Immunomodulatory effects of selected Malaysian plants on the CD18/11a expression and phagocytosis activities of leukocytes
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| collectionurl | https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 |
| date | 2015-03-09 09:20:26 |
| format | Restricted Document |
| id | 11588 |
| institution | UniSZA |
| internalnotes | [1] Underhill DM, Goodridge HS. Information processing during phagocytosis. Nat Rev Immunol 2012; 12: 492-502. [2] Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol 2013; 13: 159-175. [3] Muller WA. Getting leukocytes to the site of inflammation. Vet Pathol 2013; 50(1): 7-22. [4] Schmidt S, Moser M, Sperandio M. The molecular basis of leukocyte recruitment and its deficiencies. Mol Immunol 2013; 55(1): 49-58. [5] Zhang Y, Wang H. Integrin signalling and function in immune cells. Immunology 2012; 135: 268-275. [6] Li N, Mao D, Lü S, Tong C, Zhang Y, Long M. Distinct binding affinities of Mac-1 and LFA-1 in neutrophil activation. J Immunol 2013; 190: 4371-4381. [7] Haugland GT, Jakobsen RA, Vestvik N, Ulven K, Stokka L, Wergeland HI. Phagocytosis and respiratory burst activity in lumpsucker (Cyclopterus lumpus L.) leucocytes analysed by flow cytometry. PloS One 2012; doi: 10.1371/journal.pone.0047909. [8] Goodridge HS, Underhill DM, Touret N. Mechanisms of Fc receptor and dectin-1 activation for phagocytosis. Traffic 2012; 13(8): 1062-1071. [9] Ballanti E, Perricone C, Greco E, Ballanti M, Di Muzio G, Chimenti MS, et al. Complement and autoimmunity. Immunol Res 2013; 56: 477-491. [10] Flannagan RS, Jaumouillé V, Grinstein S. The cell biology of phagocytosis. Annu Rev Pathol 2012; 7: 61-98. [11] Kang S, Min H. Ginseng, the ‘immunity boost’: the effects of Panax ginseng on immune system. J Ginseng Res 2012; 36(4): 354-368. [12] Zhuang SR, Chiu HF, Chen SL, Tsai JH, Lee MY, Lee HS, et al. Effects of a Chinese medical herbs complex on cellular immunity and toxicity-related conditions of breast cancer patients. Br J Nutr 2012; 107: 712-718. [13] Kumar KPS, Bhowmik D, Dutta A, Pd.Yadav A, Paswan S, Srivastava S, et al. Recent trends in potential traditional indian herbs Emblica officinalis and its medicinal importance. J Pharmacogn Phytochem 2012; 1(1): 24-32. [14] Jantan I, Harun HN, Septama AW, Murad S, Mesaik MA. Inhibition of chemiluminescence and chemotactic activity of phagocytes in vitro by the extracts of selected medicinal plants. J Nat Med 2011; 65(2): 400-405. [15] Sharma U, Bala M, Kumar N, Singh B, Munshi RK, Bhalerao S. Immunomodulatory active compounds from Tinospora cordifolia. J Ethnopharmacol 2012; 141(3): 918-926. [16] Pan Li, Chai HB, Kinghorn AD. Discovery of new anticancer agents from higher plants. Front Biosci (Schol Ed) 2012; 4: 142-156. [17] Tang WM, Chan E, Kwok CY, Lee YK, Wu JH, Wan CW, et al. A review of the anticancer and immunomodulatory effects of Lycium barbarum fruit. Inflammopharmacology 2012; 20(6): 307-314. [18] Kaul S, Gupta S, Ahmed M, Dhar MK. Endophytic fungi from medicinal plants: a treasure hunt for bioactive metabolites. Phytochem Rev 2012; 11(4): 487-505. [19] Raposo MF, de Morais RM, Bernardo de Morais AM. Bioactivity and applications of sulphated polysaccharides from marine microalgae. Mar Drugs 2013; 11(1): 233-252. [20] Burkill IH. A dictionary of the economic products of the Malay Peninsula. Kuala Lumpur: Ministry of Agriculture and Cooperative; 1966. [21] Kuo MC, Chang CY, Cheng TL, Wu MJ. Immunomodulatory effect of Antrodia camphorata mycelia and culture filtrate. J Ethnopharmacol 2008; 120: 196-203. [22] Mazzone A, Ricevuti G. Leukocyte CD11/CD18 integrins: biological and clinical relevance. Haematologica 1995; 80: 161-175. [23] Cavanagh SP, Gough MJ, Homer-Vanniasinkam S. The role of neutrophil in ischaemia-reperfusion injury: potential therapeutic interventions. Cardiovasc Surg 1998; 6: 112-118. [24] Lin N, Sato T, Takayama Y, Mimaki Y, Sashida Y, Yano M, et al. Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages. Biochem Pharm 2003; 65(12): 2065-2071. [25] Pothacharoen P, Choopcheep K, Phitak T, Pompimon W, Kongtawelert P. Alpinia galanga extracts downregulate interleukin-1β-induced matrix metalloproteinases expression in human synovial fibroblast. In Vitro Cell Dev Biol Anim 2011; 47: 183-187. [26] Saelee C, Thongrakard V, Tencomnao T. Effects of Thai medicinal herb extracts with anti-psoriatic activity on the expression on Nf-κB signaling biomarkers in HaCaT keratinocytes. Molecules 2011; 16: 3908-3932. [27] Lee WL, Harrison RE, Grinstein S. Phagocytosis by neutrophils. Microbes Infect 2003; 5: 1299-1306. [28] Burg ND, Pilinger MH. The neutrophil: function and regulation in innate and humoral immunity. Clin Immunol 2001; 99: 7-17. [29] Coxon A, Cullere X, Knight S, Sethi S, Wakelin MW, Stavrakis G, et al. Fc gamma RIII mediates neutrophil recruitment to immune complexes: a mechanism for neutrophil accumulation in immune-mediated inflammation. Immunity 2001; 14: 693-704. [30] Butcher SK, Chahal H, Nayak L, Sinclair A, Henriquez NV, Sapey E, et al. Sunescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans. J Leukoc Biol 2001; 70: 881-886. [31] Indik ZK, Park JG, Hunter S. Schreiber AD. The molecular dissection of Fc gamma receptor mediated phagocytosis. Blood 1995; 86: 4389-4399. [32] Foong CP, Hamid RA. Evaluation of anti-inflammatory activities of ethanolic extract of Annona muricata leaves. Rev Bras Farmacogn 2012; 22: 1301-1307. [33] de Sousa OV, Vieira GD, de Jesus R G de Pinho J, Yamamoto CH, Alves MS. Antinonciceptive and anti-inflammatory activities of the ethanol extract of Annona muricata L. leaves in animal models. Int J Mol Sci 2010; 11: 2067-2078. [34] He HB, Wu XL, Yu B, Liu KL, Zhou GX, Qian GQ, et al. The effect of desacetylluvaricin on the expression of TLR4 and P53 protein in Hepg 2.2.15. Hepat Mon 2011; 11: 364-367. [35] Wu P, Wu M, Xu L, Xie H, Wei X. Anti-inflammatory cyclopeptides from exocarps of sugar-apples. Food Chem 2014; 152: 23-28. [36] Hsu CL, Hong BH, Yu YS, Yen GC. Antioxidant and anti-inflammatory effects of Orthosiphon aristatus and its bioactive compounds. J Agric Food Chem 2010; 58: 2150-2156. |
| originalfilename | 5847-01-FH02-FPSK-15-02634.jpg |
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| spelling | 11588 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=11588 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal UniSZA Unisza unisza image/jpeg inches 96 96 1420 25 25 2015-03-09 09:20:26 782 1420x782 5847-01-FH02-FPSK-15-02634.jpg UniSZA Private Access Immunomodulatory effects of selected Malaysian plants on the CD18/11a expression and phagocytosis activities of leukocytes Asian Pacific Journal of Tropical Biomedicine Objective: To investigate the effects of 20 methanolic extracts from Malaysian selected plants on CD18/11a expression and phagocytosis activity of leukocytes using flow cytometry analysis. Methods: The effects of methanolic extracts on CD18/11a expression and phagocytosis of leukocytes were measured by labelling the cells with CD18-fluorescein isothiocyanate and ingestion labelled with Escherichia coli-fluorescein isothiocyanate and then analyzed using flow cytometer. Results: About 12 out of 20 methanolic extracts of selected Malaysian medicinal plants significantly (P≤0.05) inhibited the CD18/11a expression of leukocytes at both concentrations of 6.25 μg/mL and 100 μg/mL in dose dependent manner. The most active inhibitory was shown in Citrus aurantifolia (Christm.) Swingle and Alpinia galangal (L.) Willd. at dosage 100 μg/mL. Moreover, the Orthosiphon aristatus (Blume) Miq (O. aristatus). showed the highest stimulatory activity at the concentration of 100 μg/mL. Other than that, four plant extracts significantly (P≤0.05) rose the phagocytosis activities of leukocytes in dose dependent manner. However, Annona muricata L. and O. aristatus showed the highest stimulated activities at the 100 μg/mL concentration. Conclusions: The results suggest that methanolic extracts of Citrus aurantifolia, Alpinia galangal, O. aristatus and Annona muricata are able to modulate innate immune system and can potentially be recognized as therapeutic agents for modulating immune system. 