In vivo study on diuretic and laxative therapeutic properties of hydro-alcoholic extract of Lu Hui (lilliaceae) on experimental rodents (rattus norvegicus)

In vivo study on diuretic and laxative therapeutic properties of hydro-alcoholic extract of Lu Hui (lilliaceae) on experimental rodents (rattus norvegicus)

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internalnotes 1. Goodman LS, Hardman JG, Limbird LE. Goodman and Gilmans. The Pharmacological Basis of Therapeutics. 10th International ed. New York: McGraw Hill; 2001. p. 757-63. 2. Bosshard W, Dreher R, Schnegg JF, Büla CJ. The treatment of chronic constipation in elderly people: An update. Drugs Aging 2004;21(14):911-30. 3. Mostafa SM, Bhandari S, Ritchie G, Gratton N, Wenstone R. Constipation and its implications in the critically ill patient. Br J Anaesth 2003;91(6):815-9. 4. Johanson JF, Kralstein J. Chronic constipation: A survey of the patient perspective. Aliment Pharmacol Ther 2007;25(5):599-608. 5. Shelton RM. Aloe vera. Its chemical and therapeutic properties. Int J Dermatol 1991;30(10):679-83. 6. Haller JS Jr. A drug for all seasons. Medical and pharmacological history of aloe. Bull N Y Acad Med 1990;66(6):647-59. 7. Atherton P. Aloe vera: Magic or medicine? Nurs Stand 1998;12(49):49- 52, 54. 8. Bensky D, Gamble A, Kaptchuk TJ. Chinese Herbal Medicine: Materia Medica. Vol. XXV. Seattle, Wash: Eastland Press; 1993. p. 556. 9. Ghazanfar SA. Handbook of Arabian Medicinal Plants. Boca Raton: CRC Press; 1994. 10. Sofowora A. Medical Plants and Traditional Medicine in Africa. 2nd ed. Ibadan, Nigeria: Spectrum Books Ltd.; 1993. p. 289. 11. Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. 12th ed. Pune: Nirali Prakashan; 1999. p. 254. 12. Khandelwal KR. Practical Pharmacognosy. New Delhi: Nirali Prakashan; 2006. 13. Ecobichon DJ. The Basis of Toxicity Testing. New York: CRS Press; 1997. 14. Murugesan T, Manikandan L, Suresh KB, Pal M, Saha BP. Evaluation of diuretic potential of Jussiaea suffruticosa Linn. extract in rats. Indian J Pharm Sci 2000;62(2):150-1. 15. Rizvi SH, Shoeb A, Kapil RS, Satya P. Two diuretic triterpenoids from Antidesma menasu. Phytochemistry 1980;19(11):2409-10. 16. Jeffery GH, Bassett J, Mendham J, Denny RC. Vogel’s Textbook of Quantitative Chemical Analysis. 5th ed. England: Addison Wesley Longman Ltd.; 1989. p. 801. 17. Beckette AH, Stenlake JB. Practical Pharmaceutical Chemistry. Part-I. 1st ed. New Delhi: CBS Publishers & Distributors; 1997. p. 197. 18. Capasso F, Mascolo N, Autore G, Romano V. Laxatives and the production of autacoids by rat colon. J Pharm Pharmacol 1986;38(8):627-9. 19. Ganapaty S, Dash GK, Subburaju T, Suresh P. Diuretic, laxative and toxicity studies of Cocculus hirsutus aerial parts. Fitoterapia 2002;73(1):28-31. 20. Reynolds T, Dweck AC. Aloe vera leaf gel: A review update. J Ethnopharmacol 1999;68(1-3):3-37. 21. Guyton AC, Hall JE. Textbook of Medical Physiology. 9th ed. Singapore: WB Saunders Company; 1998. p. 306-8. 22. Basu SK, Arivukkarasu R. Acute toxicity and diuretic studies of Rungia repens aerial parts in rats. Fitoterapia 2006;77(2):83-5. 23. Hughes S, Higgs NB, Turnberg LA. Loperamide has antisecretory activity in the human jejunum in vivo. Gut 1984;25(9):931-5. 24. Aikawa N, Ohmori K. Effect of zaldaride maleate, an antidiarrheal compound, on fecal pellet output induced by hyperpropulsion in gastrointestine of rats. Jpn J Pharmacol 2000;82(4):350-2. 25. Yamada K, Onoda Y. Comparison of the effects of T-1815, yohimbine and naloxone on mouse colonic propulsion. J Smooth Muscle Res 1993;29(2):47-53. 26. Schiller LR, Santa Ana CA, Morawski SG, Fordtran JS. Mechanism of the antidiarrheal effect of loperamide. Gastroenterology 1984;86(6):1475-80. 