Modulatory influence of Avocado on renal oxido - Lipidemic stress and mRNA expression of NOS in renal artery studied in nephropathy induced rats
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| internalnotes | 1) Chade AR, Krier JD, Galili O, et al. Role of renal cortical neovascularization in experimental hypercholesterolemia. Hypertension. 2007; 50: 729-36. 2) Deji N, et al. Structural and functional changes in the kidneys of high-fat diet-induced obese mice. Am J Physiol Renal Physiol 2009; 296, F118-F26. 3) Ying Y, Xing-kui T, Xiao-cheng L, et al. Early renal morphological changes in high cholesterol diet rats' model. J Nat Sci 2005; 10: 1063-8. 4) Parthasarathy S, Santanam N, Ramachandran S, et al. Potential role of oxidized lipids and lipoproteins in antioxidant defense. Free Radic Res 2000; 33: 197-215. 5) Rainey C, Affleck M, Bretschger K. et al. The California Avocado, a new look. Nutr Today 1994; 29: 23-7. 6) Kadam SS, Salunkhe DK. Avocado. In Handbook of fruit science and technology, pro-duction, composition, storage and processing. pp. 363-75. Salunkhe DK, Kadam SS. (Eds.), New York: Marcel Dekker Inc., 1995. 7) Bergh B. Nutritious value of Avocado, pp.123-35. California: California Avocado Society Book, 1992. 8) Sanchez-Castillo CP, Dewey PJS, De Lourdes Solano, et al. The dietary fiber content (nonstarch polysaccharides) of Mexican fruit and vegetables. J Food Comp Anal 1995; 8: 284-94. 9) Folch J, Lees M, Sloane-Stanley GH. A simple method for isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226: 497-509. 10) Parekh AC, Jung DH. Cholesterol determination with ferric chloride-uranium acetate and sulfuric acid-ferrous sulfate reagents. Anal Chem 1970; 42: 1423-27. 11) Rice EW. Triglycerides ("gneutral fat") in serum. In MacDonald RP (Ed.), Standard methods of clinical chemistry, New York, USA: Academic Press, 1970; 6: 215-22. 12) Rouser G, Fkeischer S, Yamamoto A. Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids 1970; 5: 494-6. 13 ) Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974; 47: 469-74. 14) Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972; 47: 389-94. 15) Rotruck JT, Pope AL, Ganther HE. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973; 179: 588-90. 16) Stall GEJ, Visser J, Veeger C. Purification and properties of glutathione reductase of human erythrocytes. Biochim Biophys Acta 1969; 185: 39-48. 17) Habig WH, Pabst MJ, Jakoby WB. Glutathione-S-transferases: the first enzymatic step in mercapturic acid formation. J Biol Chem 1974; 249: 7130-9. 18) Moron MS, Depierre JW, Mannervik B. Levels of glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta 1979; 582: 67-78. 19) Omaye ST, Turnbull JD, Sauberlich HE. Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Methods Enzymol 1979; 62: 3-11. 20) Baker AF, Frank G. Estimation of vitamin E in tissues. In Bollinger G, (Ed.), Dunnshchicht, chromatographic in laboratorium "Hand brich". Berlin, Germany: Springer-Verlag, 1951; 41-52. 21) Devasagayam TPA, Tarachand U. Decreased lipid peroxidation in rat kidney during gestation. Biochem Biophys Res Commun 1987; 145: 134-38. 22) Lowry OH, Rosebrough NJ, Farr AL, Randall R. Protein measurement with Folin's phe-nol reagent. J Biol Chem 1951; 193: 265-75. 23) Saini HK, Arneja AS, Dhalla NS. Role of cholesterol in cardiovascular dysfunction. Can J Cardiol 2004; 20: 333-46. 24 ) Scheuer H, Gwinner W, Hohbach, et al. Oxidant stress in hyperlipidemia-induced renal damage. Am J Physiol Renal Physiol 2000; 278: F63-F74. 25) Grone EF, Walli AK, Grone HJ, et al. The role of lipids in nephrosclerosis and glomerulosclerosis. Atherosclerosis, 1994; 107: 1-13. 26) Al-Rejaie SS, Abuohashish HM, Alkhamees OA, et al. Gender difference following high cholesterol diet induced renal injury and the protective role of rutin and ascorbic acid combination in Wistar albino rats. Lipids Health and Dis 2012; 11: 41-50. 