| _version_ |
1860797352841838592
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| building |
INTELEK Repository
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| collection |
Online Access
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| collectionurl |
https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072
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| date |
2019-11-28 16:14:01
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| format |
Restricted Document
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| id |
12375
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| institution |
UniSZA
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| originalfilename |
6675-01-FH02-FP-20-36753.pdf
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| person |
ismail - [2010]
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| recordtype |
oai_dc
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| resourceurl |
https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12375
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| spelling |
12375 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12375 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal application/pdf 13 Adobe Acrobat Pro DC 20 Paper Capture Plug-in 1.7 ismail - [2010] 2019-11-28 16:14:01 6675-01-FH02-FP-20-36753.pdf UniSZA Private Access Anxiolytic effects of thymoquinone in the rats exposed to MDMA International Medical Journal Ecstasy 3, 4-Methylenedioxymethamphetamine or MDMA is a psychostimulant drug capable of inducing psychiatric disorders in animals and humans. MDMA produces short-term pleasure effects but prompts to neuropsychiatric problems in the long-term, such as anxiety. The purpose of this study was to examine the anxiolytic potential of a natural compound known as thymoquinone (TQ) in rats that were stimulated to anxiety by MDMA. The administration of TQ into MDMA-induced 5-HT depletion rats was carried out in male Sprague Dawley via 1-week treatment dividing into four groups. The administration of TQ into MDMA-induced 5-HT depletion rats was carried out in male Sprague Dawley via a1-week treatment dividing into four groups. The studied groups involved with the treatments comprise i) Control (1 mL/kg saline), ii) MDMA (20 mg/kg MDMA), iii) MDMA-TQ (20 mg/kg MDMA + 40 mg/kg TQ) and iv) TQ (40 mg/kg TQ). Anxiety test is subject to a light-dark test and social interaction test. Our results demonstrated an increase in anxiety behaviour in the MDMA group as compared to the control group. TQ prevented anxiety after undergoing a 1-week treatment in the MDMA+TQ group as compared to the untreated MDMA group. Hence, this study proposed that TQ could protect against anxiety-like behaviour upon MDMA exposure in rats. 24 3 13
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| spellingShingle |
Anxiolytic effects of thymoquinone in the rats exposed to MDMA
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| summary |
Ecstasy 3, 4-Methylenedioxymethamphetamine or MDMA is a psychostimulant drug capable of inducing psychiatric disorders in animals and humans. MDMA produces short-term pleasure effects but prompts to neuropsychiatric problems in the long-term, such as anxiety. The purpose of this study was to examine the anxiolytic potential of a natural compound known as thymoquinone (TQ) in rats that were stimulated to anxiety by MDMA. The administration of TQ into MDMA-induced 5-HT depletion rats was carried out in male Sprague Dawley via 1-week treatment dividing into four groups. The administration of TQ into MDMA-induced 5-HT depletion rats was carried out in male Sprague Dawley via a1-week treatment dividing into four groups. The studied groups involved with the treatments comprise i) Control (1 mL/kg saline), ii) MDMA (20 mg/kg MDMA), iii) MDMA-TQ (20 mg/kg MDMA + 40 mg/kg TQ) and iv) TQ (40 mg/kg TQ). Anxiety test is subject to a light-dark test and social interaction test. Our results demonstrated an increase in anxiety behaviour in the MDMA group as compared to the control group. TQ prevented anxiety after undergoing a 1-week treatment in the MDMA+TQ group as compared to the untreated MDMA group. Hence, this study proposed that TQ could protect against anxiety-like behaviour upon MDMA exposure in rats.
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| title |
Anxiolytic effects of thymoquinone in the rats exposed to MDMA
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| title_full |
Anxiolytic effects of thymoquinone in the rats exposed to MDMA
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| title_fullStr |
Anxiolytic effects of thymoquinone in the rats exposed to MDMA
|
| title_full_unstemmed |
Anxiolytic effects of thymoquinone in the rats exposed to MDMA
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| title_short |
Anxiolytic effects of thymoquinone in the rats exposed to MDMA
|
| title_sort |
anxiolytic effects of thymoquinone in the rats exposed to mdma
|