27. Shimotoyodome A, Meguro S, Hase T, Tokimitsu I, Sakata T. Decreased colonic mucus in rats with loperamide-induced constipation. Comp Biochem Physiol A Mol Integr Physiol 2000;126(2):203-12. 28. Wintola OA, Sunmonu TO, Afolayan AJ. The effect of Aloe ferox Mill. in the treatment of loperamide-induced constipation in wistar rats. BMC Gastroenterol 2010;10:95. 29. Ishii Y, Tanizawa H, Takino Y. Studies of aloe. V. Mechanism of cathartic effect. (4). Biol Pharm Bull 1994;17(5):651-3. 30. Izzo AA, Sautebin L, Borrelli F, Longo R, Capasso F. The role of nitric oxide in aloe-induced diarrhoea in the rat. Eur J Pharmacol 1999;368(1):43-8. 31. Ishii Y, Tanizawa H, Takino Y. Studies of aloe. III. Mechanism of cathartic effect. (2). Chem Pharm Bull (Tokyo) 1990;38(1):197-200. 32. Capasso F, Mascolo N, Autore G, Duraccio MR. Effect of indomethacin on aloin and 1, 8 dioxianthraquinone-induced production of prostaglandins in rat isolated colon. Prostaglandins 1983;26(4):557-62. 33. Niwa T, Nakao M, Hoshi S, Yamada K, Inagaki K, Nishida M, et al. Effect of dietary fiber on morphine-induced constipation in rats. Biosci Biotechnol Biochem 2002;66(6):1233-40. 34. Dande P, Vaidya A, Arora P. Laxative activity of Raphanus sativus L. leaf. Asian J Pharm Clin Res 2014;7 (Suppl 2):120-4. 35. Degen L. Gastrointestinal motility – Physiology and methods of measurement. Ther Umsch 2007;64(4):195-9. 36. Capasso F, Gaginella TS. Laxatives: A Practical Guide. Milan: Springer Italia; 1997.
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spelling 11288 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=11288 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal UniSZA Unisza unisza image/jpeg inches 96 96 1417 792 43 43 2014-09-29 14:25:22 1417x792 5502-01-FH02-FPSK-06-01518.jpg UniSZA Private Access In vivo study on diuretic and laxative therapeutic properties of hydro-alcoholic extract of Lu Hui (lilliaceae) on experimental rodents (rattus norvegicus) Asian Journal of Pharmaceutical and Clinical Research Objective: In furtherance to the rising evidences for therapeutical potential of Lu Hui (Aloe vera), the existing study was carried out to evaluate the diuretic and laxative activity of its hydro-alcoholic extract on rodents. Materials and Methods: The hydro-alcoholic extract of leaves of Lu Hui (HALL) was prepared by using Soxhlet extractor and subjected to analysis by standard preliminary phytochemical tests. Assessment of both the diuretic and laxative activity was carried out using standard methods. Furosemide (20 mg/kg) was functioned as a positive control for diuretic activity, whereas gaviscon (10 mg/kg) worked as a reference drug for laxative activity. Results: The HALL showed weight diuretic activity and found to be the most potent in increasing the urinary output at 600 mg/kg when the effect was comparable to that of the standard furosemide. Besides, this extract found to be most effective in increasing urinary electrolyte concentration (sodium, potassium, chloride) at both the doses tested. On the other hand, the results for laxative activity exhibited incredible increase of feces output at the dose of 600 mg/kg, and the increase was similar to that of standard drug gaviscon. Conclusion: Altogether, the above major findings validate and support its folkloric diuretic and purgative use and lend pharmacological credence to the ethnomedical use of this leaves in the traditional system of medicine, stresses further studies to intricate its active constituents, uses and safety. 7 4 147-151 1. Goodman LS, Hardman JG, Limbird LE. Goodman and Gilmans. The Pharmacological Basis of Therapeutics. 10th International ed. New York: McGraw Hill; 2001. p. 757-63. 