Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude

Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude

Zebrafish larvae (Danio rerio) are increasingly used to translate findings regarding drug efficacy and safety from in vitro-based assays to vertebrate species, including humans. However, the limited understanding of drug exposure in this species hampers its implementation in translational research....

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Bibliographic Details
Main Authors: Kantae, Vasudev, Krekels, Elke H.J., Ordas, Anita, González, Oskar, van Wijk, Rob C., Harms, Amy C., Racz, Peter I., van der Graaf, Piet H., Spaink, Herman P., Hankemeier, Thomas
Format: Online
Language:English
Published: Mary Ann Liebert, Inc. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124745/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124745/

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