology and Pain Medicine, 2013;3(1):198-202. Carvalho GJA, Carvalho ME. Diterpenes, triterpenes and steroides from flowers of Wedelia paludosa. Quimica Nova, 2001; 24:24- 26. Chao PC, Hsu CC, Yin MC. Anti-inflammatory and anticoagulatory activities of caffeic acid and ellagic acid in cardiac tissue of diabetic mice. Nutrition and Metabolism, 2009;6(33):1-8. Das A, Datta S, Mukherjee S, Bose S, Ghosh S, Dhar P. Evaluation of antioxidative, antibacterial and probiotic growth stimulatory activities of Sesamun indicum honey containing phenolic compounds and lignans. LWT- Food Science and Technology, 2015;61:244-250. DuPen A, Shen D, Ersek M. Mechanisms of opioid-induced tolerance and hyperalgesia. Pain Management Nursing, 2007;8(3):113- 121. Farkhondeh T, Samarghandian S, Azimin-Nezhad M, Samini F. Effect of chrysin on nociception in formalin test and serum levels of noradrenalin and corticosterone in rats. Int J Clin Exp Med, 2015;2:2465- 2470. Fauzi AN, Norazmi MN, Yaacob NS. Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines. Food and Chemical Toxicology, 2011;49:871-878. Gamaro GD, Suyenaga E, Borsoi M, Lermen J, Pereira P, Ardenghi P. Effect of Rosmarinic and Caffeic Acids on Inflammatory and Nociception Process in Rats. ISRN Pharmacology, 2011;1-6. Gheldof N, Engeseth N. Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples. Journal of Agricultural and Food Chemistry, 2012;50:3050-3055. Gheldof N, Wang XH, Miller NJ, Engeseth J. Agric. Food Chem, 2002;50:5870. Goldberg R. 2014. Drugs across the spectrum. Belmont, USA: Cengage Learning. Gunduz A, Eraydin I, Turkmen S, Kalkan OF, Turedi S, Eryigit U, Ayar A. Analgesic effects of mad honey (grayanotoxin) in mice models of acute pain and painful diabetic neuropathy. Human and Environmental Toxicology, 2014;33(2):130-135. Hu CY, Zhao YT. Analgesic effects of naringenin in rats with spinal nerve ligation-induced neuropathic pain. Biomedical Reports, 2014;2:569-573. Higgs J, Wasowski C, Loscalzo LM, Marder M. In vitro binding affinities of a series of flavonoids for m-opioid receptors: analgesic effect of the synthetic flavonoid 3,3-dibromoflavanone in mice. Neuropharmacology, 2013;72:9-19. Johnston JE, Sepe HA, Miano CL, Brannan RG, Alderton AL. Honey inhibits lipid oxidation in ready-to-eat ground beef patties. Meat Science,2005;70(4):627–631. Kaulaskar S, Bhutada P, Rahigude A, Jain D, Harle U. Effect of naringenin on alldynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain. Journal of Chinese Integrative Medicine, 2012;30(12):1482-1489. Khalil MI, Alam N, Moniruzzaman M, Sulaiman SA, Gan SH. Phenolic acid composition and antioxidant properties of malaysian honeys. Journal of Food Science, 2011;76(6):921-928. Kosten TR, George TP. The neurobiology of opioid dependence: implications for treatment. Science and Practice Perspectives, 2002; 13-21. Kruger L. 2001. Methods in pain research. Florida, USA: CRC Press. Lees R, Lingford-Hughes A. Neurobiology and principles of addiction and tolerance. Medicine, 2012;40(12): 633-636. Liu M, Song S, Li H, Jiang X, Yin P, Wan C, Liu X, Liu F, Xu J. The protective effect of caffeic acid against inflammation injury of primary bovine mammary epithelial cells induced by lipopolysaccharide. J. Dairy Sci., 2014;97:2856-2865. Mansouri MT, Naghizadeh B, Ghorbanzadeh B. Ellagic acid enhances morphine analgesia and attenuates the development of morphine tolerance and dependence in mice. European Journal of Pharmacology, 2014;741:272-280. Mansouri MT, Naghizadeh B, Ghorbanzadeh B. Ellagic acid