27) Mahadeva Rao US, Adinew B. Hypolipidemic effect of dichloromethane as well as methanolic fruit and leaf extract of Ethiopian alligator pear (persea americana mill.) on tyloxapol-induced hyperlipidemic experimental rat. Asian J Research Chem 2011; 4(4): 574-8. 28) Yakubo S, Ueda Y, Tanekura N, et al. Thermogenic effect of Bofu-Tsusho-San on human interscapular adipose tissue. International Medical Journal 2012; 19(4): 378-381. 29) Khan J, Mohammed NI. Mechanisms of obesity induced higher intestinal permeability. International Medical Journal 2012; 19(4): 307-308. 30) Salem NA, Salem EA. Renoprotective effect of grape seed extract against oxidative stress induced by gentamicin and hypercholesterolemia in rats. Ren Failure 2011; 33: 824-32. 31) Akpolat M, Kanter M, Topcu-Tarladacalisir Y, et al. Protective effect of flaxseed oil on renal injury in hyperlipidaemic rats. The effect of flaxseed oil on hyperlipidaemia. Phytother Res 2011; 25: 796-802. 32) Ishiyama A, Atarashi K, Minami M, et al. Role of free radicals in the pathogenesis of lipid-induced glomerulosclerosis in rats. Kidney Int 1999; 55: 1348-58. 33) Green CO, Wheatley AB, McGrowder DA, et al. Modulation of antioxidant enzymes activities and lipid peroxidation products in diet-induced hypercholesterolemic rats fed ortanique peel polymethoxylated flavones extract. J app biomed 2012; 10: 91-101. 34) Deepa PR, Varalakshmi P. Salubrious effect of low molecular weight heparin on athero-genic diet-induced cardiac, hepatic and renal lipid peroxidation and collapse of antiox-idant defences. Mol Cell Biochem 2003; 254: 111-6. 35) Mahadeva Rao US, Adinew B. Remnant β-cell-stimulative and anti-oxidative effects of persea americana fruit extract studied in rats introduced into streptozotocin - induced hyperglycaemic state. Afr J Tradit Complement Altern Med 2011; 8(3): 210-17. 36) Martinet W, Knaapen MW, De Meyer GR, et al. Oxidtive DNA damage and repair in experimental atherosclerosis are reversed by dietary lipid lowering. Cir Res 2001; 88: 733-9. 37) Deepa PR, Varalakshmi P. Atheroprotective effect of endogenous heparin-derivative treatment on the aortic distrubances and lipoprotein oxidation in hypercholesterolemic diet fed rats. Clin Chim Acta 2005; 355: 119-30. 38) Mahadeva Rao US, Mohd KS, Abd Halim SZ, et al. Secondary metabolite screening and relative reactive oxygen species scavenging with reducing potency of fruit extract of Malaysian Mengkudu using various solvent extracts. International Medical Journal 2014; 21(3): - . 39) Chenni A, Yahia DA, Boukortt FO, et al. Effect of aqueous extract of Ajuga iva supple-mentation on plasma lipid profile and tissue antioxidant status in rats fed a high-cho-lesterol diet. J Ethnopharmacol 2007; 109: 207-13. 40) Feldstein A et al. In vivo renal vascular and tubular function in experimental hypercho-lesterolemia. Hypertension 1999; 34: 859-64. 41) Scheuer H, Gwinner W, Hohbach, et al. (2000). Oxidant stress in hyperlipidemia-in-duced renal damage. Am J Physiol Renal Physiol 278: F63-F74. 42) Yadav YC, Srivastava DN. Nephroprotective and curative effects of Ficus religiosa latex extract against cisplatin-induced acute renal failure. Pharmaceutical Biol 2013; 51: 1480-5. 43) Akpolat M, Kanter M, Topcu-Tarladacalisir Y, et al. Protective effect of flaxseed oil on renal injury in hyperlipidaemic rats, the effect of flaxseed oil on hyperlipidaemia. Phytother Res 2011; 25: 796-802. 44) Stulak JM, Lerman A, Caccitolo, et al. Impaired renal vascular endothelial function in vitro in experimental hypercholesterolemia. Atherosclerosis 2001; 154: 195-201. 45) Plotnikov EY, Chupyrkina AA, Pevzner IB, et al. Myoglobin causes oxidative stress, increase of NO production and dysfunction of kidney's mitochondria. Biochimica et Biophysica Acta 2009; 1792: 796-803. 