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https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072
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2015-12-15 09:25:24
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Restricted Document
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12587
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UniSZA
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[1] Tomoko Ichiki, Ririko Izumi, Alessandro Cataliotti, M. Amy, Larsen, M. Sharon, Sandberg, [2] John C. Burnett Jr. Peptides, 2013,48: 21–26. [3] Robert Fried, (AcademicPress, London and New York), 2014, 111–140. [4] Landmesser U, Hornig B, Drexler H. Semin Thromb Hemost. 2000. 26: 529–537 [5] Wu Y, Li J, Wang J, Si Q, Zhang J, Jiang Y, Chu L. J Ethnopharmacol. 2009 122:509–516 [6] Prasad K, Kalra J. Angiology. 1989. 40(9):835–43. [7] Cai H, Harrison DG. Circ Res. 2000. 87:840–844. [8] Stapleton PA, Goodwill AG, James ME, Brock RW, Frisbee JC. J Inflamm. 2010. 7: 54–64. [9] Berliner JA, Watson AD. N Engl J Med. 2005. 353: 9–11. [10] Zamble A, Carpentier M, Kandoussi A, Sahpaz S, Petrault O, Ouk T, et al. J Cardiovasc Pharmacol. 2006. 47: 599–608. [11] Rocha AP, Carvalho LC, Sousa MA, Madeira SV, Sousa PJ, Tano T, et al. Vasc Pharmacol. 2007.46: 97–104. [12] Shaw CY, Chen CH, Hsu CC, Chen CC, Tsai YC. Phytother Res. 2003.17(7):823–5. [13] So Young Kang, Sang Hyun Sung, long Hee Park, Young Choong Kim. Arch. Pharm. Res. 1998. 21(6):718–22. [14] Hyung-Jin Kim, Seon Il Jang, Young-Jun Kim, Hun-Taeg Chung, Yong-Gab Yun, Tai-Hyun Kang, Ok-Sam Jeong, Youn-Chul Kim. Fitoterapia. 2004. 75: 261–6. [15] Mahadeva Rao US, Ponnusamy Kumar, Naidu Jegathambigai, Sundaram C. Shanmuga, and R. Babu Janarthanam. Chinese Journal of Integerative Medicine 2013-0692 (in press). [16] Bohlmann, F. and Jakupovic, J., Phytochem. 1979.1 8: 1367–70. [17] Folch J, Lees M, Sloane-Stanley GH. J Biol Chem. 1957. 226:497-509. [18] Parekh AC, Jung DH. Anal Chem. 1970. 42: 1423–27. [19] Rice EW. New York, USA: In MacDonald RP, editor. Academic Press, Standard Methods of Clinical Chemistry.1970. 6: 215–22. [20] Rouser G, Fkeischer S, Yamamoto A. Lipids. 1970. 5: 494–6. [21] Chade AR, Rodriguez-Porcel M, Herrmann J, Zhu X, Grande JP, et al. J Am Soc Nephrol. 2004. 15: 958–66. [22] Marklund S, Marklund G. Eur J Biochem. 1974. 47: 469–74. [23] Sinha AK. Anal Biochem. 1972. 47: 389–94. [24] Rotruck JT, Pope AL, Ganther HE. Sci. 1973. 179: 588–90. [25] Omaye ST, Turnbull JD, Sauberlich HE. Methods Enzymol. 1979. 62: 3–11. [26] Baker AF, Frank G. In: Bollinger G, editor. Dunnshchicht, Chromatographic in Laboratorium “Hand brich”. Berlin, Germany: Springer-Verlag. 1951. 41–52. [27] Devasagayam TPA, Tarachand U. Biochem Biophys Res Commun. 1987. 145: 134–8. [28] Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Anal Biochem. 1982. 126:131–8. [29] Lowry OH, Rosebrough NJ, Farr AL, Randall R. J Biol Chem. 1951. 193: 265–75. [30] Balkan J, Kanbagli O, Hatipoglu A, Kucuk M, Cevikbas U, Toker G, Uysal M. Biosci Biotechnol Biochem. 