enhances the analgesic action of venlafaxine in mouse acetic acidinduced pain: An isobolographic analysis. Pharmacological Reports, 2015;67:473-477. Manyi-Loh CE, Clarke AM, Ndip RN. Identiication of volatile compounds in solvent extracts of honeys produced in South Africa. African Journal of Agricultural Research, 2011;6(18):4327–4334. Mao J, Sung B, Ji R, Lim G. Neuronal apoptosis associated with morphine tolerance: Evidence for an opioid-induced neurotoxic mechanism. The Journal of Neuroscience, 2002;22(17):7850-7861. Martin Gomez Pinheiro, M., Boylan, F. and Fernandes, P.D. 2012. Analgesic effect of the Orbignya speciosa Mart. (Babassu) leaves: Evidence for the involvement of apigenin. Life Sciences, 91, 293-300. Mayer DJ, Mao J. Mechanism of opioid tolerance: A current view of cellular mechanisms. Pain Forum, 1999;8(1):14-18. Mayer A, Slezak V, Takac P, Olejnik J. Majtan J. Treatment of nonhealing leg ulcers with honeydw honey. Journal of Tissue Viability, 2014;23:94-97. Mehrotra A, Shanbhag R, Chamallamudi MR, Singh VP, Mudgal J. Ameliorative effect of caffeic aicd against inflammatory pain in rodents. European Journal of Pharmacology, 2011;666:80-86. Meotti FC, Luiz AP, Pizzolatti MG, Kassuya CAL, Calixto JB, Santos ARS. Analysis of the analgesic effect of the flavonoid myricitrin: evidence for a role of the L-arginine- nitric oxide and protein kinase C pathways. J. Pharmacol. Exp. Ther, 2006;316:789-796. Mohamad N, Ismail R, Abdul Latif AZ, Mohamad M, Toriman ME. 2014. Terapi penggantian methadon: Penderitaan kebergantungan opiat yang boleh diubati. Kuala Terengganu, Terengganu: Penerbit UniSZA. Naidu PS, Singh A, Joshi D, Kulkarni SS. Possible mechanisms of action in quercetin reversal of morphine tolerance and dependence. Addiction Biology, 2003;8:327-336. Narita M, Suzuki M, Narita M, Niikura K, Nakamura A, Miyatake M, Yajima Y. Suzuki T. Μ-opioid recepote internalizationdependent and in-dependent mechanisms of the development of tolerance to μ-opioid receptor agonists: Comparison between etorphine and morphine. Neuroscience, 2006;138:609-619. Nsonde Ntandou GF, Bnzouzi JT, Mbatchi B, Elion-Itou RDG, Etou-Ossibi AW, Ramos S, BenoitVical F, Abena AA, Ouamba JM. Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts. Journal of Ethnopharmacology, 2010;127:108-111. Owoyele BV, Adenekan OT, Soladoye AO. Effects of honey on inflammation and nitric oxide production in Wistar rats. Zhong Xi Yi Jie He Xue Bao, 2011;9(4):447–452. Pyrzynska K. Biesaga M. Analysis of phenolic acids and flavonoids in honey. Trends In Analytical Chemistry, 2009;28(7):893-902. Raso GM, Meli R, Di Carlo G, Pacilio M, Di Carlo R. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci, 2001;68:921- 931. Richard J. Honey and healing through the ages. Journal of Apiproduct and Apimedical Science, 2009;1(1):2-5. Samarghandlan S, Borji A. Anticarcinogenic effect of saffron (Crocus sativus L.) and its ingredients. Pharmacognosy Res, 2014;6:99- 107. Santos ARS, De Campos ROP, Miguel OG, Cechinel-Filho V, Yunes RA, Calixto J.B. The involvement of Kq channels and G protein in the analgesic action of the gallic acid ethyl ester. European Journal of Pharmacology, 1999;379:7-17. Sato T, Miyata G. The nutraceutical benefit, part III:honey. Nutrition, 2000;16(6):468–469. Schildhaus N, Trink E, Polson C, DeTolla L, Tyler BM, Jallo GI, Tok S, Guarnieri M. Thermal latency studies in opiate-treated mice. J Pharm Bioallied Sci., 2014;6(1):43-47. Sherlock O, Dolan A, Athman R, Power A, Gethin G. Cowman S. Comparison of the antimicrobial