Etiologic Framework for the Study of Neurodegenerative Disorders as Well as Vascular and Metabolic Comorbidities on the Grounds of Shared Epidemiologic and Biologic Features

Background: During the last two decades, protein aggregation at all organismal levels, from viruses to humans, has emerged from a neglected area of protein science to become a central issue in biology and biomedicine. This article constitutes a risk-based review aimed at supporting an etiologic scen...

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Main Authors: de Pedro-Cuesta, Jesús, Martínez-Martín, Pablo, Rábano, Alberto, Ruiz-Tovar, María, Alcalde-Cabero, Enrique, Calero, Miguel
Format: Online
Language:English
Published: Frontiers Media S.A. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904010/
id pubmed-4904010
recordtype oai_dc
spelling pubmed-49040102016-07-04 Etiologic Framework for the Study of Neurodegenerative Disorders as Well as Vascular and Metabolic Comorbidities on the Grounds of Shared Epidemiologic and Biologic Features de Pedro-Cuesta, Jesús Martínez-Martín, Pablo Rábano, Alberto Ruiz-Tovar, María Alcalde-Cabero, Enrique Calero, Miguel Neuroscience Background: During the last two decades, protein aggregation at all organismal levels, from viruses to humans, has emerged from a neglected area of protein science to become a central issue in biology and biomedicine. This article constitutes a risk-based review aimed at supporting an etiologic scenario of selected, sporadic, protein-associated, i.e., conformational, neurodegenerative disorders (NDDs), and their vascular- and metabolic-associated ailments. Frontiers Media S.A. 2016-06-13 /pmc/articles/PMC4904010/ /pubmed/27378910 http://dx.doi.org/10.3389/fnagi.2016.00138 Text en Copyright © 2016 de Pedro-Cuesta, Martínez-Mart’in, Rábano, Ruiz-Tovar, Alcalde-Cabero and Calero. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author de Pedro-Cuesta, Jesús
Martínez-Martín, Pablo
Rábano, Alberto
Ruiz-Tovar, María
Alcalde-Cabero, Enrique
Calero, Miguel
spellingShingle de Pedro-Cuesta, Jesús
Martínez-Martín, Pablo
Rábano, Alberto
Ruiz-Tovar, María
Alcalde-Cabero, Enrique
Calero, Miguel
Etiologic Framework for the Study of Neurodegenerative Disorders as Well as Vascular and Metabolic Comorbidities on the Grounds of Shared Epidemiologic and Biologic Features
author_facet de Pedro-Cuesta, Jesús
Martínez-Martín, Pablo
Rábano, Alberto
Ruiz-Tovar, María
Alcalde-Cabero, Enrique
Calero, Miguel
author_sort de Pedro-Cuesta, Jesús
title Etiologic Framework for the Study of Neurodegenerative Disorders as Well as Vascular and Metabolic Comorbidities on the Grounds of Shared Epidemiologic and Biologic Features
title_short Etiologic Framework for the Study of Neurodegenerative Disorders as Well as Vascular and Metabolic Comorbidities on the Grounds of Shared Epidemiologic and Biologic Features
title_full Etiologic Framework for the Study of Neurodegenerative Disorders as Well as Vascular and Metabolic Comorbidities on the Grounds of Shared Epidemiologic and Biologic Features
title_fullStr Etiologic Framework for the Study of Neurodegenerative Disorders as Well as Vascular and Metabolic Comorbidities on the Grounds of Shared Epidemiologic and Biologic Features
title_full_unstemmed Etiologic Framework for the Study of Neurodegenerative Disorders as Well as Vascular and Metabolic Comorbidities on the Grounds of Shared Epidemiologic and Biologic Features
title_sort etiologic framework for the study of neurodegenerative disorders as well as vascular and metabolic comorbidities on the grounds of shared epidemiologic and biologic features
description Background: During the last two decades, protein aggregation at all organismal levels, from viruses to humans, has emerged from a neglected area of protein science to become a central issue in biology and biomedicine. This article constitutes a risk-based review aimed at supporting an etiologic scenario of selected, sporadic, protein-associated, i.e., conformational, neurodegenerative disorders (NDDs), and their vascular- and metabolic-associated ailments.
publisher Frontiers Media S.A.
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904010/
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