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10621
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Abdullaev FI, Espinosa-Aguirre JJ (2004). Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. CDP 28(6):426-432. Abel EL, Angel JM, Kiguchi K, DiGiovanni J (2009). Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications. Nat. Protoc. 4(9):1350-1362. Ames BN, Shigenaga MK, Hagen TM (1993). Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci., 90(17):7915. Ariffin OZ, Saleha IT Nor (2011). National Cancer Registry Report 2007, Malaysia Cancer Statistics - Data and Figure. Retrieved 15 Nov 2011, from http://www.makna.org.my/PDF/MalaysiaCancerStatistics2007.pdf. Athar M (2002). Oxidative stress and experimental carcinogenesis. Indian J. Exp. Biol. 40(6):656. Azuine MA, Bhide SV (1992). Chemopreventive effect of turmeric against stomach and skin tumors induced by chemical carcinogens in Swiss mice. Nutr. Cancer 17(1):77. Balkwill F, Mantovani A (2001). Inflammation and cancer: back to Virchow? The Lancet, 357(9255):539-545. Barkatullah BB, Ibrar M, Ali N, Muhammad, Rehmanullah. Antispasmodic potential of leaves, barks and fruits of Zanthoxylum armatum DC. Afr. J. Pharm. Pharmacol. 7(13):685-693. Bhattacharya S (2012). Anticarcinogenic property of medicinal plants: involvement of antioxidant role. In: Capasso A (ed.), Medicinal Plants as Antioxidant Agents: Understanding their Mechanism of Action and Therapeutic Efficacy. Research Signpost, Trivandrum. pp. 83-96. Bowden GT, Finch J, Domann F, Krieg P (1995). Molecular mechanisms involved in skin tumor initiation, promotion, and progression. Skin cancer: Mechanisms and human relevance. (pp. 99-111). CRC Press Inc., Boca Raton, FL. Brown JP (1980). A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds. Mutat. Res. 75(3):243. Canivenc-Lavier MC, Vernevaut MF, Totis M, Siess MH, Magdalou J, Suschetet M (1996). Comparative effects of flavonoids and model inducers on drug-metabolizing enzymes in rat liver. Toxicol. 114(1):19-27. Chaudhary G (2011). Inhibition of dimethylebenz (a) anthracene (dmba) or croton oil induced skin tumorigenesis in swiss albino mice by Aloe vera treatment. Int. J. Biol Med. Res. 2(3):671-678. Cibin TR, Devi DG, Abraham A (2010). Chemoprevention of skin cancer by the flavonoid fraction of Saracaasoka. Phytother. Res. 24(5):666- 672. Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A (2009). Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 30(7):1073-1081. Craig WJ (1997). Phytochemicals: Guardians of our Health. J. Am. Diet Assoc. 97(10):199-204. Cseke LJ, Kirakosyan A, Kaufman PB, Warbe SL, Duke JA, Brielmann HL (2006). Natural products from plants (ed). Taylor & Francis Group, Boca Raton. Das RK, Bhattacharya S (2004). Inhibition of DMBA-croton oil two-stage mouse skin carcinogenesis by diphenylmethyl selenocyanate through modulation of cutaneous oxidative stress and inhibition of nitric oxide production. Asian Pac. J. Cancer Prev. 5(2):151-158. Das RK, Hossain SK, Bhattacharya S (2005). Diphenylmethylselenocyanate inhibits DMBA–croton oil induced two-stage mouse skin carcinogenesis by inducing apoptosis and inhibiting cutaneous cell proliferation. Cancer Lett. 230(1):90-101. Girit IC, Jure-Kunkel M, McIntyre KW (2008). A structured light-based system for scanning subcutaneous tumors in laboratory animals. Compl. Med. 58(3):264. Greenwald P, Mcdonald S (2002). Carcinogenesis. In: Encyclopedia of Public Health. Macmillan Reference, New York, USA. 1:153-154. Huang MT, Ho CT, Wang ZY, Ferraro T, Finnegan-Olive T, Lou YR, Mitchell JM, Laskin JD, Newmark H, Yang CS (1992). Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin. Carcinogenesis 13(6):947-954. Huang MT, Ma W, Yen P, Xie JG, Han J, Frenkel K, Grunberger D, Conney AH (1997). Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis. Carcinogenesis 18(1):83-88. Itzkowitz SH, Yio X (2004). Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am. J. Physiol. Gastrointest. Liver Physiol. 287(1):G7-G17. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011). Global cancer statistics. Cancer J. Clin. 61(2):69-90. Kellen JA (1999). Chemoprevention of cancer: an ongoing saga. In vivo 13(5):423. Kelloff JG, Crowell AJ, Steele EV, Lubet AR, Malone AW, Boone WC, Kopelovich L, Hawk TE, Lieberman R, Lawrence AJ (2000). Symposium: Diet, natural products and cancer prevention: Progress and promise. Progress in cancer chemoprevention: Development of diet derived chemopreventive agents. J. Nutr. 130:467-471. Kundu JK, Surh YJ (2008). Inflammation: gearing the journey to cancer. Mutat. Res. Rev. Mutat. 659(1-2):15-30. Lamson D.W., Brignall M.S. (2001). Natural agents in the prevention of cancer, part two: preclinical data and chemoprevention for common cancers. Altern. Med. Rev. 6(2):167-187. Limtrakul P, Lipigorngoson S, Namwong O, Apisariyakul A, Dunn FW (1997). Inhibitory effect of dietary curcumin on skin carcinogenesis in mice. Cancer Lett. 116(2):197-203 Lippman SM, Lee JJ, Sabichi AL (1998). Cancer chemoprevention: progress and promise. J. Natl. Cancer Inst. 90(20):1514-1528. Nair SC, Kurumboor SK, Hasegawa JH. (1995). Saffron chemoprevention in biology and medicine: a review. Cancer Biother. 10(4):257-264. Naithani R, Huma LC, Moriarty RM, McCormick DL, Mehta RG (2008). Comprehensive review of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trials. Curr. Med. Chem. 15(11):1044-71. Nijveldt RJ, van Nood E, van Hoorn DEC, Boelens PG, van Norren K, van Leeuwen PAM (2001). Flavonoids: a review of probable mechanisms of action and potential applications. Am. J. Clin. Nutr. 74(4):418-25. Nishino H, Murakoshi M, Mou XY, Wada S, Masuda M, Ohsaka Y, Satomi Y, Jinno K (2005). Cancer prevention by phytochemicals. Oncology 69(1):38-40. O'Byrne KJ, Dalgleish AG (2001). Chronic immune activation and inflammation as the cause of malignancy. Br. J. Cancer. 85(4):473. Park KK, Chun KS, Lee JM, Lee SS, Surh YJ (1998). Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Cancer lett. 129(2):139-144. Perwez Hussain S, Harris CC (2007). Inflammation and cancer: an ancient link with novel potentials. Int. J. Cancer. 121 (11):2373-2380. Porta C, Larghi P, Rimoldi M, GraziaTotaro M, Allavena P, Mantovani A, Sica A (2009). Cellular and molecular pathways linking inflammation and cancer. Immunobiology 214(9):761-777. Rao AV, Sung MK (1995). Saponins as Anticarcinogens. J. Nutr. 0022- 3166/95 Ray G, Husain SA (2002). Oxidants, antioxidants and carcinogenesis. Indian J. Exp. Biol. 40(11):1213. Ren W, Qiao Z, Wang H, Zhu L, Zhang L (2003). Flavonoids: Promising Anticancer Agents. Med. Res. Rev. 23(4):519-534. Roslida A, Fezah O, Yeong LT (2011). Suppression of DMBA/croton oil-induced mouse skin tumor promotion by Ardisia crispa root hexane extract. Asian Pac. J. Cancer Prev. APJCP12(3):665. Selim SA, Abdel Aziz MH, Mashait MS, Warrad MF (2013). Antibacterial activities, chemical constitutes and acute toxicity of Egyptian Origanum majorana L., Peganum harmala L. and Salvia officinalis L. essential oils. Afr. J. Pharm. Pharmacol. 7(13):725-735. Sharma P, Parmar J, Verma P, Goyal PK (2009). Anti-tumor activity of Phyllanthusniruri (a medicinal plant) on chemical-induced skin carcinogenesis in mice. Asian Pac. J. Cancer Prev. 10:1089-94. Sharma S, Khan N, Sultana S (2004). Effect of Onosmaechioides on DMBA/croton oil mediated carcinogenic response, hyperproliferation and oxidative damage in murine skin. Life Sci. 75(20):2391-2410. Shih H, Pickwell GV, Quattrochi LC (2000). Differential effects of flavonoid compounds on tumor promoter-induced activation of the human CYP1A2 enhancer. Arch. Biochem. Biophys. 373(1):287-294. Siegel R, Ward E, Brawley O, Jemal A (2011). Cancer statistics, 2011. CA Cancer J. Clin. 61(4):212-36. Sporn MB (1976). Approaches to prevention of epithelial cancer during the preneoplastic period. Can. Res. 36(7 Part 2):2699-702. Steenkamp V, Nkwane O, van Tonder J, Dinsmore A, Gulumian M (2013). Evaluation of the phenolic and flavonoid contents and radical scavenging activity of three southern African medicinal plants. Afr. J. Pharm. Pharmacol. 