Estrogen receptors in merkel cell carcinoma: Its possible roles in pathogenesis
| Format: | Restricted Document |
|---|
| _version_ | 1860797148067528704 |
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| building | INTELEK Repository |
| collection | Online Access |
| collectionurl | https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 |
| date | 2018-01-28 08:35:38 |
| format | Restricted Document |
| id | 11556 |
| institution | UniSZA |
| originalfilename | 5812-01-FH02-FSK-18-13127.pdf |
| person | User user USER UsEr |
| recordtype | oai_dc |
| resourceurl | https://intelek.unisza.edu.my/intelek/pages/view.php?ref=11556 |
| spelling | 11556 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=11556 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal application/pdf 1.6 Adobe Acrobat Pro DC 20 Paper Capture Plug-in User user USER UsEr 2018-01-28 08:35:38 64 5812-01-FH02-FSK-18-13127.pdf UniSZA Private Access Estrogen receptors in merkel cell carcinoma: Its possible roles in pathogenesis Research Journal of Pharmacy and Technology Sex steroids have been postulated to influence skin development and functions as well as its pathogenesis. Merkel cell carcinoma (MCC) occurs in both genders however, the specific differences in pathogenesis amongst genders have yet to be conclusively defined. The detailed status of sex steroid receptors (androgen receptor (AR), progesterone receptor (PR) A and PRB, and estrogen receptor (ER) a, ERß) are also unknown in Merkel cell carcinoma (MCC) patients. We first immunolocalized sex steroid receptors and compared the results with immunolocalization of relevant transcription factors including SOX2, forkhead box protein A1 (FOXA1) and Bcl-2 and Ki-67 in 14 cases of MCCs. AR, PRA, PRB, ERa, ERß, Bcl-2, SOX2 and FOXA1 immunoreactivity was evaluated by employing the modified H-score method and Ki-67 were quantified using labeling index (LI%). ERß immunoreactivity was markedly present in all the cases of MCC examined with relatively weak immunoreactivity of ERa, AR and PRA. The status of ERß immunoreactivity was also significantly correlated with Ki67 LI and Bcl-2 score. These results demonstrated that ERß could be associated with regulation of both cell proliferation and apoptosis in MCCs. 10 12 27-28 |
| spellingShingle | Estrogen receptors in merkel cell carcinoma: Its possible roles in pathogenesis |
| summary | Sex steroids have been postulated to influence skin development and functions as well as its pathogenesis. Merkel cell carcinoma (MCC) occurs in both genders however, the specific differences in pathogenesis amongst genders have yet to be conclusively defined. The detailed status of sex steroid receptors (androgen receptor (AR), progesterone receptor (PR) A and PRB, and estrogen receptor (ER) a, ERß) are also unknown in Merkel cell carcinoma (MCC) patients. We first immunolocalized sex steroid receptors and compared the results with immunolocalization of relevant transcription factors including SOX2, forkhead box protein A1 (FOXA1) and Bcl-2 and Ki-67 in 14 cases of MCCs. AR, PRA, PRB, ERa, ERß, Bcl-2, SOX2 and FOXA1 immunoreactivity was evaluated by employing the modified H-score method and Ki-67 were quantified using labeling index (LI%). ERß immunoreactivity was markedly present in all the cases of MCC examined with relatively weak immunoreactivity of ERa, AR and PRA. The status of ERß immunoreactivity was also significantly correlated with Ki67 LI and Bcl-2 score. These results demonstrated that ERß could be associated with regulation of both cell proliferation and apoptosis in MCCs. |
| title | Estrogen receptors in merkel cell carcinoma: Its possible roles in pathogenesis |
| title_full | Estrogen receptors in merkel cell carcinoma: Its possible roles in pathogenesis |
| title_fullStr | Estrogen receptors in merkel cell carcinoma: Its possible roles in pathogenesis |
| title_full_unstemmed | Estrogen receptors in merkel cell carcinoma: Its possible roles in pathogenesis |
| title_short | Estrogen receptors in merkel cell carcinoma: Its possible roles in pathogenesis |
| title_sort | estrogen receptors in merkel cell carcinoma: its possible roles in pathogenesis |