Effect of Tualang (Apis dorsata) honey on development of morphine tolerance in rats
| Format: | Restricted Document |
|---|
| _version_ | 1860797025307590656 |
|---|---|
| building | INTELEK Repository |
| caption | Electronic Journal of Biology |
| collection | Online Access |
| collectionurl | https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 |
| date | 2017-02-21 20:45:48 |
| format | Restricted Document |
| id | 11089 |
| institution | UniSZA |
| originalfilename | 5283-01-FH02-FP-17-08728.pdf |
| person | Nasir Mohamad |
| recordtype | oai_dc |
| resourceurl | https://intelek.unisza.edu.my/intelek/pages/view.php?ref=11089 |
| spelling | 11089 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=11089 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal application/pdf 6 Adobe Acrobat Pro DC 20 Paper Capture Plug-in 1.7 Nasir Mohamad 2017-02-21 20:45:48 xmp.id:16322809-146d-6042-9b6f-9eeb426476c2 Electronic Journal of Biology A. dorsata honey Analgesic effects Morphine tolerance 5283-01-FH02-FP-17-08728.pdf UniSZA Private Access Effect of Tualang (Apis dorsata) honey on development of morphine tolerance in rats Electronic Journal of Biology Background: Morphine tolerance leads to decrease in analgesic effect of the drug, causing a need to increase the dose and eventually increased dependency. Previous studies demonstrated the involvement of morphine tolerance with decrease in antioxidant activities and increased oxidative stress. Honey, a traditional natural remedy possesses analgesic, antioxidant and neuroprotective effect against oxidative stress, suggesting its potential in reducing morphine tolerance. This study aimed to assess the effect of different A. dorsata honey doses on development of morphine tolerance in SpragueDawley rats. Methods: To induce morphine tolerance, rats were subcutaneously injected with 10 mg/kg morphine 30 minutes after A. dorsata honey oral administration (0.5, 1.5 and 2.5 g/kg). Analgesic effects (MPE %) were then assessed via hot plate test and mean difference between groups were analysed using Repeated Measure ANOVA. Findings: Our results showed that dose 0.5, 1.5 and 2.5 g/kg significantly prevented the development of morphine tolerance compared to control group (p<0.05, p<0.001 and p<0.05, respectively). Conclusion: A. dorsata honey can prevent development of morphine tolerance. This property highlights the potential of this honey type in the treatment of opioid tolerance and dependence. 13 1 80-85 |
| spellingShingle | Effect of Tualang (Apis dorsata) honey on development of morphine tolerance in rats |
| subject | A. dorsata honey Analgesic effects Morphine tolerance |
| summary | Background: Morphine tolerance leads to decrease in analgesic effect of the drug, causing a need to increase the dose and eventually increased dependency. Previous studies demonstrated the involvement of morphine tolerance with decrease in antioxidant activities and increased oxidative stress. Honey, a traditional natural remedy possesses analgesic, antioxidant and neuroprotective effect against oxidative stress, suggesting its potential in reducing morphine tolerance. This study aimed to assess the effect of different A. dorsata honey doses on development of morphine tolerance in SpragueDawley rats. Methods: To induce morphine tolerance, rats were subcutaneously injected with 10 mg/kg morphine 30 minutes after A. dorsata honey oral administration (0.5, 1.5 and 2.5 g/kg). Analgesic effects (MPE %) were then assessed via hot plate test and mean difference between groups were analysed using Repeated Measure ANOVA. Findings: Our results showed that dose 0.5, 1.5 and 2.5 g/kg significantly prevented the development of morphine tolerance compared to control group (p<0.05, p<0.001 and p<0.05, respectively). Conclusion: A. dorsata honey can prevent development of morphine tolerance. This property highlights the potential of this honey type in the treatment of opioid tolerance and dependence. |
| title | Effect of Tualang (Apis dorsata) honey on development of morphine tolerance in rats |
| title_full | Effect of Tualang (Apis dorsata) honey on development of morphine tolerance in rats |
| title_fullStr | Effect of Tualang (Apis dorsata) honey on development of morphine tolerance in rats |
| title_full_unstemmed | Effect of Tualang (Apis dorsata) honey on development of morphine tolerance in rats |
| title_short | Effect of Tualang (Apis dorsata) honey on development of morphine tolerance in rats |
| title_sort | effect of tualang (apis dorsata) honey on development of morphine tolerance in rats |