Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum
Proinsulin folding within the endoplasmic reticulum (ER) remains incompletely understood, but it is clear that in mutant INS gene–induced diabetes of youth (MIDY), progression of the (three) native disulfide bonds of proinsulin becomes derailed, causing insulin deficiency, β-cell ER stress, and onse...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
American Diabetes Association
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806660/ |