The unfolded protein response in neurodegenerative diseases: a neuropathological perspective
The unfolded protein response (UPR) is a stress response of the endoplasmic reticulum (ER) to a disturbance in protein folding. The so-called ER stress sensors PERK, IRE1 and ATF6 play a central role in the initiation and regulation of the UPR. The accumulation of misfolded and aggregated proteins i...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Springer Berlin Heidelberg
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541706/ |