An optimized single chain TCR scaffold relying on the assembly with the native CD3-complex prevents residual mispairing with endogenous TCRs in human T-cells

An optimized single chain TCR scaffold relying on the assembly with the native CD3-complex prevents residual mispairing with endogenous TCRs in human T-cells

Immunotherapy of cancer envisions the adoptive transfer of T-cells genetically engineered with tumor-specific heterodimeric α/β T-cell receptors (TCRα/β). However, potential mispairing of introduced TCRα/β-chains with endogenous β/α-ones may evoke unpredictable autoimmune reactivities. A novel singl...

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Bibliographic Details
Main Authors: Knies, Diana, Klobuch, Sebastian, Xue, Shao-An, Birtel, Matthias, Echchannaoui, Hakim, Yildiz, Oezlem, Omokoko, Tana, Guillaume, Philippe, Romero, Pedro, Stauss, Hans, Sahin, Ugur, Herr, Wolfgang, Theobald, Matthias, Thomas, Simone, Voss, Ralf-Holger
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008279/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008279/

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