In-vitro α-Glucosidase inhibitory potential of extracts from musa paradisiaca
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| internalnotes | Abolaji AO, Adebayo HA and Odesanmi OS (2007) Effects of ethanolic fruit extract of Parinari polyandra (Rosaceae) on serum lipid profile and some electrolytes in pregnant rabbits. Research Journal of Medicinal Plant, 1(4): 121-127. Chiba S (199) Molecular mechanism i n α -glucosidase and glucoamylase. Biosci. Biotechnol. Biochem. 61: 1233–9. Colca JR (2006) Insulin sensitizers may prevent metabolic inflammation. Biochem. Pharmacol., 72: 125–131. Di Carli MF, Janisse J, et al. (2003) Role of chronic hyperglycemia in the pathogenesis of coronary microvascular dysfunction in diabetes. Journal of the American College of Cardiology, 41(8): 1387-93. Dwivedi V, Anandan Em Fau , et al. (2012) In vivo effects of traditional Ayurvedic formulations in Drosophila melanogaster model relate with therapeutic applications. PLos One, 7(5):e37113. Eddouks M, Jouad H, et al. (2003) Inhibition of endogenous glucose production accounts for hypoglycemic effect of Spergularia purpurea in streptozotocin mice. Phytomedicine, 10(6): 594-9. Furman, Jennifer L, et al. (2012) Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease. The Journal of Neuroscience, 32(46): 16129-16140. Griffiths DW and Moseley G (1980) The effect of diets containing field beans of high or low polyphenolic content on the activity of digestive enzymes in the intestines of rats. J. Sci. Food Agric., 31: 255-259. Grimm T, Scha¨fer A and Ho¨gger, P (2004) Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (Pycnogenol), Free Radic. Biol. Med., 36: 811–822. Hara Y and Honda M (1992) Inhibition of rat small intestinal sucrase and alpha-glucosidase activities by tea polyphenol. Biosci. Biotechnol. Biochem., 57: 123-124. Heacock PM, Hertzler SR, et al. (2005) Effects of a medical food containing an herbal α-glucosidase inhibitor on postprandial glycemia and insulinemia in healthy adults. Journal of the American Dietetic Association, 105(1): 65-71. Hsieh PC, Huang G, et al. (2010) Activities of antioxidants, α-Glucosidase inhibitors and aldose reductase inhibitors of the aqueous extracts of four Flemingia species in Taiwan. Bot. Stud., 51: 293-302. Jachak SM and Saklani A (2007) Challenges and opportunities in drug discovery from plants. Curr. Sci. India, 92(9): 1251. Kim YM, Jeong YK, et al. (2005) Inhibitory effect of pine extract on α-glucosidase activity and postprandial hyperglycemia. Nutrition, 21(6): 756-61. Kim JS, Kwon CS and Son KH (2000) Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. Biosci. Biotechnol. Biochem., 64(11): 2458-61. Kimura Y, Araki Y, et al. (1999) Protective effects of dietary nasunin on paraquat-induced oxidative stress in rats. Biosci. Biotechnol. Biochem., 63(5): 799-804. Kwon CH, Luikart BW, et al. (2006) Pten regulates neuronal arborization and social interaction in mice. Neuron, 50(3): 377-88. Lebovitz HE (1998) Postprandial hyperglycemic state: importance and consequences. Diabetes Res. Clin. Pract., 40:27– 8. Li L, Zheng C Fau - Fu Y, et al. (2012) Silicate-mediated alleviation of Pb toxicity in banana grown in Pb-contaminated soil. Biol. Trace. Res., 145(1): 101-108. Madan S, Ahmad S, et al. (2010) Stevia rebaudiana (Bert.) Bertoni-areview. Indian J. Nat. Prod. Resour., 1(3): 267-86. Marie-Magdeleine C, Udino L, et al. (2014) In vitro effects of Musa paradisiaca extracts on four developmental stages of Haemonchus contortus. Res. Vet. Sci., 96(1): 127-32. Matsui TT, Ueda K, et al. (2001) Alpha-glucosidase inhibitors action of natural acylated anthocyanins. Survey of natural pigments with potent inhibitory activity. J. Agric. Food Chem., 49: 1948-1951. McCue P, Kwon YII and Shetty K (2005) Anti-diabetic and anti-hypertensive potential of sprouted and solid-state bioprocessed soybean. Asia Pac. J. Clin Nutr., 2005; 14: 145–152. McDougall GJ and Stewart D (2005) The inhibitory effects of berry polyphenols on digestive enzymes. Biofactors, 23: 189-195. Montagut Pino G (2009) Procyanidin effects on an impaired glucose metabolism: a further insight into procyanidin signalling in adipose cells. ISBN: .978-84692-5923-8. Nagappa AN, Thakurdesai, et al. (2003) Antidiabetic activity of Terminalia catappa Linn fruits. J. Ethnopharmacol., 88: 