2002. 66: 1755–8. [31] Stokes KY, Cooper D, Tailor A, Granger DN. Free Radic Biol Med. 2002. 33: 1026–36. [32] Renata da Silva Pereira, Etiane Tatsch, Guilherme Vargas Bochi, Helena Kober, Thiago Duarte, Greice Franciele Feyh dos Santos Montagner, José Edson Paz da Silva, Marta Maria Medeiros Frescura Duarte, Ivana Beatrice Mânica da Cruz, and Rafael Noal. Inflammation. 2013. 36(4): 869–77. [33] Sandhya VG, Rajamohan T. Food Chem Toxicol. 2008. 46: 3586–92. [34] Srivastava RAK, He S. Mol Cell Biochem. 2010. 345: 197–206. [35] Jadeja RN, Thounaojam MC, Jain M, Devkar RV, Ramachandran AV. Immunopharmacol and Immunotoxicol. 2012. 34: 443–53. [36] Mahadeva Rao U. S., Kumar Ponnusamy, Jegathambigai Rameshwar Naidu, C. Shanmuga Sundaram. International Medical Journal. 2014. 21(3): 353 – 8. [37] Guzik TJ, West NEJ, Black E, Mc Donald D, Ratnatunga C, Pillai R, Channon KM.. Circ. Res. 2000. 86: 85–90. [38] R. Mogana, K. Teng-Jin, and C.Wiart. Evidence-Based Complementary and Alternative Medicine. 2013: 1–7. [39] Ste´phan Dorey, Marguerite Kopp, Pierrette Geoffroy, Bernard Fritig, and Serge Kauffmann. Plant Physiology. 1999. 121: 163–71. [40] Okado-Matsumoto A, Fridovich I. J Biol Chem. 2001. 276: 38388–93. [41] Raja B, Kumar SM, Sathya G. Mol Cell Biochem. 2012. 366: 21–30. [42] Iranshahi M, Askari M, Sahebkar A, Hadjipavlou-Litina D. Daru. 2009. 17:99–103. [43] Anna Gliszczyn´ska, Peter E. Brodelius. Phytochem Rev. 2012. 11:77–96. [44] Gustav Mattiasson. Cytometry Part A. 2004. 62A(2):89–96. [45] Harrison D, Griendling K, Landmesser U, Hornig B, Drexler H. Am J Cardiol. 2003. 91: 7–11. [46] Prasad K. Atherosclerosis. 2005. 179: 269–75. [47] Jain GC, Jhalani S, Agarwal S, Jain K. Asian J. Exp. Sci. 2007. 21: 115–22. [48] So Min Lee,1,2 Yun Jung Lee, Youn Chul Kim, Jin Sook Kim, Dae Gill Kang, and Ho Sub Lee. Inflammation. 2012. 35(2): 584–93. [49] Ogita H, Liao J. 2004. Endothelial function and oxidative stress. Endothelium. 11: 123–32. [50] Deepa PR, Varalakshmi P. Int J Cardiol. 2006. 106: 338–47. [51] V. de Sandro, C. Dupuy, L. Richert, A. Cordier, J. Pommier. Analytical Biochemistry. 1992. 206(2):408–13. [52] Eui Kwang Kwon, Jin Sang Sik, Choi Min H, Hwang Kyung Taek, Shim Jin Chan, Hwang Il Taek and Han Jong Hyun. Korean Journal of Oriental Physiology and Pathology. 2002. 16(2):389–96. [53] Kubes P, McCafferty DM. Am J Med. 2000. 109: 150–8. [54] Aliev G, Shi J, Perry G, Friedland RP, Lamanna JC. Anat Rec.2000. 260: 16–25. [55] Kwok CY, Yan Wong CN, Chun Yau MY, Fu Ku PH, Shan Au AL, Wa Poon CC, et al. J fun foods.2010. 2: 176–86. [56] Sudhahar V, Kumar SA, Sudharsan PT, Varalakshmi P. Vasc Pharmacol. 2007. 46: 412–8. [57] Fujiwara N, Kobayashi K. Current Drug Targets. Inflam Allergy.2005 4: 281–6. [58]Tai-Hyun Kang, Hyun-Ock Pae, Sei-Joon Jeong, Ji-Chang Yoo, Byung-Min Choi, Chang-Duk Jun, Hun-Taeg Chung, T. Miyamoto, R. Higuchi, Youn-Chul Kim. Planta Med. 1999. 65(5): 400–3. [59] Sohn EJ, Kang DG, Mun YJ,Woo WH, Lee HS. Biol Pharm Bull. 2005.28: 1444–9.
