Inorganic Janus particles for biomedical applications

Based on recent developments regarding the synthesis and design of Janus nanoparticles, they have attracted increased scientific interest due to their outstanding properties. There are several combinations of multicomponent hetero-nanostructures including either purely organic or inorganic, as well...

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Main Authors:	Schick, Isabel, Lorenz, Steffen, Gehrig, Dominik, Tenzer, Stefan, Storck, Wiebke, Fischer, Karl, Strand, Dennis, Laquai, Frédéric, Tremel, Wolfgang
Format:	Online
Language:	English
Published:	Beilstein-Institut 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273258/

id	pubmed-4273258
recordtype	oai_dc
spelling	pubmed-42732582014-12-30 Inorganic Janus particles for biomedical applications Schick, Isabel Lorenz, Steffen Gehrig, Dominik Tenzer, Stefan Storck, Wiebke Fischer, Karl Strand, Dennis Laquai, Frédéric Tremel, Wolfgang Review Based on recent developments regarding the synthesis and design of Janus nanoparticles, they have attracted increased scientific interest due to their outstanding properties. There are several combinations of multicomponent hetero-nanostructures including either purely organic or inorganic, as well as composite organic–inorganic compounds. Janus particles are interconnected by solid state interfaces and, therefore, are distinguished by two physically or chemically distinct surfaces. They may be, for instance, hydrophilic on one side and hydrophobic on the other, thus, creating giant amphiphiles revealing the endeavor of self-assembly. Novel optical, electronic, magnetic, and superficial properties emerge in inorganic Janus particles from their dimensions and unique morphology at the nanoscale. As a result, inorganic Janus nanoparticles are highly versatile nanomaterials with great potential in different scientific and technological fields. In this paper, we highlight some advances in the synthesis of inorganic Janus nanoparticles, focusing on the heterogeneous nucleation technique and characteristics of the resulting high quality nanoparticles. The properties emphasized in this review range from the monodispersity and size-tunability and, therefore, precise control over size-dependent features, to the biomedical application as theranostic agents. Hence, we show their optical properties based on plasmonic resonance, the two-photon activity, the magnetic properties, as well as their biocompatibility and interaction with human blood serum. Beilstein-Institut 2014-12-05 /pmc/articles/PMC4273258/ /pubmed/25551063 http://dx.doi.org/10.3762/bjnano.5.244 Text en Copyright © 2014, Schick et al; licensee Beilstein-Institut. http://www.beilstein-journals.org/bjnano This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Nanotechnology terms and conditions: (http://www.beilstein-journals.org/bjnano)
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Schick, Isabel Lorenz, Steffen Gehrig, Dominik Tenzer, Stefan Storck, Wiebke Fischer, Karl Strand, Dennis Laquai, Frédéric Tremel, Wolfgang
spellingShingle	Schick, Isabel Lorenz, Steffen Gehrig, Dominik Tenzer, Stefan Storck, Wiebke Fischer, Karl Strand, Dennis Laquai, Frédéric Tremel, Wolfgang Inorganic Janus particles for biomedical applications
author_facet	Schick, Isabel Lorenz, Steffen Gehrig, Dominik Tenzer, Stefan Storck, Wiebke Fischer, Karl Strand, Dennis Laquai, Frédéric Tremel, Wolfgang
author_sort	Schick, Isabel
title	Inorganic Janus particles for biomedical applications
title_short	Inorganic Janus particles for biomedical applications
title_full	Inorganic Janus particles for biomedical applications
title_fullStr	Inorganic Janus particles for biomedical applications
title_full_unstemmed	Inorganic Janus particles for biomedical applications
title_sort	inorganic janus particles for biomedical applications
description	Based on recent developments regarding the synthesis and design of Janus nanoparticles, they have attracted increased scientific interest due to their outstanding properties. There are several combinations of multicomponent hetero-nanostructures including either purely organic or inorganic, as well as composite organic–inorganic compounds. Janus particles are interconnected by solid state interfaces and, therefore, are distinguished by two physically or chemically distinct surfaces. They may be, for instance, hydrophilic on one side and hydrophobic on the other, thus, creating giant amphiphiles revealing the endeavor of self-assembly. Novel optical, electronic, magnetic, and superficial properties emerge in inorganic Janus particles from their dimensions and unique morphology at the nanoscale. As a result, inorganic Janus nanoparticles are highly versatile nanomaterials with great potential in different scientific and technological fields. In this paper, we highlight some advances in the synthesis of inorganic Janus nanoparticles, focusing on the heterogeneous nucleation technique and characteristics of the resulting high quality nanoparticles. The properties emphasized in this review range from the monodispersity and size-tunability and, therefore, precise control over size-dependent features, to the biomedical application as theranostic agents. Hence, we show their optical properties based on plasmonic resonance, the two-photon activity, the magnetic properties, as well as their biocompatibility and interaction with human blood serum.
publisher	Beilstein-Institut
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273258/
_version_	1613169566485053440

Inorganic Janus particles for biomedical applications

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