46) Sandovici M, Henning RH, Hut RA, et al. Differential regulation of glomerular and interstitial endothelial nitric oxide synthase expression in the kidney of hibernating ground squirrel. Nitric Oxi 2004; 11: 194-200. 47) Tain YL, Muller V, Szabo AJ, et al. Renal cortex neuronal nitric oxide synthase in response to rapamycin in kidney transplantation. Nitric Oxi 2008; 18: 80-6. 48) Bhatia S, Shukla R, Venkata-Madhu S, et al. Antioxidant status, lipid peroxidation and nitric oxide end products in patients of type 2 diabetes mellitus with nephropathy. Clin Biochem 2003; 36: 557-62. 49) Feldstein A, et al. In vivo renal vascular and tubular function in experimental hyper-cholesterolemia. Hypertension 1999; 34: 859-64. 50) Amin KA, Kamel HH, Abd Eltawab MA. Protective effect of Garcinia against renal oxidative stress and biomarkers induced by high fat and sucrose diet. Lipids Health Dis 2011; 10: 6-19. 51) Li H, Forstermann U. Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease. Curr Opinion Pharmacol 2013; 13, 161-7. 52) Wessells H, Teal TH, Luttrell IP, et al. Effect of endothelial cell-based iNOS gene transfer on cavernosal eNOS expression and mouse erectile responses, Int J Imp Res 2006; 18, 438-45. 53) Ricardo SD, Van Goor H, Diamond JR. Hypercholesterolemia and progressive kidney disease, the role of macrophages and macrophage-derived products. Contrib Nephrol 1997; 120: 197-209. 54) Ishiyama A, Atarashi K, Minami M, et al. Role of free radicals in the pathogenesis of lipid-induced glomerulosclerosis in rats. Kidney Int 1999; 55: 1348-58 |
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| spelling | 11284 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=11284 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal UniSZA Unisza unisza image/jpeg inches 96 96 1418 800 33 33 2014-09-02 08:10:52 1418x800 5498-01-FH02-FPSK-14-01327.jpg UniSZA Private Access Modulatory influence of Avocado on renal oxido - Lipidemic stress and mRNA expression of NOS in renal artery studied in nephropathy induced rats International Medical Journal Objective: The present study was designed to assess the beneficial effects of alcoholic (ethanol) extract of fruit of Avocado (AEFA) on biochemical, histological, and gene expression study in hypercholesterolemic diet fed nephropathy induced albino rats. Experimental design: Avocado fruit pulp was extracted with 90% ethanol, finally filtered and dried. Group-I rats as control, Group-II fed with hypercholesterolemic diet (HCD) for 45 days [4% cholesterol and 1% cholic acid], Group-III fed with HCD for 45 days + AEFA (300 mg/kg body weight/day orally) for last 30 days and Group-IV fed with AEFA alone. Collection of blood and excision of kidney were done for various biochemical and histological analysis. Result: The levels of total cholesterol (TC), triacylglycerol (TG), phospholipids (PLs), renal markers (serum urea, creatinine and uric acid) and renal lipid peroxidation (LPO) products were markedly mitigated in AEFA treated hypercholesterolemic rats. FRSA factors were significantly increased, on supplementation with AEFA. Administration with AEFA, the mRNA levels of eNOS and iNOS genes was expressively up-regulated and down-regulated. Histomorphological observations shown that, AEFA admirably protects the renal tissues from hypercholesterolemia - mediated oxido-lipidemic damage. Discussion and conclusion: From this study it was conjectured that AEFA can act as nephroprotective agent by attenuating the serum lipid profile, renal oxidative stress, besides regulating the mRNA expression of NOS in renal artery. 21 3 353-358 1) Chade AR, Krier JD, Galili O, et al. Role of renal cortical neovascularization in experimental hypercholesterolemia. Hypertension. 2007; 50: 729-36. 