45–50. Newman DJ, Cragg Gm and Snader KM (2003) Natural products as sources of new drugs over the period 1981-2002. J. Nat. Prod., 66(7): 1022-1037. Ong KW, Hsu AF, et al. (2011) Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats. J. Ethnopharmacol., 133(2): 598-607. Ortiz-Andrade R, Garcia-Jimenez S, et al. (2007) α-Glucosidase inhibitory activity of the methanolic extract from Tournefortia hartwegiana: An anti-hyperglycemic agent. J. Ethnopharmacol., 109(1): 48-53. Prasad KV, Bharathi K, et al. (1993) Evaluation of Musa (Paradisiaca Linn. cultivar)--"Puttubale" stem juice for antilithiatic activity in albino rats. Indian J. of Pharmacol., 37(4): 337-341. Ribeiro Rde A, de Barros FF, et al. (1988) Acute diuretic effects in conscious rats produced by some medicinal plants used in the state of Sao Paulo, Brasil. .J. Ethnophrmacol., 24(1): 19-29. Schafer A and Hogger P (2007) Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol) effectively inhibit alpha-glucosidase. Diabetes Res. Clin. pract., 77(1): 41-6. Scheen AJ (1997) Drug treatment of non-insulin-dependent diabetes mellitus in the 1990s. Achievements and future developments. Drugs, 54(3): 355-368. Sharma L, Bhaga H, Srivastava P (1971) In vitro anthelmintic screening of indigenous medicinal plants against Haemonchus contortus (Rudolphi, 1803) Cobbold, 1898 of sheep and goats. Indian J. Anim. Res., 5: 33-38. Shim YJ, Doo HK, et al. (2003) Inhibitory effect of aqueous extract from the gall of Rhus chinensis on alpha-glucosidase activity and postprandial blood glucose. J. Ethnopharmacol., 85(2): 283-7. Shimabukuro M, Higa N, et al. (2006) Effects of a single administration of acarbose on postprandial glucose excursion and endothelial dysfunction in type 2 diabetic patients: a randomized crossover study, J. Clin. Endocrinol. Metab., 91: 837-842. Toeller M (1994) α‐Glucosidase inhibitors in diabetes: efficacy in NIDDM subjects. European journal of clinical investigation, 24(S3): 31-5. Trease GE, and Evans WC (1989) Trease and Evan’s Textbook of Pharmacognosy. 13th ed. Cambridge University Press, London. pp: 546. Van de Laar FA, Lucassen PL, et al. (2005) α-Glucosidase Inhibitors for Patients With Type 2 Diabetes Results from a Cochrane systematic review and meta-analysis. Diabetes care, 28(1): 154-63. Vijayakumar MV, Singh S, et al. (2005) The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway. Br. J. Pharmacol. , 14(1): 41-48. Youn JY, Park HY, Cho KH (2004) Anti-hyperglycemic activity of Commelina communis L.: inhibition of α-glucosidase. Diabetes Res Clin. Pract. , 66: 149-155. |
| originalfilename | 6445-01-FH02-FBIM-15-03511.jpg |
| person | UniSZA Unisza unisza |
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| resourceurl | https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12145 |
| spelling | 12145 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=12145 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal UniSZA Unisza unisza image/jpeg inches 96 96 1428 08 08 783 2015-07-14 11:15:58 1428x783 6445-01-FH02-FBIM-15-03511.jpg UniSZA Private Access In-vitro α-Glucosidase inhibitory potential of extracts from musa paradisiaca International Journal of Integrative Biology Recently, there has been increased interest in the development of alternative medicines for type II Diabetes mellitus, notably the screening of phytochemicals with ability to delay or even prevent completely the absorption of glucose. The aim of this study was to investigate the invitro inhibitory effect of Musa Paradisiaca flesh, skin and tepal extracts on the key enzyme linked to diabetes i.e α-glucosidase (EC 3.2.1.20). The inhibitory effect of these extracts on α-glucosidase activities was performed. The results revealed that methanolic extract of M. Paradisiaca tepal was the most potent inhibitor of α-glucosidase (with IC50 60±0.14 µg/ml), followed by the ethanolic tepal extract( with IC50 200±0.19) and then the aqeous tepal (with IC50 360±0.62) respectively . No inhibition was observed in the skin, flesh methanolic extracts and ofcourse acarbose under our assay condition. It can be inferred from this study that the α-glucosidase inhibitory potential of M. Paradisiaca may be due to the presence of phytochemicals such as glycosides and flavonoids. However, further study is required to isolate the enzyme inhibitory component of this plant. 