activity of Ulmo honey from Chile and Manuka honey against methicillin-resistant Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. BMC Complement Altern Med, 2010;10(47):5. Shi JS, Kim KS, Kim MB, Jeong IJ, Kim HBK. Synthesis and hypoglycemic effect of chrysin derivatives. Bioorg Med Chem Lett, 1999;9:869-74. Skrabalova J, Drastichova Z, Novotny J. Morphine as a Potential Oxidatie Stress-Causing Agent. Mini-Reviews In Organic Chemistry, 2013;10:376-373. Tornuk F,Karaman S, Ozturk I, Toker OS, Tastemur B, Sagdic O, Dogan M, Kayacier A. Quality characterization of artisanal and retail Turkish blossom honeys: Determination of physicochemical, microbiological, bioactive properties and aroma profile. Industrial Crops and Products, 2013;46:124-131. Vidyalakshmi K, Kamalakannan P, Viswanathan S, Ramaswamy S. Analgesic effect of certain dihydroxy flavones in mice. Pharmacol. Biochem. Behav., 2010;96(1):106. Yimam, M., Brownell, L., Hodges, M. and Jia, Q. 2012. Analgesic effects of a standardised bioflavonoid composition from scutella baicalensis and acacia catechu. J Diet Suppl, 9, 155-156. Yoburn BC, Gomes BA, Rajashekara V, Patel C, Patel M. Role of G(i)alpha2-protein in opioid tolerance and mu-opioid receptor downregulation in vivo. Synapse, 2003;4:109-11. Webster DE, He Y, Chen SN, Pauli GF, Farnsworth NR, Wang ZJ. Opioidergic mechanisms underlying the actions of Vitex agnus-castus L. Biochem Pharmacol, 2011;81:170-7. White J.W. 1962. Composition of American Honeys. USDA Washington DC, USA: Agricultural Research Service. White Jr. JW. Detection of honey adulteration by carbohydrate analysis. Journal of the Association of Official Analytical Chemists, 1980;63(1):11–18.
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spelling 12597 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12597 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal image/jpeg inches 96 96 norman 1423 53 53 773 2015-12-27 15:05:36 1423x773 6904-01-FH02-FP-15-04628.jpg UniSZA Private Access Analgesic effect of honey bioactive compounds and its role in reducing morphine tolerance Journal of Applied Pharmaceutical Science Honey has been used as a supplement nutrient in human for centuries. It exerts antibacterial, anticancer, anti-inflammatory properties as well as analgesic activity. But not many studies have been done to analyze effect of honey on morphine tolerance. Hence, this review is targeting on analgesic effect of honey bioactive compounds and their potential in morphine tolerance study. 5 11 Open Science Publishers LLP Inc. Open Science Publishers LLP Inc. 146-150 Abd. Aziz CB, Ahmad R, Mohamed M, Wan Yusof WN. The effects of Tualang honey intake during prenatal stress on pain responses in the rat offsprings. European Journal of Integrative Medicine, 2013;5:326- 331. Abdel-Zaher AO, Abdel-Rahman MS, Elwasei FM. Blockade of nitric oxideoverproduction and oxidative stress by Nigella sativa oil attenuates morphine-induced tolerance and dependence in mice. Neurochem. Res. 2010;35:1557–1565. Ahmed J, Prabhu ST, Raghavan GSV, Ngadi M. Physicochemocal, rheological, calorimetric and dielectric behavior of selected Indian honey. J Food Eng, 2007;29:1207-13. Alvarez-Suarez JM, Giampieri F, Battino M. Honey as a source of dietary antioxidants:Structures, bioavailability and evidence of protective effects against human chronic diseases. Curr Med Chem, 2013;20(5):621–638. Alzubier AA, Okechukwu PN. 2011. Investigation of antiinflammatory, antipyretic and analgesic effect of yemeni sidr honey. International Scholarly and Scientific Research and Innovation, 2011; 5(8):41-46. Backhouse N, Delporte C, Apablaza C, Farias M, Goity L, Arrau S, et al. Analgesic activity of Buddleja globosa (matico) in several models of pain. J Ethnopharmacol, 2008;119:160-5. Bannon AW, Malmberg AB, Models of nociception: hot plate, tail flick, and formalin tests in rodents. Curr. Protoc. Neurosci, 2007;41: 891-896. Berrocoso E, Sanchez-Blazquez P, Garzon J,Mico, JA. Opiates as Antidepressants. Current Pharmaceutical Design. 