2) Deji N, et al. Structural and functional changes in the kidneys of high-fat diet-induced obese mice. Am J Physiol Renal Physiol 2009; 296, F118-F26. 3) Ying Y, Xing-kui T, Xiao-cheng L, et al. Early renal morphological changes in high cholesterol diet rats' model. J Nat Sci 2005; 10: 1063-8. 4) Parthasarathy S, Santanam N, Ramachandran S, et al. Potential role of oxidized lipids and lipoproteins in antioxidant defense. Free Radic Res 2000; 33: 197-215. 5) Rainey C, Affleck M, Bretschger K. et al. The California Avocado, a new look. Nutr Today 1994; 29: 23-7. 6) Kadam SS, Salunkhe DK. Avocado. In Handbook of fruit science and technology, pro-duction, composition, storage and processing. pp. 363-75. Salunkhe DK, Kadam SS. (Eds.), New York: Marcel Dekker Inc., 1995. 7) Bergh B. Nutritious value of Avocado, pp.123-35. California: California Avocado Society Book, 1992. 8) Sanchez-Castillo CP, Dewey PJS, De Lourdes Solano, et al. The dietary fiber content (nonstarch polysaccharides) of Mexican fruit and vegetables. J Food Comp Anal 1995; 8: 284-94. 9) Folch J, Lees M, Sloane-Stanley GH. A simple method for isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226: 497-509. 10) Parekh AC, Jung DH. Cholesterol determination with ferric chloride-uranium acetate and sulfuric acid-ferrous sulfate reagents. Anal Chem 1970; 42: 1423-27. 11) Rice EW. Triglycerides ("gneutral fat") in serum. In MacDonald RP (Ed.), Standard methods of clinical chemistry, New York, USA: Academic Press, 1970; 6: 215-22. 12) Rouser G, Fkeischer S, Yamamoto A. Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids 1970; 5: 494-6. 13 ) Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974; 47: 469-74. 14) Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972; 47: 389-94. 15) Rotruck JT, Pope AL, Ganther HE. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973; 179: 588-90. 16) Stall GEJ, Visser J, Veeger C. Purification and properties of glutathione reductase of human erythrocytes. Biochim Biophys Acta 1969; 185: 39-48. 17) Habig WH, Pabst MJ, Jakoby WB. Glutathione-S-transferases: the first enzymatic step in mercapturic acid formation. J Biol Chem 1974; 249: 7130-9. 18) Moron MS, Depierre JW, Mannervik B. Levels of glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta 1979; 582: 67-78. 19) Omaye ST, Turnbull JD, Sauberlich HE. Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Methods Enzymol 1979; 62: 3-11. 20) Baker AF, Frank G. Estimation of vitamin E in tissues. In Bollinger G, (Ed.), Dunnshchicht, chromatographic in laboratorium "Hand brich". Berlin, Germany: Springer-Verlag, 1951; 41-52. 21) Devasagayam TPA, Tarachand U. Decreased lipid peroxidation in rat kidney during gestation. Biochem Biophys Res Commun 1987; 145: 134-38. 22) Lowry OH, Rosebrough NJ, Farr AL, Randall R. Protein measurement with Folin's phe-nol reagent. J Biol Chem 1951; 193: 265-75. 23) Saini HK, Arneja AS, Dhalla NS. Role of cholesterol in cardiovascular dysfunction. Can J Cardiol 2004; 20: 333-46. 24 ) Scheuer H, Gwinner W, Hohbach, et al. Oxidant stress in hyperlipidemia-induced renal damage. Am J Physiol Renal Physiol 2000; 278: F63-F74. 25) Grone EF, Walli AK, Grone HJ, et al. The role of lipids in nephrosclerosis and glomerulosclerosis. Atherosclerosis, 1994; 107: 1-13. 26) Al-Rejaie SS, Abuohashish HM, Alkhamees OA, et al. Gender difference following high cholesterol diet induced renal injury and the protective role of rutin and ascorbic acid combination in Wistar albino rats. Lipids Health and Dis 2012; 11: 41-50. 27) Mahadeva Rao US, Adinew B. Hypolipidemic effect of dichloromethane as well as methanolic fruit and leaf extract of Ethiopian alligator pear (persea americana mill.) on tyloxapol-induced hyperlipidemic experimental rat. Asian J Research Chem 2011; 4(4): 574-8. 28) Yakubo S, Ueda Y, Tanekura N, et al. Thermogenic effect of Bofu-Tsusho-San on human interscapular adipose tissue. International Medical Journal 2012; 19(4): 378-381. 