Identification of the Conformational transition pathway in PIP2 Opening Kir Channels

Identification of the Conformational transition pathway in PIP2 Opening Kir Channels

The gating of Kir channels depends critically on phosphatidylinositol 4,5-bisphosphate (PIP2), but the detailed mechanism by which PIP2 regulates Kir channels remains obscure. Here, we performed a series of Targeted molecular dynamics simulations on the full-length Kir2.1 channel and, for the first...

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Bibliographic Details
Main Authors: Li, Junwei, Lü, Shouqin, Liu, Yuzhi, Pang, Chunli, Chen, Yafei, Zhang, Suhua, Yu, Hui, Long, Mian, Zhang, Hailin, Logothetis, Diomedes E., Zhan, Yong, An, Hailong
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462750/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462750/

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