2009;15:1612-1622. Boroumand , Zamani MM, Saeedi M, Rouhbakhshfar O, Motlagh SRH, Moghaddam FA. Post tonsillectomy pain: can honey reduce the analgesic requirements?. Anesthesiology and Pain Medicine, 2013;3(1):198-202. Carvalho GJA, Carvalho ME. Diterpenes, triterpenes and steroides from flowers of Wedelia paludosa. Quimica Nova, 2001; 24:24- 26. Chao PC, Hsu CC, Yin MC. Anti-inflammatory and anticoagulatory activities of caffeic acid and ellagic acid in cardiac tissue of diabetic mice. Nutrition and Metabolism, 2009;6(33):1-8. Das A, Datta S, Mukherjee S, Bose S, Ghosh S, Dhar P. Evaluation of antioxidative, antibacterial and probiotic growth stimulatory activities of Sesamun indicum honey containing phenolic compounds and lignans. LWT- Food Science and Technology, 2015;61:244-250. DuPen A, Shen D, Ersek M. Mechanisms of opioid-induced tolerance and hyperalgesia. Pain Management Nursing, 2007;8(3):113- 121. Farkhondeh T, Samarghandian S, Azimin-Nezhad M, Samini F. Effect of chrysin on nociception in formalin test and serum levels of noradrenalin and corticosterone in rats. Int J Clin Exp Med, 2015;2:2465- 2470. Fauzi AN, Norazmi MN, Yaacob NS. Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines. Food and Chemical Toxicology, 2011;49:871-878. Gamaro GD, Suyenaga E, Borsoi M, Lermen J, Pereira P, Ardenghi P. Effect of Rosmarinic and Caffeic Acids on Inflammatory and Nociception Process in Rats. ISRN Pharmacology, 2011;1-6. Gheldof N, Engeseth N. Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples. Journal of Agricultural and Food Chemistry, 2012;50:3050-3055. Gheldof N, Wang XH, Miller NJ, Engeseth J. Agric. Food Chem, 2002;50:5870. Goldberg R. 2014. Drugs across the spectrum. Belmont, USA: Cengage Learning. Gunduz A, Eraydin I, Turkmen S, Kalkan OF, Turedi S, Eryigit U, Ayar A. Analgesic effects of mad honey (grayanotoxin) in mice models of acute pain and painful diabetic neuropathy. Human and Environmental Toxicology, 2014;33(2):130-135. Hu CY, Zhao YT. Analgesic effects of naringenin in rats with spinal nerve ligation-induced neuropathic pain. Biomedical Reports, 2014;2:569-573. Higgs J, Wasowski C, Loscalzo LM, Marder M. In vitro binding affinities of a series of flavonoids for m-opioid receptors: analgesic effect of the synthetic flavonoid 3,3-dibromoflavanone in mice. Neuropharmacology, 2013;72:9-19. Johnston JE, Sepe HA, Miano CL, Brannan RG, Alderton AL. Honey inhibits lipid oxidation in ready-to-eat ground beef patties. Meat Science,2005;70(4):627–631. Kaulaskar S, Bhutada P, Rahigude A, Jain D, Harle U. Effect of naringenin on alldynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain. Journal of Chinese Integrative Medicine, 2012;30(12):1482-1489. Khalil MI, Alam N, Moniruzzaman M, Sulaiman SA, Gan SH. Phenolic acid composition and antioxidant properties of malaysian honeys. Journal of Food Science, 2011;76(6):921-928. Kosten TR, George TP. The neurobiology of opioid dependence: implications for treatment. Science and Practice Perspectives, 2002; 13-21. Kruger L. 