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6894-01-FH02-FP-15-04482.jpg
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norman
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oai_dc
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https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12587
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12587 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12587 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal image/jpeg inches 96 96 norman 75 75 731 1409 2015-12-15 09:25:24 1409x731 6894-01-FH02-FP-15-04482.jpg UniSZA Private Access Regulatory efficacy of scopoletin, a biocoumarin on aortic oxido lipidemic stress through antioxidant potency as well as suppression of mRNA expression of inos gene in hypercholesterolemic rats Der Pharmacia Lettre Preceding work in our laboratory has revealed that scopoletin, one of the main bioactive coumarin from fruits of Morinda citrifolia, exerts anti-diabetic activity in in vitro partly by averting α glucosidase and α amylase action. However, its aorto/vaso protective impact-based research is still incomprehensible. The present study looks into the regulatory efficacy of scopoletin on aortic lipid profile, radical scavenging status, endothelial factors and aortic morphology in dyslipidemic rats. Rats fed with normal diet serve as control [Group (G) 1], rats fed with cholesterolenriched diet (CED) (4 % cholesterol and 1 % cholic acid) for 45 days (G2), rats fed with CED for 45 days + scopoletin (10 mg/kg, body weight/day orally) for the last 30 days (G3) and scopoletin alone rats (G4). Blood and aortic tissue were taken immediately and used for various biochemical, histological and molecular analyses. A pronounced increase in the levels of aortic lipid profile, lipid peroxidation along with substantial suppression in the activities of aortic antioxidant and endothelial factor was observed in G2. The mRNA expression levels of iNOS gene were significantly up-regulated in aortic tissue of G2. On treatment with scopoletin, all the levels were reverted to near normalcy G3. Morphology of aorta in G2 indicated numerous foam cells with intimal changes, whereas the aorta of G3 exhibited fewer foam cells with normal intima. These results support that scopoletin expressively represses the aortic oxido-lipidemic stress and thereby upholding normal morphology of the aorta, and thus minimizing the peril of CVD. 7 10 57-67 [1] Tomoko Ichiki, Ririko Izumi, Alessandro Cataliotti, M. Amy, Larsen, M. Sharon, Sandberg, [2] John C. Burnett Jr. Peptides, 2013,48: 21–26. [3] Robert Fried, (AcademicPress, London and New York), 2014, 111–140. [4] Landmesser U, Hornig B, Drexler H. Semin Thromb Hemost. 2000. 26: 529–537 [5] Wu Y, Li J, Wang J, Si Q, Zhang J, Jiang Y, Chu L. J Ethnopharmacol. 2009 122:509–516 [6] Prasad K, Kalra J. Angiology. 1989. 40(9):835–43. [7] Cai H, Harrison DG. Circ Res. 2000. 87:840–844. [8] Stapleton PA, Goodwill AG, James ME, Brock RW, Frisbee JC. J Inflamm. 2010. 7: 54–64. [9] Berliner JA, Watson AD. N Engl J Med. 2005. 353: 9–11. [10] Zamble A, Carpentier M, Kandoussi A, Sahpaz S, Petrault O, Ouk T, et al. J Cardiovasc Pharmacol. 2006. 47: 599–608. [11] Rocha AP, Carvalho LC, Sousa MA, Madeira SV, Sousa PJ, Tano T, et al. Vasc Pharmacol. 2007.46: 97–104. [12] Shaw CY, Chen CH, Hsu CC, Chen CC, Tsai YC. Phytother Res. 2003.17(7):823–5. [13] So Young Kang, Sang Hyun Sung, long Hee Park, Young Choong Kim. Arch. Pharm. Res. 1998. 21(6):718–22. [14] Hyung-Jin Kim, Seon Il Jang, Young-Jun Kim, Hun-Taeg Chung, Yong-Gab Yun, Tai-Hyun Kang, Ok-Sam Jeong, Youn-Chul Kim. Fitoterapia. 2004. 75: 261–6. [15] Mahadeva Rao US, Ponnusamy Kumar, Naidu Jegathambigai, Sundaram C. Shanmuga, and R. Babu Janarthanam. Chinese Journal of Integerative Medicine 2013-0692 (in press). [16] Bohlmann, F. and Jakupovic, J., Phytochem. 