Distinct Dasatinib-Induced Mechanisms of Apoptotic Response and Exosome Release in Imatinib-Resistant Human Chronic Myeloid Leukemia Cells

Distinct Dasatinib-Induced Mechanisms of Apoptotic Response and Exosome Release in Imatinib-Resistant Human Chronic Myeloid Leukemia Cells

Although dasatinib is effective in most imatinib mesylate (IMT)-resistant chronic myeloid leukemia (CML) patients, the underlying mechanism of its effectiveness in eliminating imatinib-resistant cells is only partially understood. This study investigated the effects of dasatinib on signaling mechani...

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Bibliographic Details
Main Authors: Liu, Juan, Zhang, Yujing, Liu, Aichun, Wang, Jinghua, Li, Lianqiao, Chen, Xi, Gao, Xinyu, Xue, Yanming, Zhang, Xiaomin, Liu, Yao
Format: Online
Language:English
Published: MDPI 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848987/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848987/

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