Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance

Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance

A more complete understanding of the genetic basis of drug resistance in Mycobacterium tuberculosis is critical for prompt diagnosis and optimal treatment, particularly for toxic second-line drugs like D-cycloserine. Here, we used whole-genome sequences from 498 strains of M. tuberculosis to identif...

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Bibliographic Details
Main Authors: Desjardins, Christopher A., Cohen, Keira A., Munsamy, Vanisha, Abeel, Thomas, Maharaj, Kashmeel, Walker, Bruce J., Shea, Terrance P., Almeida, Deepak V., Manson, Abigail L., Salazar, Alex, Padayatchi, Nesri, O’Donnell, Max R., Mlisana, Koleka P., Wortman, Jennifer, Birren, Bruce W., Grosset, Jacques, Earl, Ashlee M., Pym, Alexander S.
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848111/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848111/

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