16 1 1-6 Abolaji AO, Adebayo HA and Odesanmi OS (2007) Effects of ethanolic fruit extract of Parinari polyandra (Rosaceae) on serum lipid profile and some electrolytes in pregnant rabbits. Research Journal of Medicinal Plant, 1(4): 121-127. Chiba S (199) Molecular mechanism i n α -glucosidase and glucoamylase. Biosci. Biotechnol. Biochem. 61: 1233–9. Colca JR (2006) Insulin sensitizers may prevent metabolic inflammation. Biochem. Pharmacol., 72: 125–131. Di Carli MF, Janisse J, et al. (2003) Role of chronic hyperglycemia in the pathogenesis of coronary microvascular dysfunction in diabetes. Journal of the American College of Cardiology, 41(8): 1387-93. Dwivedi V, Anandan Em Fau , et al. (2012) In vivo effects of traditional Ayurvedic formulations in Drosophila melanogaster model relate with therapeutic applications. PLos One, 7(5):e37113. Eddouks M, Jouad H, et al. (2003) Inhibition of endogenous glucose production accounts for hypoglycemic effect of Spergularia purpurea in streptozotocin mice. Phytomedicine, 10(6): 594-9. Furman, Jennifer L, et al. (2012) Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease. The Journal of Neuroscience, 32(46): 16129-16140. Griffiths DW and Moseley G (1980) The effect of diets containing field beans of high or low polyphenolic content on the activity of digestive enzymes in the intestines of rats. J. Sci. Food Agric., 31: 255-259. Grimm T, Scha¨fer A and Ho¨gger, P (2004) Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (Pycnogenol), Free Radic. Biol. Med., 36: 811–822. Hara Y and Honda M (1992) Inhibition of rat small intestinal sucrase and alpha-glucosidase activities by tea polyphenol. Biosci. Biotechnol. Biochem., 57: 123-124. Heacock PM, Hertzler SR, et al. (2005) Effects of a medical food containing an herbal α-glucosidase inhibitor on postprandial glycemia and insulinemia in healthy adults. Journal of the American Dietetic Association, 105(1): 65-71. Hsieh PC, Huang G, et al. (2010) Activities of antioxidants, α-Glucosidase inhibitors and aldose reductase inhibitors of the aqueous extracts of four Flemingia species in Taiwan. Bot. Stud., 51: 293-302. Jachak SM and Saklani A (2007) Challenges and opportunities in drug discovery from plants. Curr. Sci. India, 92(9): 1251. Kim YM, Jeong YK, et al. (2005) Inhibitory effect of pine extract on α-glucosidase activity and postprandial hyperglycemia. Nutrition, 21(6): 756-61. Kim JS, Kwon CS and Son KH (2000) Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. Biosci. Biotechnol. Biochem., 64(11): 2458-61. Kimura Y, Araki Y, et al. (1999) Protective effects of dietary nasunin on paraquat-induced oxidative stress in rats. Biosci. Biotechnol. Biochem., 63(5): 799-804. Kwon CH, Luikart BW, et al. (2006) Pten regulates neuronal arborization and social interaction in mice. Neuron, 50(3): 377-88. Lebovitz HE (1998) Postprandial hyperglycemic state: importance and consequences. Diabetes Res. Clin. Pract., 40:27– 8. Li L, Zheng C Fau - Fu Y, et al. (2012) Silicate-mediated alleviation of Pb toxicity in banana grown in Pb-contaminated soil. Biol. Trace. Res., 145(1): 101-108. Madan S, Ahmad S, et al. (2010) Stevia rebaudiana (Bert.) Bertoni-areview. Indian J. Nat. Prod. Resour., 1(3): 267-86. Marie-Magdeleine C, Udino L, et al. (2014) In vitro effects of Musa paradisiaca extracts on four developmental stages of Haemonchus contortus. Res. Vet. Sci., 96(1): 127-32. Matsui TT, Ueda K, et al. (2001) Alpha-glucosidase inhibitors action of natural acylated anthocyanins. Survey of natural pigments with potent inhibitory activity. J. Agric. Food Chem., 49: 1948-1951. McCue P, Kwon YII and Shetty K (2005) Anti-diabetic and anti-hypertensive potential of sprouted and solid-state bioprocessed soybean. Asia Pac. J. Clin Nutr., 2005; 14: 145–152. McDougall GJ and Stewart D (2005) The inhibitory effects of berry polyphenols on digestive enzymes. Biofactors, 23: 189-195. Montagut Pino G (2009) Procyanidin effects on an impaired glucose metabolism: a further insight into procyanidin signalling in adipose cells. ISBN: .978-84692-5923-8. Nagappa AN, Thakurdesai, et al. (2003) Antidiabetic activity of Terminalia catappa Linn fruits. J. Ethnopharmacol., 88: 45–50. Newman DJ, Cragg Gm and Snader KM (2003) Natural products as sources of new drugs over the period 