Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation

Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation

Purpose. To investigate the effect of EPO administration on postresuscitation renal function. Methods. Twenty-four female Landrace/Large-White piglets aged 10–15 weeks with average weight of 19 ± 2 kg were randomly assigned to 2 different groups of 12 subjects each. After the end of an 8-minute ven...

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Main Authors: Pantazopoulos, Charalampos, Iacovidou, Nicoletta, Kouskouni, Evangelia, Pliatsika, Paraskevi, Papalois, Apostolos, Kaparos, Georgios, Barouxis, Dimitrios, Vasileiou, Panagiotis, Lelovas, Pavlos, Kotsilianou, Olympia, Pantazopoulos, Ioannis, Gkiokas, Georgios, Garosa, Clara, Faa, Gavino, Xanthos, Theodoros
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099488/
id pubmed-5099488
recordtype oai_dc
spelling pubmed-50994882016-11-15 Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation Pantazopoulos, Charalampos Iacovidou, Nicoletta Kouskouni, Evangelia Pliatsika, Paraskevi Papalois, Apostolos Kaparos, Georgios Barouxis, Dimitrios Vasileiou, Panagiotis Lelovas, Pavlos Kotsilianou, Olympia Pantazopoulos, Ioannis Gkiokas, Georgios Garosa, Clara Faa, Gavino Xanthos, Theodoros Research Article Purpose. To investigate the effect of EPO administration on postresuscitation renal function. Methods. Twenty-four female Landrace/Large-White piglets aged 10–15 weeks with average weight of 19 ± 2 kg were randomly assigned to 2 different groups of 12 subjects each. After the end of an 8-minute ventricular fibrillation, the control group (Group C) received saline as placebo, whereas the EPO group (Group E) received EPO 5000 U/kg. The animals were resuscitated according to the 2010 European Resuscitation Council Guidelines for Resuscitation. Results. Five animals (41.67%) from Group C and 11 animals (91.67%) from Group E achieved ROSC (p = 0.027). Eight animals (66.67%, 5 surviving and 3 nonsurviving) from Group C suffered severe kidney damage or AKI compared to animals from Group E, in which none of the swine had evidence of severe kidney damage or AKI (p = 0.001). There was a statistically significant difference in all tested biochemical markers between the two groups, as well as a positive correlation of creatinine with NGAL, L-FABP, and IL-18 (summed mean values' p = 0.049, 0.01, and 0.004, resp.). Conclusions. Administration of EPO protected swine from postresuscitation acute kidney injury. Hindawi Publishing Corporation 2016 2016-10-25 /pmc/articles/PMC5099488/ /pubmed/27847811 http://dx.doi.org/10.1155/2016/3567275 Text en Copyright © 2016 Charalampos Pantazopoulos et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Pantazopoulos, Charalampos
Iacovidou, Nicoletta
Kouskouni, Evangelia
Pliatsika, Paraskevi
Papalois, Apostolos
Kaparos, Georgios
Barouxis, Dimitrios
Vasileiou, Panagiotis
Lelovas, Pavlos
Kotsilianou, Olympia
Pantazopoulos, Ioannis
Gkiokas, Georgios
Garosa, Clara
Faa, Gavino
Xanthos, Theodoros
spellingShingle Pantazopoulos, Charalampos
Iacovidou, Nicoletta
Kouskouni, Evangelia
Pliatsika, Paraskevi
Papalois, Apostolos
Kaparos, Georgios
Barouxis, Dimitrios
Vasileiou, Panagiotis
Lelovas, Pavlos
Kotsilianou, Olympia
Pantazopoulos, Ioannis
Gkiokas, Georgios
Garosa, Clara
Faa, Gavino
Xanthos, Theodoros
Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation
author_facet Pantazopoulos, Charalampos
Iacovidou, Nicoletta
Kouskouni, Evangelia
Pliatsika, Paraskevi
Papalois, Apostolos
Kaparos, Georgios
Barouxis, Dimitrios
Vasileiou, Panagiotis
Lelovas, Pavlos
Kotsilianou, Olympia
Pantazopoulos, Ioannis
Gkiokas, Georgios
Garosa, Clara
Faa, Gavino
Xanthos, Theodoros
author_sort Pantazopoulos, Charalampos
title Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation
title_short Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation
title_full Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation
title_fullStr Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation
title_full_unstemmed Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation
title_sort effect of erythropoietin on postresuscitation renal function in a swine model of ventricular fibrillation
description Purpose. To investigate the effect of EPO administration on postresuscitation renal function. Methods. Twenty-four female Landrace/Large-White piglets aged 10–15 weeks with average weight of 19 ± 2 kg were randomly assigned to 2 different groups of 12 subjects each. After the end of an 8-minute ventricular fibrillation, the control group (Group C) received saline as placebo, whereas the EPO group (Group E) received EPO 5000 U/kg. The animals were resuscitated according to the 2010 European Resuscitation Council Guidelines for Resuscitation. Results. Five animals (41.67%) from Group C and 11 animals (91.67%) from Group E achieved ROSC (p = 0.027). Eight animals (66.67%, 5 surviving and 3 nonsurviving) from Group C suffered severe kidney damage or AKI compared to animals from Group E, in which none of the swine had evidence of severe kidney damage or AKI (p = 0.001). There was a statistically significant difference in all tested biochemical markers between the two groups, as well as a positive correlation of creatinine with NGAL, L-FABP, and IL-18 (summed mean values' p = 0.049, 0.01, and 0.004, resp.). Conclusions. Administration of EPO protected swine from postresuscitation acute kidney injury.
publisher Hindawi Publishing Corporation
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099488/
_version_ 1613717089587036160

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