Enhancement of Blood–Brain Barrier Permeability and Delivery of Antisense Oligonucleotides or Plasmid DNA to the Brain by the Combination of Bubble Liposomes and High-Intensity Focused Ultrasound

Enhancement of Blood–Brain Barrier Permeability and Delivery of Antisense Oligonucleotides or Plasmid DNA to the Brain by the Combination of Bubble Liposomes and High-Intensity Focused Ultrasound

The blood–brain barrier (BBB) is a major obstacle that prevents therapeutic drugs or genes from being delivered to the central nervous system. Therefore, it is important to develop methods to enhance the permeability of the BBB. We have developed echo-contrast gas (C3F8) entrapping liposomes (Bubble...

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Bibliographic Details
Main Authors: Negishi, Yoichi, Yamane, Masaya, Kurihara, Naho, Endo-Takahashi, Yoko, Sashida, Sanae, Takagi, Norio, Suzuki, Ryo, Maruyama, Kazuo
Format: Online
Language:English
Published: MDPI 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588205/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588205/

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