1981-2002. J. Nat. Prod., 66(7): 1022-1037. Ong KW, Hsu AF, et al. (2011) Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats. J. Ethnopharmacol., 133(2): 598-607. Ortiz-Andrade R, Garcia-Jimenez S, et al. (2007) α-Glucosidase inhibitory activity of the methanolic extract from Tournefortia hartwegiana: An anti-hyperglycemic agent. J. Ethnopharmacol., 109(1): 48-53. Prasad KV, Bharathi K, et al. (1993) Evaluation of Musa (Paradisiaca Linn. cultivar)--"Puttubale" stem juice for antilithiatic activity in albino rats. Indian J. of Pharmacol., 37(4): 337-341. Ribeiro Rde A, de Barros FF, et al. (1988) Acute diuretic effects in conscious rats produced by some medicinal plants used in the state of Sao Paulo, Brasil. .J. Ethnophrmacol., 24(1): 19-29. Schafer A and Hogger P (2007) Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol) effectively inhibit alpha-glucosidase. Diabetes Res. Clin. pract., 77(1): 41-6. Scheen AJ (1997) Drug treatment of non-insulin-dependent diabetes mellitus in the 1990s. Achievements and future developments. Drugs, 54(3): 355-368. Sharma L, Bhaga H, Srivastava P (1971) In vitro anthelmintic screening of indigenous medicinal plants against Haemonchus contortus (Rudolphi, 1803) Cobbold, 1898 of sheep and goats. Indian J. Anim. Res., 5: 33-38. Shim YJ, Doo HK, et al. (2003) Inhibitory effect of aqueous extract from the gall of Rhus chinensis on alpha-glucosidase activity and postprandial blood glucose. J. Ethnopharmacol., 85(2): 283-7. Shimabukuro M, Higa N, et al. (2006) Effects of a single administration of acarbose on postprandial glucose excursion and endothelial dysfunction in type 2 diabetic patients: a randomized crossover study, J. Clin. Endocrinol. Metab., 91: 837-842. Toeller M (1994) α‐Glucosidase inhibitors in diabetes: efficacy in NIDDM subjects. European journal of clinical investigation, 24(S3): 31-5. Trease GE, and Evans WC (1989) Trease and Evan’s Textbook of Pharmacognosy. 13th ed. Cambridge University Press, London. pp: 546. Van de Laar FA, Lucassen PL, et al. (2005) α-Glucosidase Inhibitors for Patients With Type 2 Diabetes Results from a Cochrane systematic review and meta-analysis. Diabetes care, 28(1): 154-63. Vijayakumar MV, Singh S, et al. (2005) The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway. Br. J. Pharmacol. , 14(1): 41-48. Youn JY, Park HY, Cho KH (2004) Anti-hyperglycemic activity of Commelina communis L.: inhibition of α-glucosidase. Diabetes Res Clin. Pract. , 66: 149-155. |
| spellingShingle | In-vitro α-Glucosidase inhibitory potential of extracts from musa paradisiaca |
| summary | Recently, there has been increased interest in the development of alternative medicines for type II Diabetes mellitus, notably the screening of phytochemicals with ability to delay or even prevent completely the absorption of glucose. The aim of this study was to investigate the invitro inhibitory effect of Musa Paradisiaca flesh, skin and tepal extracts on the key enzyme linked to diabetes i.e α-glucosidase (EC 3.2.1.20). The inhibitory effect of these extracts on α-glucosidase activities was performed. The results revealed that methanolic extract of M. Paradisiaca tepal was the most potent inhibitor of α-glucosidase (with IC50 60±0.14 µg/ml), followed by the ethanolic tepal extract( with IC50 200±0.19) and then the aqeous tepal (with IC50 360±0.62) respectively . No inhibition was observed in the skin, flesh methanolic extracts and ofcourse acarbose under our assay condition. It can be inferred from this study that the α-glucosidase inhibitory potential of M. Paradisiaca may be due to the presence of phytochemicals such as glycosides and flavonoids. However, further study is required to isolate the enzyme inhibitory component of this plant. |
| title | In-vitro α-Glucosidase inhibitory potential of extracts from musa paradisiaca |
| title_full | In-vitro α-Glucosidase inhibitory potential of extracts from musa paradisiaca |
| title_fullStr | In-vitro α-Glucosidase inhibitory potential of extracts from musa paradisiaca |
| title_full_unstemmed | In-vitro α-Glucosidase inhibitory potential of extracts from musa paradisiaca |
| title_short | In-vitro α-Glucosidase inhibitory potential of extracts from musa paradisiaca |
| title_sort | in-vitro α-glucosidase inhibitory potential of extracts from musa paradisiaca |