29) Khan J, Mohammed NI. Mechanisms of obesity induced higher intestinal permeability. International Medical Journal 2012; 19(4): 307-308. 30) Salem NA, Salem EA. Renoprotective effect of grape seed extract against oxidative stress induced by gentamicin and hypercholesterolemia in rats. Ren Failure 2011; 33: 824-32. 31) Akpolat M, Kanter M, Topcu-Tarladacalisir Y, et al. Protective effect of flaxseed oil on renal injury in hyperlipidaemic rats. The effect of flaxseed oil on hyperlipidaemia. Phytother Res 2011; 25: 796-802. 32) Ishiyama A, Atarashi K, Minami M, et al. Role of free radicals in the pathogenesis of lipid-induced glomerulosclerosis in rats. Kidney Int 1999; 55: 1348-58. 33) Green CO, Wheatley AB, McGrowder DA, et al. Modulation of antioxidant enzymes activities and lipid peroxidation products in diet-induced hypercholesterolemic rats fed ortanique peel polymethoxylated flavones extract. J app biomed 2012; 10: 91-101. 34) Deepa PR, Varalakshmi P. Salubrious effect of low molecular weight heparin on athero-genic diet-induced cardiac, hepatic and renal lipid peroxidation and collapse of antiox-idant defences. Mol Cell Biochem 2003; 254: 111-6. 35) Mahadeva Rao US, Adinew B. Remnant β-cell-stimulative and anti-oxidative effects of persea americana fruit extract studied in rats introduced into streptozotocin - induced hyperglycaemic state. Afr J Tradit Complement Altern Med 2011; 8(3): 210-17. 36) Martinet W, Knaapen MW, De Meyer GR, et al. Oxidtive DNA damage and repair in experimental atherosclerosis are reversed by dietary lipid lowering. Cir Res 2001; 88: 733-9. 37) Deepa PR, Varalakshmi P. Atheroprotective effect of endogenous heparin-derivative treatment on the aortic distrubances and lipoprotein oxidation in hypercholesterolemic diet fed rats. Clin Chim Acta 2005; 355: 119-30. 38) Mahadeva Rao US, Mohd KS, Abd Halim SZ, et al. Secondary metabolite screening and relative reactive oxygen species scavenging with reducing potency of fruit extract of Malaysian Mengkudu using various solvent extracts. International Medical Journal 2014; 21(3): - . 39) Chenni A, Yahia DA, Boukortt FO, et al. Effect of aqueous extract of Ajuga iva supple-mentation on plasma lipid profile and tissue antioxidant status in rats fed a high-cho-lesterol diet. J Ethnopharmacol 2007; 109: 207-13. 40) Feldstein A et al. In vivo renal vascular and tubular function in experimental hypercho-lesterolemia. Hypertension 1999; 34: 859-64. 41) Scheuer H, Gwinner W, Hohbach, et al. (2000). Oxidant stress in hyperlipidemia-in-duced renal damage. Am J Physiol Renal Physiol 278: F63-F74. 42) Yadav YC, Srivastava DN. Nephroprotective and curative effects of Ficus religiosa latex extract against cisplatin-induced acute renal failure. Pharmaceutical Biol 2013; 51: 1480-5. 43) Akpolat M, Kanter M, Topcu-Tarladacalisir Y, et al. Protective effect of flaxseed oil on renal injury in hyperlipidaemic rats, the effect of flaxseed oil on hyperlipidaemia. Phytother Res 2011; 25: 796-802. 44) Stulak JM, Lerman A, Caccitolo, et al. Impaired renal vascular endothelial function in vitro in experimental hypercholesterolemia. Atherosclerosis 2001; 154: 195-201. 45) Plotnikov EY, Chupyrkina AA, Pevzner IB, et al. Myoglobin causes oxidative stress, increase of NO production and dysfunction of kidney's mitochondria. Biochimica et Biophysica Acta 2009; 1792: 796-803. 46) Sandovici M, Henning RH, Hut RA, et al. Differential regulation of glomerular and interstitial endothelial nitric oxide synthase expression in the kidney of hibernating ground squirrel. Nitric Oxi 2004; 11: 194-200. 47) Tain YL, Muller V, Szabo AJ, et al. Renal cortex neuronal nitric oxide synthase in response to rapamycin in kidney transplantation. Nitric Oxi 2008; 18: 80-6. 