7(13):703-709. Uto T, Sakamoto A, Tung NH, T Fujiki T, Kishihara K, Oiso S, Kariyazono H, Morinaga O, Shoyama Y (2013). Anti-Proliferative Activities and Apoptosis Induction by Triterpenes Derived from Eriobotrya japonica in Human Leukemia Cell Lines. Int. J. Mol. Sci.14:4106-4120. Wu X, Pandolfi PP (2001). Mouse models for multistep tumorigenesis. Trends Cell Biol. 11(11):S2-9. Yang CS, Lambert JD, Sang S (2009). Antioxidative and anti-carcinogenic activities of tea polyphenols. Arch. Toxicol. 83:11-21. Yang CS, Landau JM, Huang MT, Newmark HL (2001). Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu. Rev. Nutr. 21(1):381-406. Yuspa SH (1994). The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis—thirty-third GHA Clowes Memorial Award Lecture. Can. Res. 54(5):1178. Zakaria ZA, Ghani Z, Nor R, Gopalan HK, Sulaiman MR, Abdullah FC (2006). Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals. J. Pharm. Soc. Japan. 126(11):1197-203. Zakaria ZA, Ghani ZDF, Nor R, Gopalan HK, Sulaiman MR, Mat Jais AM, Somchit MN, Kader AA, Ripin J (2008). Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models. J. Nat. Med. 62(2):179-87.
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4675-01-FH02-FBIM-16-06789.pdf
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Enwefah
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oai_dc
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https://intelek.unisza.edu.my/intelek/pages/view.php?ref=10621
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10621 https://intelek.unisza.edu.my/intelek/pages/view.php?ref=10621 https://intelek.unisza.edu.my/intelek/pages/search.php?search=!collection407072 Restricted Document Article Journal application/pdf 15 1.6 Adobe Acrobat Pro DC 20 Paper Capture Plug-in Enwefah 2013-10-02 16:11:23 4675-01-FH02-FBIM-16-06789.pdf UniSZA Private Access Chemopreventive potential of methanol extract of Dicranopteris linearis leaf on DMBA/croton oil-induced mouse skin carcinogenesis African Journal of Pharmacy and Pharmacology The present study was carried out to elucidate the chemopreventive potential of methanol extract of Dicranopteris linearis (MEDL) in a two-stage mouse skin carcinogenesis model due to the interrelated inflammation, oxidative stress and tumor promotion pathways. MEDL was prepared in a dose range of 30 to 300 mg/kg body weight. A total of 48 imprinting control region (ICR) female mice (6 to 8 weeks old) were randomly assorted into six groups. To induce skin tumor formation, a single topical application of 7,12-dimethylbenz[a]anthracene (DMBA) at 100 μg/100 μl was applied to the shaved dorsal region of mice, followed by repetitive administration of 1% croton oil, twice weekly for 15 weeks. Topical application of MEDL, 30 min prior to the croton oil application significantly reduced the tumor incidence to 12.5% in 300 mg/kg MEDL-treated group as compared to 87.5% in carcinogen control. The latency period of tumor formation was increased from sixth week in the carcinogen control to ninth and fifteenth weeks in 100 and 300 mg/kg MEDL-treated groups, respectively. The tumor burden of MEDL-treated groups (30, 100, and 300 mg/kg) were significantly lessen (5.67 ± 1.28, 5.00 ± 1.13, and 1.00 ± 0.13), as compared to carcinogen control (7.86 ± 2.37). The tumor volume was also significantly reduced from 9.00 ± 2.27 mm3 in carcinogen control to 3.70 ± 0.96, 2.39 ± 0.54 and 0.26 ± 0.03 mm3 in 30, 100 and 300 mg/kg MEDL-treated groups, respectively. In conclusion, the MEDL exhibited anti-carcinogenic effect in a dose-dependent manner, indicating its chemopreventive potential, which worth further study. 7 35 2484-2498 Abdullaev FI, Espinosa-Aguirre JJ (2004). Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. CDP 28(6):426-432. Abel EL, Angel JM, Kiguchi K, DiGiovanni J (2009). Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications. Nat. Protoc. 4(9):1350-1362. Ames BN, Shigenaga MK, Hagen TM (1993). Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci., 90(17):7915. Ariffin OZ, Saleha IT Nor (2011). National Cancer Registry Report 2007, Malaysia Cancer Statistics - Data and Figure. Retrieved 15 Nov 2011, from http://www.makna.org.my/PDF/MalaysiaCancerStatistics2007.pdf. Athar M (2002). Oxidative stress and experimental carcinogenesis. Indian J. Exp. Biol. 40(6):656. Azuine MA, Bhide SV (1992). Chemopreventive effect of turmeric against stomach and skin tumors induced by chemical carcinogens in Swiss mice. Nutr. Cancer 17(1):77. Balkwill F, Mantovani A (2001). Inflammation and cancer: back to Virchow? The Lancet, 357(9255):539-545. Barkatullah BB, Ibrar M, Ali N, Muhammad, Rehmanullah. Antispasmodic potential of leaves, barks and fruits of Zanthoxylum armatum DC. Afr. J. Pharm. Pharmacol. 7(13):685-693. Bhattacharya S (2012). Anticarcinogenic property of medicinal plants: involvement of antioxidant role. In: Capasso A (ed.), Medicinal Plants as Antioxidant Agents: Understanding their Mechanism of Action and Therapeutic Efficacy. Research Signpost, Trivandrum. pp. 83-96. Bowden GT, Finch J, Domann F, Krieg P (1995). Molecular mechanisms involved in skin tumor initiation, promotion, and progression. Skin cancer: Mechanisms and human relevance. (pp. 99-111). CRC Press Inc., Boca Raton, FL. Brown JP (1980). A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds. Mutat. Res. 75(3):243. Canivenc-Lavier MC, Vernevaut MF, Totis M, Siess MH, Magdalou J, Suschetet M (1996). Comparative effects of flavonoids and model inducers on drug-metabolizing enzymes in rat liver. Toxicol. 114(1):19-27. Chaudhary G (2011). Inhibition of dimethylebenz (a) anthracene (dmba) or croton oil induced skin tumorigenesis in swiss albino mice by Aloe vera treatment. Int. J. Biol Med. Res. 2(3):671-678. Cibin TR, Devi DG, Abraham A (2010). Chemoprevention of skin cancer by the flavonoid fraction of Saracaasoka. Phytother. Res. 24(5):666- 672. Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A (2009). Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 30(7):1073-1081. Craig WJ (1997). Phytochemicals: Guardians of our Health. J. Am. Diet Assoc. 97(10):199-204. Cseke LJ, Kirakosyan A, Kaufman PB, Warbe SL, Duke JA, Brielmann HL (2006). Natural products from plants (ed). Taylor & Francis Group, Boca Raton. Das RK, Bhattacharya S (2004). Inhibition of DMBA-croton oil two-stage mouse skin carcinogenesis by diphenylmethyl selenocyanate through modulation of cutaneous oxidative stress and inhibition of nitric oxide production. Asian Pac. J. Cancer Prev. 5(2):151-158. Das RK, Hossain SK, Bhattacharya S (2005). Diphenylmethylselenocyanate inhibits DMBA–croton oil induced two-stage mouse skin carcinogenesis by inducing apoptosis and inhibiting cutaneous cell proliferation. Cancer Lett. 230(1):90-101. Girit IC, Jure-Kunkel M, McIntyre KW (2008). A structured light-based system for scanning subcutaneous tumors in laboratory animals. Compl. Med. 58(3):264. Greenwald P, Mcdonald S (2002). Carcinogenesis. In: Encyclopedia of Public Health. Macmillan Reference, New York, USA. 1:153-154. Huang MT, Ho CT, Wang ZY, Ferraro T, Finnegan-Olive T, Lou YR, Mitchell JM, Laskin JD, Newmark H, Yang CS (1992). Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin. Carcinogenesis 13(6):947-954. Huang MT, Ma W, Yen P, Xie JG, Han J, Frenkel K, Grunberger D, Conney AH (1997). Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis. Carcinogenesis 18(1):83-88. Itzkowitz SH, Yio X (2004). Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am. J. Physiol. Gastrointest. Liver Physiol. 287(1):G7-G17. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011). Global cancer statistics. Cancer J. Clin. 61(2):69-90. Kellen JA (1999). Chemoprevention of cancer: an ongoing saga. In vivo 13(5):423. Kelloff JG, Crowell AJ, Steele EV, Lubet AR, Malone AW, Boone WC, Kopelovich L, Hawk TE, Lieberman R, Lawrence AJ (2000). Symposium: Diet, natural products and cancer prevention: Progress and promise. Progress in cancer chemoprevention: Development of diet derived chemopreventive agents. J. Nutr. 130:467-471. Kundu JK, Surh YJ (2008). Inflammation: gearing the journey to cancer. Mutat. Res. Rev. Mutat. 659(1-2):15-30. Lamson D.W., Brignall M.S. (2001). Natural agents in the prevention of cancer, part two: preclinical data and chemoprevention for common cancers. Altern. Med. Rev. 6(2):167-187. Limtrakul P, Lipigorngoson S, Namwong O, Apisariyakul A, Dunn FW (1997). Inhibitory effect of dietary curcumin on skin carcinogenesis in mice. Cancer Lett. 116(2):197-203 Lippman SM, Lee JJ, Sabichi AL (1998). Cancer chemoprevention: progress and promise. J. Natl. Cancer Inst. 90(20):1514-1528. Nair SC, Kurumboor SK, Hasegawa JH. (1995). Saffron chemoprevention in biology and medicine: a review. Cancer Biother. 10(4):257-264. Naithani R, Huma LC, Moriarty RM, McCormick DL, Mehta RG (2008). Comprehensive review of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trials. Curr. Med. Chem. 15(11):1044-71. Nijveldt RJ, van Nood E, van Hoorn DEC, Boelens PG, van Norren K, van Leeuwen PAM (2001). Flavonoids: a review of probable mechanisms of action and potential applications. Am. J. Clin. Nutr. 74(4):418-25. Nishino H, Murakoshi M, Mou XY, Wada S, Masuda M, Ohsaka Y, Satomi Y, Jinno K (2005). Cancer prevention by phytochemicals. Oncology 69(1):38-40. O'Byrne KJ, Dalgleish AG (2001). Chronic immune activation and inflammation as the cause of malignancy. Br. J. Cancer. 85(4):473. Park KK, Chun KS, Lee JM, Lee SS, Surh YJ (1998). Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Cancer lett. 129(2):139-144. Perwez Hussain S, Harris CC (2007). Inflammation and cancer: an ancient link with novel potentials. Int. J. Cancer. 121 (11):2373-2380. Porta C, Larghi P, Rimoldi M, GraziaTotaro M, Allavena P, Mantovani A, Sica A (2009). Cellular and molecular pathways linking inflammation and cancer. Immunobiology 214(9):761-777. Rao AV, Sung MK (1995). Saponins as Anticarcinogens. J. Nutr. 0022- 3166/95 Ray G, Husain SA (2002). Oxidants, antioxidants and carcinogenesis. Indian J. Exp. Biol. 40(11):1213. Ren W, Qiao Z, Wang H, Zhu L, Zhang L (2003). Flavonoids: Promising Anticancer Agents. Med. Res. Rev. 23(4):519-534. Roslida A, Fezah O, Yeong LT (2011). Suppression of DMBA/croton oil-induced mouse skin tumor promotion by Ardisia crispa root hexane extract. Asian Pac. J. Cancer Prev. APJCP12(3):665. Selim SA, Abdel Aziz MH, Mashait MS, Warrad MF (2013). Antibacterial activities, chemical constitutes and acute toxicity of Egyptian Origanum majorana L., Peganum harmala L. and Salvia officinalis L. essential oils. Afr. J. Pharm. Pharmacol. 7(13):725-735. Sharma P, Parmar J, Verma P, Goyal PK (2009). Anti-tumor activity of Phyllanthusniruri (a medicinal plant) on chemical-induced skin carcinogenesis in mice. Asian Pac. J. Cancer Prev. 10:1089-94. Sharma S, Khan N, Sultana S (2004). Effect of Onosmaechioides on DMBA/croton oil mediated carcinogenic response, hyperproliferation and oxidative damage in murine skin. Life Sci. 75(20):2391-2410. Shih H, Pickwell GV, Quattrochi LC (2000). Differential effects of flavonoid compounds on tumor promoter-induced activation of the human CYP1A2 enhancer. Arch. Biochem. Biophys. 373(1):287-294. Siegel R, Ward E, Brawley O, Jemal A (2011). Cancer statistics, 2011. CA Cancer J. Clin. 61(4):212-36. Sporn MB (1976). Approaches to prevention of epithelial cancer during the preneoplastic period. Can. Res. 36(7 Part 2):2699-702. Steenkamp V, Nkwane O, van Tonder J, Dinsmore A, Gulumian M (2013). Evaluation of the phenolic and flavonoid contents and radical scavenging activity of three southern African medicinal plants. Afr. J. Pharm. Pharmacol. 