1979.1 8: 1367–70. [17] Folch J, Lees M, Sloane-Stanley GH. J Biol Chem. 1957. 226:497-509. [18] Parekh AC, Jung DH. Anal Chem. 1970. 42: 1423–27. [19] Rice EW. New York, USA: In MacDonald RP, editor. Academic Press, Standard Methods of Clinical Chemistry.1970. 6: 215–22. [20] Rouser G, Fkeischer S, Yamamoto A. Lipids. 1970. 5: 494–6. [21] Chade AR, Rodriguez-Porcel M, Herrmann J, Zhu X, Grande JP, et al. J Am Soc Nephrol. 2004. 15: 958–66. [22] Marklund S, Marklund G. Eur J Biochem. 1974. 47: 469–74. [23] Sinha AK. Anal Biochem. 1972. 47: 389–94. [24] Rotruck JT, Pope AL, Ganther HE. Sci. 1973. 179: 588–90. [25] Omaye ST, Turnbull JD, Sauberlich HE. Methods Enzymol. 1979. 62: 3–11. [26] Baker AF, Frank G. In: Bollinger G, editor. Dunnshchicht, Chromatographic in Laboratorium “Hand brich”. Berlin, Germany: Springer-Verlag. 1951. 41–52. [27] Devasagayam TPA, Tarachand U. Biochem Biophys Res Commun. 1987. 145: 134–8. [28] Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Anal Biochem. 1982. 126:131–8. [29] Lowry OH, Rosebrough NJ, Farr AL, Randall R. J Biol Chem. 1951. 193: 265–75. [30] Balkan J, Kanbagli O, Hatipoglu A, Kucuk M, Cevikbas U, Toker G, Uysal M. Biosci Biotechnol Biochem. 2002. 66: 1755–8. [31] Stokes KY, Cooper D, Tailor A, Granger DN. Free Radic Biol Med. 2002. 33: 1026–36. [32] Renata da Silva Pereira, Etiane Tatsch, Guilherme Vargas Bochi, Helena Kober, Thiago Duarte, Greice Franciele Feyh dos Santos Montagner, José Edson Paz da Silva, Marta Maria Medeiros Frescura Duarte, Ivana Beatrice Mânica da Cruz, and Rafael Noal. Inflammation. 2013. 36(4): 869–77. [33] Sandhya VG, Rajamohan T. Food Chem Toxicol. 2008. 46: 3586–92. [34] Srivastava RAK, He S. Mol Cell Biochem. 2010. 345: 197–206. [35] Jadeja RN, Thounaojam MC, Jain M, Devkar RV, Ramachandran AV. Immunopharmacol and Immunotoxicol. 2012. 34: 443–53. [36] Mahadeva Rao U. S., Kumar Ponnusamy, Jegathambigai Rameshwar Naidu, C. Shanmuga Sundaram. International Medical Journal. 2014. 21(3): 353 – 8. [37] Guzik TJ, West NEJ, Black E, Mc Donald D, Ratnatunga C, Pillai R, Channon KM.. Circ. Res. 2000. 86: 85–90. [38] R. Mogana, K. Teng-Jin, and C.Wiart. Evidence-Based Complementary and Alternative Medicine. 2013: 1–7. [39] Ste´phan Dorey, Marguerite Kopp, Pierrette Geoffroy, Bernard Fritig, and Serge Kauffmann. Plant Physiology. 1999. 121: 163–71. [40] Okado-Matsumoto A, Fridovich I. J Biol Chem. 2001. 276: 38388–93. [41] Raja B, Kumar SM, Sathya G. Mol Cell Biochem. 2012. 366: 21–30. [42] Iranshahi M, Askari M, Sahebkar A, Hadjipavlou-Litina D. Daru. 2009. 17:99–103. [43] Anna Gliszczyn´ska, Peter E. Brodelius. Phytochem Rev. 2012. 11:77–96. [44] Gustav Mattiasson. Cytometry Part A. 2004. 62A(2):89–96. [45] Harrison D, Griendling K, Landmesser U, Hornig B, Drexler H. Am J Cardiol. 2003. 91: 7–11. [46] Prasad K. Atherosclerosis. 2005. 179: 269–75. [47] Jain GC, Jhalani S, Agarwal S, Jain K. Asian J. Exp. Sci. 2007. 21: 115–22. [48] So Min Lee,1,2 Yun Jung Lee, Youn Chul Kim, Jin Sook Kim, Dae Gill Kang, and Ho Sub Lee. Inflammation. 2012. 35(2): 584–93. [49] Ogita H, Liao J. 2004. Endothelial function and oxidative stress. Endothelium. 11: 123–32. [50] Deepa PR, Varalakshmi P. Int J Cardiol. 2006. 106: 338–47. [51] V. de Sandro, C. Dupuy, L. Richert, A. Cordier, J. Pommier. Analytical Biochemistry. 1992. 206(2):408–13. [52] Eui Kwang Kwon, Jin Sang Sik, Choi Min H, Hwang Kyung Taek, Shim Jin Chan, Hwang Il Taek and Han Jong Hyun. Korean Journal of Oriental Physiology and Pathology. 2002. 16(2):389–96. [53] Kubes P, McCafferty DM. Am J Med. 2000. 109: 150–8. [54] Aliev G, Shi J, Perry G, Friedland RP, Lamanna JC. Anat Rec.2000. 260: 16–25. [55] Kwok CY, Yan Wong CN, Chun Yau MY, Fu Ku PH, Shan Au AL, Wa Poon CC, et al. J fun foods.2010. 2: 176–86. [56] Sudhahar V, Kumar SA, Sudharsan PT, Varalakshmi P. Vasc Pharmacol. 2007. 46: 412–8. [57] Fujiwara N, Kobayashi K. Current Drug Targets. Inflam Allergy.2005 4: 281–6. [58]Tai-Hyun Kang, Hyun-Ock Pae, Sei-Joon Jeong, Ji-Chang Yoo, Byung-Min Choi, Chang-Duk Jun, Hun-Taeg Chung, T. Miyamoto, R. Higuchi, Youn-Chul Kim. Planta Med. 1999. 65(5): 400–3. [59] Sohn EJ, Kang DG, Mun YJ,Woo WH, Lee HS. Biol Pharm Bull. 2005.28: 1444–9.