2001. Methods in pain research. Florida, USA: CRC Press. Lees R, Lingford-Hughes A. Neurobiology and principles of addiction and tolerance. Medicine, 2012;40(12): 633-636. Liu M, Song S, Li H, Jiang X, Yin P, Wan C, Liu X, Liu F, Xu J. The protective effect of caffeic acid against inflammation injury of primary bovine mammary epithelial cells induced by lipopolysaccharide. J. Dairy Sci., 2014;97:2856-2865. Mansouri MT, Naghizadeh B, Ghorbanzadeh B. Ellagic acid enhances morphine analgesia and attenuates the development of morphine tolerance and dependence in mice. European Journal of Pharmacology, 2014;741:272-280. Mansouri MT, Naghizadeh B, Ghorbanzadeh B. Ellagic acid enhances the analgesic action of venlafaxine in mouse acetic acidinduced pain: An isobolographic analysis. Pharmacological Reports, 2015;67:473-477. Manyi-Loh CE, Clarke AM, Ndip RN. Identiication of volatile compounds in solvent extracts of honeys produced in South Africa. African Journal of Agricultural Research, 2011;6(18):4327–4334. Mao J, Sung B, Ji R, Lim G. Neuronal apoptosis associated with morphine tolerance: Evidence for an opioid-induced neurotoxic mechanism. The Journal of Neuroscience, 2002;22(17):7850-7861. Martin Gomez Pinheiro, M., Boylan, F. and Fernandes, P.D. 2012. Analgesic effect of the Orbignya speciosa Mart. (Babassu) leaves: Evidence for the involvement of apigenin. Life Sciences, 91, 293-300. Mayer DJ, Mao J. Mechanism of opioid tolerance: A current view of cellular mechanisms. Pain Forum, 1999;8(1):14-18. Mayer A, Slezak V, Takac P, Olejnik J. Majtan J. Treatment of nonhealing leg ulcers with honeydw honey. Journal of Tissue Viability, 2014;23:94-97. Mehrotra A, Shanbhag R, Chamallamudi MR, Singh VP, Mudgal J. Ameliorative effect of caffeic aicd against inflammatory pain in rodents. European Journal of Pharmacology, 2011;666:80-86. Meotti FC, Luiz AP, Pizzolatti MG, Kassuya CAL, Calixto JB, Santos ARS. Analysis of the analgesic effect of the flavonoid myricitrin: evidence for a role of the L-arginine- nitric oxide and protein kinase C pathways. J. Pharmacol. Exp. Ther, 2006;316:789-796. Mohamad N, Ismail R, Abdul Latif AZ, Mohamad M, Toriman ME. 2014. Terapi penggantian methadon: Penderitaan kebergantungan opiat yang boleh diubati. Kuala Terengganu, Terengganu: Penerbit UniSZA. Naidu PS, Singh A, Joshi D, Kulkarni SS. Possible mechanisms of action in quercetin reversal of morphine tolerance and dependence. Addiction Biology, 2003;8:327-336. Narita M, Suzuki M, Narita M, Niikura K, Nakamura A, Miyatake M, Yajima Y. Suzuki T. Μ-opioid recepote internalizationdependent and in-dependent mechanisms of the development of tolerance to μ-opioid receptor agonists: Comparison between etorphine and morphine. Neuroscience, 2006;138:609-619. Nsonde Ntandou GF, Bnzouzi JT, Mbatchi B, Elion-Itou RDG, Etou-Ossibi AW, Ramos S, BenoitVical F, Abena AA, Ouamba JM. Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts. Journal of Ethnopharmacology, 2010;127:108-111. Owoyele BV, Adenekan OT, Soladoye AO. Effects of honey on inflammation and nitric oxide production in Wistar rats. Zhong Xi Yi Jie He Xue Bao, 2011;9(4):447–452. Pyrzynska K. Biesaga M. Analysis of phenolic acids and flavonoids in honey. Trends In Analytical Chemistry, 2009;28(7):893-902. Raso GM, Meli R, Di Carlo G, Pacilio M, Di Carlo R. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci, 2001;68:921- 931. Richard J. Honey and healing through the ages. Journal of Apiproduct and Apimedical Science, 2009;1(1):2-5. Samarghandlan S, Borji A. Anticarcinogenic effect of saffron (Crocus sativus L.) and its ingredients. Pharmacognosy Res, 2014;6:99- 107. Santos ARS, De Campos ROP, Miguel OG, Cechinel-Filho V, Yunes RA, Calixto J.B. The involvement of Kq channels and G protein in the analgesic action of the gallic acid ethyl ester. European Journal of Pharmacology, 1999;379:7-17. Sato T, Miyata G. The nutraceutical benefit, part III:honey. Nutrition, 2000;16(6):468–469. Schildhaus N, Trink E, Polson C, DeTolla L, Tyler BM, Jallo GI, Tok S, Guarnieri M. Thermal latency studies in opiate-treated mice. J Pharm Bioallied Sci., 2014;6(1):43-47. Sherlock O, Dolan A, Athman R, Power A, Gethin G. Cowman S. Comparison of the antimicrobial activity of Ulmo honey from Chile and Manuka honey against methicillin-resistant Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. BMC Complement Altern Med, 2010;10(47):5. Shi JS, Kim KS, Kim MB, Jeong IJ, Kim HBK. Synthesis and hypoglycemic effect of chrysin derivatives. Bioorg Med Chem Lett, 1999;9:869-74. Skrabalova J, Drastichova Z, Novotny J. Morphine as a Potential Oxidatie Stress-Causing Agent. Mini-Reviews In Organic Chemistry, 2013;10:376-373. Tornuk F,Karaman S, Ozturk I, Toker OS, Tastemur B, Sagdic O, Dogan M, Kayacier A. Quality characterization of artisanal and retail Turkish blossom honeys: Determination of physicochemical, microbiological, bioactive properties and aroma profile. Industrial Crops and Products, 2013;46:124-131. Vidyalakshmi K, Kamalakannan P, Viswanathan S, Ramaswamy S. Analgesic effect of certain dihydroxy flavones in mice. Pharmacol. Biochem. Behav., 2010;96(1):106. Yimam, M., Brownell, L., Hodges, M. and Jia, Q. 2012. Analgesic effects of a standardised bioflavonoid composition from scutella baicalensis and acacia catechu. J Diet Suppl, 9, 155-156. Yoburn BC, Gomes BA, Rajashekara V, Patel C, Patel M. Role of G(i)alpha2-protein in opioid tolerance and mu-opioid receptor downregulation in vivo. Synapse, 2003;4:109-11. Webster DE, He Y, Chen SN, Pauli GF, Farnsworth NR, Wang ZJ. Opioidergic mechanisms underlying the actions of Vitex agnus-castus L. Biochem Pharmacol, 2011;81:170-7. White J.W. 1962. Composition of American Honeys. USDA Washington DC, USA: Agricultural Research Service. White Jr. JW. Detection of honey adulteration by carbohydrate analysis. Journal of the Association of Official Analytical Chemists, 1980;63(1):11–18.
spellingShingle Analgesic effect of honey bioactive compounds and its role in reducing morphine tolerance
summary Honey has been used as a supplement nutrient in human for centuries. It exerts antibacterial, anticancer, anti-inflammatory properties as well as analgesic activity. But not many studies have been done to analyze effect of honey on morphine tolerance. Hence, this review is targeting on analgesic effect of honey bioactive compounds and their potential in morphine tolerance study.
title Analgesic effect of honey bioactive compounds and its role in reducing morphine tolerance
title_full Analgesic effect of honey bioactive compounds and its role in reducing morphine tolerance
title_fullStr Analgesic effect of honey bioactive compounds and its role in reducing morphine tolerance
title_full_unstemmed Analgesic effect of honey bioactive compounds and its role in reducing morphine tolerance
title_short Analgesic effect of honey bioactive compounds and its role in reducing morphine tolerance
title_sort analgesic effect of honey bioactive compounds and its role in reducing morphine tolerance

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