Genomic amplification of 9p24.1 targeting JAK2, PD-L1, and PD-L2 is enriched in high-risk triple negative breast cancer

Genomic amplification of 9p24.1 targeting JAK2, PD-L1, and PD-L2 is enriched in high-risk triple negative breast cancer

We used DNA content flow cytometry followed by oligonucleotide array based comparative genomic hybridization to survey the genomes of 326 tumors, including 41 untreated surgically resected triple negative breast cancers (TNBC). A high level (log2ratio ≥1) 9p24 amplicon was found in TNBC (12/41), gli...

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Bibliographic Details
Main Authors: Barrett, Michael T., Anderson, Karen S., Lenkiewicz, Elizabeth, Andreozzi, Mariacarla, Cunliffe, Heather E., Klassen, Christine L., Dueck, Amylou C., McCullough, Ann E., Reddy, Srikanth K., Ramanathan, Ramesh K., Northfelt, Donald W., Pockaj, Barbara A.
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694916/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694916/

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