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| spellingShingle |
Regulatory efficacy of scopoletin, a biocoumarin on aortic oxido lipidemic stress through antioxidant potency as well as suppression of mRNA expression of inos gene in hypercholesterolemic rats
|
| summary |
Preceding work in our laboratory has revealed that scopoletin, one of the main bioactive coumarin from fruits of Morinda citrifolia, exerts anti-diabetic activity in in vitro partly by averting α glucosidase and α amylase action. However, its aorto/vaso protective impact-based research is still incomprehensible. The present study looks into the regulatory efficacy of scopoletin on aortic lipid profile, radical scavenging status, endothelial factors and aortic morphology in dyslipidemic rats. Rats fed with normal diet serve as control [Group (G) 1], rats fed with cholesterolenriched diet (CED) (4 % cholesterol and 1 % cholic acid) for 45 days (G2), rats fed with CED for 45 days + scopoletin (10 mg/kg, body weight/day orally) for the last 30 days (G3) and scopoletin alone rats (G4). Blood and aortic tissue were taken immediately and used for various biochemical, histological and molecular analyses. A pronounced increase in the levels of aortic lipid profile, lipid peroxidation along with substantial suppression in the activities of aortic antioxidant and endothelial factor was observed in G2. The mRNA expression levels of iNOS gene were significantly up-regulated in aortic tissue of G2. On treatment with scopoletin, all the levels were reverted to near normalcy G3. Morphology of aorta in G2 indicated numerous foam cells with intimal changes, whereas the aorta of G3 exhibited fewer foam cells with normal intima. These results support that scopoletin expressively represses the aortic oxido-lipidemic stress and thereby upholding normal morphology of the aorta, and thus minimizing the peril of CVD.
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| title |
Regulatory efficacy of scopoletin, a biocoumarin on aortic oxido lipidemic stress through antioxidant potency as well as suppression of mRNA expression of inos gene in hypercholesterolemic rats
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| title_full |
Regulatory efficacy of scopoletin, a biocoumarin on aortic oxido lipidemic stress through antioxidant potency as well as suppression of mRNA expression of inos gene in hypercholesterolemic rats
|
| title_fullStr |
Regulatory efficacy of scopoletin, a biocoumarin on aortic oxido lipidemic stress through antioxidant potency as well as suppression of mRNA expression of inos gene in hypercholesterolemic rats
|
| title_full_unstemmed |
Regulatory efficacy of scopoletin, a biocoumarin on aortic oxido lipidemic stress through antioxidant potency as well as suppression of mRNA expression of inos gene in hypercholesterolemic rats
|
| title_short |
Regulatory efficacy of scopoletin, a biocoumarin on aortic oxido lipidemic stress through antioxidant potency as well as suppression of mRNA expression of inos gene in hypercholesterolemic rats
|
| title_sort |
regulatory efficacy of scopoletin, a biocoumarin on aortic oxido lipidemic stress through antioxidant potency as well as suppression of mrna expression of inos gene in hypercholesterolemic rats
|