Registered report: Widespread potential for growth factor-driven resistance to anticancer kinase inhibitors

The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012. This Registered Report describes the proposed replication plan of key exp...

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Main Authors:	Greenfield, Edward, Griner, Erin, Iorns, Elizabeth, Gunn, William, Tan, Fraser, Lomax, Joelle, Errington, Timothy
Format:	Online
Language:	English
Published:	eLife Sciences Publications, Ltd 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270159/

id	pubmed-4270159
recordtype	oai_dc
spelling	pubmed-42701592015-01-29 Registered report: Widespread potential for growth factor-driven resistance to anticancer kinase inhibitors Greenfield, Edward Griner, Erin Iorns, Elizabeth Gunn, William Tan, Fraser Lomax, Joelle Errington, Timothy Biochemistry The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012. This Registered Report describes the proposed replication plan of key experiments from ‘Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors’ by Wilson and colleagues, published in Nature in 2012 (Wilson et al., 2012). The experiments that will be replicated are those reported in Figure 2B and C. In these experiments, Wilson and colleagues show that sensitivity to receptor tyrosine kinase (RTK) inhibitors can be bypassed by various ligands through reactivation of downstream signaling pathways (Figure 2A; Wilson et al., 2012), and that blocking the receptors for these bypassing ligands abrogates their ability to block sensitivity to the original RTK inhibitor (Figure 2C; Wilson et al., 2012). The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange, and the results of the replications will be published by eLife. eLife Sciences Publications, Ltd 2014-12-10 /pmc/articles/PMC4270159/ /pubmed/25490934 http://dx.doi.org/10.7554/eLife.04037 Text en Copyright © 2014, Greenfield et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Greenfield, Edward Griner, Erin Iorns, Elizabeth Gunn, William Tan, Fraser Lomax, Joelle Errington, Timothy
spellingShingle	Greenfield, Edward Griner, Erin Iorns, Elizabeth Gunn, William Tan, Fraser Lomax, Joelle Errington, Timothy Registered report: Widespread potential for growth factor-driven resistance to anticancer kinase inhibitors
author_facet	Greenfield, Edward Griner, Erin Iorns, Elizabeth Gunn, William Tan, Fraser Lomax, Joelle Errington, Timothy
author_sort	Greenfield, Edward
title	Registered report: Widespread potential for growth factor-driven resistance to anticancer kinase inhibitors
title_short	Registered report: Widespread potential for growth factor-driven resistance to anticancer kinase inhibitors
title_full	Registered report: Widespread potential for growth factor-driven resistance to anticancer kinase inhibitors
title_fullStr	Registered report: Widespread potential for growth factor-driven resistance to anticancer kinase inhibitors
title_full_unstemmed	Registered report: Widespread potential for growth factor-driven resistance to anticancer kinase inhibitors
title_sort	registered report: widespread potential for growth factor-driven resistance to anticancer kinase inhibitors
description	The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012. This Registered Report describes the proposed replication plan of key experiments from ‘Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors’ by Wilson and colleagues, published in Nature in 2012 (Wilson et al., 2012). The experiments that will be replicated are those reported in Figure 2B and C. In these experiments, Wilson and colleagues show that sensitivity to receptor tyrosine kinase (RTK) inhibitors can be bypassed by various ligands through reactivation of downstream signaling pathways (Figure 2A; Wilson et al., 2012), and that blocking the receptors for these bypassing ligands abrogates their ability to block sensitivity to the original RTK inhibitor (Figure 2C; Wilson et al., 2012). The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange, and the results of the replications will be published by eLife.
publisher	eLife Sciences Publications, Ltd
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270159/
_version_	1613168673758904320

Registered report: Widespread potential for growth factor-driven resistance to anticancer kinase inhibitors

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