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1860797191649492992
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| building |
INTELEK Repository
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| caption |
Pharmacy
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| collection |
Online Access
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| collectionurl |
https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072
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| date |
2018-07-10 23:57:52
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| format |
Restricted Document
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| id |
11724
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| institution |
UniSZA
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| originalfilename |
6004-01-FH02-FP-18-21214.pdf
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administrator
Administrator
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| recordtype |
oai_dc
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| resourceurl |
https://intelek.unisza.edu.my/intelek/pages/view.php?ref=11724
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| spelling |
11724 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=11724 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal application/pdf 2 Adobe Acrobat Pro DC 20 Paper Capture Plug-in 1.7 administrator Administrator 2018-07-10 23:57:52 Pharmacy Pharmacy 6004-01-FH02-FP-18-21214.pdf UniSZA Private Access Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine dependence in mice British Journal of Pharmacy A Combination of 0.3mg/kg buprenorphine and 1.0 mg/kg naltrexone treatment shows a promising result due to its ability to attenuate reinstatement (relapse) in morphine/methamphetamine (polydrug)-dependent mice in a conditioned place preference (CPP) model. This prompted us to identify which opioid receptor that contributes to its anti-relapse activity. Using the same CPP model, 10 mg/kg nor- BNI (a selective kappa opioid receptor [KOR] antagonist) was used to evaluate the involvement of KOR in mediating relapse to polydrug dependence. By applying the immunohistochemistry (IHC) technique, the investigation was extended to the mice brain using KOR antibody (EPR18881), focusing on the brain regions that are abundant in KOR density. The results showed that nor-BNI alone failed to attenuate relapse to polydrug dependence. However, the IHC results proved that the number of KOR significantly increased in the striatum during reinstatement compared to post-conditioning (p <0.05). The KOR was significantly suppressed in the treatment group which strengthens the findings from previous studies proving that the KOR plays an important role in mediating relapse to polydrug dependence. 2 2 21-22
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| spellingShingle |
Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine dependence in mice
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| subject |
Pharmacy
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| summary |
A Combination of 0.3mg/kg buprenorphine and 1.0 mg/kg naltrexone treatment shows a promising result due to its ability to attenuate reinstatement (relapse) in morphine/methamphetamine (polydrug)-dependent mice in a conditioned place preference (CPP) model. This prompted us to identify which opioid receptor that contributes to its anti-relapse activity. Using the same CPP model, 10 mg/kg nor- BNI (a selective kappa opioid receptor [KOR] antagonist) was used to evaluate the involvement of KOR in mediating relapse to polydrug dependence. By applying the immunohistochemistry (IHC) technique, the investigation was extended to the mice brain using KOR antibody (EPR18881), focusing on the brain regions that are abundant in KOR density. The results showed that nor-BNI alone failed to attenuate relapse to polydrug dependence. However, the IHC results proved that the number of KOR significantly increased in the striatum during reinstatement compared to post-conditioning (p <0.05). The KOR was significantly suppressed in the treatment group which strengthens the findings from previous studies proving that the KOR plays an important role in mediating relapse to polydrug dependence.
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| title |
Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine dependence in mice
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| title_full |
Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine dependence in mice
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| title_fullStr |
Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine dependence in mice
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| title_full_unstemmed |
Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine dependence in mice
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| title_short |
Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine dependence in mice
|
| title_sort |
distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine dependence in mice
|