Bufalin Induces Mitochondria-Dependent Apoptosis in Pancreatic and Oral Cancer Cells by Downregulating hTERT Expression via Activation of the JNK/p38 Pathway

Bufalin Induces Mitochondria-Dependent Apoptosis in Pancreatic and Oral Cancer Cells by Downregulating hTERT Expression via Activation of the JNK/p38 Pathway

Bufalin, a digoxin-like active component of the traditional Chinese medicine Chan Su, exhibits potent antitumor activities in many human cancers. Bufalin induces mitochondria-dependent apoptosis in cancer cells, but the detailed molecular mechanisms are largely unknown. hTERT, the catalytic subunit...

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Bibliographic Details
Main Authors: Tian, Xin, Dai, Shundong, Sun, Jing, Jiang, Shenyi, Sui, Chengguang, Meng, Fandong, Li, Yan, Fu, Liye, Jiang, Tao, Wang, Yang, Su, Jia, Jiang, Youhong
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689913/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689913/

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