7(13):703-709. Uto T, Sakamoto A, Tung NH, T Fujiki T, Kishihara K, Oiso S, Kariyazono H, Morinaga O, Shoyama Y (2013). Anti-Proliferative Activities and Apoptosis Induction by Triterpenes Derived from Eriobotrya japonica in Human Leukemia Cell Lines. Int. J. Mol. Sci.14:4106-4120. Wu X, Pandolfi PP (2001). Mouse models for multistep tumorigenesis. Trends Cell Biol. 11(11):S2-9. Yang CS, Lambert JD, Sang S (2009). Antioxidative and anti-carcinogenic activities of tea polyphenols. Arch. Toxicol. 83:11-21. Yang CS, Landau JM, Huang MT, Newmark HL (2001). Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu. Rev. Nutr. 21(1):381-406. Yuspa SH (1994). The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis—thirty-third GHA Clowes Memorial Award Lecture. Can. Res. 54(5):1178. Zakaria ZA, Ghani Z, Nor R, Gopalan HK, Sulaiman MR, Abdullah FC (2006). Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals. J. Pharm. Soc. Japan. 126(11):1197-203. Zakaria ZA, Ghani ZDF, Nor R, Gopalan HK, Sulaiman MR, Mat Jais AM, Somchit MN, Kader AA, Ripin J (2008). Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models. J. Nat. Med. 62(2):179-87.
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| spellingShingle |
Chemopreventive potential of methanol extract of Dicranopteris linearis leaf on DMBA/croton oil-induced mouse skin carcinogenesis
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| summary |
The present study was carried out to elucidate the chemopreventive potential of methanol extract of Dicranopteris linearis (MEDL) in a two-stage mouse skin carcinogenesis model due to the interrelated inflammation, oxidative stress and tumor promotion pathways. MEDL was prepared in a dose range of 30 to 300 mg/kg body weight. A total of 48 imprinting control region (ICR) female mice (6 to 8 weeks old) were randomly assorted into six groups. To induce skin tumor formation, a single topical application of 7,12-dimethylbenz[a]anthracene (DMBA) at 100 μg/100 μl was applied to the shaved dorsal region of mice, followed by repetitive administration of 1% croton oil, twice weekly for 15 weeks. Topical application of MEDL, 30 min prior to the croton oil application significantly reduced the tumor incidence to 12.5% in 300 mg/kg MEDL-treated group as compared to 87.5% in carcinogen control. The latency period of tumor formation was increased from sixth week in the carcinogen control to ninth and fifteenth weeks in 100 and 300 mg/kg MEDL-treated groups, respectively. The tumor burden of MEDL-treated groups (30, 100, and 300 mg/kg) were significantly lessen (5.67 ± 1.28, 5.00 ± 1.13, and 1.00 ± 0.13), as compared to carcinogen control (7.86 ± 2.37). The tumor volume was also significantly reduced from 9.00 ± 2.27 mm3 in carcinogen control to 3.70 ± 0.96, 2.39 ± 0.54 and 0.26 ± 0.03 mm3 in 30, 100 and 300 mg/kg MEDL-treated groups, respectively. In conclusion, the MEDL exhibited anti-carcinogenic effect in a dose-dependent manner, indicating its chemopreventive potential, which worth further study.
|
| title |
Chemopreventive potential of methanol extract of Dicranopteris linearis leaf on DMBA/croton oil-induced mouse skin carcinogenesis
|
| title_full |
Chemopreventive potential of methanol extract of Dicranopteris linearis leaf on DMBA/croton oil-induced mouse skin carcinogenesis
|
| title_fullStr |
Chemopreventive potential of methanol extract of Dicranopteris linearis leaf on DMBA/croton oil-induced mouse skin carcinogenesis
|
| title_full_unstemmed |
Chemopreventive potential of methanol extract of Dicranopteris linearis leaf on DMBA/croton oil-induced mouse skin carcinogenesis
|
| title_short |
Chemopreventive potential of methanol extract of Dicranopteris linearis leaf on DMBA/croton oil-induced mouse skin carcinogenesis
|
| title_sort |
chemopreventive potential of methanol extract of dicranopteris linearis leaf on dmba/croton oil-induced mouse skin carcinogenesis
|