2. Bosshard W, Dreher R, Schnegg JF, Büla CJ. The treatment of chronic constipation in elderly people: An update. Drugs Aging 2004;21(14):911-30. 3. Mostafa SM, Bhandari S, Ritchie G, Gratton N, Wenstone R. Constipation and its implications in the critically ill patient. Br J Anaesth 2003;91(6):815-9. 4. Johanson JF, Kralstein J. Chronic constipation: A survey of the patient perspective. Aliment Pharmacol Ther 2007;25(5):599-608. 5. Shelton RM. Aloe vera. Its chemical and therapeutic properties. Int J Dermatol 1991;30(10):679-83. 6. Haller JS Jr. A drug for all seasons. Medical and pharmacological history of aloe. Bull N Y Acad Med 1990;66(6):647-59. 7. Atherton P. Aloe vera: Magic or medicine? Nurs Stand 1998;12(49):49- 52, 54. 8. Bensky D, Gamble A, Kaptchuk TJ. Chinese Herbal Medicine: Materia Medica. Vol. XXV. Seattle, Wash: Eastland Press; 1993. p. 556. 9. Ghazanfar SA. Handbook of Arabian Medicinal Plants. Boca Raton: CRC Press; 1994. 10. Sofowora A. Medical Plants and Traditional Medicine in Africa. 2nd ed. Ibadan, Nigeria: Spectrum Books Ltd.; 1993. p. 289. 11. Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. 12th ed. Pune: Nirali Prakashan; 1999. p. 254. 12. Khandelwal KR. Practical Pharmacognosy. New Delhi: Nirali Prakashan; 2006. 13. Ecobichon DJ. The Basis of Toxicity Testing. New York: CRS Press; 1997. 14. Murugesan T, Manikandan L, Suresh KB, Pal M, Saha BP. Evaluation of diuretic potential of Jussiaea suffruticosa Linn. extract in rats. Indian J Pharm Sci 2000;62(2):150-1. 15. Rizvi SH, Shoeb A, Kapil RS, Satya P. Two diuretic triterpenoids from Antidesma menasu. Phytochemistry 1980;19(11):2409-10. 16. Jeffery GH, Bassett J, Mendham J, Denny RC. Vogel’s Textbook of Quantitative Chemical Analysis. 5th ed. England: Addison Wesley Longman Ltd.; 1989. p. 801. 17. Beckette AH, Stenlake JB. Practical Pharmaceutical Chemistry. Part-I. 1st ed. New Delhi: CBS Publishers & Distributors; 1997. p. 197. 18. Capasso F, Mascolo N, Autore G, Romano V. Laxatives and the production of autacoids by rat colon. J Pharm Pharmacol 1986;38(8):627-9. 19. Ganapaty S, Dash GK, Subburaju T, Suresh P. Diuretic, laxative and toxicity studies of Cocculus hirsutus aerial parts. Fitoterapia 2002;73(1):28-31. 20. Reynolds T, Dweck AC. Aloe vera leaf gel: A review update. J Ethnopharmacol 1999;68(1-3):3-37. 21. Guyton AC, Hall JE. Textbook of Medical Physiology. 9th ed. Singapore: WB Saunders Company; 1998. p. 306-8. 22. Basu SK, Arivukkarasu R. Acute toxicity and diuretic studies of Rungia repens aerial parts in rats. Fitoterapia 2006;77(2):83-5. 23. Hughes S, Higgs NB, Turnberg LA. Loperamide has antisecretory activity in the human jejunum in vivo. Gut 1984;25(9):931-5. 24. Aikawa N, Ohmori K. Effect of zaldaride maleate, an antidiarrheal compound, on fecal pellet output induced by hyperpropulsion in gastrointestine of rats. Jpn J Pharmacol 2000;82(4):350-2. 25. Yamada K, Onoda Y. Comparison of the effects of T-1815, yohimbine and naloxone on mouse colonic propulsion. J Smooth Muscle Res 1993;29(2):47-53. 26. Schiller LR, Santa Ana CA, Morawski SG, Fordtran JS. Mechanism of the antidiarrheal effect of loperamide. Gastroenterology 1984;86(6):1475-80. 27. Shimotoyodome A, Meguro S, Hase T, Tokimitsu I, Sakata T. Decreased colonic mucus in rats with loperamide-induced constipation. Comp Biochem Physiol A Mol Integr Physiol 2000;126(2):203-12. 28. Wintola OA, Sunmonu TO, Afolayan AJ. The effect of Aloe ferox Mill. in the treatment of loperamide-induced constipation in wistar rats. BMC Gastroenterol 2010;10:95. 29. Ishii Y, Tanizawa H, Takino Y. Studies of aloe. V. Mechanism of cathartic effect. (4). Biol Pharm Bull 1994;17(5):651-3. 