48) Bhatia S, Shukla R, Venkata-Madhu S, et al. Antioxidant status, lipid peroxidation and nitric oxide end products in patients of type 2 diabetes mellitus with nephropathy. Clin Biochem 2003; 36: 557-62. 49) Feldstein A, et al. In vivo renal vascular and tubular function in experimental hyper-cholesterolemia. Hypertension 1999; 34: 859-64. 50) Amin KA, Kamel HH, Abd Eltawab MA. Protective effect of Garcinia against renal oxidative stress and biomarkers induced by high fat and sucrose diet. Lipids Health Dis 2011; 10: 6-19. 51) Li H, Forstermann U. Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease. Curr Opinion Pharmacol 2013; 13, 161-7. 52) Wessells H, Teal TH, Luttrell IP, et al. Effect of endothelial cell-based iNOS gene transfer on cavernosal eNOS expression and mouse erectile responses, Int J Imp Res 2006; 18, 438-45. 53) Ricardo SD, Van Goor H, Diamond JR. Hypercholesterolemia and progressive kidney disease, the role of macrophages and macrophage-derived products. Contrib Nephrol 1997; 120: 197-209. 54) Ishiyama A, Atarashi K, Minami M, et al. Role of free radicals in the pathogenesis of lipid-induced glomerulosclerosis in rats. Kidney Int 1999; 55: 1348-58 |
| spellingShingle | Modulatory influence of Avocado on renal oxido - Lipidemic stress and mRNA expression of NOS in renal artery studied in nephropathy induced rats |
| summary | Objective: The present study was designed to assess the beneficial effects of alcoholic (ethanol) extract of fruit of Avocado (AEFA) on biochemical, histological, and gene expression study in hypercholesterolemic diet fed nephropathy induced albino rats. Experimental design: Avocado fruit pulp was extracted with 90% ethanol, finally filtered and dried. Group-I rats as control, Group-II fed with hypercholesterolemic diet (HCD) for 45 days [4% cholesterol and 1% cholic acid], Group-III fed with HCD for 45 days + AEFA (300 mg/kg body weight/day orally) for last 30 days and Group-IV fed with AEFA alone. Collection of blood and excision of kidney were done for various biochemical and histological analysis. Result: The levels of total cholesterol (TC), triacylglycerol (TG), phospholipids (PLs), renal markers (serum urea, creatinine and uric acid) and renal lipid peroxidation (LPO) products were markedly mitigated in AEFA treated hypercholesterolemic rats. FRSA factors were significantly increased, on supplementation with AEFA. Administration with AEFA, the mRNA levels of eNOS and iNOS genes was expressively up-regulated and down-regulated. Histomorphological observations shown that, AEFA admirably protects the renal tissues from hypercholesterolemia - mediated oxido-lipidemic damage. Discussion and conclusion: From this study it was conjectured that AEFA can act as nephroprotective agent by attenuating the serum lipid profile, renal oxidative stress, besides regulating the mRNA expression of NOS in renal artery. |
| title | Modulatory influence of Avocado on renal oxido - Lipidemic stress and mRNA expression of NOS in renal artery studied in nephropathy induced rats |
| title_full | Modulatory influence of Avocado on renal oxido - Lipidemic stress and mRNA expression of NOS in renal artery studied in nephropathy induced rats |
| title_fullStr | Modulatory influence of Avocado on renal oxido - Lipidemic stress and mRNA expression of NOS in renal artery studied in nephropathy induced rats |
| title_full_unstemmed | Modulatory influence of Avocado on renal oxido - Lipidemic stress and mRNA expression of NOS in renal artery studied in nephropathy induced rats |
| title_short | Modulatory influence of Avocado on renal oxido - Lipidemic stress and mRNA expression of NOS in renal artery studied in nephropathy induced rats |
| title_sort | modulatory influence of avocado on renal oxido - lipidemic stress and mrna expression of nos in renal artery studied in nephropathy induced rats |