In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines
| Format: | Restricted Document |
|---|
| _version_ | 1860797222121111552 |
|---|---|
| building | INTELEK Repository |
| caption | Natural Product Research, 2018. doi: 10.1080/14786419.2018.1517120 |
| collection | Online Access |
| collectionurl | https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 |
| copyright | © 2018 Informa UK Limited, trading as Taylor & Francis Group |
| date | 2018-11-29 15:02:55 |
| format | Restricted Document |
| id | 11841 |
| institution | UniSZA |
| originalfilename | 6141-01-FH02-FF-18-19751.pdf |
| person | Nordin Norsyafikah Asyilla Lawai Vannessa Ngaini Zainab Abd Halim Ainaa Nadiah Hwang Siaw San Linton Reagan Entigu Lee Boon Kiat Neilsen Paul Matthew |
| recordtype | oai_dc |
| resourceurl | https://intelek.unisza.edu.my/intelek/pages/view.php?ref=11841 |
| spelling | 11841 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=11841 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal application/pdf 11 1.6 Adobe Acrobat Pro DC 20 Paper Capture Plug-in Nordin Norsyafikah Asyilla Lawai Vannessa Ngaini Zainab Abd Halim Ainaa Nadiah Hwang Siaw San Linton Reagan Entigu Lee Boon Kiat Neilsen Paul Matthew © 2018 Informa UK Limited, trading as Taylor & Francis Group 2018-11-29 15:02:55 Natural Product Research, 2018. doi: 10.1080/14786419.2018.1517120 Aspirin thiourea cytotoxicity molecular docking cyclooxygenase-2 In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines 6141-01-FH02-FF-18-19751.pdf In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines UniSZA Private Access In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines Natural Product Research In searching for drugs from natural product scaffolds has gained interest among researchers. In this study, a series of twelve halogenated thiourea (ATX 1-12) via chemical modification of aspirin (a natural product derivative) and evaluated for cytotoxic activity against nasopharyngeal carcinoma (NPC) cell lines, HK-1 via MTS-based colorimetric assay. The cytotoxicity studies demonstrated that halogens at meta position of ATX showed promising activity against HK-1 cells (IC50 value �15 mM) in comparison to cisplatin, a positive cytotoxic drug (IC50 value ¼8.9±1.9 mM). ATX 11, bearing iodine at meta position, showed robust cytotoxicity against HK-1 cells with an IC50 value of 4.7±0.7mM. Molecular docking interactions between ATX 11 and cyclooxygenase-2 demonstrated a robust binding affinity value of �8.1 kcal/mol as compared to aspirin’s binding affinity value of �6.4 kcal/mol. The findings represent a promising lead molecule from natural product with excellent cytotoxic activity against NPC cell lines. 1 1 1-10 |
| spellingShingle | In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines |
| subject | Aspirin thiourea cytotoxicity molecular docking cyclooxygenase-2 |
| summary | In searching for drugs from natural product scaffolds has gained interest among researchers. In this study, a series of twelve halogenated thiourea (ATX 1-12) via chemical modification of aspirin (a natural product derivative) and evaluated for cytotoxic activity against nasopharyngeal carcinoma (NPC) cell lines, HK-1 via MTS-based colorimetric assay. The cytotoxicity studies demonstrated that halogens at meta position of ATX showed promising activity against HK-1 cells (IC50 value �15 mM) in comparison to cisplatin, a positive cytotoxic drug (IC50 value ¼8.9±1.9 mM). ATX 11, bearing iodine at meta position, showed robust cytotoxicity against HK-1 cells with an IC50 value of 4.7±0.7mM. Molecular docking interactions between ATX 11 and cyclooxygenase-2 demonstrated a robust binding affinity value of �8.1 kcal/mol as compared to aspirin’s binding affinity value of �6.4 kcal/mol. The findings represent a promising lead molecule from natural product with excellent cytotoxic activity against NPC cell lines. |
| title | In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines |
| title_full | In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines |
| title_fullStr | In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines |
| title_full_unstemmed | In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines |
| title_short | In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines |
| title_sort | in vitro cytotoxicity evaluation of thiourea derivatives bearing salix sp. constituent against hk-1 cell lines |