30. Izzo AA, Sautebin L, Borrelli F, Longo R, Capasso F. The role of nitric oxide in aloe-induced diarrhoea in the rat. Eur J Pharmacol 1999;368(1):43-8. 31. Ishii Y, Tanizawa H, Takino Y. Studies of aloe. III. Mechanism of cathartic effect. (2). Chem Pharm Bull (Tokyo) 1990;38(1):197-200. 32. Capasso F, Mascolo N, Autore G, Duraccio MR. Effect of indomethacin on aloin and 1, 8 dioxianthraquinone-induced production of prostaglandins in rat isolated colon. Prostaglandins 1983;26(4):557-62. 33. Niwa T, Nakao M, Hoshi S, Yamada K, Inagaki K, Nishida M, et al. Effect of dietary fiber on morphine-induced constipation in rats. Biosci Biotechnol Biochem 2002;66(6):1233-40. 34. Dande P, Vaidya A, Arora P. Laxative activity of Raphanus sativus L. leaf. Asian J Pharm Clin Res 2014;7 (Suppl 2):120-4. 35. Degen L. Gastrointestinal motility – Physiology and methods of measurement. Ther Umsch 2007;64(4):195-9. 36. Capasso F, Gaginella TS. Laxatives: A Practical Guide. Milan: Springer Italia; 1997.
spellingShingle In vivo study on diuretic and laxative therapeutic properties of hydro-alcoholic extract of Lu Hui (lilliaceae) on experimental rodents (rattus norvegicus)
summary Objective: In furtherance to the rising evidences for therapeutical potential of Lu Hui (Aloe vera), the existing study was carried out to evaluate the diuretic and laxative activity of its hydro-alcoholic extract on rodents. Materials and Methods: The hydro-alcoholic extract of leaves of Lu Hui (HALL) was prepared by using Soxhlet extractor and subjected to analysis by standard preliminary phytochemical tests. Assessment of both the diuretic and laxative activity was carried out using standard methods. Furosemide (20 mg/kg) was functioned as a positive control for diuretic activity, whereas gaviscon (10 mg/kg) worked as a reference drug for laxative activity. Results: The HALL showed weight diuretic activity and found to be the most potent in increasing the urinary output at 600 mg/kg when the effect was comparable to that of the standard furosemide. Besides, this extract found to be most effective in increasing urinary electrolyte concentration (sodium, potassium, chloride) at both the doses tested. On the other hand, the results for laxative activity exhibited incredible increase of feces output at the dose of 600 mg/kg, and the increase was similar to that of standard drug gaviscon. Conclusion: Altogether, the above major findings validate and support its folkloric diuretic and purgative use and lend pharmacological credence to the ethnomedical use of this leaves in the traditional system of medicine, stresses further studies to intricate its active constituents, uses and safety.
title In vivo study on diuretic and laxative therapeutic properties of hydro-alcoholic extract of Lu Hui (lilliaceae) on experimental rodents (rattus norvegicus)
title_full In vivo study on diuretic and laxative therapeutic properties of hydro-alcoholic extract of Lu Hui (lilliaceae) on experimental rodents (rattus norvegicus)
title_fullStr In vivo study on diuretic and laxative therapeutic properties of hydro-alcoholic extract of Lu Hui (lilliaceae) on experimental rodents (rattus norvegicus)
title_full_unstemmed In vivo study on diuretic and laxative therapeutic properties of hydro-alcoholic extract of Lu Hui (lilliaceae) on experimental rodents (rattus norvegicus)
title_short In vivo study on diuretic and laxative therapeutic properties of hydro-alcoholic extract of Lu Hui (lilliaceae) on experimental rodents (rattus norvegicus)
title_sort in vivo study on diuretic and laxative therapeutic properties of hydro-alcoholic extract of lu hui (lilliaceae) on experimental rodents (rattus norvegicus)

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