5 1 48-53 [1] Underhill DM, Goodridge HS. Information processing during phagocytosis. Nat Rev Immunol 2012; 12: 492-502. [2] Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol 2013; 13: 159-175. [3] Muller WA. Getting leukocytes to the site of inflammation. Vet Pathol 2013; 50(1): 7-22. [4] Schmidt S, Moser M, Sperandio M. The molecular basis of leukocyte recruitment and its deficiencies. Mol Immunol 2013; 55(1): 49-58. [5] Zhang Y, Wang H. Integrin signalling and function in immune cells. Immunology 2012; 135: 268-275. [6] Li N, Mao D, Lü S, Tong C, Zhang Y, Long M. Distinct binding affinities of Mac-1 and LFA-1 in neutrophil activation. J Immunol 2013; 190: 4371-4381. [7] Haugland GT, Jakobsen RA, Vestvik N, Ulven K, Stokka L, Wergeland HI. Phagocytosis and respiratory burst activity in lumpsucker (Cyclopterus lumpus L.) leucocytes analysed by flow cytometry. PloS One 2012; doi: 10.1371/journal.pone.0047909. [8] Goodridge HS, Underhill DM, Touret N. Mechanisms of Fc receptor and dectin-1 activation for phagocytosis. Traffic 2012; 13(8): 1062-1071. [9] Ballanti E, Perricone C, Greco E, Ballanti M, Di Muzio G, Chimenti MS, et al. Complement and autoimmunity. Immunol Res 2013; 56: 477-491. [10] Flannagan RS, Jaumouillé V, Grinstein S. The cell biology of phagocytosis. Annu Rev Pathol 2012; 7: 61-98. [11] Kang S, Min H. Ginseng, the ‘immunity boost’: the effects of Panax ginseng on immune system. J Ginseng Res 2012; 36(4): 354-368. [12] Zhuang SR, Chiu HF, Chen SL, Tsai JH, Lee MY, Lee HS, et al. Effects of a Chinese medical herbs complex on cellular immunity and toxicity-related conditions of breast cancer patients. Br J Nutr 2012; 107: 712-718. [13] Kumar KPS, Bhowmik D, Dutta A, Pd.Yadav A, Paswan S, Srivastava S, et al. Recent trends in potential traditional indian herbs Emblica officinalis and its medicinal importance. J Pharmacogn Phytochem 2012; 1(1): 24-32. [14] Jantan I, Harun HN, Septama AW, Murad S, Mesaik MA. Inhibition of chemiluminescence and chemotactic activity of phagocytes in vitro by the extracts of selected medicinal plants. J Nat Med 2011; 65(2): 400-405. [15] Sharma U, Bala M, Kumar N, Singh B, Munshi RK, Bhalerao S. Immunomodulatory active compounds from Tinospora cordifolia. J Ethnopharmacol 2012; 141(3): 918-926. [16] Pan Li, Chai HB, Kinghorn AD. Discovery of new anticancer agents from higher plants. Front Biosci (Schol Ed) 2012; 4: 142-156. [17] Tang WM, Chan E, Kwok CY, Lee YK, Wu JH, Wan CW, et al. A review of the anticancer and immunomodulatory effects of Lycium barbarum fruit. Inflammopharmacology 2012; 20(6): 307-314. [18] Kaul S, Gupta S, Ahmed M, Dhar MK. Endophytic fungi from medicinal plants: a treasure hunt for bioactive metabolites. Phytochem Rev 2012; 11(4): 487-505. [19] Raposo MF, de Morais RM, Bernardo de Morais AM. Bioactivity and applications of sulphated polysaccharides from marine microalgae. Mar Drugs 2013; 11(1): 233-252. [20] Burkill IH. A dictionary of the economic products of the Malay Peninsula. Kuala Lumpur: Ministry of Agriculture and Cooperative; 1966. [21] Kuo MC, Chang CY, Cheng TL, Wu MJ. Immunomodulatory effect of Antrodia camphorata mycelia and culture filtrate. J Ethnopharmacol 2008; 120: 196-203. [22] Mazzone A, Ricevuti G. Leukocyte CD11/CD18 integrins: biological and clinical relevance. Haematologica 1995; 80: 161-175. [23] Cavanagh SP, Gough MJ, Homer-Vanniasinkam S. The role of neutrophil in ischaemia-reperfusion injury: potential therapeutic interventions. Cardiovasc Surg 1998; 6: 112-118. [24] Lin N, Sato T, Takayama Y, Mimaki Y, Sashida Y, Yano M, et al. Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages. Biochem Pharm 2003; 65(12): 2065-2071. [25] Pothacharoen P, Choopcheep K, Phitak T, Pompimon W, Kongtawelert P. Alpinia galanga extracts downregulate interleukin-1β-induced matrix metalloproteinases expression in human synovial fibroblast. In Vitro Cell Dev Biol Anim 2011; 47: 183-187. [26] Saelee C, Thongrakard V, Tencomnao T. Effects of Thai medicinal herb extracts with anti-psoriatic activity on the expression on Nf-κB signaling biomarkers in HaCaT keratinocytes. Molecules 2011; 16: 3908-3932. [27] Lee WL, Harrison RE, Grinstein S. Phagocytosis by neutrophils. Microbes Infect 2003; 5: 1299-1306. [28] Burg ND, Pilinger MH. The neutrophil: function and regulation in innate and humoral immunity. Clin Immunol 2001; 99: 7-17. [29] Coxon A, Cullere X, Knight S, Sethi S, Wakelin MW, Stavrakis G, et al. Fc gamma RIII mediates neutrophil recruitment to immune complexes: a mechanism for neutrophil accumulation in immune-mediated inflammation. Immunity 2001; 14: 693-704. [30] Butcher SK, Chahal H, Nayak L, Sinclair A, Henriquez NV, Sapey E, et al. Sunescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans. J Leukoc Biol 2001; 70: 881-886. [31] Indik ZK, Park JG, Hunter S. Schreiber AD. The molecular dissection of Fc gamma receptor mediated phagocytosis. Blood 1995; 86: 4389-4399. [32] Foong CP, Hamid RA. Evaluation of anti-inflammatory activities of ethanolic extract of Annona muricata leaves. Rev Bras Farmacogn 2012; 22: 1301-1307. [33] de Sousa OV, Vieira GD, de Jesus R G de Pinho J, Yamamoto CH, Alves MS. Antinonciceptive and anti-inflammatory activities of the ethanol extract of Annona muricata L. leaves in animal models. Int J Mol Sci 2010; 11: 2067-2078. [34] He HB, Wu XL, Yu B, Liu KL, Zhou GX, Qian GQ, et al. The effect of desacetylluvaricin on the expression of TLR4 and P53 protein in Hepg 2.2.15. Hepat Mon 2011; 11: 364-367. [35] Wu P, Wu M, Xu L, Xie H, Wei X. Anti-inflammatory cyclopeptides from exocarps of sugar-apples. Food Chem 2014; 152: 23-28. [36] Hsu CL, Hong BH, Yu YS, Yen GC. Antioxidant and anti-inflammatory effects of Orthosiphon aristatus and its bioactive compounds. J Agric Food Chem 2010; 58: 2150-2156. |
| spellingShingle | Immunomodulatory effects of selected Malaysian plants on the CD18/11a expression and phagocytosis activities of leukocytes |
| summary | Objective: To investigate the effects of 20 methanolic extracts from Malaysian selected plants on CD18/11a expression and phagocytosis activity of leukocytes using flow cytometry analysis. Methods: The effects of methanolic extracts on CD18/11a expression and phagocytosis of leukocytes were measured by labelling the cells with CD18-fluorescein isothiocyanate and ingestion labelled with Escherichia coli-fluorescein isothiocyanate and then analyzed using flow cytometer. Results: About 12 out of 20 methanolic extracts of selected Malaysian medicinal plants significantly (P≤0.05) inhibited the CD18/11a expression of leukocytes at both concentrations of 6.25 μg/mL and 100 μg/mL in dose dependent manner. The most active inhibitory was shown in Citrus aurantifolia (Christm.) Swingle and Alpinia galangal (L.) Willd. at dosage 100 μg/mL. Moreover, the Orthosiphon aristatus (Blume) Miq (O. aristatus). showed the highest stimulatory activity at the concentration of 100 μg/mL. Other than that, four plant extracts significantly (P≤0.05) rose the phagocytosis activities of leukocytes in dose dependent manner. However, Annona muricata L. and O. aristatus showed the highest stimulated activities at the 100 μg/mL concentration. Conclusions: The results suggest that methanolic extracts of Citrus aurantifolia, Alpinia galangal, O. aristatus and Annona muricata are able to modulate innate immune system and can potentially be recognized as therapeutic agents for modulating immune system. |
| title | Immunomodulatory effects of selected Malaysian plants on the CD18/11a expression and phagocytosis activities of leukocytes |
| title_full | Immunomodulatory effects of selected Malaysian plants on the CD18/11a expression and phagocytosis activities of leukocytes |
| title_fullStr | Immunomodulatory effects of selected Malaysian plants on the CD18/11a expression and phagocytosis activities of leukocytes |
| title_full_unstemmed | Immunomodulatory effects of selected Malaysian plants on the CD18/11a expression and phagocytosis activities of leukocytes |
| title_short | Immunomodulatory effects of selected Malaysian plants on the CD18/11a expression and phagocytosis activities of leukocytes |
| title_sort | immunomodulatory effects of selected malaysian plants on the cd18/11a expression and phagocytosis activities of leukocytes |