A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative

Blebbistatin is a commonly used molecular tool for the specific inhibition of various myosin II isoforms both in vitro and in vivo. Despite its popularity, the use of blebbistatin is hindered by its poor water-solubility (below 10 micromolar in aqueous buffer) and blue-light sensitivity, resulting i...

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Bibliographic Details
Main Authors: Várkuti, Boglárka H., Képiró, Miklós, Horváth, István Ádám, Végner, László, Ráti, Szilvia, Zsigmond, Áron, Hegyi, György, Lenkei, Zsolt, Varga, Máté, Málnási-Csizmadia, András
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886532/