Shenfu Injection for Intradialytic Hypotension: A Systematic Review and Meta-Analysis

Objective. To evaluate the effectiveness and safety of Shenfu injection (SFI) for intradialytic hypotension (IDH). Methods. A systematic review of data sources published as of April 2014 was conducted. These included the Cochrane Central Register of Controlled Trials (2014 issue 4), Pubmed, Embase,...

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Main Authors:	Mo, Yenan, Liu, Xusheng, Qin, Xindong, Huang, Jing, He, Zhiren, Lin, Junjie, Hu, Qinqing, Cai, Youqing, Liu, Zhuangzhu, Wang, Lixin
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284991/

id	pubmed-4284991
recordtype	oai_dc
spelling	pubmed-42849912015-01-13 Shenfu Injection for Intradialytic Hypotension: A Systematic Review and Meta-Analysis Mo, Yenan Liu, Xusheng Qin, Xindong Huang, Jing He, Zhiren Lin, Junjie Hu, Qinqing Cai, Youqing Liu, Zhuangzhu Wang, Lixin Review Article Objective. To evaluate the effectiveness and safety of Shenfu injection (SFI) for intradialytic hypotension (IDH). Methods. A systematic review of data sources published as of April 2014 was conducted. These included the Cochrane Central Register of Controlled Trials (2014 issue 4), Pubmed, Embase, CBM, CNKI, VIP, and Wangfang Data. Randomized controlled trials (RCTs) involving SFI for treatment and prevention of IDH were identified. Two researchers independently selected articles, extracted data, assessed quality, and cross checked the results. Revman 5.2 was used to analyze the results. Results. Eight RCTs were included. The meta-analysis indicated that compared with conventional therapies alone, SFI could elevate systolic blood pressure (SBP), increase the clinical effective rate, decrease the incidence of hypotension, increase serum albumin (ALB) levels, and reduce C-reactive protein (CRP) levels without serious adverse effects. GRADE Quality of Evidence. the quality of SBP, the effective rate, ALB, and CRP were low, and hypotension incidence and DBP were very low. Conclusions. SFI is more effective than conventional therapies for prevention and treatment of IDH. However, a clinical recommendation is not warranted due to the small number of studies included and low methodology quality. Multi-center and high-quality RCTs with large sample sizes are needed to provide stronger evidence. Hindawi Publishing Corporation 2014 2014-12-22 /pmc/articles/PMC4284991/ /pubmed/25587340 http://dx.doi.org/10.1155/2014/279853 Text en Copyright © 2014 Yenan Mo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Mo, Yenan Liu, Xusheng Qin, Xindong Huang, Jing He, Zhiren Lin, Junjie Hu, Qinqing Cai, Youqing Liu, Zhuangzhu Wang, Lixin
spellingShingle	Mo, Yenan Liu, Xusheng Qin, Xindong Huang, Jing He, Zhiren Lin, Junjie Hu, Qinqing Cai, Youqing Liu, Zhuangzhu Wang, Lixin Shenfu Injection for Intradialytic Hypotension: A Systematic Review and Meta-Analysis
author_facet	Mo, Yenan Liu, Xusheng Qin, Xindong Huang, Jing He, Zhiren Lin, Junjie Hu, Qinqing Cai, Youqing Liu, Zhuangzhu Wang, Lixin
author_sort	Mo, Yenan
title	Shenfu Injection for Intradialytic Hypotension: A Systematic Review and Meta-Analysis
title_short	Shenfu Injection for Intradialytic Hypotension: A Systematic Review and Meta-Analysis
title_full	Shenfu Injection for Intradialytic Hypotension: A Systematic Review and Meta-Analysis
title_fullStr	Shenfu Injection for Intradialytic Hypotension: A Systematic Review and Meta-Analysis
title_full_unstemmed	Shenfu Injection for Intradialytic Hypotension: A Systematic Review and Meta-Analysis
title_sort	shenfu injection for intradialytic hypotension: a systematic review and meta-analysis
description	Objective. To evaluate the effectiveness and safety of Shenfu injection (SFI) for intradialytic hypotension (IDH). Methods. A systematic review of data sources published as of April 2014 was conducted. These included the Cochrane Central Register of Controlled Trials (2014 issue 4), Pubmed, Embase, CBM, CNKI, VIP, and Wangfang Data. Randomized controlled trials (RCTs) involving SFI for treatment and prevention of IDH were identified. Two researchers independently selected articles, extracted data, assessed quality, and cross checked the results. Revman 5.2 was used to analyze the results. Results. Eight RCTs were included. The meta-analysis indicated that compared with conventional therapies alone, SFI could elevate systolic blood pressure (SBP), increase the clinical effective rate, decrease the incidence of hypotension, increase serum albumin (ALB) levels, and reduce C-reactive protein (CRP) levels without serious adverse effects. GRADE Quality of Evidence. the quality of SBP, the effective rate, ALB, and CRP were low, and hypotension incidence and DBP were very low. Conclusions. SFI is more effective than conventional therapies for prevention and treatment of IDH. However, a clinical recommendation is not warranted due to the small number of studies included and low methodology quality. Multi-center and high-quality RCTs with large sample sizes are needed to provide stronger evidence.
publisher	Hindawi Publishing Corporation
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284991/
_version_	1613173613932838912

Shenfu Injection for Intradialytic Hypotension: A Systematic Review and Meta-Analysis

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