The role of maternal serum and breast milk adipokines in determining infant adiposity development
| Format: | Restricted Document |
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| building | INTELEK Repository |
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| collectionurl | https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 |
| date | 2018-01-28 08:35:38 |
| format | Restricted Document |
| id | 11548 |
| institution | UniSZA |
| originalfilename | 5802-01-FH02-FSK-18-13123.pdf |
| person | User user USER UsEr |
| recordtype | oai_dc |
| resourceurl | https://intelek.unisza.edu.my/intelek/pages/view.php?ref=11548 |
| spelling | 11548 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=11548 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal application/pdf 1.6 Adobe Acrobat Pro DC 20 Paper Capture Plug-in User user USER UsEr 2018-01-28 08:35:38 64 5802-01-FH02-FSK-18-13123.pdf UniSZA Private Access The role of maternal serum and breast milk adipokines in determining infant adiposity development Research Journal of Pharmacy and Technology Obesity has been a great concern in Malaysia since there is an alarming increase in its prevalence. Besides storing fat, adipose tissue is also an endocrine organ that secretes a large number of adipokines. Pregnancy, a state with metabolic changes, has been recognized as a critical period for the development of infant adiposity as a result of imbalanced adipokines production. Hence, the Universiti Sains Malaysia Pregnancy Cohort Study was established to investigate the role of maternal serum and breast milk adipokines (adiponectin and leptin) in determining the first year infant adiposity development. This study was conducted from April 2010 until December 2012. A total of 155 healthy pregnant mothers aged 19 to 40 years were recruited at first and second trimester of pregnancy in Kelantan, Malaysia. Data collection was consisted of maternal sociodemography, anthropometry and clinical biochemistry analysis; and infant‟s anthropometry and feeding patterns. Fasting serum samples were taken during pregnancy for adiponectin and leptin levels analyses. Breast milk samples were collected at birth and 2 months postpartum. Data collection was performed at second and third trimester of pregnancy, continued with follow-up visits at birth, 2 months, 6 months and 12 months postpartum. Multiple linear regression (MLR) analyses were performed to examine the associations of maternal serum and breast milk adiponectin and leptin on infant adiposity development. MLR models showed that in the first year of age, as maternal serum and breast milk adiponectin increased, infant weight, BMI-for-age Z-scores, abdominal circumference and triceps skinfold significantly decreased (p<0.05). Maternal serum and/or breast milk adiponectin were associated with the first year infant adiposity development. The favourable results of breast milk adiponectin indicated the potential role of breastfeeding practice in the prevention of obesity since infanthood. 10 12 24-24 |
| spellingShingle | The role of maternal serum and breast milk adipokines in determining infant adiposity development |
| summary | Obesity has been a great concern in Malaysia since there is an alarming increase in its prevalence. Besides storing fat, adipose tissue is also an endocrine organ that secretes a large number of adipokines. Pregnancy, a state with metabolic changes, has been recognized as a critical period for the development of infant adiposity as a result of imbalanced adipokines production. Hence, the Universiti Sains Malaysia Pregnancy Cohort Study was established to investigate the role of maternal serum and breast milk adipokines (adiponectin and leptin) in determining the first year infant adiposity development. This study was conducted from April 2010 until December 2012. A total of 155 healthy pregnant mothers aged 19 to 40 years were recruited at first and second trimester of pregnancy in Kelantan, Malaysia. Data collection was consisted of maternal sociodemography, anthropometry and clinical biochemistry analysis; and infant‟s anthropometry and feeding patterns. Fasting serum samples were taken during pregnancy for adiponectin and leptin levels analyses. Breast milk samples were collected at birth and 2 months postpartum. Data collection was performed at second and third trimester of pregnancy, continued with follow-up visits at birth, 2 months, 6 months and 12 months postpartum. Multiple linear regression (MLR) analyses were performed to examine the associations of maternal serum and breast milk adiponectin and leptin on infant adiposity development. MLR models showed that in the first year of age, as maternal serum and breast milk adiponectin increased, infant weight, BMI-for-age Z-scores, abdominal circumference and triceps skinfold significantly decreased (p<0.05). Maternal serum and/or breast milk adiponectin were associated with the first year infant adiposity development. The favourable results of breast milk adiponectin indicated the potential role of breastfeeding practice in the prevention of obesity since infanthood. |
| title | The role of maternal serum and breast milk adipokines in determining infant adiposity development |
| title_full | The role of maternal serum and breast milk adipokines in determining infant adiposity development |
| title_fullStr | The role of maternal serum and breast milk adipokines in determining infant adiposity development |
| title_full_unstemmed | The role of maternal serum and breast milk adipokines in determining infant adiposity development |
| title_short | The role of maternal serum and breast milk adipokines in determining infant adiposity development |
| title_sort | role of maternal serum and breast milk adipokines in determining infant adiposity development |